DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment N and notch3

DIOPT Version :10

Sequence 1:NP_476859.2 Gene:N / 31293 FlyBaseID:FBgn0004647 Length:2703 Species:Drosophila melanogaster
Sequence 2:XP_017948007.1 Gene:notch3 / 100494244 XenbaseID:XB-GENE-6450008 Length:2413 Species:Xenopus tropicalis


Alignment Length:2676 Identity:1130/2676 - (42%)
Similarity:1480/2676 - (55%) Gaps:381/2676 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly    67 CQNGGTCVTQLNGKTYCACDSHYVGDYCEHRNPCNSMRCQNGGTCQVTFRNGRPGISCKCPLGFD 131
            |||||.|....||:..|.|.:.::|:.|:.::||....|.|||.||.:.|               
 Frog    34 CQNGGRCTMYSNGEAACVCLTSWIGELCQFKDPCVPSPCINGGACQSSIR--------------- 83

  Fly   132 ESLCEIAVPNACDHVTCLNGGTCQLKTLEEYTCACANGYTGERCETKNLCASSPCRNGATCTALA 196
                               |||.|      |.|:||.|:.|:.|...:.|||:||.|||.||...
 Frog    84 -------------------GGTVQ------YECSCAKGFRGQDCSLIDACASNPCENGARCTNWN 123

  Fly   197 GSSSFTCSCPPGFTGDTCSYDIEECQS-NPCKYGGTCVNTHGSYQCMCPTGYTGKDCDTKYKPCS 260
            |  .:.|:||||:.|.:|..||:||:: ..|:.||.||||.||::|.||:||||:.|:..|.||:
 Frog   124 G--RYNCTCPPGYQGRSCRVDIDECRTPGLCQNGGQCVNTPGSFRCRCPSGYTGQFCEAIYVPCA 186

  Fly   261 PSPCQNGGICRSNG-LSYECKCPKGFEGKNCEQNYDDCLGHLCQNGGTCIDGISDYTCRCPPNFT 324
            ||.|||||.||..| |:|:|.|..||||.|||.|.|||.||.|.|||||:||::.|.|:|.|.:|
 Frog   187 PSQCQNGGTCRQTGDLTYQCACLPGFEGPNCEINVDDCPGHKCMNGGTCVDGVNTYNCQCAPEWT 251

  Fly   325 GRFCQDDVDECAQRDHPVCQNGATCTNTHGSYSCICVNGWAGLDCSNNTDDCKQAACFYGATCID 389
            |::|.:||||| |.....|.||.||.||.|.::|:|||||.|..||.|.|||..|.||.||||.|
 Frog   252 GQYCTEDVDEC-QLQPNACHNGGTCFNTQGGHTCVCVNGWTGESCSENIDDCATAVCFNGATCHD 315

  Fly   390 GVGSFYCQCTKGKTGLLCHLDDACTSNPCHADAICDTSPINGSYACSCATGYKGVDCSEDIDECD 454
            .|.||||:|..|||||||||:|||.|||||.||:|||:|:||...|:|..|:.|..|.:|:|||.
 Frog   316 RVASFYCECPMGKTGLLCHLEDACVSNPCHKDAMCDTNPVNGRAICTCPPGFTGGACDQDVDECS 380

  Fly   455 QG-SPCEHNGICVNTPGSYRCNCSQGFTGPRCETNINECESHPCQNEGSCLDDPGTFRCVCMPGF 518
            .| :||||.|.||||.||::|.|.:|:|||||||::|||.|.||||:.:|||..|.|.|:||.||
 Frog   381 IGANPCEHFGRCVNTQGSFQCQCGRGYTGPRCETDVNECLSTPCQNDATCLDRIGEFTCICMAGF 445

  Fly   519 TGTQCEIDIDECQSNPCLNDGTCHDKINGFKCSCALGFTGARCQINIDDCQSQPCRNRGICHDSI 583
            |||.||::|:||:|:||:|.|.|.|.:|||.|||..||||:.|||:||:|.|.||:|...|.|..
 Frog   446 TGTFCELNINECESSPCVNGGVCKDVVNGFTCSCPAGFTGSMCQIDIDECASTPCKNGAKCVDRP 510

  Fly   584 AGYSCECPPGYTGTSCEININDCDSNPCHRGKCIDDVNSFKCLCDPGYTGYICQKQINECESNPC 648
            .||.|.|..|:.|..|:.||:||..:|||.|||.|.:.||.|.|:||||||.|:.|||||.||||
 Frog   511 NGYECRCAEGFEGPLCDRNIDDCSPDPCHHGKCRDGIASFTCTCEPGYTGYRCENQINECHSNPC 575

  Fly   649 QFDGHCQDRVGSYYCQCQAGTSGKNCEVNVNECHSNPCNNGATCIDGINSYKCQCVPGFTGQHCE 713
            ...|.|.|.|..|.|.||.||||.:||.|.::|.||||:.| .|.||||.|.|.|..||||..|.
 Frog   576 MHGGKCIDLVNKYLCYCQQGTSGVHCEHNYDDCASNPCDYG-ECRDGINRYDCVCKAGFTGPLCN 639

  Fly   714 KNVDECISSPCANNGVCIDQVNGYKCECP--RGFYDAHC--LSDVDECASNP-CVNEGRCEDGIN 773
            ..|..|.|:||...|.|....||::|.||  ||..|..|  ..|.|:....| ||: |.|....:
 Frog   640 IEVSPCASNPCRAGGTCQVTQNGFRCLCPEGRGTRDFLCNPTQDPDKELCPPGCVH-GVCRRLSD 703

  Fly   774 EFICHCPPGYTGKRCE-LDIDECSSNPCQHGGTCYDKLNAFSCQCMPGYTGQKCETNIDDCVTNP 837
            .:.|.|..|:||:.|: ...|.|:.||||:||.|.|......|:|..|:.|..|..:||:|.:.|
 Frog   704 GYSCDCKVGWTGRMCDRRGSDVCTPNPCQNGGNCIDHQGVPICRCRDGFRGPTCMIDIDECASAP 768

  Fly   838 CGNGGTCIDKVNGYKCVCKVPFTGRDCESKMDPCASNRCKNEAKCTPSSNFLDFSCTCKLGYTGR 902
            |.|||.|:|.:.||.|:|.:|:||:.||:.:||||.:.|.|...|:|:.::....|.|..|:.|.
 Frog   769 CLNGGKCMDGIAGYSCLCTLPYTGQKCETILDPCAPDPCHNGGICSPTPDYESHMCQCSPGWRGE 833

  Fly   903 YCDEDIDECSLSSPCRNGASCLNVPGSYRCLCTKGYEGRDCAINTDDCASFPCQNGGTCLDGIGD 967
            .||:|||||: .|||:||..|.|:.|.|.|.|..|:.|:||..:.:||...||.|||.|.|||..
 Frog   834 TCDDDIDECA-RSPCKNGGFCTNMQGGYSCACLSGFNGQDCETDINDCNPNPCLNGGACKDGINS 897

  Fly   968 YSCLCVDGFDGKHCETDINECLSQPCQNGATCSQYVNSYTCTCPLGFSGINCQTNDEDCTESSCL 1032
            ::|.|:.||.|..|..:||||||.||:|||||..|||||.|:|..|::|..|:||.:|||||||.
 Frog   898 FACSCIPGFTGSRCTDEINECLSNPCRNGATCKDYVNSYVCSCAPGYTGPICETNIQDCTESSCF 962

  Fly  1033 NGGSCIDGINGYNCSCLAGYSGANCQYKLNKCDSNPCLNGATCHEQNNEYTCHCPSGFTGKQCSE 1097
            |||:|:||:|.|.|.|..|::|::||.::::|.|.||.|||.|.:....|.|.||.|:||.||..
 Frog   963 NGGTCVDGVNSYTCRCRPGFTGSHCQNEVDECASRPCQNGAMCVDGVESYRCICPYGYTGAQCQN 1027

  Fly  1098 YVDWCGQSPCENGATCSQMKHQFSCKCSAGWTGKLCDVQTISCQDAADRKGLSLRQLCNN-GTCK 1161
            .||.|.:|||:||..|:|....|.|:|.|||.|..|||..:||:.||.|:.:...|||:: |.|.
 Frog  1028 LVDLCRRSPCQNGGRCTQTGPSFRCECPAGWAGSYCDVPRVSCEVAAARRNVRADQLCHSGGICM 1092

  Fly  1162 DYGNSHVCYCSQGYAGSYCQKEIDECQSQPCQNGGTCRDLIGAYECQCRQGFQGQNCELNIDDCA 1226
            :.|:||.|.|..||.||||:..|::|...||.|||.|...:|.|.|:|..|::|:|||.:|::|.
 Frog  1093 NAGSSHHCICRGGYTGSYCENPINQCDPDPCHNGGACHSYLGGYVCECPSGYEGKNCEYDINECQ 1157

  Fly  1227 PNPCQNGGTCHDRVMNFSCSCPPGTMGIICEINKDDCK------PGACHNNGSCIDRVGGFECVC 1285
            .:||||||||.|.:..:.|||||||:|::||||:|||.      |..|.|||:|||:|||:.|.|
 Frog  1158 SHPCQNGGTCIDLIGRYICSCPPGTLGVLCEINEDDCSPLSISGPPKCLNNGTCIDKVGGYRCNC 1222

  Fly  1286 QPGFVGARCEGDINECLSNPCSNAGTLDCVQLVNNYHCNCRPGHMGRHCEHKVDFCAQSPCQNGG 1350
            .||:.|.|||||||||||.||....|..||||.|:|.|.|:.|:.||.|:..::.|...||||||
 Frog  1223 PPGYTGERCEGDINECLSGPCHAQNTRHCVQLANDYQCVCKSGYTGRRCQSVMNTCESRPCQNGG 1287

  Fly  1351 NCNIRQS---GHHCICNNGFYGKNCELSGQDCDSNPCRVGNCVVADEGFGYRCECPRGTLGEHCE 1412
            .|::..:   |:.|.|..||.|.:||.....|....|..|:..:... .|.||.||.|.|   |.
 Frog  1288 VCSVTVNTPLGYTCRCPLGFTGPSCERPPLSCRELSCPSGSTCLPPP-LGPRCICPPGVL---CR 1348

  Fly  1413 IDTLDE--------CSPNPCAQGAACEDLL--GDYECLCPSKWKGKRCDIYDANYPGWNGGSGSG 1467
            ......        ||.:||..||.|...:  ..|:|.|.....|.||||               
 Frog  1349 TPNNSSAPTPAPLPCSNSPCRNGATCIPNIHFPYYQCKCHPGMIGPRCDI--------------- 1398

  Fly  1468 NDRYAADLEQQRAM-CDKRGCTEKQGNGICDSDCNTYACNFDGNDCSLGI-NPWANCTANECWNK 1530
              |....|.|..|. |....|..|.|:|.||.:||..||.:||.||||.: :||.||...||.:.
 Frog  1399 --RTPRILTQTPAPGCTPSHCPGKAGDGHCDRECNVAACKWDGGDCSLSVDDPWRNCPRQECRSL 1461

  Fly  1531 FKNGKCNEECNNAACHYDGHDCE-RKLKSCDSLFDAYCQKHYGDGFCDYGCNNAECSWDGLDCEN 1594
            |.|.:|::||.:|.|.||..||. |:.:||:.:::.||..|||||.||.|||:.||.||||||..
 Frog  1462 FNNSQCDKECTSADCLYDNFDCRGREERSCNPVYEKYCMDHYGDGRCDKGCNSEECGWDGLDCAK 1526

  Fly  1595 KTQSPVLAEGAMSVVMLMNVEAFREIQAQFLRNMSHMLRTTVRLKKDALGHDIIINWKDNVRVPE 1659
            .:...|||:|.:.||:|:....|.:....||:.:|.:|.|::|...|:.|     |:|  ::...
 Frog  1527 NSDKEVLADGVLVVVVLVPPNEFLKQSTAFLQRLSSLLHTSLRFCTDSNG-----NYK--IKPYR 1584

  Fly  1660 IEDTDFARKNKILYTQQVHQTGIQIYLEIDNRKCT----ECFTHAVEAAEFLAATAAKHQLRNDF 1720
            ...|...||.:.|.:..:   |.::.||||||.|.    :||.:...||.||||.:...:|:..:
 Frog  1585 KSQTWDGRKKRELDSDII---GSEVMLEIDNRICVKEMPDCFPNTETAARFLAALSVLERLQFPY 1646

  Fly  1721 QIHSVRGIKNPGDEDNGE--PPANVKYVITGIILVIIALAFFGMVLSTQRKRAHGVTWFPEGFRA 1783
            .|.:||..|.....||..  |    .:.:.|::::|:|:  .|:::| :|||||...||||||  
 Frog  1647 PIKAVRSEKIEEVIDNFRFLP----LFAVAGVLILIVAV--LGVIVS-RRKRAHSTLWFPEGF-- 1702

  Fly  1784 PAAVMSRRRRDPHGQEMRNLNKQVAMQSQGVGQPGAHWSDDESDMPLPKRQRSDPVSGVGLGNNG 1848
             .....|.||:|.||:...| |.:|...:.:..|...|:  |:|.|..|:.:::.:|        
 Frog  1703 -ILKKERDRREPVGQDALGL-KNIAKAERLMEDPSEDWT--ETDCPETKKLKTEELS-------- 1755

  Fly  1849 GYASDHTMVSEYEEADQRVWSQAHLDVVDVR----AIMTPPA---HQDGGKHDVDARGPCGLTPL 1906
                    ....:..|.|.|:|.||...|:|    ..:|||.   ..||  .||:.|||.|.|||
 Frog  1756 --------PCRQDPVDPRPWTQHHLAAADIRLPPATALTPPQGDYESDG--MDVNVRGPDGFTPL 1810

  Fly  1907 MIAAVRGGGLDTGEDIENNEDSTAQVISDLLAQGAELNATMDKTGETSLHLAARFARADAAKRLL 1971
            |:|:..||||:. |..|..|:..|..|:||:.|||.|.|..|:||||:||||||:||||||||||
 Frog  1811 MLASFLGGGLEP-ESQEEEEEGEASAITDLICQGASLGAQTDRTGETALHLAARYARADAAKRLL 1874

  Fly  1972 DAGADANCQDNTGRTPLHAAVAADAMGVFQILLRNRATNLNARMHDGTTPLILAARLAIEGMVED 2036
            |||||.|.||:||||||||||||||.||||||:|||:|:|:|||.||:|.||||||||:|||||:
 Frog  1875 DAGADPNAQDHTGRTPLHAAVAADAQGVFQILIRNRSTDLDARMGDGSTALILAARLAVEGMVEE 1939

  Fly  2037 LITADADINAADNSGKTALHWAAAVNNTEAVNILLMHHANRDAQDDKDETPLFLAAREGSYEACK 2101
            |||..||:||.|..||:||||||||||.||...||.:.||:|.||.|:|||||||||||||||.|
 Frog  1940 LITCHADVNAVDELGKSALHWAAAVNNIEATLALLKNGANKDMQDSKEETPLFLAAREGSYEAAK 2004

  Fly  2102 ALLDNFANREITDHMDRLPRDVASERLHHDIVRLLDEH-VPRSPQMLSMTPQAMIGSPPPGQQQP 2165
            .|||::|||||||||||||||:|.||||||||:||:|| ..|:.|           .|..|....
 Frog  2005 VLLDHYANREITDHMDRLPRDIAQERLHHDIVQLLEEHNTVRNSQ-----------GPMGGHTMS 2058

  Fly  2166 QLITQPTVISAGNGGNNGNG-NASGKQSNQTAKQKAAKKAKLIEGSPDNGLDATGSLRRKASSKK 2229
            .|:..|            || ..|.||:.|..|.:.| .||           |.|:...:|.:|.
 Frog  2059 PLLCPP------------NGFMGSVKQTPQGKKNRRA-NAK-----------ANGASLSRAEAKD 2099

  Fly  2230 TSAASKKAANLNGLNPGQLTGGV--SGVPGVPPTNSAAQAAAAAAAAVAAMSHELEGSPVGVGMG 2292
            .....||.:  ...:||  :||:  |.|. :.|.:|.....|.:|.         .||||     
 Frog  2100 AKGRGKKLS--LDCHPG--SGGLLESSVT-LSPVDSLDSPRAYSAN---------PGSPV----- 2145

  Fly  2293 GNLPSP--YDTSSMYSNAMAAPLANGNPNTGAKQPPSYEDCIKNAQSMQSLQGNGLDMIKLDNYA 2355
              :|.|  ::..||  :..:.||.|     |..:.| :...:.....:..:||.|  |:.|....
 Frog  2146 --MPVPGTFNLGSM--SVPSTPLVN-----GLMEGP-FAVSLARLNELGEIQGGG--MMALQGRV 2198

  Fly  2356 YSMGSPFQQE---LLNGQGLGM-NGNGQRNGVGPGVLPGGLCGMGGLSGAGNGNSHEQGLSPPYS 2416
                 |.|:.   ::||..||| |.|                .|..:...|...||         
 Frog  2199 -----PLQRAPSCVVNGLNLGMVNTN----------------AMPFIWQTGVPTSH--------- 2233

  Fly  2417 NQSPPHSVQSSLALSPHAYLGSPSPAKSRPSLPTSPTHIQAMRHATQ----QKQFGGSNLNSLLG 2477
                           ||..:.:.:||.|.|:|     |   ..||.|    |.|..         
 Frog  2234 ---------------PHRNVMTGAPAASVPNL-----H---QLHAQQVLMLQNQMA--------- 2266

  Fly  2478 GANGGGVVGGGGGGGGGVGQGPQNSPVSLGIISPTGSDMGIMLAPPQSSKNSAIMQTISPQQQQQ 2542
                                  ..|||.:.:    .....::..||            :|...:|
 Frog  2267 ----------------------MQSPVKMAM----DQQCQMVSMPP------------NPVHMRQ 2293

  Fly  2543 QQQQQQQQHQQQQQQQQQQQQQQQQQLGGLEFGSAGLDLNGFCGSPDSFHSGQMNPPSIQSSMSG 2607
            |......:...|.....:....:||.:                          .|..::|:|.:.
 Frog  2294 QSMPHVAERSVQPLTPTEGSYFKQQSV--------------------------PNDVTMQTSPAM 2332

  Fly  2608 SSPSTNMLSPSSQHNQQAFYQYLTPSSQHSGGHTPQHLVQTLDSYP--TPSPESPGHWSSSSPRS 2670
            |:|.....:||.:                   .||:|.:...:.:|  |||||||..|||.||.|
 Frog  2333 SAPPQQTFAPSQE-------------------DTPKHYLHIPNEHPYLTPSPESPEQWSSPSPHS 2378

  Fly  2671 NSDWSEGVQSP 2681
            .|:||:...||
 Frog  2379 VSEWSDATPSP 2389

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NNP_476859.2 EGF_CA 179..214 CDD:238011 17/34 (50%)
EGF_CA 217..252 CDD:238011 20/35 (57%)
EGF_CA 260..291 CDD:238011 19/31 (61%)
EGF_CA 295..329 CDD:238011 19/33 (58%)
EGF_CA 331..369 CDD:238011 21/37 (57%)
EGF_CA 449..486 CDD:238011 23/37 (62%)
EGF_CA 488..524 CDD:238011 21/35 (60%)
EGF_CA 526..562 CDD:238011 20/35 (57%)
EGF_CA 564..600 CDD:238011 15/35 (43%)
EGF_CA 602..637 CDD:238011 21/34 (62%)
EGF_CA 640..675 CDD:238011 20/34 (59%)
EGF_CA 677..713 CDD:238011 19/35 (54%)
EGF_CA 715..750 CDD:238011 15/36 (42%)
EGF_CA 753..789 CDD:238011 12/36 (33%)
EGF_CA 791..827 CDD:238011 14/35 (40%)
EGF_CA 829..865 CDD:238011 17/35 (49%)
EGF_CA 907..943 CDD:238011 18/35 (51%)
EGF_CA 946..982 CDD:238011 16/35 (46%)
EGF_CA 984..1020 CDD:238011 22/35 (63%)
EGF_CA 1027..1058 CDD:238011 17/30 (57%)
EGF_CA 1062..1095 CDD:238011 15/32 (47%)
EGF_CA 1184..1219 CDD:238011 15/34 (44%)
EGF_CA 1221..1257 CDD:238011 19/35 (54%)
EGF_CA 1259..1295 CDD:238011 21/41 (51%)
EGF_CA 1297..1335 CDD:238011 21/37 (57%)
EGF_CA 1338..1373 CDD:238011 14/37 (38%)
EGF_CA 1417..1450 CDD:238011 11/42 (26%)
NL 1476..1512 CDD:197463 15/36 (42%)
Notch 1519..1553 CDD:459658 15/33 (45%)
Notch 1565..1593 CDD:459658 19/27 (70%)
NOD 1598..1652 CDD:462014 17/53 (32%)
NODP 1679..1731 CDD:462229 21/55 (38%)
JMTM_dNotch 1719..1806 CDD:411989 30/88 (34%)
ANK repeat 1902..1948 CDD:293786 22/45 (49%)
ANKYR 1936..2139 CDD:440430 154/202 (76%)
ANK repeat 1951..1981 CDD:293786 25/29 (86%)
ANK repeat 1984..2015 CDD:293786 25/30 (83%)
ANK repeat 2017..2048 CDD:293786 23/30 (77%)
ANK repeat 2050..2081 CDD:293786 19/30 (63%)
ANK repeat 2083..2114 CDD:293786 25/30 (83%)
notch3XP_017948007.1 EGF_CA 105..139 CDD:238011 17/35 (49%)
EGF_CA 142..179 CDD:238011 20/36 (56%)
EGF_CA 220..256 CDD:238011 20/35 (57%)
EGF_CA 258..295 CDD:238011 21/37 (57%)
EGF_CA 298..333 CDD:238011 23/34 (68%)
EGF_CA 375..413 CDD:238011 23/37 (62%)
EGF_CA 415..451 CDD:238011 21/35 (60%)
EGF_CA 453..489 CDD:238011 20/35 (57%)
EGF_CA 491..526 CDD:238011 15/34 (44%)
EGF_CA 529..564 CDD:238011 21/34 (62%)
EGF_CA 567..602 CDD:238011 20/34 (59%)
EGF 726..756 CDD:394967 13/29 (45%)
EGF_CA 760..796 CDD:238011 17/35 (49%)
EGF_CA 838..874 CDD:238011 19/36 (53%)
EGF_CA 876..912 CDD:238011 16/35 (46%)
EGF_CA 915..950 CDD:238011 22/34 (65%)
EGF_CA 952..988 CDD:238011 20/35 (57%)
EGF_CA 991..1026 CDD:238011 16/34 (47%)
EGF_CA 1029..1063 CDD:238011 17/33 (52%)
EGF_CA 1115..1150 CDD:238011 15/34 (44%)
EGF_CA 1152..1188 CDD:238011 19/35 (54%)
EGF_CA 1190..1232 CDD:238011 21/41 (51%)
EGF_CA 1234..1272 CDD:238011 21/37 (57%)
EGF_CA 1276..1313 CDD:238011 14/36 (39%)
Notch 1410..1443 CDD:459658 14/32 (44%)
Notch 1450..1484 CDD:459658 15/33 (45%)
Notch 1498..1524 CDD:459658 18/25 (72%)
NOD 1531..1584 CDD:462014 18/59 (31%)
NODP 1601..1658 CDD:462229 21/59 (36%)
JMTM_Notch3 1640..1726 CDD:411987 32/96 (33%)
ANK repeat 1805..1851 CDD:293786 22/46 (48%)
ANKYR 1833..2056 CDD:440430 163/233 (70%)
ANK repeat 1853..1884 CDD:293786 26/30 (87%)
ANK repeat 1887..1918 CDD:293786 25/30 (83%)
ANK repeat 1920..1951 CDD:293786 23/30 (77%)
ANK repeat 1953..1984 CDD:293786 19/30 (63%)
ANK repeat 1986..2017 CDD:293786 25/30 (83%)
Atrophin-1 2262..>2403 CDD:460830 42/220 (19%)

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