Protein Alignment CG10793 and FIGNL1

DIOPT Version :10

• Sequence 1: NP_570054.2
• Gene: CG10793 / 31308
• FlyBaseID: FBgn0288967
• Length: 479
• Species: Drosophila melanogaster
• Sequence 2: NP_071399.2
• Gene: FIGNL1 / 63979
• HGNCID: 13286
• Length: 674
• Species: Homo sapiens
• Alignment Length: 428
• Identity: 141/428 - (32%)
• Similarity: 204/428 - (47%)
• Gaps: 69/428 - (16%)

  Fly    91 ILKKVGAKIKVEMGGGKAHEKTPAKELPKKPPTTDASLANWHIGVGAATQALSNEQPLQIKKMET 155
            ||.|  |..|.|..|.|.....|..:..|:....|.. ..:|     ..|..|......:||...
Human   273 ILNK--ACSKTEDNGPKEDSSLPTFKTAKEQLWVDQQ-KKYH-----QPQRASGSSYGGVKKSLG 329

  Fly   156 ATESNG-----------QDNACEIEHVHLGGD---------------------DVLFSSLEWQSL 188
            |:.|.|           ||          ||:                     |....:|| ..:
Human   330 ASRSRGILGKFVPPIPKQD----------GGEQNGGMQCKPYGAGPTEPAHPVDERLKNLE-PKM 383

  Fly   189 AELVKTSILQENIKIKWSDVCGNQRAIELIKEAVLTPIEFPQLFAHGLK-PWRSLLLHGPPGSGK 252
            .||:...|:.....:.|.|:.|.:.|...|||.|:.|:..|.:|. ||: |.:.:||.||||:||
Human   384 IELIMNEIMDHGPPVNWEDIAGVEFAKATIKEIVVWPMLRPDIFT-GLRGPPKGILLFGPPGTGK 447

  Fly   253 TLLAKALYSETQGQVTFFNITASIMVSKWRGESEKILRVLFHMAAKRAPSVIFFDEIESLTSKRD 317
            ||:.|.:.|  |...|||:|:||.:.|||.||.||::|.||.:|..:.|:|||.|||:||.|:|.
Human   448 TLIGKCIAS--QSGATFFSISASSLTSKWVGEGEKMVRALFAVARCQQPAVIFIDEIDSLLSQRG 510

  Fly   318 RATDHESSKRFKNELLQLLDG-MEHSLNGVFVLASTNLPWDIDEAFLRRFEKKLLVQLPNA-AER 380
            .. :||||:|.|.|.|..||| ...|.:.:.|:.:||.|.:||||..||..|:|.:.||.| |.:
Human   511 DG-EHESSRRIKTEFLVQLDGATTSSEDRILVVGATNRPQEIDEAARRRLVKRLYIPLPEASARK 574

  Fly   381 SCLINRLLGSSISLNPRLLEQLVEISDHFTGDEIRLACKEISMHRVRCATKIGDRSIGLLAKESP 445
            ..:||.:......|:...:||:|:.||.|:|.::...|:|.|:..:| :.:..|     :|..:|
Human   575 QIVINLMSKEQCCLSEEEIEQIVQQSDAFSGADMTQLCREASLGPIR-SLQTAD-----IATITP 633

  Fly   446 AAIE----ANVEKAFRQVRP-LGQKLLAKHEQWQQENG 478
            ..:.    .:.|.|||.||| :..|.|..:|.|.:..|
Human   634 DQVRPIAYIDFENAFRTVRPSVSPKDLELYENWNKTFG 671

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10793	NP_570054.2	LisH	31..55	CDD:462501
		RecA-like_VPS4-like	208..372	CDD:410917	77/165 (47%)
FIGNL1	NP_071399.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	157..179
		Necessary and sufficient for interaction with RAD51. /evidence=ECO:0000305|PubMed:23754376	295..344		10/54 (19%)
		RecA-like_Figl-1	380..565	CDD:410933	83/189 (44%)
		AAA_lid_3	590..>621	CDD:465537	10/30 (33%)
		Vps4_C	<631..671	CDD:462762	12/39 (31%)