Protein Alignment dnc and pde1b

DIOPT Version :10

• Sequence 1: NP_726846.1
• Gene: dnc / 31309
• FlyBaseID: FBgn0000479
• Length: 1209
• Species: Drosophila melanogaster
• Sequence 2: XP_017946519.1
• Gene: pde1b / 100036722
• XenbaseID: XB-GENE-987197
• Length: 554
• Species: Xenopus tropicalis
• Alignment Length: 539
• Identity: 154/539 - (28%)
• Similarity: 252/539 - (46%)
• Gaps: 83/539 - (15%)

  Fly   670 LDWCLDQLET-----IQTHRSVSDMASL-------KFKRML--NKELSHFSESSRSGNQISEYIC 720
            |.:.:.|||.     ::..:::...|||       :.:::|  :.||... .|....:::.:::.
 Frog    57 LKYMVKQLENGEVNIVELKKNLEYTASLLEAVYIDETRQILDTDDELPEM-RSDSVPSEVRDWLA 120

  Fly   721 STFLDKQQEFDLPSLRVEDNPEL--VAANAAAGQQSAGQYARSRSPRGPPMSQISGVKRPLSHTN 783
            |||   .|:......|.|:.|..  :.....||......:.||.:..||..|  :.|...|.|
 Frog   121 STF---TQQTRSTGRRSEEKPRFRSIVHAVQAGIFVERMFRRSYTAVGPNYS--AAVVNSLKH-- 178

  Fly   784 SFTGERLPTFGVETPRENELGTLLGELDTWGIQIFSIGEFSVNRPLTCVAYTIFQSRELLTSLMI 848
                                      ||.|...:|.:...|.:..|..:.:.:.....|.:...|
 Frog   179 --------------------------LDLWDFDVFVLNRVSEDHALKTIVFELLSRHNLNSRFKI 217

  Fly   849 PPKTFLNFMSTLEDHYVK-DNPFHNSLHAADVTQSTNVLLNTPALEGVFTPLEVGGALFAACIHD 912
            |....::|:.:||..|.| .||:||.:|||||||:.:..|....:......:|:...:|||.|||
 Frog   218 PVAFLMSFLDSLESGYGKYKNPYHNQIHAADVTQTVHCFLLRTGMVHCLNEIEILAIIFAAAIHD 282

  Fly   913 VDHPGLTNQFLVNSSSELALMYNDESVLENHHLAVAFKLLQNQGCDIFCNMQKKQRQTLRKMVID 977
            .:|.|.||.|.:.:.|:.|::|||.|||||||::..::::|:...:||.|:.|.:...||.:||:
 Frog   283 FEHTGTTNSFHIQTKSDCAILYNDRSVLENHHVSAVYRIMQDDEMNIFVNLTKDEFTELRSLVIE 347

  Fly   978 IVLSTDMSKHMSLLADLKTMVETKKVAGSGVLLLDNYTDRIQVLENLVHCADLSNPTKPLPLYKR 1042
            :||:||||.|...:..:||.::..:.           .|:.:.|..|:|.||:|:|||...::.|
 Frog   348 MVLATDMSCHFQQVKTMKTSLQQLET-----------IDKSKALSLLLHAADISHPTKQWKVHAR 401

  Fly  1043 WVALLMEEFFLQGDKERESGMDISPMCDRHNATIEKSQVGFIDYIVHPLWETWADLVHPDAQDIL 1107
            |...||||||.|||||.|.|:..||:|||.:..:.:||:|||::||.|.:....|:    |:..:
 Frog   402 WTKALMEEFFRQGDKEAEMGLPFSPLCDRKSTLVAQSQIGFIEFIVDPTFSVLTDV----AEKTV 462

  Fly  1108 DTLEENRDYYQSMIPPSPPPS-----GVDENPQEDRIR-----FQVTLEESDQENLAELEEGDES 1162
            ..|.|.|...:|....:...|     .:|::.:...|.     |:.|..:..|||       .:.
 Frog   463 LPLVEERSKSKSTASVNQSSSQWRQPSIDDHSEMGDINADIKSFRTTWTKYIQEN-------KQK 520

  Fly  1163 GGESTTTGTTGTTAASALS 1181
            ..|...:|.|..|:...||
 Frog   521 WKERAASGITNQTSVDELS 539

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dnc	NP_726846.1	PDE4_UCR	603..725	CDD:465648	14/68 (21%)
		PDEase_I	870..1110	CDD:459723	92/239 (38%)
pde1b	XP_017946519.1	PDEase_I_N	95..155	CDD:462497	13/63 (21%)
		PDEase_I	240..467	CDD:459723	93/241 (39%)