DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment N and Notch4

DIOPT Version :9

Sequence 1:NP_001245510.1 Gene:N / 31293 FlyBaseID:FBgn0004647 Length:2703 Species:Drosophila melanogaster
Sequence 2:XP_006523861.1 Gene:Notch4 / 18132 MGIID:107471 Length:1968 Species:Mus musculus


Alignment Length:2230 Identity:771/2230 - (34%)
Similarity:1034/2230 - (46%) Gaps:463/2230 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    36 LLLLTLAFANLPNTVRGTDTALVAASCTSVGCQNGGTCVTQLNGKTYCACDSHYVGDYCEHRNPC 100
            ||||.|...|.|..:....:..:....:...|.|||||:....|:..|.|...::|:.|:..:||
Mouse     5 LLLLLLLPLNFPVILTRVSSPELLCGGSPEPCANGGTCLRLSRGQGICQCAPGFLGETCQFPDPC 69

  Fly   101 -NSMRCQNGGTCQV---TFRNGR-------PGISCKCPLGFDESLCEIAVPNACDHVTCLNGGTC 154
             ::..|:|||:||.   |..:.|       |..||.||.||....|:..:...|....|.|||.|
Mouse    70 RDTQLCKNGGSCQALLPTPPSSRSPTSPLTPHFSCTCPSGFTGDRCQTHLEELCPPSFCSNGGHC 134

  Fly   155 QLKTLEEYTCACANGYTGERCETKNLCASSPCRNGATCTALAGSSSFTCSCPPGFTGDTCSYDIE 219
            .::......|:|..|:|||:|:.::.|:::||.||..|  ||......|.|||||.|.||..||.
Mouse   135 YVQASGRPQCSCEPGWTGEQCQLRDFCSANPCANGGVC--LATYPQIQCRCPPGFEGHTCERDIN 197

  Fly   220 EC--QSNPCKYGGTCVNTHGSYQCMCPTGYTGKDCDTKYKPCSPSPCQNGGICR----SNGLSYE 278
            ||  :..||..|.:|.||.|||||:||.|..|..|..:...|.|..|.|||.|:    .:...:.
Mouse   198 ECFLEPGPCPQGTSCHNTLGSYQCLCPVGQEGPQCKLRKGACPPGSCLNGGTCQLVPEGHSTFHL 262

  Fly   279 CKCPKGFEGKNCEQNYDDCLGHLCQNGGTCIDGISDYTCRCPPNFTGRFCQDDVDECAQRDHPVC 343
            |.||.||.|.:||.|.|||:.|.||||.||:||:..|||.||..:.|..|.:|:|||..|..|.|
Mouse   263 CLCPPGFTGLDCEMNPDDCVRHQCQNGATCLDGLDTYTCLCPKTWKGWDCSEDIDECEARGPPRC 327

  Fly   344 QNGATCTNTHGSYSCICVNGWAGLDCSNNTDDCKQAACFYGATCIDGVGSFYCQCTKGKTGLLCH 408
            :||.||.||.||:.|:||:||.|..|..|.|||..|.|..|:||||.||||.|.|..|:||||||
Mouse   328 RNGGTCQNTAGSFHCVCVSGWGGAGCEENLDDCAAATCAPGSTCIDRVGSFSCLCPPGRTGLLCH 392

  Fly   409 LDDACTSNPCHADAICDTSPINGSYACSCATGYKGVDCSEDIDEC---DQG-SPCEHNGICVNTP 469
            |:|.|.|.|||.:|.|.|:|:.||..|.|..||.|..|.:|:|||   .|| |||||.|.|:|||
Mouse   393 LEDMCLSQPCHVNAQCSTNPLTGSTLCICQPGYSGSTCHQDLDECQMAQQGPSPCEHGGSCINTP 457

  Fly   470 GSYRCNCSQGFTGPRCETNINECESHPCQNEGSCLDDPGTFRCVCMPGFTGTQCEIDIDECQSNP 534
            ||:.|.|..|:||.|||.:.|||.|.||....:|||...||.|:|.||..|..||::::||.|||
Mouse   458 GSFNCLCLPGYTGSRCEADHNECLSQPCHPGSTCLDLLATFHCLCPPGLEGRLCEVEVNECTSNP 522

  Fly   535 CLNDGTCHDKINGFKCSCALGFTGARCQINIDDCQSQPCRNRGICHDSIAGYSCECPPGYTGTSC 599
            |||...|||.:|||:|.|..|||||||:.::|:|.|.||.|                        
Mouse   523 CLNQAACHDLLNGFQCLCLPGFTGARCEKDMDECSSTPCAN------------------------ 563

  Fly   600 EININDCDSNPCHRGKCIDDVNSFKCLCDPGYTGYICQKQINECESNPCQFDGHCQDRVGSYYCQ 664
                                                               .|.|:|:.|::||:
Mouse   564 ---------------------------------------------------GGRCRDQPGAFYCE 577

  Fly   665 CQAGTSGKNCEVNVNECHSNPCNNGATCIDGINSYKCQCVPGFTGQHCEKNVDECISSPCANNGV 729
            |..|..|.:||..|:||.|:||..||:|:|...::.|.|.||||||.||                
Mouse   578 CLPGFEGPHCEKEVDECLSDPCPVGASCLDLPGAFFCLCRPGFTGQLCE---------------- 626

  Fly   730 CIDQVNGYKCECPRGFYDAHCLSDVDECASNPCVNEGRCEDGINEFICHCPPGYTGKRCELDIDE 794
                                    |..|..|.|....:|:...:...|.||.|..|  |....|.
Mouse   627 ------------------------VPLCTPNMCQPGQQCQGQEHRAPCLCPDGSPG--CVPAEDN 665

  Fly   795 CSSNPCQHGGTCYDKLNAFSCQCMPGYTGQKCETNIDDCVTNPCGNGGTCIDKVNGYKCVCKVPF 859
            |   ||.| |.|...|    |.|..|:||.:|||.:..|::.||.:||||..:.:||        
Mouse   666 C---PCHH-GHCQRSL----CVCDEGWTGPECETELGGCISTPCAHGGTCHPQPSGY-------- 714

  Fly   860 TGRDCESKMDPCASNRCKNEAKCTPSSNFLDFSCTCKLGYTGRYCDEDIDECSLSSPCRNGASCL 924
                                            :|||..||.|..|.|::..|. |.||.||.||.
Mouse   715 --------------------------------NCTCPAGYMGLTCSEEVTACH-SGPCLNGGSCS 746

  Fly   925 NVPGSYRCLCTKGYEGRDCAINTDDCASFPCQNGGTCLDGIGDYSCLCVDGFDGKHCETDIN-EC 988
            ..|..|.|.|...:.||.|....|.|.|..|.|||||::..|.:.|||..||.|.|||...| .|
Mouse   747 IRPEGYSCTCLPSHTGRHCQTAVDHCVSASCLNGGTCVNKPGTFFCLCATGFQGLHCEEKTNPSC 811

  Fly   989 LSQPCQNGATCSQYVNSYTCTCPLGFSGINCQTNDEDCTESSCLNGGSCIDGINGYNCSCLAGYS 1053
            ...||:|.|||.                                      |...|..|.|..||:
Mouse   812 ADSPCRNKATCQ--------------------------------------DTPRGARCLCSPGYT 838

  Fly  1054 GANCQYKLNKCDSNPCLNGATCHEQNNEYTCHCPSGFTGKQCSEYVDWCGQSPCENGATCSQMKH 1118
            |::||                                      ..:|.|.:.||.:.|.|.|...
Mouse   839 GSSCQ--------------------------------------TLIDLCARKPCPHTARCLQSGP 865

  Fly  1119 QFSCKCSAGWTGKLCDVQTISCQDAADRKGLSLRQLC-NNGTCKDYGNSHVCYCSQGYAGSYCQK 1182
            .|.|.|..||||.|||. .:|||.||..:|:.:..|| |.|.|.|.|:|:.|.|..|:.|..||.
Mouse   866 SFQCLCLQGWTGALCDF-PLSCQKAAMSQGIEISGLCQNGGLCIDTGSSYFCRCPPGFQGKLCQD 929

  Fly  1183 EIDECQSQPCQNGGTCRDLIGAYECQCRQGFQGQNCELNIDDCAPNPCQNGGTCHDRVMNFSCSC 1247
            .::.|:..||.:|.||......|.|||..|::||||...:|.|...|                  
Mouse   930 NVNPCEPNPCHHGSTCVPQPSGYVCQCAPGYEGQNCSKVLDACQSQP------------------ 976

  Fly  1248 PPGTMGIICEINKDDCKPGACHNNGSCIDRVGGFECVCQPGFVGARCEGDINECLSNPCSNAGTL 1312
                                |||:|:|..|.|||.|.|.|||||.|||||::|||..||..:||.
Mouse   977 --------------------CHNHGTCTSRPGGFHCACPPGFVGLRCEGDVDECLDRPCHPSGTA 1021

  Fly  1313 DCVQLVNNYHCNCRPGHMGRHCEHKVDFCAQSPCQNGGNCNIRQS---GHHCICNNGFYGKNCEL 1374
            .|..|.|.::|.|.|||.|:.||.::|.|...||.|||:|.|...   |..|.|..||.|..|..
Mouse  1022 ACHSLANAFYCQCLPGHTGQRCEVEMDLCQSQPCSNGGSCEITTGPPPGFTCHCPKGFEGPTCSH 1086

  Fly  1375 SGQDCDSNPCRVGN-CVVADE-GFGYRCECPRGTLGEHCEIDTLDE-CS-PNPCAQGAACEDLLG 1435
            ....|..:.|..|. |:.:.: |....|.|..|..|..|....... |. |:||.....|.:..|
Mouse  1087 KALSCGIHHCHNGGLCLPSPKPGSPPLCACLSGFGGPDCLTPPAPPGCGPPSPCLHNGTCTETPG 1151

  Fly  1436 ----DYECLCPSKWKGKRCDIYDANYPGWNGGSGSGNDRYAADLEQQRAMCDKRGCTEKQGNGIC 1496
                .::|.||....|.||     ..||.:|                   |:.||     |:|.|
Mouse  1152 LGNPGFQCTCPPDSPGPRC-----QRPGASG-------------------CEGRG-----GDGTC 1187

  Fly  1497 DSDCNTYACNFDGNDCSLGI-NPWANCTA-NECWNKFKNGKCNEECNNAACHYDGHDCERKLKSC 1559
            |:.|:....::||.|||||: :||..|.. ::||..|::|:|:.:|::..|.:||:|||..| :|
Mouse  1188 DAGCSGPGGDWDGGDCSLGVPDPWKGCPPHSQCWLLFRDGRCHPQCDSEECLFDGYDCEIPL-TC 1251

  Fly  1560 DSLFDAYCQKHYGDGFCDYGCNNAECSWDGLDCENKTQSPVLAEG--AMSVVMLMNVEAFREIQA 1622
            ...:|.||:.|:.:|.|:.|||||||.|||.||..:.:.   :||  ::::::::...|..:...
Mouse  1252 IPAYDQYCRDHFHNGHCEKGCNNAECGWDGGDCRPEGED---SEGRPSLALLVVLRPPALDQQLL 1313

  Fly  1623 QFLRNMSHMLRTTVRLKKDALGHDIIINWKDNVRVPEIEDTDFARKNKILYTQQVHQT------- 1680
            ...|.:|..||..:.::||:.|.:::..:.......|:.    ..::...:.:|...|       
Mouse  1314 ALARVLSLTLRVGLWVRKDSEGRNMVFPYPGTRAKEELS----GARDSSSWERQAPPTQPLGKET 1374

  Fly  1681 -----GIQIYLEIDNRKC------TECFTHAVEAAEFLAATAAKHQLRNDFQIHSVRGIKNPGDE 1734
                 |..:.:.:|..:|      :.|...:.....||||.||...|....          ||..
Mouse  1375 ESLGAGFVVVMGVDLSRCGPEHPASRCPWDSGLLLRFLAAMAAVGALEPLL----------PGPL 1429

  Fly  1735 DNGEPPANVK------------YVITGIILVIIALAFFGMVLSTQRKRAHGVTWFPEGF-RAPAA 1786
            ....|.|..:            ..:.|::|:.:. |...:.|..:|:|.||..|.|.|| |.|..
Mouse  1430 LAAHPQAGTRPSANQLPWPILCSPVVGVLLLALG-ALLVLQLIRRRRREHGALWLPPGFIRRPQT 1493

  Fly  1787 VMS-RRRRDPHGQE---MRNLNKQVAMQSQGVGQPGAHWSDDESDMPLPKRQRSDPV-SGVGLGN 1846
            ..: .|||.|.|::   ::.|..:..:...||.........:..:.....|.:..|: ||.|   
Mouse  1494 QQAPHRRRPPLGEDNIGLKALKPEAEVDEDGVAMCSGPEEGEAEETASASRCQLWPLNSGCG--- 1555

  Fly  1847 NGGYASDHTMVSEYEEADQRVWSQAHLDVVDVRAIMTPPAHQDGGKHDVDARGPCGLTPLMIAAV 1911
                        |..:|                |::|||...:....|||..||.|:||||.|..
Mouse  1556 ------------ELPQA----------------AMLTPPQECESEVLDVDTCGPDGVTPLMSAVF 1592

  Fly  1912 RGGGLDTGEDIENNEDSTAQVI--------SDLLAQGAELNATMDKTGETSLHLAARFARADAAK 1968
            .||       :::...::.|.:        ..||.:||...|....||||.|||||||:|..||:
Mouse  1593 CGG-------VQSTTGASPQRLGLGNLEPWEPLLDRGACPQAHTVGTGETPLHLAARFSRPTAAR 1650

  Fly  1969 RLLDAGADANCQDNTGRTPLHAAVAADAMGVFQILLRNRATNLNARMHDGTTPLILAARLAIEGM 2033
            |||:|||:.|..|..||||||.||||||..|.|:||.:|.|.::||..||||||:||||||:|.:
Mouse  1651 RLLEAGANPNQPDRAGRTPLHTAVAADAREVCQLLLASRQTTVDARTEDGTTPLMLAARLAVEDL 1715

  Fly  2034 VEDLITADADINAADNSGKTALHWAAAVNNTEAVNILLMHHANRDAQDDKDETPLFLAAREGSYE 2098
            ||:||.|.||:.|.|..|||||||||||||..|...||...|::||||.:::||||||||||:.|
Mouse  1716 VEELIAARADVGARDKRGKTALHWAAAVNNARAARSLLQAGADKDAQDSREQTPLFLAAREGAVE 1780

  Fly  2099 ACKALLDNFANREITDHMDRLPRDVASERLHHDIVRLLDEHVPRSPQMLSMTPQAMIGSPPPGQQ 2163
            ..:.||:..|.|.:.|.....|.|||.:|.|.|::.||:...|.:.:     .:|...:.|.|..
Mouse  1781 VAQLLLELGAARGLRDQAGLAPGDVARQRSHWDLLTLLEGAGPTTQE-----ARAHARTTPGGGA 1840

  Fly  2164 QPQLITQPTVISAG---NGG 2180
            .|:..|    :|||   .||
Mouse  1841 APRCRT----LSAGARPRGG 1856

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NNP_001245510.1 EGF_CA 179..214 CDD:238011 15/34 (44%)
EGF_CA 217..252 CDD:238011 19/36 (53%)
EGF_CA 260..291 CDD:238011 12/34 (35%)
EGF_CA 295..329 CDD:238011 18/33 (55%)
EGF_CA 331..369 CDD:238011 21/37 (57%)
EGF_CA 449..486 CDD:238011 24/40 (60%)
EGF_CA 488..524 CDD:238011 16/35 (46%)
EGF_CA 526..562 CDD:238011 22/35 (63%)
EGF_CA 564..600 CDD:238011 6/35 (17%)
EGF_CA 602..637 CDD:238011 0/34 (0%)
EGF_CA 640..675 CDD:238011 9/34 (26%)
EGF_CA 677..713 CDD:238011 18/35 (51%)
EGF_CA 715..750 CDD:238011 0/34 (0%)
EGF_CA 753..789 CDD:238011 10/35 (29%)
EGF_CA 791..827 CDD:238011 13/35 (37%)
EGF_CA 829..865 CDD:238011 9/35 (26%)
EGF_CA 907..943 CDD:238011 14/35 (40%)
EGF_CA 946..982 CDD:238011 17/35 (49%)
EGF_CA 984..1020 CDD:238011 8/36 (22%)
EGF_CA 1027..1058 CDD:238011 7/30 (23%)
EGF_CA 1062..1095 CDD:238011 0/32 (0%)
EGF_CA 1184..1219 CDD:238011 14/34 (41%)
EGF_CA 1221..1257 CDD:238011 3/35 (9%)
EGF_CA 1259..1295 CDD:238011 17/35 (49%)
EGF_CA 1297..1335 CDD:238011 17/37 (46%)
EGF_CA 1417..1450 CDD:238011 10/38 (26%)
NL 1476..1512 CDD:197463 10/35 (29%)
Notch 1519..1553 CDD:278494 12/34 (35%)
Notch 1565..1593 CDD:278494 16/27 (59%)
NOD 1599..1648 CDD:284282 10/50 (20%)
NODP 1680..1731 CDD:284987 12/68 (18%)
ANK 1896..2038 CDD:238125 74/149 (50%)
ANK repeat 1902..1948 CDD:293786 14/53 (26%)
ANK repeat 1951..1981 CDD:293786 20/29 (69%)
Ank_5 1970..2025 CDD:290568 33/54 (61%)
ANK 1978..2104 CDD:238125 76/125 (61%)
ANK repeat 1984..2015 CDD:293786 19/30 (63%)
ANK repeat 2017..2048 CDD:293786 21/30 (70%)
Ank_2 2022..2114 CDD:289560 53/91 (58%)
ANK repeat 2050..2081 CDD:293786 19/30 (63%)
ANK repeat 2083..2114 CDD:293786 15/30 (50%)
DUF3454 2627..2682 CDD:288764
Notch4XP_006523861.1 EGF_CA 162..193 CDD:238011 15/32 (47%)
EGF_CA 195..233 CDD:214542 19/37 (51%)
EGF_CA 315..354 CDD:238011 21/38 (55%)
EGF_CA 356..391 CDD:238011 21/34 (62%)
EGF_CA 433..474 CDD:238011 24/40 (60%)
EGF_CA 476..512 CDD:238011 16/35 (46%)
EGF_CA 515..550 CDD:238011 22/34 (65%)
EGF_CA 552..588 CDD:238011 15/110 (14%)
EGF_CA 591..626 CDD:238011 18/34 (53%)
EGF_CA <700..727 CDD:238011 14/66 (21%)
EGF_CA 769..804 CDD:238011 17/34 (50%)
EGF_CA <814..843 CDD:238011 13/66 (20%)
EGF_CA 896..928 CDD:238011 12/31 (39%)
EGF_CA 930..965 CDD:238011 13/34 (38%)
EGF_CA 970..1004 CDD:238011 20/71 (28%)
EGF_CA 1006..1044 CDD:238011 17/37 (46%)
NL 1207..1245 CDD:197463 12/37 (32%)
Notch 1257..1285 CDD:365847 16/27 (59%)
Ank_2 <1575..1663 CDD:372319 40/94 (43%)
ANK repeat 1582..1629 CDD:293786 14/53 (26%)
ANK repeat 1633..1663 CDD:293786 20/29 (69%)
Ank_2 1637..1730 CDD:372319 59/92 (64%)
ANKYR 1644..1819 CDD:223738 98/174 (56%)
ANK repeat 1665..1697 CDD:293786 19/31 (61%)
ANK repeat 1699..1730 CDD:293786 21/30 (70%)
ANK repeat 1732..1763 CDD:293786 19/30 (63%)
ANK repeat 1765..1796 CDD:293786 15/30 (50%)
ANK repeat 1798..1826 CDD:293786 10/27 (37%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 58 1.000 Domainoid score I10716
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D5821at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100271
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
54.820

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