DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kirre and Igsf9

DIOPT Version :9

Sequence 1:	NP_001245505.1	Gene:	kirre / 31292	FlyBaseID:	FBgn0028369	Length:	956	Species:	Drosophila melanogaster
Sequence 2:	NP_001139272.1	Gene:	Igsf9 / 93842	MGIID:	2135283	Length:	1179	Species:	Mus musculus

Alignment Length:	1141	Identity:	216/1141 - (18%)
Similarity:	331/1141 - (29%)	Gaps:	447/1141 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    96 GSRVTLPCRVMEKVG-----ALQWTKDDFGLGQHRNLSGFERYSMVGSDEEGDF----------S 145
            |....|.|.::...|     .::|.:  ||.    .|..|.::.:.....:.|:          |
Mouse    34 GESAVLGCDLLPPAGHPPLHVIEWLR--FGF----LLPIFIQFGLYSPRIDPDYVGRVRLQTGAS 92

  Fly   146 LDIYPLMLDDDAKYQCQV------GPGPQGEQGIRSRFAKLTVLVPP---EAPKITQGDYLVTTE 201
            |.|..|.::|...|:|:|      .|......|   .:..|||..||   |.|.:.    |...|
Mouse    93 LQIEGLRVEDQGWYECRVLFLDQHSPEQDFANG---SWVHLTVNSPPQFQETPPLV----LEVKE 150

  Fly   202 DREIELECVSQGGKPAAEITWI-------DGLGNV-LTKGIEYVKEPLADSRRITARSILKLAPK 258
            ...:.|.||:: |.|...:||.       .|.|.| :..|..::       ||:...|.
Mouse   151 LEAVTLRCVAR-GSPQPYVTWKFRGQDLGKGQGQVQVQNGTLWI-------RRVERGSA------ 201

  Fly   259 KEHHNTTFTCQAQNTADRTYRSAKLLLEVKYAPKVIVSVVGGALAGGKIPEGAEVILSCQADANP 323
                 ..:||||.::......:.:||:   ..|.|||.    ..:...:....:|.|:|:|:|.|
Mouse   202 -----GDYTCQASSSEGSITHATQLLV---LGPPVIVV----PPSNSTVNSSQDVSLACRAEAYP 254

  Fly   324 HELSYRWF-------------------INDELM--------TGDFT---TKMIIHNVSRQYH--- 355
            ..|:|.||                   ::..|.        .|.:|   :...:|..|...:
Mouse   255 ANLTYSWFQDGVNVFHISRLQSRVRILVDGSLWLQATQPDDAGHYTCVPSNGFLHPPSASAYLTV 319

  Fly   356 -------------------DAIVKCEV-VN------AVGKSEQSKKLD----ISFGP-------- 382
                               ..:::|.| .|      ...|..|:.:||    .|.||
Mouse   320 LYPAQVTVMPPETPLPTGMRGVIRCPVRANPPLLFVTWTKDGQALQLDKFPGWSLGPEGSLIIAL 384

  Fly   383 ----------------------------VFRQRPVSVE-------ADLGATVSMRCDVAGNPEPE 412
                                        :.:..|..::       .::|..:.:.|...|:|.|.
Mouse   385 GNENALGEYSCTPYNSLGTAGPSPVTQVLLKAPPAFIDQPKEEYFQEVGRELLIPCSARGDPPPI 449

  Fly   413 IEWISENSDQVVGVAAELKLKVSS-----------ETAGRYFCKAVVNGFPEIGAEATLYVKRAP 466
            :.|..      ||...:.:.:|.|           |..||:.|.|         :.|.     |.
Mouse   450 VSWAK------VGRGLQGQAQVDSNNSLVLRPLTKEAQGRWECSA---------SNAV-----AR 494

  Fly   467 IITSHKVQFGGVGGRVKIDCLAFSIPKAEHILW--SFEGKIINMSSA-------DPDIYIFEEHH 522
            :.||..|...|....|..:.....:||..::.|  .|:|..:...|.       .||    ..||
Mouse   495 VTTSTNVYVLGTSPHVVTNVSVVPLPKGANVSWEPGFDGGYLQRFSVWYTPLAKRPD----RAHH 555

  Fly   523 LPEGVRAALIIRDSKATHF--------GKYNCTVM--NSYGGDSLVITLLREPGNIPVLLVVMG- 576
              :.|..|:.|   .|||.        .:|..:|:  |..|.......:|..|..:|......|
Mouse   556 --DWVSLAVPI---GATHLLVPGLQAHAQYQFSVLAQNKLGSGPFSEIVLSIPEGLPTTPAAPGL 615

  Fly   577 -----------SMFCVAIILMIVMIIIVYRKRRSRKKPM---PADVIP-----------EASRGG 616
                       ....||:             |..|...:   |.::||           :.|:|.
Mouse   616 PPTEIPPPLSPPRGLVAV-------------RTPRGVLLHWDPPELIPGRLDGYILEGRQGSQGW 667

  Fly   617 DKLNE--------------LKS---ELRSKAYDVEY-------SEAGGDGLAI--NLTQSP--MP 653
            :.|::              :|.   |.|..|:...|       :.....||.:  :.||.|  :|
Mouse   668 EILDQGVAGTEIQLLVPGLIKDVLYEFRLVAFADSYVSDPSNVANISTSGLEVYPSRTQLPGLLP 732

  Fly   654 DVQMKGATLGVPLAGPVKFDERFSGDFGGDRYNRQCHIKNLKNQQETAYKGSPQANGYAHYFEYA 718
            ...:.|...||...|........:......|...:.|.|.|:.                   :..
Mouse   733 QPVLAGVVGGVCFLGVAVLVSILAACLMNRRRAARRHRKRLRQ-------------------DPP 778

  Fly   719 LDYSPPGGEGAAVVVGSG---GVGKLKNGGMNSATL--------------PHSAAATVNGGG--- 763
            |.:||.|..|:....|||   .|.|.|..|....:|              ||..:..  |.|
Mouse   779 LIFSPRGKSGSHSAPGSGSPDSVTKFKLQGSPVPSLRQSLLWGEPARPPSPHPDSPL--GRGPLP 841

  Fly   764 -----AGNGG-----------------GASLPRNQRHEIQQ----SQQSNGFLGQPLLQNGIDSR 802
                 .|..|                 ..|.||.....:.|    |..|...:.|||....|..
Mouse   842 LEPICRGPDGRFVMGPTVAPSQEKLCLERSEPRTSAKRLAQSFDCSSSSPSGVPQPLCITDISP- 905

  Fly   803 FSAIYGNPYLRTNSSL-----------LP------------------PLPPPS--TANPAAT--- 833
                .|.|.....|.|           ||                  |.|||.  .:.|..|
Mouse   906 ----VGQPLAAVPSPLPGPGPLLQYLSLPFFREMNVDGDWPPLEEPTPAPPPDFMDSQPCPTSSF 966

  Fly   834 -PAP-----------------------PPYHAARHGHAHHANGGLKHFVGGAVITTSPVGNVNIN 874
             |.|                       |||.|.       |:..|:..|...:::.:|.|::...
Mouse   967 LPPPDSPPANLRAVLPGTLMGVGVSSEPPYTAL-------ADWTLRERVLPGLLSAAPRGSLTSQ 1024

  Fly   875 GGGGGG-------STPSGGGGVGVGVAAGGSVSGSS 903
            ..|.|.       ||....||..:..|.|.:.|.:|
Mouse  1025 SSGRGSASFLRPPSTAPSAGGSYLSPAPGDTSSWAS 1060

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kirre	NP_001245505.1	Ig	87..183	CDD:299845	22/107 (21%)
		IG_like	88..182	CDD:214653	21/106 (20%)
		C2-set_2	189..279	CDD:285423	21/97 (22%)
		Ig_2	307..379	CDD:290606	22/134 (16%)
		I-set	382..462	CDD:254352	18/133 (14%)
		IGc2	396..446	CDD:197706	14/60 (23%)
		Ig	466..561	CDD:299845	25/113 (22%)
		IG_like	478..561	CDD:214653	21/101 (21%)
Igsf9	NP_001139272.1	IG_like	28..110	CDD:214653	17/81 (21%)
		Ig	136..223	CDD:386229	24/109 (22%)
		Ig_3	227..305	CDD:372822	16/81 (20%)
		Ig	341..404	CDD:386229	10/62 (16%)
		Ig	436..500	CDD:319273	18/83 (22%)
		FN3	508..599	CDD:238020	21/99 (21%)
		FN3	625..715	CDD:238020	15/102 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	767..807		14/58 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	819..842		4/24 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	942..974		8/31 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1016..1079		12/45 (27%)
		PDZ-binding	1177..1179
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900