DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment N and VCAN

DIOPT Version :9

Sequence 1:	NP_001245510.1	Gene:	N / 31293	FlyBaseID:	FBgn0004647	Length:	2703	Species:	Drosophila melanogaster
Sequence 2:	NP_004376.2	Gene:	VCAN / 1462	HGNCID:	2464	Length:	3396	Species:	Homo sapiens

Alignment Length:	407	Identity:	93/407 - (22%)
Similarity:	135/407 - (33%)	Gaps:	159/407 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   793 DECSSNPCQHGGTCYDKLNAFSCQCMPGYTGQKCETNIDDCVTNPCGNGGTCIDKVNGYKCVCKV 857
            |.|..|||.:|||||....::.|.|:|||:|.:||.:.|:|.:|||.||.||:|..|.::|:
Human  3091 DRCKMNPCLNGGTCYPTETSYVCTCVPGYSGDQCELDFDECHSNPCRNGATCVDGFNTFRCL--- 3152

  Fly   858 PFTGRDCESKMDPCASNRCKNEAKCTPSSNFLDFSCTCKLGYTGRYCDEDIDECSLSSPCRNGAS 922
                                    |.||             |.|..|::|.:.|....
Human  3153 ------------------------CLPS-------------YVGALCEQDTETCDYGW------- 3173

  Fly   923 CLNVPGSYRCLCTKGYEGRDCAINTDDCASFPCQNGGTCLDGI-------------GDYSCLCVD 974
                 ..::..|.|.:..|    .|.|.|...|:..|..|..|             .||..:
Human  3174 -----HKFQGQCYKYFAHR----RTWDAAERECRLQGAHLTSILSHEEQMFVNRVGHDYQWI--- 3226

  Fly   975 GFDGKHCETDINECLSQPCQNGATCSQYVNSYTCTCPLGFSGINCQTNDEDCTESSCLNGGSCID 1039
            |.:.|..|.|..      ..:|:|. ||.              |.:.|..|...|:   |..|:.
Human  3227 GLNDKMFEHDFR------WTDGSTL-QYE--------------NWRPNQPDSFFSA---GEDCVV 3267

  Fly  1040 GI---NGYNCSCLAGYSGANCQYKLNKCDSNPCLNGATCHEQNNEYTCHCPSGFTGKQCSEYVDW 1101
            .|   ||.       ::...|.|.|.                   ||  |..|...
Human  3268 IIWHENGQ-------WNDVPCNYHLT-------------------YT--CKKGTVA--------- 3295

  Fly  1102 CGQSP-CENGATCSQMKHQFSCK------CSAGWTGKLCDVQTISC--------------QDAAD 1145
            |||.| .||..|..:||.::...      |..|:..:  .:.||.|              ..:|.
Human  3296 CGQPPVVENAKTFGKMKPRYEINSLIRYHCKDGFIQR--HLPTIRCLGNGRWAIPKITCMNPSAY 3358

  Fly  1146 RKGLSLRQLCNNGTCKD 1162
            ::..|::...|:.:.||
Human  3359 QRTYSMKYFKNSSSAKD 3375

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
N	NP_001245510.1	EGF_CA	179..214	CDD:238011
		EGF_CA	217..252	CDD:238011
		EGF_CA	260..291	CDD:238011
		EGF_CA	295..329	CDD:238011
		EGF_CA	331..369	CDD:238011
		EGF_CA	449..486	CDD:238011
		EGF_CA	488..524	CDD:238011
		EGF_CA	526..562	CDD:238011
		EGF_CA	564..600	CDD:238011
		EGF_CA	602..637	CDD:238011
		EGF_CA	640..675	CDD:238011
		EGF_CA	677..713	CDD:238011
		EGF_CA	715..750	CDD:238011
		EGF_CA	753..789	CDD:238011
		EGF_CA	791..827	CDD:238011	16/33 (48%)
		EGF_CA	829..865	CDD:238011	12/35 (34%)
		EGF_CA	907..943	CDD:238011	5/35 (14%)
		EGF_CA	946..982	CDD:238011	11/48 (23%)
		EGF_CA	984..1020	CDD:238011	6/35 (17%)
		EGF_CA	1027..1058	CDD:238011	6/33 (18%)
		EGF_CA	1062..1095	CDD:238011	4/32 (13%)
		EGF_CA	1184..1219	CDD:238011
		EGF_CA	1221..1257	CDD:238011
		EGF_CA	1259..1295	CDD:238011
		EGF_CA	1297..1335	CDD:238011
		EGF_CA	1417..1450	CDD:238011
		NL	1476..1512	CDD:197463
		Notch	1519..1553	CDD:278494
		Notch	1565..1593	CDD:278494
		NOD	1599..1648	CDD:284282
		NODP	1680..1731	CDD:284987
		ANK	1896..2038	CDD:238125
		ANK repeat	1902..1948	CDD:293786
		ANK repeat	1951..1981	CDD:293786
		Ank_5	1970..2025	CDD:290568
		ANK	1978..2104	CDD:238125
		ANK repeat	1984..2015	CDD:293786
		ANK repeat	2017..2048	CDD:293786
		Ank_2	2022..2114	CDD:289560
		ANK repeat	2050..2081	CDD:293786
		ANK repeat	2083..2114	CDD:293786
		DUF3454	2627..2682	CDD:288764
VCAN	NP_004376.2	IG_like	29..147	CDD:214653
		Ig_Versican	36..151	CDD:143309
		Link_domain_CSPGs_modules_1_3	150..244	CDD:239594
		Link_domain_CSPGs_modules_2_4	251..346	CDD:239597
		GAG-alpha (glucosaminoglycan attachment domain)	348..1335
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	420..439
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	603..622
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	807..829
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1126..1154
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1277..1316
		GAG-beta	1336..3089
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1420..1497
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1510..1539
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1717..1737
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1759..1789
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1962..1994
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2107..2134
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2168..2188
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2371..2396
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2445..2473
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2493..2518
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2598..2617
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2834..2856
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2881..2905
		EGF_CA	3091..3125	CDD:238011	16/33 (48%)
		EGF_CA	3127..3163	CDD:238011	17/75 (23%)
		CLECT_CSPGs	3169..3292	CDD:153058	36/193 (19%)
		CCP	3296..3352	CDD:153056	14/57 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3371..3396		2/5 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	56	1.000	Domainoid score	I11074
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22804
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.100