DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment N and DNER

DIOPT Version :9

Sequence 1:NP_001245510.1 Gene:N / 31293 FlyBaseID:FBgn0004647 Length:2703 Species:Drosophila melanogaster
Sequence 2:NP_620711.3 Gene:DNER / 92737 HGNCID:24456 Length:737 Species:Homo sapiens


Alignment Length:615 Identity:193/615 - (31%)
Similarity:273/615 - (44%) Gaps:91/615 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly   181 CASSPCRNGATCT----------ALAGSSSFTCSCPPGFTGDTCSYDIEECQSNPCKYGGTCVNT 235
            ||:.|||||..||          |.||...::|:||.|.:|..|....:.|.||||.: |.|.::
Human    48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHH-GNCSSS 111

  Fly   236 HGS----YQCMCPTGYTGKDCDTKYKPCSPSPCQNGGICRSNGLSYECKCPKGFEGKNCEQNYDD 296
            ..|    |.|:|..||.|.:|: :..|..|          :.|.: |...|:..:.....|..|.
Human   112 SSSSSDGYLCICNEGYEGPNCE
-QALPSLP----------ATGWT-ESMAPRQLQPVPATQEPDK 164

  Fly   297 CLGHLCQNGGTCIDGISDYTCRCP---PNFTGRFCQDDVDECAQRDHPVCQNGATCTNTHGSYSC 358
            .|..            |..|...|   |....:..:...|:........|.|.::.::..|..  
Human   165 ILPR------------SQATVTLPTWQPKTGQKVVEMKWDQVEVIPDIACGNASSNSSAGGRL-- 215

  Fly   359 ICVNGWAGLDCSNNTD-DCKQ-------------AACFYGATCIDGVGSFYCQCTKGKTGLLCHL 409
                  ...:...||. ..:|             |..|...:.|||......|.:.|    |..|
Human   216 ------VSFEVPQNTSVKIRQDATASLILLWKVTATGFQQCSLIDGRSVTPLQASGG----LVLL 270

  Fly   410 DDACTSNPCHADAICDTSPINGSYA------CSCATGYKGVDCSEDIDECDQGSPCEHNGICVNT 468
            ::.......|.....:.|......|      ...:|...|...:.|::       |...|.|...
Human   271 EEMLALGNNHFIGFVNDSVTKSIVALRLTLVVKVSTCVPGESHANDLE-------CSGKGKCTTK 328

  Fly   469 P--GSYRCNCSQGFTGPRCETNINECESHPCQNEGSCLD-----DPGTFRCVCMPGFTGTQCEID 526
            |  .::.|.|.:.:.|..|| ..:.|:..||||..||:|     |...|.|||:||:||..|:..
Human   329 PSEATFSCTCEEQYVGTFCE-EYDACQRKPCQNNASCIDANEKQDGSNFTCVCLPGYTGELCQSK 392

  Fly   527 IDECQSNPCLNDGTCHDKINGFKCSCALGFTGARCQINIDDCQSQPCRNRGICHDSIAGYSCECP 591
            ||.|..:||.|..||...::||.|.|..|:.|:.|:..:|.|.|.||:|.|.|:.....::|.|.
Human   393 IDYCILDPCRNGATCISSLSGFTCQCPEGYFGSACEEKVDPCASSPCQNNGTCYVDGVHFTCNCS 457

  Fly   592 PGYTGTSCEININDCDSNPCHRGKCIDDVNSFKCLCDPGYTGYICQKQINECESNPCQFDGHCQD 656
            ||:||.:|...|:.|..:||..|.|.....|:||||||||.|..|:::.|||.|.||.....|:|
Human   458 PGFTGPTCAQLIDFCALSPCAHGTCRSVGTSYKCLCDPGYHGLYCEEEYNECLSAPCLNAATCRD 522

  Fly   657 RVGSYYCQCQAGTSGKNCEVNVNECHSNPCNNGATC-IDGINSYKCQCVPGFTGQHCEKNVDECI 720
            .|..|.|.|.|...|.:||:..:.|.:..|.||||| .||:|. .|.|.|||||:.|:.:::||.
Human   523 LVNGYECVCLAEYKGTHCELYKDPCANVSCLNGATCDSDGLNG-TCICAPGFTGEECDIDINECD 586

  Fly   721 SSPCANNGVCIDQVNGYKCECPRGFYDAHC 750
            |:||.:.|.|:||.|||.|.||.|:..|:|
Human   587 SNPCHHGGSCLDQPNGYNCHCPHGWVGANC 616

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NNP_001245510.1 EGF_CA 179..214 CDD:238011 17/42 (40%)
EGF_CA 217..252 CDD:238011 14/38 (37%)
EGF_CA 260..291 CDD:238011 4/30 (13%)
EGF_CA 295..329 CDD:238011 6/36 (17%)
EGF_CA 331..369 CDD:238011 4/37 (11%)
EGF_CA 449..486 CDD:238011 8/38 (21%)
EGF_CA 488..524 CDD:238011 17/40 (43%)
EGF_CA 526..562 CDD:238011 14/35 (40%)
EGF_CA 564..600 CDD:238011 14/35 (40%)
EGF_CA 602..637 CDD:238011 16/34 (47%)
EGF_CA 640..675 CDD:238011 14/34 (41%)
EGF_CA 677..713 CDD:238011 17/36 (47%)
EGF_CA 715..750 CDD:238011 17/34 (50%)
EGF_CA 753..789 CDD:238011
EGF_CA 791..827 CDD:238011
EGF_CA 829..865 CDD:238011
EGF_CA 907..943 CDD:238011
EGF_CA 946..982 CDD:238011
EGF_CA 984..1020 CDD:238011
EGF_CA 1027..1058 CDD:238011
EGF_CA 1062..1095 CDD:238011
EGF_CA 1184..1219 CDD:238011
EGF_CA 1221..1257 CDD:238011
EGF_CA 1259..1295 CDD:238011
EGF_CA 1297..1335 CDD:238011
EGF_CA 1417..1450 CDD:238011
NL 1476..1512 CDD:197463
Notch 1519..1553 CDD:278494
Notch 1565..1593 CDD:278494
NOD 1599..1648 CDD:284282
NODP 1680..1731 CDD:284987
ANK 1896..2038 CDD:238125
ANK repeat 1902..1948 CDD:293786
ANK repeat 1951..1981 CDD:293786
Ank_5 1970..2025 CDD:290568
ANK 1978..2104 CDD:238125
ANK repeat 1984..2015 CDD:293786
ANK repeat 2017..2048 CDD:293786
Ank_2 2022..2114 CDD:289560
ANK repeat 2050..2081 CDD:293786
ANK repeat 2083..2114 CDD:293786
DUF3454 2627..2682 CDD:288764
DNERNP_620711.3 Interaction with NOTCH1. /evidence=ECO:0000250 44..133 32/85 (38%)
EGF_CA 393..428 CDD:238011 14/34 (41%)
EGF_CA 431..465 CDD:238011 14/33 (42%)
EGF_CA 469..503 CDD:238011 16/33 (48%)
EGF_CA 507..541 CDD:238011 14/33 (42%)
EGF_CA 581..617 CDD:238011 18/36 (50%)
Interaction with AP1G1 and somatodendritic targeting. /evidence=ECO:0000250 677..680
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D7525at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.920

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