DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment N and NOTCH4

DIOPT Version :9

Sequence 1:NP_001245510.1 Gene:N / 31293 FlyBaseID:FBgn0004647 Length:2703 Species:Drosophila melanogaster
Sequence 2:NP_004548.3 Gene:NOTCH4 / 4855 HGNCID:7884 Length:2003 Species:Homo sapiens


Alignment Length:2415 Identity:807/2415 - (33%)
Similarity:1074/2415 - (44%) Gaps:540/2415 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    31 PASLPLLLLTLAFANLPNTVRGTDTALVAASCTSV-------------GCQNGGTCVTQLNGKTY 82
            |.||.||||                 |:...|.||             .|.|||||::...|:..
Human     3 PPSLLLLLL-----------------LLLLLCVSVVRPRGLLCGSFPEPCANGGTCLSLSLGQGT 50

  Fly    83 CACDSHYVGDYCEHRNPC-NSMRCQNGGTCQVTFRNG----------RPGISCKCPLGFDESLCE 136
            |.|...::|:.|:..:|| |:..|||||:||......          .|...|.|..||....|:
Human    51 CQCAPGFLGETCQFPDPCQNAQLCQNGGSCQALLPAPLGLPSSPSPLTPSFLCTCLPGFTGERCQ 115

  Fly   137 IAVPNACDHVTCLNGGTCQLKTLEEYTCACANGYTGERCETKNLCASSPCRNGATCTALAGSSSF 201
            ..:.:.|....|...|.|.::......|:|..|:|||:|:.::.|:::||.||..|  ||.....
Human   116 AKLEDPCPPSFCSKRGRCHIQASGRPQCSCMPGWTGEQCQLRDFCSANPCVNGGVC--LATYPQI 178

  Fly   202 TCSCPPGFTGDTCSYDIEEC--QSNPCKYGGTCVNTHGSYQCMCPTGYTGKDCDTKYKPCSPSPC 264
            .|.|||||.|..|..|:.||  ...||..|.:|.||.||:||:||.|..|..|:.:..||.|..|
Human   179 QCHCPPGFEGHACERDVNECFQDPGPCPKGTSCHNTLGSFQCLCPVGQEGPRCELRAGPCPPRGC 243

  Fly   265 QNGGICR----SNGLSYECKCPKGFEGKNCEQNYDDCLGHLCQNGGTCIDGISDYTCRCPPNFTG 325
            .|||.|:    .:...:.|.||.||.|.:||.|.|:|:.|.|||||||.||:..|||.||..:||
Human   244 SNGGTCQLMPEKDSTFHLCLCPPGFIGPDCEVNPDNCVSHQCQNGGTCQDGLDTYTCLCPETWTG 308

  Fly   326 RFCQDDVDECAQRDHPVCQNGATCTNTHGSYSCICVNGWAGLDCSNNTDDCKQAACFYGATCIDG 390
            ..|.:|||||..:..|.|:||.||.|:.||:.|:||:||.|..|..|.|||..|.|..|:||||.
Human   309 WDCSEDVDECETQGPPHCRNGGTCQNSAGSFHCVCVSGWGGTSCEENLDDCIAATCAPGSTCIDR 373

  Fly   391 VGSFYCQCTKGKTGLLCHLDDACTSNPCHADAICDTSPINGSYACSCATGYKGVDCSEDIDEC-- 453
            ||||.|.|..|:|||||||:|.|.|.|||.||.|.|:|:.||..|.|..||.|..|.:|:|||  
Human   374 VGSFSCLCPPGRTGLLCHLEDMCLSQPCHGDAQCSTNPLTGSTLCLCQPGYSGPTCHQDLDECLM 438

  Fly   454 -DQG-SPCEHNGICVNTPGSYRCNCSQGFTGPRCETNINECESHPCQNEGSCLDDPGTFRCVCMP 516
             .|| |||||.|.|:|||||:.|.|..|:||.|||.:.|||.|.||....:|||...||.|:|.|
Human   439 AQQGPSPCEHGGSCLNTPGSFNCLCPPGYTGSRCEADHNECLSQPCHPGSTCLDLLATFHCLCPP 503

  Fly   517 GFTGTQCEIDIDECQSNPCLNDGTCHDKINGFKCSCALGFTGARCQINIDDCQSQPCRNRGICHD 581
            |..|..||::.:||.|.||||...|||.:|||:|.|..||:|.||:.:||:|:|.||.|      
Human   504 GLEGQLCEVETNECASAPCLNHADCHDLLNGFQCICLPGFSGTRCEEDIDECRSSPCAN------ 562

  Fly   582 SIAGYSCECPPGYTGTSCEININDCDSNPCHRGKCIDDVNSFKCLCDPGYTGYICQKQINECESN 646
                                                                             
Human   563 ----------------------------------------------------------------- 562

  Fly   647 PCQFDGHCQDRVGSYYCQCQAGTSGKNCEVNVNECHSNPCNNGATCIDGINSYKCQCVPGFTGQH 711
                .|.|||:.|:::|:|..|..|..|:..|:||.|:||..||:|:|...::.|.|..|||||.
Human   563 ----GGQCQDQPGAFHCKCLPGFEGPRCQTEVDECLSDPCPVGASCLDLPGAFFCLCPSGFTGQL 623

  Fly   712 CEKNVDECISSPCANNGVCIDQVNGYKCECPRGFYDAHCLSDVDECASNPCVNEGRCEDGINEFI 776
            ||                                        |..||.|.|..:..|:|..::..
Human   624 CE----------------------------------------VPLCAPNLCQPKQICKDQKDKAN 648

  Fly   777 CHCPPGYTGKRCELDIDECSSNPCQHGGTCYDKLNAFSCQCMPGYTGQKCETNIDDCVTNPCGNG 841
            |.||.|..|  |....|.|:   |.||     .....||.|..|:||.:||..:..|::.||.:|
Human   649 CLCPDGSPG--CAPPEDNCT---CHHG-----HCQRSSCVCDVGWTGPECEAELGGCISAPCAHG 703

  Fly   842 GTCIDKVNGYKCVCKVPFTGRDCESKMDPCASNRCKNEAKCTPSSNFLDFSCTCKLGYTGRYCDE 906
            |||..:.:||                                        :|||..||||..|.|
Human   704 GTCYPQPSGY----------------------------------------NCTCPTGYTGPTCSE 728

  Fly   907 DIDECSLSSPCRNGASCLNVPGSYRCLCTKGYEGRDCAINTDDCASFPCQNGGTCLDGIGDYSCL 971
            ::..|. |.||.||.||...||.|.|.|...:.|..|..:||.|.|.||.|||||::..|.:|||
Human   729 EMTACH-SGPCLNGGSCNPSPGGYYCTCPPSHTGPQCQTSTDYCVSAPCFNGGTCVNRPGTFSCL 792

  Fly   972 CVDGFDGKHCETDINECLSQPCQNGATCSQYVNSYTCTCPLGFSGINCQTNDEDCTESSCLNGGS 1036
            |..||.|..||..:..                                                |
Human   793 CAMGFQGPRCEGKLRP------------------------------------------------S 809

  Fly  1037 CIDGINGYNCSCLAGYSGANCQYKLNKCDSNPCLNGATCHEQNNEYTCHCPSGFTGKQCSEYVDW 1101
            |.|                           :||.|.|||.:......|.||:|:||..|...:|.
Human   810 CAD---------------------------SPCRNRATCQDSPQGPRCLCPTGYTGGSCQTLMDL 847

  Fly  1102 CGQSPCENGATCSQMKHQFSCKCSAGWTGKLCDVQTISCQDAADRKGLSLRQLCNN-GTCKDYGN 1165
            |.|.||...:.|.|....|.|.|..||||.||::...|||.||..:|:.:..||:| |.|.|.|.
Human   848 CAQKPCPRNSHCLQTGPSFHCLCLQGWTGPLCNLPLSSCQKAALSQGIDVSSLCHNGGLCVDSGP 912

  Fly  1166 SHVCYCSQGYAGSYCQKEIDECQSQPCQNGGTCRDLIGAYECQCRQGFQGQNCELNIDDCAPNPC 1230
            |:.|:|..|:.||.||..::.|:|:|||||.||......|.|||..|:.||||...:|.|...| 
Human   913 SYFCHCPPGFQGSLCQDHVNPCESRPCQNGATCMAQPSGYLCQCAPGYDGQNCSKELDACQSQP- 976

  Fly  1231 QNGGTCHDRVMNFSCSCPPGTMGIICEINKDDCKPGACHNNGSCIDRVGGFECVCQPGFVGARCE 1295
                                                 |||:|:|..:.|||.|.|.|||||.|||
Human   977 -------------------------------------CHNHGTCTPKPGGFHCACPPGFVGLRCE 1004

  Fly  1296 GDINECLSNPCSNAGTLDCVQLVNNYHCNCRPGHMGRHCEHKVDFCAQSPCQNGGNCNIRQS--- 1357
            ||::|||..||...||..|..|.|.::|.|.|||.|:.||.::|.|...||.:||.|.....   
Human  1005 GDVDECLDQPCHPTGTAACHSLANAFYCQCLPGHTGQWCEVEIDPCHSQPCFHGGTCEATAGSPL 1069

  Fly  1358 GHHCICNNGFYGKNCELSGQDCDSNPCRVGN-CVVADE-GFGYRCECPRGTLGEHCEIDTLDE-C 1419
            |..|.|..||.|..|......|..:.|..|. |:.:.: ||..||.|..|..|..|......: |
Human  1070 GFICHCPKGFEGPTCSHRAPSCGFHHCHHGGLCLPSPKPGFPPRCACLSGYGGPDCLTPPAPKGC 1134

  Fly  1420 S-PNPCAQGAACEDLLG----DYECLCPSKWKGKRCDIYDANYPGWNGGSGSGNDRYAADLEQQR 1479
            . |:||....:|.:..|    .:.|.||....|.||     ..||                    
Human  1135 GPPSPCLYNGSCSETTGLGGPGFRCSCPHSSPGPRC-----QKPG-------------------- 1174

  Fly  1480 AMCDKRGCTEKQGNGICDSDCNTYACNFDGNDCSLGI-NPWANCTA-NECWNKFKNGKCNEECNN 1542
                .:||..:.|:|.||:.|:....|:||.|||||: :||..|.: :.||..|::|:|:.:|::
Human  1175 ----AKGCEGRSGDGACDAGCSGPGGNWDGGDCSLGVPDPWKGCPSHSRCWLLFRDGQCHPQCDS 1235

  Fly  1543 AACHYDGHDCERKLKSCDSLFDAYCQKHYGDGFCDYGCNNAECSWDGLDCENKTQSPVLAEGAMS 1607
            ..|.:||:|||.. .:|...:|.||..|:.:|.|:.|||.|||.|||.||..:...|.... :::
Human  1236 EECLFDGYDCETP-PACTPAYDQYCHDHFHNGHCEKGCNTAECGWDGGDCRPEDGDPEWGP-SLA 1298

  Fly  1608 VVMLMNVEAFREIQAQFLRNMSHMLRTTVRLKKDALGHDIIINWK--------DNVRVPEIEDTD 1664
            ::::::..|..:......|.:|..||..:.::||..|.|::..:.        ...|.|..::..
Human  1299 LLVVLSPPALDQQLFALARVLSLTLRVGLWVRKDRDGRDMVYPYPGARAEEKLGGTRDPTYQERA 1363

  Fly  1665 FARKNKILYTQQVHQTGIQIYLEIDNRKC------TECFTHAVEAAEFLAATAAKHQLR-----N 1718
            ..:...:.........|..:.:.:|..:|      :.|.........||||.||...|.     .
Human  1364 APQTQPLGKETDSLSAGFVVVMGVDLSRCGPDHPASRCPWDPGLLLRFLAAMAAVGALEPLLPGP 1428

  Fly  1719 DFQIHSVRGIKNPGDEDNGEPPAN------VKYVITGIILVIIALAFFGMVLSTQRKRAHGVTWF 1777
            ...:|...|.         .||||      :...:.|:||:.:. |...:.|..:|:|.||..|.
Human  1429 LLAVHPHAGT---------APPANQLPWPVLCSPVAGVILLALG-ALLVLQLIRRRRREHGALWL 1483

  Fly  1778 PEGF-RAPAAVMS-RRRRDPHGQEMRNLNKQVAMQSQGVGQPGAHWSDDESDMPLPKRQRSDPVS 1840
            |.|| |.|....: .|||.|.|::...|...         :|.|...:|...|          .|
Human  1484 PPGFTRRPRTQSAPHRRRPPLGEDSIGLKAL---------KPKAEVDEDGVVM----------CS 1529

  Fly  1841 GVGLGNNGGYASDHTMVSEYEEADQRVWS-QAHLDVVDVRAIMTPPAHQDGGKHDVDARGPCGLT 1904
            |...|...|.|.:....|..:     :|| ......:...|::|||...:....|:|.|||.|:|
Human  1530 GPEEGEEVGQAEETGPPSTCQ-----LWSLSGGCGALPQAAMLTPPQESEMEAPDLDTRGPDGVT 1589

  Fly  1905 PLMIA---------AVRGGGLDTGEDIENNEDSTAQVISDLLAQGAELNATMDKTGETSLHLAAR 1960
            |||.|         ..:|..|...|..|           .||..||...|....||||.||||||
Human  1590 PLMSAVCCGEVQSGTFQGAWLGCPEPWE-----------PLLDGGACPQAHTVGTGETPLHLAAR 1643

  Fly  1961 FARADAAKRLLDAGADANCQDNTGRTPLHAAVAADAMGVFQILLRNRATNLNARMHDGTTPLILA 2025
            |:|..||:|||:|||:.|..|..|||||||||||||..|.|:|||:|.|.::||..||||||:||
Human  1644 FSRPTAARRLLEAGANPNQPDRAGRTPLHAAVAADAREVCQLLLRSRQTAVDARTEDGTTPLMLA 1708

  Fly  2026 ARLAIEGMVEDLITADADINAADNSGKTALHWAAAVNNTEAVNILLMHHANRDAQDDKDETPLFL 2090
            ||||:|.:||:||.|.||:.|.|..|||||||||||||..|...||...|::||||::::|||||
Human  1709 ARLAVEDLVEELIAAQADVGARDKWGKTALHWAAAVNNARAARSLLQAGADKDAQDNREQTPLFL 1773

  Fly  2091 AAREGSYEACKALLDNFANREITDHMDRLPRDVASERLHHDIVRLLDEHVPRSPQMLSMTPQAMI 2155
            |||||:.|..:.||...|.||:.|.....|.|||.:|.|.|::.||:...|...:. ..||....
Human  1774 AAREGAVEVAQLLLGLGAARELRDQAGLAPADVAHQRNHWDLLTLLEGAGPPEARH-KATPGREA 1837

  Fly  2156 G----------SPPP--GQQQPQLITQPTVISAGNGGNNGNGNASGKQSNQTAKQKAAKKAKLIE 2208
            |          |.||  |...|:..|    :|||.|...|.               |..:|:   
Human  1838 GPFPRARTVSVSVPPHGGGALPRCRT----LSAGAGPRGGG---------------ACLQAR--- 1880

  Fly  2209 GSPDNGLDATGSLRRKASSKKTSAASKKAANLNGLNPG--------QLTGGVSGVPGVPPTNSAA 2265
                     |.|:...|   :...|.....:|:|:..|        :.:.|:.|    |..|.|.
Human  1881 ---------TWSVDLAA---RGGGAYSHCRSLSGVGAGGGPTPRGRRFSAGMRG----PRPNPAI 1929

  Fly  2266 Q-----AAAAAAAAVAAMSHELEGSPVGV-GMGGNLPSPYDTSSMYSNAMAAPLANGNPNTGAKQ 2324
            .     .||.....|:......:...:|. |...|:|.|            .|....:|..|:.|
Human  1930 MRGRYGVAAGRGGRVSTDDWPCDWVALGACGSASNIPIP------------PPCLTPSPERGSPQ 1982

  Fly  2325 ----PPSYED 2330
                ||:.::
Human  1983 LDCGPPALQE 1992

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NNP_001245510.1 EGF_CA 179..214 CDD:238011 15/34 (44%)
EGF_CA 217..252 CDD:238011 17/36 (47%)
EGF_CA 260..291 CDD:238011 12/34 (35%)
EGF_CA 295..329 CDD:238011 19/33 (58%)
EGF_CA 331..369 CDD:238011 20/37 (54%)
EGF_CA 449..486 CDD:238011 24/40 (60%)
EGF_CA 488..524 CDD:238011 16/35 (46%)
EGF_CA 526..562 CDD:238011 19/35 (54%)
EGF_CA 564..600 CDD:238011 7/35 (20%)
EGF_CA 602..637 CDD:238011 0/34 (0%)
EGF_CA 640..675 CDD:238011 9/34 (26%)
EGF_CA 677..713 CDD:238011 17/35 (49%)
EGF_CA 715..750 CDD:238011 0/34 (0%)
EGF_CA 753..789 CDD:238011 12/35 (34%)
EGF_CA 791..827 CDD:238011 11/35 (31%)
EGF_CA 829..865 CDD:238011 9/35 (26%)
EGF_CA 907..943 CDD:238011 14/35 (40%)
EGF_CA 946..982 CDD:238011 19/35 (54%)
EGF_CA 984..1020 CDD:238011 0/35 (0%)
EGF_CA 1027..1058 CDD:238011 3/30 (10%)
EGF_CA 1062..1095 CDD:238011 12/32 (38%)
EGF_CA 1184..1219 CDD:238011 17/34 (50%)
EGF_CA 1221..1257 CDD:238011 3/35 (9%)
EGF_CA 1259..1295 CDD:238011 16/35 (46%)
EGF_CA 1297..1335 CDD:238011 17/37 (46%)
EGF_CA 1417..1450 CDD:238011 10/38 (26%)
NL 1476..1512 CDD:197463 10/35 (29%)
Notch 1519..1553 CDD:278494 12/34 (35%)
Notch 1565..1593 CDD:278494 15/27 (56%)
NOD 1599..1648 CDD:284282 10/48 (21%)
NODP 1680..1731 CDD:284987 13/61 (21%)
ANK 1896..2038 CDD:238125 78/150 (52%)
ANK repeat 1902..1948 CDD:293786 15/54 (28%)
ANK repeat 1951..1981 CDD:293786 20/29 (69%)
Ank_5 1970..2025 CDD:290568 35/54 (65%)
ANK 1978..2104 CDD:238125 78/125 (62%)
ANK repeat 1984..2015 CDD:293786 21/30 (70%)
ANK repeat 2017..2048 CDD:293786 21/30 (70%)
Ank_2 2022..2114 CDD:289560 54/91 (59%)
ANK repeat 2050..2081 CDD:293786 19/30 (63%)
ANK repeat 2083..2114 CDD:293786 16/30 (53%)
DUF3454 2627..2682 CDD:288764
NOTCH4NP_004548.3 EGF_CA 194..232 CDD:238011 17/37 (46%)
EGF_CA 314..353 CDD:238011 20/38 (53%)
EGF_CA 432..473 CDD:238011 24/40 (60%)
EGF_CA 475..511 CDD:238011 16/35 (46%)
EGF_CA 515..549 CDD:238011 19/33 (58%)
EGF_CA 551..587 CDD:238011 16/110 (15%)
EGF_CA 590..625 CDD:238011 17/34 (50%)
EGF_CA <699..726 CDD:238011 15/66 (23%)
EGF_CA <736..765 CDD:238011 12/28 (43%)
EGF_CA 769..803 CDD:238011 18/33 (55%)
EGF_CA <899..928 CDD:238011 13/28 (46%)
EGF_CA 931..965 CDD:238011 16/33 (48%)
EGF_CA 970..1004 CDD:238011 19/71 (27%)
Notch 1165..1203 CDD:321927 15/66 (23%)
LNR 1 1170..1213 20/71 (28%)
NL 1207..1245 CDD:197463 12/37 (32%)
LNR 2 1214..1250 13/36 (36%)
Notch 1249..1285 CDD:306554 17/35 (49%)
LNR 3 1251..1294 19/42 (45%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1347..1371 2/23 (9%)
NODP 1380..>1420 CDD:311559 10/39 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1485..1508 9/22 (41%)
ANK 1586..1721 CDD:238125 74/145 (51%)
ANK repeat 1586..1630 CDD:293786 15/54 (28%)
ANK 1 1633..1665 21/31 (68%)
ANK repeat 1634..1664 CDD:293786 20/29 (69%)
ANK 1661..1787 CDD:238125 78/125 (62%)
ANK repeat 1666..1698 CDD:293786 21/31 (68%)
ANK 2 1666..1698 21/31 (68%)
ANK 3 1700..1732 21/31 (68%)
ANK repeat 1700..1731 CDD:293786 21/30 (70%)
ANK 4 1733..1765 20/31 (65%)
ANK repeat 1733..1764 CDD:293786 19/30 (63%)
Ank_5 1753..>1851 CDD:330893 38/98 (39%)
ANK 5 1766..1798 16/31 (52%)
ANK repeat 1766..1797 CDD:293786 16/30 (53%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1900..1927 6/30 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1968..2003 7/37 (19%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 64 1.000 Domainoid score I10109
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D5821at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100271
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
54.820

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