DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment N and Acan

DIOPT Version :9

Sequence 1:	NP_001245510.1	Gene:	N / 31293	FlyBaseID:	FBgn0004647	Length:	2703	Species:	Drosophila melanogaster
Sequence 2:	NP_001348429.1	Gene:	Acan / 11595	MGIID:	99602	Length:	2170	Species:	Mus musculus

Alignment Length:	640	Identity:	133/640 - (20%)
Similarity:	203/640 - (31%)	Gaps:	232/640 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly  2159 PPGQQQPQLITQPTVISAGNGGNNGNGNASGKQSNQTAKQKAAKKAKLIEGSPDNGLDATGSLRR 2223
            |.|:..|:       .|....|::.:|..|||:..:|    :|..|:.:.|.|....|..||...
Mouse  1168 PSGRGDPE-------TSVSGVGDDFSGLPSGKEGLET----SASGAEDLSGLPSGKEDLVGSASG 1221

  Fly  2224 KASSKKT---SAASKKAANLNGLNPGQL---------TGGVSGVP---GVP---PTNSAAQAAAA 2270
            .....|.   :..|.:...:||...|..         :|..||:|   |:|   ||.|... :..
Mouse  1222 ALDFGKLPPGTLGSGQTPEVNGFPSGFSGEYSGADIGSGPSSGLPDFSGLPSGFPTVSLVD-STL 1285

  Fly  2271 AAAAVAAMSHELEG-SPVGV-GMG-------GNLPSPYDTSSMYSNAMAAPLANGNPNTGAK--- 2323
            .....|..|.|||| ..:|: |.|       |.|.|..|.|.:.|....:..|:|:|::..:
Mouse  1286 VEVITATTSSELEGRGTIGISGSGEVSGLPLGELDSSADISGLPSGTELSGQASGSPDSSGETSG 1350

  Fly  2324 ------QPPSYEDCIKNAQSMQSLQG-----------NGLDMIKLDNYAYSMGSPFQQELLNGQG 2371
                  ||.......:....:..:.|           :|:..:.    ..|.|.|.    ::|.|
Mouse  1351 FFDVSGQPFGSSGVSEETSGIPEISGQPSGTPDTTATSGVTELN----ELSSGQPD----VSGDG 1407

  Fly  2372 LG-MNGNGQRNGVGPGVLPGGLCGMGGLSG-----------------------AGNGNS------ 2406
            .| :.|:||.:|:..  :.|...|:..|||                       :|:|.|
Mouse  1408 SGILFGSGQSSGITS--VSGETSGISDLSGQPSGFPVFSGTATRTPDLASGTISGSGESSGITFV 1470

  Fly  2407 -------------HEQGLSPPYSNQSPPH-------------SVQSSLALSPHAYLGSPSPAKSR 2445
                         .|:||.....:..|..             |.|||.|:.... |.||:|..|
Mouse  1471 DTSFVEVTPTTFREEEGLGSVELSGFPSGETELSGTSGTVDVSEQSSGAIDSSG-LTSPTPEFS- 1533

  Fly  2446 PSLPTSPTHIQAMRHATQQKQFGGSNLNSLL--GGANGGGVVGGGGGGGGGVGQGPQNSPVSLGI 2508
             .||:....:..        :|.|....|.|  |..:|.|:|.|
Mouse  1534 -GLPSGVAEVSG--------EFSGVETGSSLPSGAFDGSGLVSG--------------------- 1568

  Fly  2509 ISPTGSDMGIMLAPPQSSKNSAIMQTISPQQQQQQQQQQQQQHQQQQQQQQQQQQQQQQQLGGLE 2573
                        .|..|..:..::::|:                    |....|:..:...|.||
Mouse  1569 ------------FPTVSLVDRTLVESIT--------------------QAPTAQEAGEGPSGILE 1601

  Fly  2574 FGSAGLDLNGFCGSPDSFHSGQMNPPSIQSSMSGSSPSTNMLSPSSQHNQQAFYQYLTPSSQHSG 2638
            |..|              |||   .|.|...:|||...:.:.|...:.:.:      ||||.:..
Mouse  1602 FSGA--------------HSG---TPDISGELSGSLDLSTLQSGQMETSTE------TPSSPYFS 1643

  Fly  2639 GHTPQHLVQTLD------SYPTPSPESPGHWSSSSPR---SNSDWSEGVQSPAAN 2684
            |    ....|.|      :..|.|.||.|     .|.   :.|:..|||..|..:
Mouse  1644 G----DFSSTTDVSGESIAATTGSGESSG-----LPEVTLNTSELVEGVTEPTVS 1689

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
N	NP_001245510.1	EGF_CA	179..214	CDD:238011
		EGF_CA	217..252	CDD:238011
		EGF_CA	260..291	CDD:238011
		EGF_CA	295..329	CDD:238011
		EGF_CA	331..369	CDD:238011
		EGF_CA	449..486	CDD:238011
		EGF_CA	488..524	CDD:238011
		EGF_CA	526..562	CDD:238011
		EGF_CA	564..600	CDD:238011
		EGF_CA	602..637	CDD:238011
		EGF_CA	640..675	CDD:238011
		EGF_CA	677..713	CDD:238011
		EGF_CA	715..750	CDD:238011
		EGF_CA	753..789	CDD:238011
		EGF_CA	791..827	CDD:238011
		EGF_CA	829..865	CDD:238011
		EGF_CA	907..943	CDD:238011
		EGF_CA	946..982	CDD:238011
		EGF_CA	984..1020	CDD:238011
		EGF_CA	1027..1058	CDD:238011
		EGF_CA	1062..1095	CDD:238011
		EGF_CA	1184..1219	CDD:238011
		EGF_CA	1221..1257	CDD:238011
		EGF_CA	1259..1295	CDD:238011
		EGF_CA	1297..1335	CDD:238011
		EGF_CA	1417..1450	CDD:238011
		NL	1476..1512	CDD:197463
		Notch	1519..1553	CDD:278494
		Notch	1565..1593	CDD:278494
		NOD	1599..1648	CDD:284282
		NODP	1680..1731	CDD:284987
		ANK	1896..2038	CDD:238125
		ANK repeat	1902..1948	CDD:293786
		ANK repeat	1951..1981	CDD:293786
		Ank_5	1970..2025	CDD:290568
		ANK	1978..2104	CDD:238125
		ANK repeat	1984..2015	CDD:293786
		ANK repeat	2017..2048	CDD:293786
		Ank_2	2022..2114	CDD:289560
		ANK repeat	2050..2081	CDD:293786
		ANK repeat	2083..2114	CDD:293786
		DUF3454	2627..2682	CDD:288764	17/63 (27%)
Acan	NP_001348429.1	Ig_Aggrecan	43..154	CDD:143308
		G1-A	48..140
		G1-B	152..247
		Link_domain_CSPGs_modules_1_3	153..247	CDD:239594
		G1-B'	253..349
		Link_domain_CSPGs_modules_2_4	254..349	CDD:239597
		G2-B	486..580
		Link_domain_CSPGs_modules_1_3	487..581	CDD:239594
		G2-B'	587..682
		Link_domain_CSPGs_modules_2_4	588..683	CDD:239597
		KS	685..803
		Herpes_ICP4_C	689..>1027	CDD:332854
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	737..1079
		CS-1	805..1231		18/73 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1108..1239		19/81 (23%)
		AidA	<1171..>1630	CDD:330218	113/561 (20%)
		Cell attachment site. /evidence=ECO:0000255	1171..1173		0/1 (0%)
		CS-2	1232..1917		115/565 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1299..1465		34/175 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1491..1538		13/49 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1586..1671		27/116 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1782..1838
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1861..1914
		EGF_CA	1918..1954	CDD:238011
		CLECT_CSPGs	1960..2083	CDD:153058
		CCP	2087..2143	CDD:153056
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22804
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100