DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment N and CRB2

DIOPT Version :9

Sequence 1:NP_001245510.1 Gene:N / 31293 FlyBaseID:FBgn0004647 Length:2703 Species:Drosophila melanogaster
Sequence 2:NP_775960.4 Gene:CRB2 / 286204 HGNCID:18688 Length:1285 Species:Homo sapiens


Alignment Length:1298 Identity:320/1298 - (24%)
Similarity:442/1298 - (34%) Gaps:461/1298 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   412 ACTSNPCHADAICDTSPINGSYAC------SCATGYKGVDCSEDIDECDQGSPCEHNGICV---N 467
            ||.|:||.....|..:. :|.|.|      .|||                 .||.|..:||   .
Human    41 ACASDPCAPGTECQATE-SGGYTCGPMEPRGCAT-----------------QPCHHGALCVPQGP 87

  Fly   468 TPGSYRCNCSQGFTGPRCETNINECESHPCQNEGSCLDDPGTFRCVCMPGFTGTQCEIDIDECQS 532
            .|..:||.|..||.|||||.:|:||.|.||.:..:|.:....:.|.|..|:.|..||:::|||.|
Human    88 DPTGFRCYCVPGFQGPRCELDIDECASRPCHHGATCRNLADRYECHCPLGYAGVTCEMEVDECAS 152

  Fly   533 NPCLNDGTCHDKINGFKCSCALGFTGARCQINIDDCQSQPCRNRGICHDSIAGYSCECP-PGYTG 596
            .|||:.|:|.|.:..|:|.||.|:.|.|||:::|:||||||.:.|.|||.:.|:.|:|. .||.|
Human   153 APCLHGGSCLDGVGSFRCVCAPGYGGTRCQLDLDECQSQPCAHGGTCHDLVNGFRCDCAGTGYEG 217

  Fly   597 TSCEININDCDSNPC-HRGKCIDDVNSFKCLCDPGYTGYICQKQINECESNPCQFDGHCQDR--- 657
            |.||..:.:|.|.|| |...|::.:.||:|||.|||:|.:|:...:||.|:|||..|.|..|   
Human   218 THCEREVLECASAPCEHNASCLEGLGSFRCLCWPGYSGELCEVDEDECASSPCQHGGRCLQRSDP 282

  Fly   658 ------------------VGSYYCQCQAGTSGKNCEVNVNECHSNPCNNGATCIDGINSYKCQCV 704
                              ...:.|.|..|..|.:|.|.|:||.|.||.||..|.|..|.::|.|.
Human   283 ALYGGVQAAFPGAFSFRHAAGFLCHCPPGFEGADCGVEVDECASRPCLNGGHCQDLPNGFQCHCP 347

  Fly   705 PGFTGQHCEKNVDECISSPCANNGVCIDQVNGYKCECPRGFYDAHCLSDVDECASNPCVNEGRC- 768
            .|:.|..||::||||:|.||.:.|.|.|.|.||.|.||..:....|...:..|..:.|.....| 
Human   348 DGYAGPTCEEDVDECLSDPCLHGGTCSDTVAGYICRCPETWGGRDCSVQLTGCQGHTCPLAATCI 412

  Fly   769 ---EDGINEFICHCPPGYTGKRC------------------------------------------ 788
               |.|::.::||||||..|..|                                          
Human   413 PIFESGVHSYVCHCPPGTHGPFCGQNTTFSVMAGSPIQASVPAGGPLGLALRFRTTLPAGTLATR 477

  Fly   789 ------------------------------------------------------ELDI--DECSS 797
                                                                  ||.:  :.|.:
Human   478 NDTKESLELALVAATLQATLWSYSTTVLVLRLPDLALNDGHWHQVEVVLHLATLELRLWHEGCPA 542

  Fly   798 NPCQHGGT----------------------------CYDKLNAFSCQCMPGYTGQK----CETNI 830
            ..|...|.                            |...:.......:|...|:.    ||.. 
Human   543 RLCVASGPVALASTASATPLPAGISSAQLGDATFAGCLQDVRVDGHLLLPEDLGENVLLGCERR- 606

  Fly   831 DDCVTNPCGNGGTCIDKVNGYKCVCKVPFTGRDCESKMD---------PCASNRCKNEAKCTPSS 886
            :.|...||.:||:|:|....::|.|..|..|..|..::.         |.:::....|   .|..
Human   607 EQCRPLPCVHGGSCVDLWTHFRCDCARPHRGPTCADEIPAATFGLGGAPSSASFLLQE---LPGP 668

  Fly   887 N---------------FLDFSCTCKLGYT---------------------GRY------------ 903
            |               .|.|:.....|.|                     ||:            
Human   669 NLTVSFLLRTRESAGLLLQFANDSAAGLTVFLSEGRIRAEVPGSPAVVLPGRWDDGLRHLVMLSF 733

  Fly   904 --------------------------------CDED--IDECSL---SSPCRNGASCLNVPGSYR 931
                                            |.:|  :|.|.|   ..|..|.:....:.|...
Human   734 GPDQLQDLGQHVHVGGRLLAADSQPWGGPFRGCLQDLRLDGCHLPFFPLPLDNSSQPSELGGRQS 798

  Fly   932 CLCTKGYEGRDCAINTDDCASFPCQNGGTCLDGIGDYSCLCVDGFDGKHCETDINECLSQPCQNG 996
            ...|.|      .::.|.|:..||.||||||....|:.|.|...|.|..|...: .|..|||...
Human   799 WNLTAG------CVSEDMCSPDPCFNGGTCLVTWNDFHCTCPANFTGPTCAQQL-WCPGQPCLPP 856

  Fly   997 ATCSQYVNSYTCTC--------PLGFSGINC-------------QTNDEDC----TESSCLNG-- 1034
            |||.:..:.:.|..        |..|||.|.             :|.|.:.    ..:..|.|  
Human   857 ATCEEVPDGFVCVAEATFREGPPAAFSGHNASSGRLLGGLSLAFRTRDSEAWLLRAAAGALEGVW 921

  Fly  1035 -----GSCIDGINGYNCSCLAGYSGA-----------NCQYKLNKCDSNPC---------LNGAT 1074
                 ||...|:.|.:     |..||           ...:::......|.         |:||.
Human   922 LAVRNGSLAGGVRGGH-----GLPGAVLPIPGPRVADGAWHRVRLAMERPAATTSRWLLWLDGAA 981

  Fly  1075 CH-------------EQNNEYTCHCPSGFTGKQCSEYVDWCGQSPC-----ENGATCSQMKHQFS 1121
            ..             :............|||  |...|. .|..|.     ..||.....:|   
Human   982 TPVALRGLASDLGFLQGPGAVRILLAENFTG--CLGRVA-LGGLPLPLARPRPGAAPGAREH--- 1040

  Fly  1122 CKCSAGWTGKLCDVQTISCQDAADRKGLSLRQLCNNGTCKDYGNSHVCYCSQGYAGSYCQKEIDE 1186
               .|.|.|....:  :.|:.|                                         ..
Human  1041 ---FASWPGTPAPI--LGCRGA-----------------------------------------PV 1059

  Fly  1187 CQSQPCQNGGTCRDLIGAYECQCRQGFQGQNCELNIDDCAPNPCQNGGTCHDRV-MNFSCSCPPG 1250
            |...||.:.|.||||..|:.|.|..|::|..||.::|.|...||.. |.||... ..|.|.||||
Human  1060 CAPSPCLHDGACRDLFDAFACACGPGWEGPRCEAHVDPCHSAPCAR-GRCHTHPDGRFECRCPPG 1123

  Fly  1251 TMGIICEI---NKDDCKPGACHNNGSCIDRVGGFECVCQPGFVGARCEGDINECLSNPCSNAGTL 1312
            ..|..|.:   :|:      |..|.:|:|              |:.|||      .:|.:|    
Human  1124 FGGPRCRLPVPSKE------CSLNVTCLD--------------GSPCEG------GSPAAN---- 1158

  Fly  1313 DCVQLVNNYHCNCRPGHMGRHCEHKVDFCAQSPCQNGGNCNIRQSGHHCICNNGFYGKNCELS 1375
                      |:|..|..|:.|:.....|..:||.|||.|........||||..|.|:.||::
Human  1159 ----------CSCLEGLAGQRCQVPTLPCEANPCLNGGTCRAAGGVSECICNARFSGQFCEVA 1211

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NNP_001245510.1 EGF_CA 179..214 CDD:238011
EGF_CA 217..252 CDD:238011
EGF_CA 260..291 CDD:238011
EGF_CA 295..329 CDD:238011
EGF_CA 331..369 CDD:238011
EGF_CA 449..486 CDD:238011 14/39 (36%)
EGF_CA 488..524 CDD:238011 11/35 (31%)
EGF_CA 526..562 CDD:238011 17/35 (49%)
EGF_CA 564..600 CDD:238011 18/36 (50%)
EGF_CA 602..637 CDD:238011 15/35 (43%)
EGF_CA 640..675 CDD:238011 13/55 (24%)
EGF_CA 677..713 CDD:238011 15/35 (43%)
EGF_CA 715..750 CDD:238011 16/34 (47%)
EGF_CA 753..789 CDD:238011 13/135 (10%)
EGF_CA 791..827 CDD:238011 6/69 (9%)
EGF_CA 829..865 CDD:238011 11/35 (31%)
EGF_CA 907..943 CDD:238011 9/40 (23%)
EGF_CA 946..982 CDD:238011 15/35 (43%)
EGF_CA 984..1020 CDD:238011 13/56 (23%)
EGF_CA 1027..1058 CDD:238011 9/48 (19%)
EGF_CA 1062..1095 CDD:238011 7/54 (13%)
EGF_CA 1184..1219 CDD:238011 13/34 (38%)
EGF_CA 1221..1257 CDD:238011 14/36 (39%)
EGF_CA 1259..1295 CDD:238011 6/35 (17%)
EGF_CA 1297..1335 CDD:238011 6/37 (16%)
EGF_CA 1417..1450 CDD:238011
NL 1476..1512 CDD:197463
Notch 1519..1553 CDD:278494
Notch 1565..1593 CDD:278494
NOD 1599..1648 CDD:284282
NODP 1680..1731 CDD:284987
ANK 1896..2038 CDD:238125
ANK repeat 1902..1948 CDD:293786
ANK repeat 1951..1981 CDD:293786
Ank_5 1970..2025 CDD:290568
ANK 1978..2104 CDD:238125
ANK repeat 1984..2015 CDD:293786
ANK repeat 2017..2048 CDD:293786
Ank_2 2022..2114 CDD:289560
ANK repeat 2050..2081 CDD:293786
ANK repeat 2083..2114 CDD:293786
DUF3454 2627..2682 CDD:288764
CRB2NP_775960.4 Required for maximum inhibition of APP amyloid-beta peptide secretion. /evidence=ECO:0000269|PubMed:20299451 1..350 124/326 (38%)
EGF_CA 108..144 CDD:238011 11/35 (31%)
EGF_CA 147..182 CDD:238011 17/34 (50%)
EGF_CA 184..221 CDD:238011 18/36 (50%)
EGF_CA 226..259 CDD:238011 15/32 (47%)
EGF_CA 321..356 CDD:238011 15/34 (44%)
EGF_CA 358..393 CDD:238011 16/34 (47%)
Laminin_G_2 465..588 CDD:280389 6/122 (5%)
LamG 653..773 CDD:238058 12/122 (10%)
EGF_CA 812..842 CDD:238011 13/29 (45%)
LamG 900..1024 CDD:304605 21/131 (16%)
EGF 1060..1090 CDD:278437 13/29 (45%)
Interaction with EPB41L5. /evidence=ECO:0000269|PubMed:17920587 1249..1285
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E33208_3BAFT
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100271
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.710

Return to query results.
Submit another query.