DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment N and Fbn1

DIOPT Version :9

Sequence 1:NP_001245510.1 Gene:N / 31293 FlyBaseID:FBgn0004647 Length:2703 Species:Drosophila melanogaster
Sequence 2:NP_032019.2 Gene:Fbn1 / 14118 MGIID:95489 Length:2873 Species:Mus musculus


Alignment Length:2342 Identity:595/2342 - (25%)
Similarity:812/2342 - (34%) Gaps:936/2342 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly    62 CTSVGCQNGGTCVTQLNGKTYCACDSHYVGDYCE---HRNPC----NSMRCQN------------ 107
            |.| ||.|||.||    ....|||...:.|..||   ...||    ::..||.            
Mouse   150 CES-GCLNGGRCV----APNRCACTYGFTGPQCERDYRTGPCFTVVSNQMCQGQLSGIVCTKTLC 209

  Fly   108 --------GGTCQV--------------TFRNGR----------PGI-------------SCKCP 127
                    |..|::              ..|.|.          ||:             .||||
Mouse   210 CATVGRAWGHPCEMCPAQPHPCRRGFIPNIRTGACQDVDECQAIPGMCQGGNCINTVGSFECKCP 274

  Fly   128 LG--FDE--SLCE-----IAVPNACDHVTCLNGGTCQLKTLEEYTCACANG-YT---GERC---- 175
            .|  |:|  ..||     ..:|..||      ||.| ..|:..|.|.|..| ||   |.||    
Mouse   275 AGHKFNEVSQKCEDIDECSTIPGVCD------GGEC-TNTVSSYFCKCPPGFYTSPDGTRCVDVR 332

  Fly   176 ---------------------------------------------------ETKNLCA------- 182
                                                               :...||:       
Mouse   333 PGYCYTALANGRCSNQLPQSITKMQCCCDLGRCWSPGVTVAPEMCPIRSTEDFNKLCSVPLVIPG 397

  Fly   183 ---------------------------------------SSP----------------------C 186
                                                   .||                      |
Mouse   398 RPEYPPPPIGPLPPVQPVPPGYPPGPVIPAPRPPPEYPYPSPSREPPRVLPFNVTDYCQLVRYLC 462

  Fly   187 RNGATCTALAGSSSFTCSCPPGFTGD---TCSYDIEECQSNPCKYGGTCVNTHGSYQCMCPTGY- 247
            :|| .|....|  |:.|.|..||..|   .| .|::||:.|||. ||.|:|..|||.|.|..|| 
Mouse   463 QNG-RCIPTPG--SYRCECNKGFQLDIRGEC-IDVDECEKNPCT-GGECINNQGSYTCHCRAGYQ 522

  Fly   248 ---TGKDCDTKYKPCSPSPCQNGGICRSNGL------SYECKCPKGF----EGKNCEQNYDDC-L 298
               |..:| .....|    .|||.|| :||.      |:.|.|..||    :||||| :.|:| :
Mouse   523 STLTRTEC-RDIDEC----LQNGRIC-NNGRCINTDGSFHCVCNAGFHVTRDGKNCE-DMDECSI 580

  Fly   299 GHLCQNGGTCIDGISDYTCRCPPNF----TGRFCQDDVDECAQRDHP-VCQNGATCTNTHGSYSC 358
            .::|.| |.||:....:.|.|.|.|    .||:|: |::||   :.| :|.|| .|.||.|||.|
Mouse   581 RNMCLN-GMCINEDGSFKCICKPGFQLASDGRYCK-DINEC---ETPGICMNG-RCVNTDGSYRC 639

  Fly   359 ICVNGWA-GLDCSNNTDDCKQAACFYGATCIDGVGSFYC-------QCTKGKTGLLCHLDDACTS 415
            .|..|.| |||               |..|:|......|       ||.|...|.:...:..|.|
Mouse   640 ECFPGLAVGLD---------------GRVCVDTHMRSTCYGGYRRGQCVKPLFGAVTKSECCCAS 689

  Fly   416 ---------NPCHA------DAICDTSP--------------------------INGSYACSCAT 439
                     .||.|      .|:|.:.|                          :.|:|.|.|.:
Mouse   690 TEYAFGEPCQPCPAQNSAEYQALCSSGPGMTSAGTDINECALDPDICPNGICENLRGTYKCICNS 754

  Fly   440 GYK----GVDCSEDIDECDQGSPCEHNGICVNTPGSYRCNCSQGFT-GPRCET--NINECESHPC 497
            ||:    |.:| .||:||...|....||.|.|||||:.|.|.:||. .|..:|  :|:||||.||
Mouse   755 GYEVDITGKNC-VDINECVLNSLLCDNGQCRNTPGSFVCTCPKGFVYKPDLKTCEDIDECESSPC 818

  Fly   498 QNEGSCLDDPGTFRCVCMP---------------------------------------------- 516
            .| |.|.:.||:|.|.|.|                                              
Mouse   819 IN-GVCKNSPGSFICECSPESTLDPTKTICIETIKGTCWQTVIDGRCEININGATLKSECCSSLG 882

  Fly   517 ------------------GFT---GTQCEIDIDECQSNP--CLNDGTCHDKINGFKCSCALGFT- 557
                              ||:   ||||| ||:||:..|  |.| |.|.:....|||.|..|.| 
Mouse   883 AAWGSPCTICQLDPICGKGFSRIKGTQCE-DINECEVFPGVCKN-GLCVNSRGSFKCECPNGMTL 945

  Fly   558 --------------------GARCQINI-------------------DDCQSQPCRN-------- 575
                                ...|.:.|                   ::|:..|.||        
Mouse   946 DATGRICLDIRLETCFLKYDDEECTLPIAGRHRMDACCCSVGAAWGTEECEECPLRNSREYEELC 1010

  Fly   576 --------------------------------RGICHDSIAGYSCECPPGYTGTSCEIN---IND 605
                                            .|.|.::|..:.|.|..|:...|.|.|   |::
Mouse  1011 PRGPGFATKDITNGKPFFKDINECKMIPSLCTHGKCRNTIGSFKCRCDSGFALDSEERNCTDIDE 1075

  Fly   606 CDSNP--CHRGKCIDDVNSFKCLCDPGY-TGYICQK---QINECESNP--CQFDGHCQDRVGSYY 662
            |..:|  |.||:|::....|:|.||.|| :|::..|   .|:||:.:|  |: .|.|.:..|||.
Mouse  1076 CRISPDLCGRGQCVNTPGDFECKCDEGYESGFMMMKNCMDIDECQRDPLLCR-GGICHNTEGSYR 1139

  Fly   663 CQCQAG---TSGKNCEVNVNECH--SNPCNNGATCIDGINSYKCQCVPGFTGQH----CEKNVDE 718
            |:|..|   :...:..:::|||.  :|.|.:| .|::.|..|:|.|.||:...|    | .::||
Mouse  1140 CECPPGHQLSPNISACIDINECELSANLCPHG-RCVNLIGKYQCACNPGYHPTHDRLFC-VDIDE 1202

  Fly   719 CISSPCANNG---VCIDQVNGYKCECPRGFY---DAHCLSDVDECASNP-------CVN------ 764
            |   ...|.|   .|.:....|:|.|..||.   |....:|:|||..||       |.|      
Mouse  1203 C---SIMNGGCETFCTNSDGSYECSCQPGFALMPDQRSCTDIDECEDNPNICDGGQCTNIPGEYR 1264

  Fly   765 ------------------------------EGRCEDGINEFICHCPPGYTGKR----CELDIDEC 795
                                          .|.||:....|||||..||:||:    | .||:||
Mouse  1265 CLCYDGFMASEDMKTCVDVNECDLNPNICLSGTCENTKGSFICHCDMGYSGKKGKTGC-TDINEC 1328

  Fly   796 --SSNPCQHGGTCYDKLNAFSCQCMPGYTGQ--KCETNIDDCV--TNPCGNGGTCIDKVNGYKCV 854
              .::.|.....|.:...:|.|.|.||:.|.  || |::|:|.  |:.|.....|.:.:..|:|:
Mouse  1329 EIGAHNCGRHAVCTNTAGSFKCSCSPGWIGDGIKC-TDLDECSNGTHMCSQHADCKNTMGSYRCL 1392

  Fly   855 CKVPFTG--------RDCESKMDPCASNRCKNEAKCTPSSNFLDFSCTCKLGYT----GRYCDED 907
            ||..:||        .:|...::.|.:.:|.|    .|..    :.|.|.:|:.    |:.| ||
Mouse  1393 CKDGYTGDGFTCTDLDECSENLNLCGNGQCLN----APGG----YRCECDMGFVPSADGKAC-ED 1448

  Fly   908 IDECSLSSPCRNGASCLNVPGSYRCLCTKGYE----GRDC------------------------- 943
            ||||||.:.|..| :|.|:||.:||.|..|||    |.:|                         
Mouse  1449 IDECSLPNICVFG-TCHNLPGLFRCECEIGYELDRSGGNCTDVNECLDPTTCISGNCVNTPGSYT 1512

  Fly   944 ----------------------------------------------------------------- 943
                                                                             
Mouse  1513 CDCPPDFELNPTRVGCVDTRSGNCYLDIRPRGDNGDTACSNEIGVGVSKASCCCSLGKAWGTPCE 1577

  Fly   944 ---AINT-------------------------DDCASFP--CQNGGTCLDGIGDYSCLCVDGF-- 976
               ::||                         |:|...|  || ||.|::..|.:.|.|..|:  
Mouse  1578 LCPSVNTSEYKILCPGGEGFRPNPITVILEDIDECQELPGLCQ-GGKCINTFGSFQCRCPTGYYL 1641

  Fly   977 --DGKHCETDINECLSQPCQNGATCSQYVNSYTCTCPLGFSGINCQTNDEDCTESSC-----LNG 1034
              |.:.|: |:|||.:.......||...|.:|||.||..:..:|...|..|...|.|     .:.
Mouse  1642 NEDTRVCD-DVNECETPGICGPGTCYNTVGNYTCICPPDYMQVNGGNNCMDMRRSLCYRNYYADN 1705

  Fly  1035 GSCIDGINGYN-----CSC-------------------------LAG----------YSGANCQY 1059
            .:| ||...:|     |.|                         |.|          |:|  ...
Mouse  1706 QTC-DGELLFNMTKKMCCCSYNIGRAWNKPCEQCPIPSTDEFATLCGSQRPGFVIDIYTG--LPV 1767

  Fly  1060 KLNKCDSNP--CLNGATCHEQNNEYTCHCPSGFTGKQ----CSEYVDWCGQSP-CENGATCSQMK 1117
            .:::|...|  |.|| .|......:.|.||.||....    | |.:|.|...| |:..|.|....
Mouse  1768 DIDECREIPGVCENG-VCINMVGSFRCECPVGFFYNDKLLVC-EDIDECQNGPVCQRNAECINTA 1830

  Fly  1118 HQFSCKCSAGW----TGKLCDVQTISCQDAADRKGLSLRQLCNNGTCKDYGNSHVCYCSQGYAGS 1178
            ..:.|.|..|:    ||:..|..  .||:        :..:|::|.|.|...|..|.|..|:..:
Mouse  1831 GSYRCDCKPGYRLTSTGQCNDRN--ECQE--------IPNICSHGQCIDTVGSFYCLCHTGFKTN 1885

  Fly  1179 YCQK---EIDECQSQPCQNGGTCRDLIGAYECQCRQGF---QGQNCELNIDDCAP---NPCQNGG 1234
            ..|.   :|:||:...|.| ||||:.||::.|:|..||   ...:| :::|:||.   |.|:| |
Mouse  1886 VDQTMCLDINECERDACGN-GTCRNTIGSFNCRCNHGFILSHNNDC-IDVDECATGNGNLCRN-G 1947

  Fly  1235 TCHDRVMNFSCSC-------PPGTMGI---ICEINKDDCKPGACHNNGSCIDRVGGFECVCQPGF 1289
            .|.:.|.:|.|.|       |.|...:   .|.::...|.||.|.|    :|  |.:.|:|.||:
Mouse  1948 QCVNTVGSFQCRCNEGYEVAPDGRTCVDINECVLDPGKCAPGTCQN----LD--GSYRCICPPGY 2006

  Fly  1290 --VGARCEGDINECLSNP--CSNAGTLDCVQLVNNYHCNCRPG----HMGRHCEH-KVDFCAQSP 1345
              ...:|| ||:||:..|  |: .||  |.....::.|.|..|    ..||.|:. ::.:|... 
Mouse  2007 SLQNDKCE-DIDECVEEPEICA-LGT--CSNTEGSFKCLCPEGFSLSSTGRRCQDLRMSYCYAK- 2066

  Fly  1346 CQNGGNCNIRQSGHH----CIC---NNGFYGKNCEL-------------------------SGQD 1378
             ..||.|:..:|.:|    |.|   ..| :|..|||                         |..|
Mouse  2067 -FEGGKCSSPKSRNHSKQECCCALKGEG-WGDPCELCPTEPDEAFRQICPFGSGIIVGPDDSAVD 2129

  Fly  1379 CDS----NPCRVGNCVVADEGFGYRCECPRGTL--GEHCEIDTLDECS-PNPCAQGAACEDLLGD 1436
            .|.    :.||.|.|:..|.  .||||||.|.:  |..| :|| |||| .|||..| .|::::|.
Mouse  2130 MDECKEPDVCRHGQCINTDG--SYRCECPFGYILEGNEC-VDT-DECSVGNPCGNG-TCKNVIGG 2189

  Fly  1437 YECLCPSKWK-GKRCDIYDANYPGWNG-----------GSGSGNDRYAADLEQQRAMC------- 1482
            :||.|...:: |......|.|....|.           ||..........|.:.|.||       
Mouse  2190 FECTCEEGFEPGPMMTCEDINECAQNPLLCAFRCVNTYGSYECKCPVGYVLREDRRMCKDEDECA 2254

  Fly  1483 -DKRGCTEKQGNGICDSDCNTYAC--------NFDGNDCSLGINPWANCTANECWNK---FKNGK 1535
             .|..|||||..  |.:...||.|        ..||..|         ...|||..|   .:||:
Mouse  2255 EGKHDCTEKQME--CKNLIGTYMCICGPGYQRRPDGEGC---------IDENECQTKPGICENGR 2308

  Fly  1536 CNE-------ECNNAACHYDGHDCERKLKSCDSLFDAYCQKHYGDGFCDYGCNN------AECSW 1587
            |..       |||      ||.........|....:.||........|..|.:|      :||..
Mouse  2309 CLNTLGSYTCECN------DGFTASPTQDECLDNREGYCFSEVLQNMCQIGSSNRNPVTKSECCC 2367

  Fly  1588 DG 1589
            ||
Mouse  2368 DG 2369

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NNP_001245510.1 EGF_CA 179..214 CDD:238011 15/105 (14%)
EGF_CA 217..252 CDD:238011 18/38 (47%)
EGF_CA 260..291 CDD:238011 15/40 (38%)
EGF_CA 295..329 CDD:238011 13/38 (34%)
EGF_CA 331..369 CDD:238011 19/39 (49%)
EGF_CA 449..486 CDD:238011 18/37 (49%)
EGF_CA 488..524 CDD:238011 21/102 (21%)
EGF_CA 526..562 CDD:238011 15/58 (26%)
EGF_CA 564..600 CDD:238011 12/94 (13%)
EGF_CA 602..637 CDD:238011 15/40 (38%)
EGF_CA 640..675 CDD:238011 13/39 (33%)
EGF_CA 677..713 CDD:238011 14/41 (34%)
EGF_CA 715..750 CDD:238011 12/40 (30%)
EGF_CA 753..789 CDD:238011 20/82 (24%)
EGF_CA 791..827 CDD:238011 13/39 (33%)
EGF_CA 829..865 CDD:238011 11/45 (24%)
EGF_CA 907..943 CDD:238011 20/39 (51%)
EGF_CA 946..982 CDD:238011 15/66 (23%)
EGF_CA 984..1020 CDD:238011 13/35 (37%)
EGF_CA 1027..1058 CDD:238011 12/75 (16%)
EGF_CA 1062..1095 CDD:238011 11/38 (29%)
EGF_CA 1184..1219 CDD:238011 15/37 (41%)
EGF_CA 1221..1257 CDD:238011 14/48 (29%)
EGF_CA 1259..1295 CDD:238011 11/37 (30%)
EGF_CA 1297..1335 CDD:238011 14/43 (33%)
EGF_CA 1417..1450 CDD:238011 14/34 (41%)
NL 1476..1512 CDD:197463 15/51 (29%)
Notch 1519..1553 CDD:278494 12/43 (28%)
Notch 1565..1593 CDD:278494 9/31 (29%)
NOD 1599..1648 CDD:284282
NODP 1680..1731 CDD:284987
ANK 1896..2038 CDD:238125
ANK repeat 1902..1948 CDD:293786
ANK repeat 1951..1981 CDD:293786
Ank_5 1970..2025 CDD:290568
ANK 1978..2104 CDD:238125
ANK repeat 1984..2015 CDD:293786
ANK repeat 2017..2048 CDD:293786
Ank_2 2022..2114 CDD:289560
ANK repeat 2050..2081 CDD:293786
ANK repeat 2083..2114 CDD:293786
DUF3454 2627..2682 CDD:288764
Fbn1NP_032019.2 TB 1707..1751 CDD:366245 7/44 (16%)
EGF_CA 1768..>1799 CDD:214542 9/31 (29%)
EGF_CA 1810..1842 CDD:214542 9/31 (29%)
EGF_CA 1932..1973 CDD:311536 14/41 (34%)
EGF_CA 1975..2010 CDD:238011 12/40 (30%)
EGF_CA 2015..2055 CDD:389777 14/42 (33%)
TB 2072..2114 CDD:366245 10/42 (24%)
EGF_CA 2129..2167 CDD:214542 16/40 (40%)
EGF_CA 2168..2207 CDD:214542 16/40 (40%)
TB 2358..2393 CDD:366245 4/12 (33%)
vWFA <2444..2484 CDD:381780
cEGF 2467..2490 CDD:372248
EGF_CA 2487..>2518 CDD:389777
EGF_CA 2526..2568 CDD:214542
EGF_CA 2569..>2598 CDD:214542
EGF_CA 2609..2640 CDD:214542
Fibrillin_U_N 48..82 CDD:375622
TB 194..>228 CDD:366245 4/33 (12%)
EGF_CA 246..>276 CDD:214542 6/29 (21%)
EGF_CA 288..329 CDD:214542 15/47 (32%)
TB 344..389 CDD:366245 0/44 (0%)
EGF_CA 492..523 CDD:214542 17/31 (55%)
EGF_CA 532..573 CDD:214542 16/45 (36%)
EGF_CA 574..614 CDD:214542 13/40 (33%)
EGF_CA 615..648 CDD:214542 17/36 (47%)
TB 671..713 CDD:366245 10/41 (24%)
EGF_CA 725..765 CDD:389777 7/39 (18%)
EGF_CA 767..>798 CDD:214542 15/30 (50%)
cEGF 789..812 CDD:372248 8/22 (36%)
TB 863..>892 CDD:366245 0/28 (0%)
TB 968..1011 CDD:366245 6/42 (14%)
EGF_CA 1072..1106 CDD:214542 13/33 (39%)
EGF_CA 1115..1151 CDD:214542 13/36 (36%)
EGF_CA 1157..1192 CDD:238011 13/35 (37%)
FXa_inhibition 1203..1238 CDD:373209 10/37 (27%)
EGF_3 1328..1363 CDD:372403 9/34 (26%)
EGF_3 1369..1404 CDD:372403 10/34 (29%)
cEGF 1428..1451 CDD:372248 8/27 (30%)
EGF_CA 1448..1488 CDD:214542 20/40 (50%)
EGF_CA 1489..1520 CDD:214542 0/30 (0%)
TB 1551..1592 CDD:366245 2/40 (5%)
EGF_CA 1608..1640 CDD:214542 12/32 (38%)
EGF_CA 1650..1689 CDD:214542 13/38 (34%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.910

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