DRSC/TRiP Functional Genomics Resources

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Protein Alignment N and Crb2

DIOPT Version :9

Sequence 1:NP_001245510.1 Gene:N / 31293 FlyBaseID:FBgn0004647 Length:2703 Species:Drosophila melanogaster
Sequence 2:NP_001157038.1 Gene:Crb2 / 241324 MGIID:2679260 Length:1282 Species:Mus musculus


Alignment Length:1424 Identity:355/1424 - (24%)
Similarity:476/1424 - (33%) Gaps:482/1424 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   176 ETKNLCASSPCRNGATCTALAGSSSFTCSCPPGFTGDTCSYDIEECQSNPCKYGGTCVNTHGSYQ 240
            ||.::|||.||..|..|.| ..|..:||.  |...|.        |.:.||.:|..||       
Mouse    41 ETPSVCASDPCAPGTKCQA-TESGGYTCE--PSELGG--------CATQPCHHGALCV------- 87

  Fly   241 CMCPTGYTGKDCDTKYKPCSPSPCQNGGICRSNGLSYECKCPKGFEGKNCEQNYDDCLGHLCQNG 305
                             |..|.|           .|:.|.|..||:|.:||.             
Mouse    88 -----------------PQGPDP-----------NSFRCYCVPGFQGPHCEL------------- 111

  Fly   306 GTCIDGISDYTCRCPPNFTGRFCQDDVDECAQRDHPVCQNGATCTNTHGSYSCICVNGWAGLDCS 370
                                     |:||||.|.   ||:|.||.|....|.|.|..|:||:.|.
Mouse   112 -------------------------DIDECASRP---CQHGGTCQNLADHYECHCPLGYAGVTCE 148

  Fly   371 NNTDDCKQAACFYGATCIDGVGSFYCQCTKGKTGLLCHLDDACTSNPCHADAICDTSPINGSYAC 435
            ...|:|..|.|.:|.:|:|||                                       |||.|
Mouse   149 AEVDECSSAPCLHGGSCLDGV---------------------------------------GSYRC 174

  Fly   436 SCATGYKGVDCSEDIDECDQGSPCEHNGICVNTPGSYRCNCSQ-GFTGPRCETNINECESHPCQN 499
            .||.||.|.:|..|:||| |..||.|.|:|.:....:||:|:. |:.|.|||..:.||.|.||.:
Mouse   175 VCAPGYAGANCQLDVDEC-QSQPCAHGGVCHDLVNGFRCDCADTGYEGARCEQEVLECASAPCAH 238

  Fly   500 EGSCLDDPGTFRCVCMPGFTGTQCEIDIDECQSNPCLNDGTCHDKINGFKCSCALGFTGARCQIN 564
            ..||||...:|||:|.|||:|.:||:|.|||.|.||.|.|.|..:                    
Mouse   239 NASCLDGFRSFRCLCWPGFSGERCEVDEDECASGPCQNGGQCLQR-------------------- 283

  Fly   565 IDDCQSQPCRNRGI--------CHDSIAGYSCECPPGYTGTSCEININDCDSNPC-HRGKCIDDV 620
                 |.|....|:        .....||:.|.||.|:.|..|.:::::|.|.|| :.|.|.|..
Mouse   284 -----SDPTLYGGVQAIFPGAFSFSHAAGFLCSCPLGFAGNDCSMDVDECASGPCLNGGSCQDLP 343

  Fly   621 NSFKCLCDPGYTGYICQKQINECESNPCQFDGHCQDRVGSYYCQCQAGTSGKNCEVNVNECHSNP 685
            |.|:|.|..||||..||:.::||:|.||...|.|.|.|..|.|||.....|.:|.|.:..|..:.
Mouse   344 NGFQCYCQDGYTGLTCQEDMDECQSEPCLHGGTCSDTVAGYICQCPEAWGGHDCSVQLTGCQGHT 408

  Fly   686 CNNGATCI----DGINSYKCQCVPGFTGQHCEKNVDECISS---------PCANNGVCI------ 731
            |...||||    .|::.|.|:|.||..|..|.:|....:.|         ..|:.|:.:      
Mouse   409 CPLAATCIPTFKSGLHGYFCRCPPGTYGPFCGQNTTFSVVSGSSVWGLVPAAASLGLALRFRTTL 473

  Fly   732 ---------DQVNGYKCECPRGFYDA----H-------CLSDV---------------------- 754
                     |..:..:.........|    |       .|.|:                      
Mouse   474 LAGTLATLKDTRDSLELVLVGAVLQATLSRHGTAVLILTLPDLALNDGHWHQVEVTLHLGTLELR 538

  Fly   755 ---DECASNPCVNEGRCEDGINEFICHCPPG----YTGKRCELDIDECSSNPCQHGGT---CYDK 809
               :.|....||..|....|....:...|||    |.|                 ||.   |:..
Mouse   539 LWHEGCPGQLCVASGPVATGPTASVASGPPGSYSIYLG-----------------GGVFAGCFQD 586

  Fly   810 LNAFSCQCMP----GYTGQKCETNIDDCVTNPCGNGGTCIDKVNGYKCVCKVPFTGRDCESKMDP 870
            :.......:|    |.....||.. :.|...||.:||.|:|....::|.|..|:.|..|..:: |
Mouse   587 VRVEGHLLLPEELKGTVLLGCERR-EPCQPLPCAHGGACVDLWTHFRCDCPRPYRGATCTDEV-P 649

  Fly   871 CASNRCKNEAKCTPSSNF------------------------LDF------SCTCKLG------- 898
            .|:   ......|.|::|                        |.|      |.|..|.       
Mouse   650 AAT---FGLGGATSSASFLLHQLGPNLTVSFFLRTREPAGLLLQFANDSVASLTVFLSEGQIRAE 711

  Fly   899 -------------------------------------YTG---------------RYCDEDIDEC 911
                                                 |.|               |.|.:|:...
Mouse   712 GLGHPAVVLPGRWDDGLPHLVMLSFGPDQLQDLGQRLYVGGRFYPDDTQLWGGPFRGCLQDLQLN 776

  Fly   912 SL-----SSPCRNGASCLNVPGSYRCLCTKGYEGRDCAINTDDCASFPCQNGGTCLDGIGDYSCL 971
            |:     |||..|.:....:........|:|      .::.|.|...||.|||||.....|:.|.
Mouse   777 SIHLPFFSSPMENSSWPSELEAGQSSNLTQG------CVSEDTCNPNPCFNGGTCHVTWNDFYCT 835

  Fly   972 CVDGFDGKHCETDINECLSQPCQNGATCSQYVNSYTCTC--------PLGFSGINCQTNDEDCTE 1028
            |.:.|.|..|... ..|..|||...|||.:..:.:.|..        |..|:|.|.         
Mouse   836 CSENFTGPTCAQQ-RWCPRQPCLPPATCEEVPDGFVCVAEATFREGPPAVFTGHNV--------- 890

  Fly  1029 SSCLNGGSCIDGINGYNCSCLAGYSGANCQYKLNKCDSNPCLNGATCHE----------QNNEYT 1083
            ||.|:|.:............|...|.|.....:.....|..|.|.....          ....:.
Mouse   891 SSSLSGLTLAFRTRDSEAGLLRAVSAAGAHSNIWLAVRNGSLAGDVAGSVLPAPGPRVADGAWHR 955

  Fly  1084 CHCPSGFTGKQCSEYVDWCG------------------QSPCENGATCSQMKHQFSCKCSAGWTG 1130
            ......|.....|.::.|..                  |.|   ||....:...|:     |..|
Mouse   956 VRLAREFPQAAASRWLLWLDGAATPVALHGLGGDLGFLQGP---GAVPLLLAENFT-----GCLG 1012

  Fly  1131 KLCDVQTISCQD-----AADRKGLSLRQLCNNGTCKDY----GNSHVCYCSQGYAGSYCQKEIDE 1186
            :      ::..|     |..|.|..      :|..:.:    |:..|   |.|..|.      ..
Mouse  1013 R------VALGDFPLPLAPPRSGTV------SGAREHFVAWPGSPAV---SLGCRGG------PV 1056

  Fly  1187 CQSQPCQNGGTCRDLIGAYECQCRQGFQGQNCELNIDDCAPNPCQNGGTCHDRV-MNFSCSCPPG 1250
            |...||.:||.||||..|:.|.|...::|..||:..|.|...||.. |.||.|. ..|.|.||||
Mouse  1057 CSPSPCLHGGACRDLFDAFACSCGPAWEGPRCEIRADPCRSTPCVR-GQCHARPDGRFECRCPPG 1120

  Fly  1251 TMGIICEINKDDCKPGACHNNGSCIDRVGGFECVCQPGFVGARCEGDINECLSNPCSNAGTLDCV 1315
            ..|..|.:   ...|..|:.|.:|.|              ||.|||          ...||    
Mouse  1121 FSGPRCRL---PVLPQGCNLNSTCKD--------------GAPCEG----------GPLGT---- 1154

  Fly  1316 QLVNNYHCNCRPGHMGRHCEHKVDFCAQSPCQNGGNCNIRQSGHHCICNNGFYGKNCEL 1374
                  :|:|:.|..|..|:.....|..|||.|||.|.:......|.|:.||.|:.||:
Mouse  1155 ------NCSCQEGLAGLRCQSLDKPCEASPCLNGGTCRVASGIFECTCSAGFSGQFCEV 1207

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NNP_001245510.1 EGF_CA 179..214 CDD:238011 13/34 (38%)
EGF_CA 217..252 CDD:238011 6/34 (18%)
EGF_CA 260..291 CDD:238011 8/30 (27%)
EGF_CA 295..329 CDD:238011 0/33 (0%)
EGF_CA 331..369 CDD:238011 18/37 (49%)
EGF_CA 449..486 CDD:238011 16/37 (43%)
EGF_CA 488..524 CDD:238011 17/35 (49%)
EGF_CA 526..562 CDD:238011 10/35 (29%)
EGF_CA 564..600 CDD:238011 10/43 (23%)
EGF_CA 602..637 CDD:238011 15/35 (43%)
EGF_CA 640..675 CDD:238011 14/34 (41%)
EGF_CA 677..713 CDD:238011 13/39 (33%)
EGF_CA 715..750 CDD:238011 7/69 (10%)
EGF_CA 753..789 CDD:238011 11/64 (17%)
EGF_CA 791..827 CDD:238011 5/42 (12%)
EGF_CA 829..865 CDD:238011 11/35 (31%)
EGF_CA 907..943 CDD:238011 8/40 (20%)
EGF_CA 946..982 CDD:238011 14/35 (40%)
EGF_CA 984..1020 CDD:238011 12/43 (28%)
EGF_CA 1027..1058 CDD:238011 7/30 (23%)
EGF_CA 1062..1095 CDD:238011 4/42 (10%)
EGF_CA 1184..1219 CDD:238011 13/34 (38%)
EGF_CA 1221..1257 CDD:238011 15/36 (42%)
EGF_CA 1259..1295 CDD:238011 7/35 (20%)
EGF_CA 1297..1335 CDD:238011 6/37 (16%)
EGF_CA 1417..1450 CDD:238011
NL 1476..1512 CDD:197463
Notch 1519..1553 CDD:278494
Notch 1565..1593 CDD:278494
NOD 1599..1648 CDD:284282
NODP 1680..1731 CDD:284987
ANK 1896..2038 CDD:238125
ANK repeat 1902..1948 CDD:293786
ANK repeat 1951..1981 CDD:293786
Ank_5 1970..2025 CDD:290568
ANK 1978..2104 CDD:238125
ANK repeat 1984..2015 CDD:293786
ANK repeat 2017..2048 CDD:293786
Ank_2 2022..2114 CDD:289560
ANK repeat 2050..2081 CDD:293786
ANK repeat 2083..2114 CDD:293786
DUF3454 2627..2682 CDD:288764
Crb2NP_001157038.1 EGF_CA <79..110 CDD:238011 14/65 (22%)
EGF_CA 112..148 CDD:238011 18/38 (47%)
EGF_CA 151..186 CDD:238011 18/73 (25%)
EGF_CA 188..225 CDD:238011 16/37 (43%)
EGF_CA 230..263 CDD:238011 17/32 (53%)
EGF_CA 324..360 CDD:238011 15/35 (43%)
EGF_CA 362..397 CDD:238011 14/34 (41%)
Laminin_G_2 469..592 CDD:280389 18/139 (13%)
EGF 613..643 CDD:278437 11/29 (38%)
LamG 666..776 CDD:238058 10/109 (9%)
EGF 814..844 CDD:278437 13/29 (45%)
Laminin_G_2 901..1018 CDD:280389 16/130 (12%)
EGF_CA 1058..1089 CDD:238011 12/30 (40%)
EGF_CA 1175..1206 CDD:238011 12/30 (40%)
Interaction with EPB41L5. /evidence=ECO:0000250|UniProtKB:Q5IJ48 1246..1282
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 51 1.000 Domainoid score I11481
eggNOG 1 0.900 - - E33208_3BAFT
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100271
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
43.710

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