DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment N and FBN3

DIOPT Version :9

Sequence 1:NP_001245510.1 Gene:N / 31293 FlyBaseID:FBgn0004647 Length:2703 Species:Drosophila melanogaster
Sequence 2:XP_016882868.1 Gene:FBN3 / 84467 HGNCID:18794 Length:2851 Species:Homo sapiens


Alignment Length:2516 Identity:598/2516 - (23%)
Similarity:825/2516 - (32%) Gaps:1085/2516 - (43%)


- Green bases have known domain annotations that are detailed below.


  Fly    43 FANLPNTVRGTDTALVAASC-------TSVGCQNGGTCVTQLNGKTYCACDSHYVGDYCEHRNPC 100
            |.:.||.....|..| |.||       .||.|.|||||    .|.: |.|...|.|..|  ..|.
Human    94 FCSQPNLCTCADGTL-APSCGVSRGSGCSVSCMNGGTC----RGAS-CLCQKGYTGTVC--GQPI 150

  Fly   101 NSMRCQNGG-----------------TCQVTFRNGRP---------------------------- 120
            ....|.|||                 .|:..:|.| |                            
Human   151 CDRGCHNGGRCIGPNRCACVYGFMGPQCERDYRTG-PCFGQVGPEGCQHQLTGLVCTKALCCATV 214

  Fly   121 ----GISCK-CPL-------GF----------DESLCEIAVPNACDHVTCLN------------- 150
                |:.|: ||.       ||          |...|: |||..|...:|:|             
Human   215 GRAWGLPCELCPAQPHPCRRGFIPNIHTGACQDVDECQ-AVPGLCQGGSCVNMVGSFHCRCPVGH 278

  Fly   151 -----------------------GGTCQLKTLEEYTCACANGYT--------------------- 171
                                   ||.| ..|:..|.|.|:.|:.                     
Human   279 RLSDSSAACEDVNECLSLSGLCSGGDC-TNTVGSYVCTCSQGFASSLDGTHCLNYRAGACFSVLF 342

  Fly   172 GERC------------------------------------ETKNLCAS----------------- 183
            |.||                                    |.:.|||.                 
Human   343 GGRCAGDLAGHYTRRQCCCDRGRCWAAGPVPELCPPRGSNEFQQLCAQRLPLLPGHPGLFPGLLG 407

  Fly   184 ----------SPCR-------------------NGATCT-------------------ALAGSSS 200
                      .|.|                   |..|.|                   .|...||
Human   408 FGSNGMGPPLGPARLNPHGSDARGIPSLGPGNSNIGTATLNQTIDICRHFTNLCLNGRCLPTPSS 472

  Fly   201 FTCSCPPGFTGDT---CSYDIEECQSNPCKYGGTCVNTHGSYQCMCPTGY----TGKDCDTKYKP 258
            :.|.|..|:|.|.   | .|::||.|:||.: |.|||..|:|.|.|..|:    |.:.| .....
Human   473 YRCECNVGYTQDVRGEC-IDVDECTSSPCHH-GDCVNIPGTYHCRCYPGFQATPTRQAC-VDVDE 534

  Fly   259 CSPSPCQNGGIC------RSNGLSYECKCPKGFE----GKNCEQNYDDCLGHLCQNGGTCIDGIS 313
            |..|    ||:|      .:.| |::|.|..|||    ||||..:.:.....:|.| |.|::...
Human   535 CIVS----GGLCHLGRCVNTEG-SFQCVCNAGFELSPDGKNCVDHNECATSTMCVN-GVCLNEDG 593

  Fly   314 DYTCRCPPNFT----GRFCQDDVDECAQRDHPVCQNGATCTNTHGSYSCICVNGWA-GLD----- 368
            .::|.|.|.|.    |.:|. |:|||  :...:|.|| .||||.||:.|.|:.|.| |.|     
Human   594 SFSCLCKPGFLLAPGGHYCM-DIDEC--QTPGICVNG-HCTNTEGSFRCQCLGGLAVGTDGRVCV 654

  Fly   369 ------------------------------CSNNTD-----DCK----------QAACFYG---- 384
                                          |..|.|     .|:          ||.|..|    
Human   655 DTHVRSTCYGAIEKGSCARPFPGTVTKSECCCANPDHGFGEPCQLCPAKDSAEFQALCSSGLGIT 719

  Fly   385 -------------ATCIDGV-----GSFYCQCT----KGKTGLLCHLDDACTSNPCHAD-AICDT 426
                         ..|.:||     ||:.|.|.    .|.:|..|...|.|..|....| ..|..
Human   720 TDGRDINECALDPEVCANGVCENLRGSYRCVCNLGYEAGASGKDCTDVDECALNSLLCDNGWCQN 784

  Fly   427 SPINGSYACSCATGY---KGVDCSEDIDECDQGSPCEHNGICVNTPGSYRCNCSQG--------- 479
            ||  |||:|||..|:   :..:..:|:||| ..|||. :|:|.|..|||.|.|..|         
Human   785 SP--GSYSCSCPPGFHFWQDTEICKDVDEC-LSSPCV-SGVCRNLAGSYTCKCGPGSRLDPSGTF 845

  Fly   480 ------------FTGPRCETN-------------------------------------------- 488
                        ....|||.|                                            
Human   846 CLDSTKGTCWLKIQESRCEVNLQGASLRSECCATLGAAWGSPCERCEIDPACARGFARMTGVTCD 910

  Fly   489 -INECESHP--CQNEGSCLDDPGTFRCVC---------------------------------MPG 517
             :|||||.|  |.| |.|::..|:|||.|                                 :||
Human   911 DVNECESFPGVCPN-GRCVNTAGSFRCECPEGLMLDASGRLCVDVRLEPCFLRWDEDECGVTLPG 974

  Fly   518 -------------FTGTQCEI--------------------------------DIDECQSNPCL- 536
                         ..|.:||.                                |::||:..|.| 
Human   975 KYRMDVCCCSIGAVWGVECEACPDPESLEFASLCPRGLGFASRDFLSGRPFYKDVNECKVFPGLC 1039

  Fly   537 NDGTCHDKINGFKCSCALGF---TGARCQINIDDCQSQP--CRNRGICHDSIAGYSCECPPGYTG 596
            ..|||.:.:..|.|:||.||   ...|...:||:|:..|  | .:|.|.::...:.|||.|||..
Human  1040 THGTCRNTVGSFHCACAGGFALDAQERNCTDIDECRISPDLC-GQGTCVNTPGSFECECFPGYES 1103

  Fly   597 -----TSCEININDCDSNP--CHRGKCIDDVNSFKCLCDPGY----TGYICQKQINECESNP--C 648
                 .:| :::::|..:|  |..|.|.:...|:||.|.||:    .|..|: .|:||..:.  |
Human  1104 GFMLMKNC-MDVDECARDPLLCRGGTCTNTDGSYKCQCPPGHELTAKGTACE-DIDECSLSDGLC 1166

  Fly   649 QFDGHCQDRVGSYYCQCQAG---TSGKNCEVNVNECHSNPCNNGAT--CIDGINSYKCQCVPGFT 708
            . .|.|.:.:|::.|.|.||   |..:...|::|||...  |.|..  ||:...||:|.|..|::
Human  1167 P-HGQCVNVIGAFQCSCHAGFQSTPDRQGCVDINECRVQ--NGGCDVHCINTEGSYRCSCGQGYS 1228

  Fly   709 ----GQHCEKNVDECISSP-CANNGVCIDQVNGYKCECPRGFY---DAHCLSDVDECASNP--CV 763
                |:.| .:||||..:| ..:.|.|.:...|::|.|..||.   |.....|||||..||  |:
Human  1229 LMPDGRAC-ADVDECEENPRVCDQGHCTNMPGGHRCLCYDGFMATPDMRTCVDVDECDLNPHICL 1292

  Fly   764 NEGRCEDGINEFICHCPPGYTGKR----CELDIDEC--SSNPCQHGGTCYDKLNAFSCQCMPGYT 822
            : |.||:....|:|||..||..::    |. |:|||  ..:.|....:|.:...:|||:|:||:.
Human  1293 H-GDCENTKGSFVCHCQLGYMVRKGATGCS-DVDECEVGGHNCDSHASCLNIPGSFSCRCLPGWV 1355

  Fly   823 GQKCET-NIDDCVT--NPCGNGGTCIDKVNGYKCVCKVPFTG-------RD-CESKMDPCASNRC 876
            |...|. ::|:||:  :.|...|.|::....|:|.|:..|.|       || |...:|.|.:.:|
Human  1356 GDGFECHDLDECVSQEHRCSPRGDCLNVPGSYRCTCRQGFAGDGFFCEDRDECAENVDLCDNGQC 1420

  Fly   877 KNEAKCTPSSNFLDFSCTCKLGY----TGRYCDEDIDECSLSSPCRNGASCLNVPGSYRCLCTKG 937
            .|    .|..    :.|.|::|:    ..|.| :|:|||:..:.|..| ||.|:||.:||:|..|
Human  1421 LN----APGG----YRCECEMGFDPTEDHRAC-QDVDECAQGNLCAFG-SCENLPGMFRCICNGG 1475

  Fly   938 YE----GRDCAINTDDCAS-FPCQNGGTCLDGIGDYSCLCVDGFD-------------------- 977
            ||    |.:|. :.::||. ..|.| |.|::..|.|.|.|...|:                    
Human  1476 YELDRGGGNCT-DINECADPVNCIN-GVCINTPGSYLCSCPQDFELNPSGVGCVDTRAGNCFLET 1538

  Fly   978 -------------------------------GKHCE----------------------------- 982
                                           |..||                             
Human  1539 HDRGDSGISCSAEIGVGVTRASCCCSLGRAWGNPCELCPMANTTEYRTLCPGGEGFQPNRITVIL 1603

  Fly   983 TDINECLSQP--CQNGATCSQYVNSYTCTCPLGFSGIN----CQTNDEDCTESSCLNGGSCIDGI 1041
            .||:||...|  || |..|.....|:.|.||.|:....    |:..||..|.|.....|:|.:.:
Human  1604 EDIDECQELPGLCQ-GGDCVNTFGSFQCECPPGYHLSEHTRICEDIDECSTHSGICGPGTCYNTL 1667

  Fly  1042 NGYNCSCLAGY---SGAN--------------------------------CQYKLNK-----CDS 1066
            ..|.|.|.|.|   :|.|                                |.|.:.:     |::
Human  1668 GNYTCVCPAEYLQVNGGNNCMDMRKSVCFRHYNGTCQNELAFNVTRKMCCCSYNIGQAWNRPCEA 1732

  Fly  1067 NP---------------------------------------CLNGATCHEQNNEYTCHCPSGFTG 1092
            .|                                       |.|| .|..|...:.|.||:||..
Human  1733 CPTPISPDYQILCGNQAPGFLTDIHTGKPLDIDECGEIPAICANG-ICINQIGSFRCECPAGFNY 1796

  Fly  1093 KQ---CSEYVDWCG--QSPCENGATCSQMKHQFSCKCSAGW---TGKLCDVQTISCQDAADRKGL 1149
            ..   ..|.||.||  :|||:..|.|..:...:.|||:.|:   .|..| |....|::       
Human  1797 NSILLACEDVDECGSRESPCQQNADCINIPGSYRCKCTRGYKLSPGGAC-VGRNECRE------- 1853

  Fly  1150 SLRQLCNNGTCKDYGNSHVCYCSQGYAGSYCQ---KEIDECQSQPCQNGGTCRDLIGAYECQCRQ 1211
             :..:|::|.|.|...|::|.|.:|:..|..|   .:||||..|||.| |||:::||:|.|.|..
Human  1854 -IPNVCSHGDCMDTEGSYMCLCHRGFQASADQTLCMDIDECDRQPCGN-GTCKNIIGSYNCLCFP 1916

  Fly  1212 GF---QGQNCELNIDDCAP------------NP-------CQNG--------------------- 1233
            ||   ...:| ::.|:|..            |.       ||:|                     
Human  1917 GFVVTHNGDC-VDFDECTTLVGQVCRFGHCLNTAGSFHCLCQDGFELTADGKNCVDTNECLSLAG 1980

  Fly  1234 ----GTCHDRVMNFSCSCPPGTMGIICEINKDDC--------KPGACHNNGSCIDRVGGFECVCQ 1286
                |||.:...:|.|.||||     .::..|.|        :|..| ..|:|.:..|.|:|:|.
Human  1981 TCLPGTCQNLEGSFRCICPPG-----FQVQSDHCIDIDECSEEPNLC-LFGTCTNSPGSFQCLCP 2039

  Fly  1287 PGFV----GARC-------------------------------------------------EG-- 1296
            ||||    |.||                                                 ||  
Human  2040 PGFVLSDNGHRCFDTRQSFCFTRFEAGKCSVPKAFNTTKTRCCCSKRPGEGWGDPCELCPQEGSA 2104

  Fly  1297 ---------------------DINECLSNP--CSNAGTLDCVQLVNNYHCNCRPGH----MGRHC 1334
                                 |:|||..||  |:|.   .||....::.|.|..|:    .|.:|
Human  2105 AFQELCPFGHGAVPGPDDSREDVNECAENPGVCTNG---VCVNTDGSFRCECPFGYSLDFTGINC 2166

  Fly  1335 EHKVDFCAQSPCQNGGNCNIRQSGHHCICNNGF---YGKNCELSGQDCDSNP--C--RVGNCVVA 1392
            ....:.....|| ..|.|.....|..|.|.:||   ....|| ...:|..||  |  |..|    
Human  2167 VDTDECSVGHPC-GQGTCTNVIGGFECACADGFEPGLMMTCE-DIDECSLNPLLCAFRCHN---- 2225

  Fly  1393 DEGFGYRCECPRG-TL---GEHCEIDTLDECS--PNPC-AQGAACEDLLGDYECLCPSKWKGKRC 1450
            .|| .|.|.||.| ||   |..|.  .:|||:  ...| |:|..|::|:|.:.|:||        
Human  2226 TEG-SYLCTCPAGYTLREDGAMCR--DVDECADGQQDCHARGMECKNLIGTFACVCP-------- 2279

  Fly  1451 DIYDANYPGWNGGSGSGNDRYAADLEQQRAMCDKRGCTEKQG---------NGICDSDCNTYACN 1506
                   ||.....|||                 .|||:...         ||.|.:...::.| 
Human  2280 -------PGMRPLPGSG-----------------EGCTDDNECHAQPDLCVNGRCVNTAGSFRC- 2319

  Fly  1507 FDGNDCSLGINPWANCTANECWNKFKNGKC---------------NEECNNAAC----------- 1545
                ||..|..|  :.|..|| :..:.|.|               :|....|.|           
Human  2320 ----DCDEGFQP--SPTLTEC-HDIRQGPCFAEVLQTMCRSLSSSSEAVTRAECCCGGGRGWGPR 2377

  Fly  1546 -----------------HYDGHDCE-RKLKSCDSL---------------FDAYCQKHYGDGF-- 1575
                             |..|:..| |.:..|..|               |..:||..|....  
Human  2378 CELCPLPGTSAYRKLCPHGSGYTAEGRDVDECRMLAHLCAHGECINSLGSFRCHCQAGYTPDATA 2442

  Fly  1576 ---------------CDYGCNNAECSW------------DGLDCEN 1594
                           |.:.|.|.:.|:            ||..|::
Human  2443 TTCLDMDECSQVPKPCTFLCKNTKGSFLCSCPRGYLLEEDGRTCKD 2488

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NNP_001245510.1 EGF_CA 179..214 CDD:238011 16/102 (16%)
EGF_CA 217..252 CDD:238011 16/38 (42%)
EGF_CA 260..291 CDD:238011 14/40 (35%)
EGF_CA 295..329 CDD:238011 9/37 (24%)
EGF_CA 331..369 CDD:238011 19/73 (26%)
EGF_CA 449..486 CDD:238011 17/57 (30%)
EGF_CA 488..524 CDD:238011 19/128 (15%)
EGF_CA 526..562 CDD:238011 15/39 (38%)
EGF_CA 564..600 CDD:238011 13/42 (31%)
EGF_CA 602..637 CDD:238011 12/40 (30%)
EGF_CA 640..675 CDD:238011 12/39 (31%)
EGF_CA 677..713 CDD:238011 13/41 (32%)
EGF_CA 715..750 CDD:238011 13/38 (34%)
EGF_CA 753..789 CDD:238011 17/41 (41%)
EGF_CA 791..827 CDD:238011 13/37 (35%)
EGF_CA 829..865 CDD:238011 13/45 (29%)
EGF_CA 907..943 CDD:238011 18/39 (46%)
EGF_CA 946..982 CDD:238011 12/87 (14%)
EGF_CA 984..1020 CDD:238011 14/41 (34%)
EGF_CA 1027..1058 CDD:238011 11/65 (17%)
EGF_CA 1062..1095 CDD:238011 12/79 (15%)
EGF_CA 1184..1219 CDD:238011 18/37 (49%)
EGF_CA 1221..1257 CDD:238011 15/79 (19%)
EGF_CA 1259..1295 CDD:238011 17/96 (18%)
EGF_CA 1297..1335 CDD:238011 14/43 (33%)
EGF_CA 1417..1450 CDD:238011 12/35 (34%)
NL 1476..1512 CDD:197463 7/44 (16%)
Notch 1519..1553 CDD:278494 10/76 (13%)
Notch 1565..1593 CDD:278494 9/56 (16%)
NOD 1599..1648 CDD:284282
NODP 1680..1731 CDD:284987
ANK 1896..2038 CDD:238125
ANK repeat 1902..1948 CDD:293786
ANK repeat 1951..1981 CDD:293786
Ank_5 1970..2025 CDD:290568
ANK 1978..2104 CDD:238125
ANK repeat 1984..2015 CDD:293786
ANK repeat 2017..2048 CDD:293786
Ank_2 2022..2114 CDD:289560
ANK repeat 2050..2081 CDD:293786
ANK repeat 2083..2114 CDD:293786
DUF3454 2627..2682 CDD:288764
FBN3XP_016882868.1 None
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 55 1.000 Domainoid score I11146
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.910

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