DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment N and ACAN

DIOPT Version :9

Sequence 1:	NP_001245510.1	Gene:	N / 31293	FlyBaseID:	FBgn0004647	Length:	2703	Species:	Drosophila melanogaster
Sequence 2:	NP_001356197.1	Gene:	ACAN / 176	HGNCID:	319	Length:	2568	Species:	Homo sapiens

Alignment Length:	309	Identity:	83/309 - (26%)
Similarity:	119/309 - (38%)	Gaps:	85/309 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   757 CASNPCVNEGRCEDGINEFICHCPPGYTGKRCELDIDECSSNPCQHGGTCYDKLNAFSCQCMPGY 821
            ||..|| ..|.|::.....||.|||||||:.|.:|||||.|:||.:|.||.|.:::|:|.|:|.|
Human  2283 CAEEPC-GAGTCKETEGHVICLCPPGYTGEHCNIDIDECLSSPCLNGATCVDAIDSFTCLCLPSY 2346

  Fly   822 TGQKCETNIDDCVTNPCGNGGTCIDKVNGYKCVCKVPFTGRDCESKMDPCASNRCKNEAK----- 881
            .|..||  ||..|         |.:..|.|:..|...|..|  |:.:|  |..||:.:..
Human  2347 EGDLCE--IDQEV---------CEEGWNKYQGHCYRHFPDR--ETWVD--AERRCREQQSHLSSI 2396

  Fly   882 CTP------SSNFLDFSCTCKLGYTGRYCDEDIDECSLSSPCRNGASCLNVPGSYRCLCTKGYEG 940
            .||      ::|..|:..   :|...|..:.|. ..|...|.:......|.|.::..      .|
Human  2397 VTPEEQEFVNNNAQDYQW---IGLNDRTIEGDF-RWSDGHPMQFENWRPNQPDNFFA------AG 2451

  Fly   941 RDCAI---------NTDDC---ASFPCQNGGTCLDGIGDYSCLCVDGFDGKHCET--------DI 985
            .||.:         |...|   ..|.|:.|          :..|.:....:|..|        :|
Human  2452 EDCVVMIWHEKGEWNDVPCNYHLPFTCKKG----------TVACGEPPVVEHARTFGQKKDRYEI 2506

  Fly   986 NECLSQPCQNGATCSQYVNSYTCTCPLGFSGINCQTNDE------DCTE 1028
            |..:...|..|     :|..:..|       |.||.:..      .||:
Human  2507 NSLVRYQCTEG-----FVQRHMPT-------IRCQPSGHWEEPQITCTD 2543

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
N	NP_001245510.1	EGF_CA	179..214	CDD:238011
		EGF_CA	217..252	CDD:238011
		EGF_CA	260..291	CDD:238011
		EGF_CA	295..329	CDD:238011
		EGF_CA	331..369	CDD:238011
		EGF_CA	449..486	CDD:238011
		EGF_CA	488..524	CDD:238011
		EGF_CA	526..562	CDD:238011
		EGF_CA	564..600	CDD:238011
		EGF_CA	602..637	CDD:238011
		EGF_CA	640..675	CDD:238011
		EGF_CA	677..713	CDD:238011
		EGF_CA	715..750	CDD:238011
		EGF_CA	753..789	CDD:238011	15/31 (48%)
		EGF_CA	791..827	CDD:238011	18/35 (51%)
		EGF_CA	829..865	CDD:238011	9/35 (26%)
		EGF_CA	907..943	CDD:238011	6/35 (17%)
		EGF_CA	946..982	CDD:238011	7/38 (18%)
		EGF_CA	984..1020	CDD:238011	7/35 (20%)
		EGF_CA	1027..1058	CDD:238011	1/2 (50%)
		EGF_CA	1062..1095	CDD:238011
		EGF_CA	1184..1219	CDD:238011
		EGF_CA	1221..1257	CDD:238011
		EGF_CA	1259..1295	CDD:238011
		EGF_CA	1297..1335	CDD:238011
		EGF_CA	1417..1450	CDD:238011
		NL	1476..1512	CDD:197463
		Notch	1519..1553	CDD:278494
		Notch	1565..1593	CDD:278494
		NOD	1599..1648	CDD:284282
		NODP	1680..1731	CDD:284987
		ANK	1896..2038	CDD:238125
		ANK repeat	1902..1948	CDD:293786
		ANK repeat	1951..1981	CDD:293786
		Ank_5	1970..2025	CDD:290568
		ANK	1978..2104	CDD:238125
		ANK repeat	1984..2015	CDD:293786
		ANK repeat	2017..2048	CDD:293786
		Ank_2	2022..2114	CDD:289560
		ANK repeat	2050..2081	CDD:293786
		ANK repeat	2083..2114	CDD:293786
		DUF3454	2627..2682	CDD:288764
ACAN	NP_001356197.1	Ig_Aggrecan	43..154	CDD:143308
		G1-A	48..141
		G1-B	152..247
		Link_domain_CSPGs_modules_1_3	153..247	CDD:239594
		G1-B'	253..349
		Link_domain_CSPGs_modules_2_4	254..349	CDD:239597
		G2-B	477..571
		Link_domain_CSPGs_modules_1_3	478..572	CDD:239594
		G2-B'	578..673
		Link_domain_CSPGs_modules_2_4	579..674	CDD:239597
		KS	677..849
		PHA03307	716..>975	CDD:223039
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	734..979
		12 X 6 AA approximate tandem repeats of E-[GVE]-P-[SFY]-[APT]-[TSP]	773..844
		CS-1	852..1612
		35 X 19 AA approximate tandem repeats of E-[IVDG]-[LV]-[EV]-[GTI]-[STA]-[ATV]-[SP]-[GA]-[VIFAD]- [GEDL]-[DE]-[LVI]-[SG]-[GERK]-[LV]-P-S-G	942..1612
		PRK15387	<1433..>1614	CDD:185285
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1499..1526
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1543..1649
		CS-2	1613..2277
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1687..1772
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1784..1827
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1883..1902
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1948..1977
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2048..2204
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2249..2281
		EGF_CA	2283..2313	CDD:238011	15/30 (50%)
		EGF_CA	2316..2352	CDD:238011	18/35 (51%)
		CLECT_CSPGs	2358..2481	CDD:153058	29/136 (21%)
		CCP	2485..2541	CDD:153056	12/67 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2548..2568
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22804
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100