DRSC/TRiP Functional Genomics Resources

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Protein Alignment N and JAG2

DIOPT Version :9

Sequence 1:NP_001245510.1 Gene:N / 31293 FlyBaseID:FBgn0004647 Length:2703 Species:Drosophila melanogaster
Sequence 2:NP_002217.3 Gene:JAG2 / 3714 HGNCID:6189 Length:1238 Species:Homo sapiens


Alignment Length:1189 Identity:345/1189 - (29%)
Similarity:492/1189 - (41%) Gaps:270/1189 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly   127 PLGFDESLCEIAVPNACDHV---TCLNG-------GTCQLKTLEEYTCACANGYTGERCETKNLC 181
            |:|:.| |...|:.|....:   .|.:|       |.|.....:.|...|...|..:      :.
Human    26 PMGYFE-LQLSALRNVNGELLSGACCDGDGRTTRAGGCGHDECDTYVRVCLKEYQAK------VT 83

  Fly   182 ASSPCRNGATCTALAGSSSFTCSCPPGFTGDTCSYDIEECQSNPCKYGGTCVNTHGSYQCMCPTG 246
            .:.||..|...|.:.|.:||... |.|..||...   ...::...:..|..|.   .:|...|..
Human    84 PTGPCSYGHGATPVLGGNSFYLP-PAGAAGDRAR---ARARAGGDQDPGLVVI---PFQFAWPRS 141

  Fly   247 YT----GKDCDTKYKPCSPSPCQNGGICRSNGLSYECKCPK-GFEGK----------NCEQNYDD 296
            :|    ..|.|....|......:.  :..:..::.|.:... .|.|.          .|::||  
Human   142 FTLIVEAWDWDNDTTPNEELLIER--VSHAGMINPEDRWKSLHFSGHVAHLELQIRVRCDENY-- 202

  Fly   297 CLGHLCQNGGTCIDGISDYTCRCPPNFTGRFCQDDVDECAQRDHPVCQNGATCTNTHGSYSC--- 358
                              |:..|     .:||:...|                  ..|.|:|   
Human   203 ------------------YSATC-----NKFCRPRND------------------FFGHYTCDQY 226

  Fly   359 ---ICVNGWAGLDCSNNTDDCKQAACFYGATCIDG----VGSFYCQCTKGKTGLLCHLDDACTSN 416
               .|::||.|       .:||:|.|..|...:.|    .|.  |:|:.|..|..|   |.|...
Human   227 GNKACMDGWMG-------KECKEAVCKQGCNLLHGGCTVPGE--CRCSYGWQGRFC---DECVPY 279

  Fly   417 P-CHADAICDTSPINGS----YACSCATGYKGVDCSEDIDECDQGSPCEHNGICVNT-PGSYRCN 475
            | |          ::||    :.|:|.|.:.|:.|.:|::.|....||.:.|.|:|. |..|||.
Human   280 PGC----------VHGSCVEPWQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCT 334

  Fly   476 CSQGFTGPRCETNINECESHPCQNEGSCLDDPGTFRCVCMPGFTGTQCEIDIDECQSNPCLNDGT 540
            |..|::|..||...:.|.|:||.|.|||.:.|..|.|.|..|::|..|.:|||||.||||...||
Human   335 CPDGYSGRNCEKAEHACTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASNPCAAGGT 399

  Fly   541 CHDKINGFKCSCALGFTGARCQINIDDCQSQPCRNRGICHDSIAGYSCECPPGYTGTSCEININD 605
            |.|:::||:|.|...:.||.||::.::|:.:||.|...|.:.|.||.|:|.||:.|.:|.||:||
Human   400 CVDQVDGFECICPEQWVGATCQLDANECEGKPCLNAFSCKNLIGGYYCDCIPGWKGINCHINVND 464

  Fly   606 CDSNPCHRGKCIDDVNSFKCLCDPGYTGYICQKQINECESNPCQFDGHCQDRVGSYYCQCQAGTS 670
            |.....|.|.|.|.||.::|:|..|:.|..|:.:.:||.|:||...|.|:|....::|.|..|.|
Human   465 CRGQCQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECASSPCHSGGLCEDLADGFHCHCPQGFS 529

  Fly   671 GKNCEVNVNECHSNPCNNGATCIDGINSYKCQCVPGFTGQHCEKNVDECISSPCANNGVCIDQVN 735
            |..|||:|:.|..:||.|||.|.:....|.|.|...|.|::|....:.|....|.       .::
Human   530 GPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPREPCPGGACR-------VID 587

  Fly   736 GYKCECPRGFYDAHCLSDV-----DECASNPCVNEGRC--EDGINEFICHCPPGYTGKRCELDID 793
            |             |.||.     ...||..|...|||  :.|.| |.|.|..|:||..|..:||
Human   588 G-------------CGSDAGPGMPGTAASGVCGPHGRCVSQPGGN-FSCICDSGFTGTYCHENID 638

  Fly   794 ECSSNPCQHGGTCYDKLNAFSCQCMPGYTGQKCETNIDDCVTNPCGNGGTCIDKVNGYKCVCKVP 858
            :|...||::||||.|:::||.|.|..|:.|:.|:||.:||:.:||.:.|.|.|.||.:.|.|...
Human   639 DCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVNDFYCACDDG 703

  Fly   859 FTGRDCESKMDPCASNRCKNEAKCTPSSNFLDFSCTCKLGYTGRYCDEDIDECSLSSPCRNGASC 923
            :.|:.|.|:...|.:..|.|...|..|.:  .|.|.|..|:.|..|....:...|.:||.||.:|
Human   704 WKGKTCHSREFQCDAYTCSNGGTCYDSGD--TFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTC 766

  Fly   924 LNVPGSYRCLCTKGYEGRDCAINTDDCASFPCQNGGTCLDGIGDYSCLCVDGFDGKHCETDINEC 988
            :....|:.|:|..|:|||.|..||:||...||.|||.|:||:..:.|.|..||.|..|..:|:||
Human   767 VGSGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDEC 831

  Fly   989 LSQPCQNGATCSQYVNSYTCTCPLGFSGINCQTNDEDCTESSCLNGGSCIDGINGYNCSCLAGYS 1053
            .|.||..||||...:|.|.|:||.|.:|..||.                   :.|:..||.:   
Human   832 QSSPCAYGATCVDEINGYRCSCPPGRAGPRCQE-------------------VIGFGRSCWS--- 874

  Fly  1054 GANCQYKLNKCDSNPCLNGATCHEQNNEYTCHCPSGFTGKQCSEYVDWCGQSPCENGATCSQMKH 1118
                       ...|..:|::..|..|  :|.|..|  .:.||:.  |||..||    ..:....
Human   875 -----------RGTPFPHGSSWVEDCN--SCRCLDG--RRDCSKV--WCGWKPC----LLAGQPE 918

  Fly  1119 QFSCKCSAGWTGKLCDVQTISCQDAADRKGLSLRQLCNNGTCKDYGNSHVCYCSQGYAGSYCQKE 1183
            ..|.:|..|                         |.|                        .:|.
Human   919 ALSAQCPLG-------------------------QRC------------------------LEKA 934

  Fly  1184 IDECQSQPCQNGGTCRDLIGAYE-----CQCRQGFQGQNC---ELNID-DCAPNPCQNGGTC--- 1236
            ..:|...||:..|.|    ||.|     |..|.|....||   .|:.: |..|.....|..|   
Human   935 PGQCLRPPCEAWGEC----GAEEPPSTPCLPRSGHLDNNCARLTLHFNRDHVPQGTTVGAICSGI 995

  Fly  1237 ----------HDRVMNFSC 1245
                      .||::...|
Human   996 RSLPATRAVARDRLLVLLC 1014

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NNP_001245510.1 EGF_CA 179..214 CDD:238011 11/34 (32%)
EGF_CA 217..252 CDD:238011 5/38 (13%)
EGF_CA 260..291 CDD:238011 3/41 (7%)
EGF_CA 295..329 CDD:238011 3/33 (9%)
EGF_CA 331..369 CDD:238011 8/43 (19%)
EGF_CA 449..486 CDD:238011 14/37 (38%)
EGF_CA 488..524 CDD:238011 14/35 (40%)
EGF_CA 526..562 CDD:238011 19/35 (54%)
EGF_CA 564..600 CDD:238011 13/35 (37%)
EGF_CA 602..637 CDD:238011 14/34 (41%)
EGF_CA 640..675 CDD:238011 13/34 (38%)
EGF_CA 677..713 CDD:238011 13/35 (37%)
EGF_CA 715..750 CDD:238011 3/34 (9%)
EGF_CA 753..789 CDD:238011 15/42 (36%)
EGF_CA 791..827 CDD:238011 16/35 (46%)
EGF_CA 829..865 CDD:238011 13/35 (37%)
EGF_CA 907..943 CDD:238011 13/35 (37%)
EGF_CA 946..982 CDD:238011 17/35 (49%)
EGF_CA 984..1020 CDD:238011 17/35 (49%)
EGF_CA 1027..1058 CDD:238011 3/30 (10%)
EGF_CA 1062..1095 CDD:238011 7/32 (22%)
EGF_CA 1184..1219 CDD:238011 13/42 (31%)
EGF_CA 1221..1257 CDD:238011 7/39 (18%)
EGF_CA 1259..1295 CDD:238011
EGF_CA 1297..1335 CDD:238011
EGF_CA 1417..1450 CDD:238011
NL 1476..1512 CDD:197463
Notch 1519..1553 CDD:278494
Notch 1565..1593 CDD:278494
NOD 1599..1648 CDD:284282
NODP 1680..1731 CDD:284987
ANK 1896..2038 CDD:238125
ANK repeat 1902..1948 CDD:293786
ANK repeat 1951..1981 CDD:293786
Ank_5 1970..2025 CDD:290568
ANK 1978..2104 CDD:238125
ANK repeat 1984..2015 CDD:293786
ANK repeat 2017..2048 CDD:293786
Ank_2 2022..2114 CDD:289560
ANK repeat 2050..2081 CDD:293786
ANK repeat 2083..2114 CDD:293786
DUF3454 2627..2682 CDD:288764
JAG2NP_002217.3 MNNL 28..102 CDD:284966 17/80 (21%)
DSL 178..240 CDD:279722 17/111 (15%)
EGF_CA 307..345 CDD:238011 14/37 (38%)
EGF 351..381 CDD:278437 14/29 (48%)
EGF_CA 385..421 CDD:238011 19/35 (54%)
EGF_CA 423..458 CDD:238011 13/34 (38%)
EGF_CA 461..496 CDD:238011 14/34 (41%)
EGF_CA 500..534 CDD:238011 13/33 (39%)
EGF_CA 536..571 CDD:238011 13/34 (38%)
EGF_CA 636..671 CDD:238011 16/34 (47%)
EGF_CA 676..709 CDD:238011 12/32 (38%)
EGF 716..746 CDD:278437 10/31 (32%)
EGF_CA 757..787 CDD:238011 12/29 (41%)
EGF_CA 789..824 CDD:238011 17/34 (50%)
EGF_CA 827..863 CDD:238011 17/35 (49%)
VWC_out 872..943 CDD:214565 22/143 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1114..1139
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1156..1238
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E33208_3BAFT
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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