Protein Alignment kirre and KIRREL3

DIOPT Version :10

• Sequence 1: NP_525059.2
• Gene: kirre / 31292
• FlyBaseID: FBgn0028369
• Length: 956
• Species: Drosophila melanogaster
• Sequence 2: NP_001428181.1
• Gene: KIRREL3 / 84623
• HGNCID: 23204
• Length: 814
• Species: Homo sapiens
• Alignment Length: 844
• Identity: 221/844 - (26%)
• Similarity: 341/844 - (40%)
• Gaps: 169/844 - (20%)

  Fly    32 KSKKNKSSQSSH----HGDSSSSSSSSSSSSGSSSAAASSANDESKPKGGDNGGQ--HFAMEPQD 90
            |.::...:::||    .||.::...:.|:....:..          |:.....||  .|:.:|||
Human    38 KFRRMNEARNSHCFLQFGDKAAKGPACSAPRPPAPT----------PEASTFSGQVYSFSQQPQD 92

  Fly    91 QTAVVGSRVTLPCRVMEKVGALQWTKDDFGLGQHRNLSGFERYSMVGSDEEGDFSLDIYPLMLDD 155
            |..|.|..|||.|.:.|..|.:.|.||...||..|:||.:.:|.:||:...|:..|.|....|.|
Human    93 QVVVSGQPVTLLCAIPEYDGFVLWIKDGLALGVGRDLSSYPQYLVVGNHLSGEHHLKILRAELQD 157

  Fly   156 DAKYQCQVGPGPQGEQGIRSRFAKLTVLVPPEAPKITQGDYLVTTEDREIELECVSQGGKPAAEI 220
            ||.|:||.     .:..||||.|:|||||||:.|.|..|..:.......:.|.|.:...||||.|
Human   158 DAVYECQA-----IQAAIRSRPARLTVLVPPDDPVILGGPVISLRAGDPLNLTCHADNAKPAASI 217

  Fly   221 TWIDGLGNVLTKGIEYVKEPLADSRRITARSILKLAPKKEHHNTTFTCQAQNTADRTYRSAKLLL 285
            .|: ..|.|: .|..|.|..|.|.:|.:..|.|.::|....:..:..|:|.|.|....:...:.:
Human   218 IWL-RKGEVI-NGATYSKTLLRDGKRESIVSTLFISPGDVENGQSIVCRATNKAIPGGKETSVTI 280

  Fly   286 EVKYAPKVIVSVVGGALAGGKIPEGAEVILSCQADANPHELSYRWFINDELM----------TGD 340
            ::::.|.|.:||     ....:.|...|...|.|.|||....|||....:::          |.|
Human   281 DIQHPPLVNLSV-----EPQPVLEDNVVTFHCSAKANPAVTQYRWAKRGQIIKEASGEVYRTTVD 340

  Fly   341 FTTKMIIHNVSRQYHDAIVKCEVVNAVGKSEQSKKLDISFGPVFRQRPVSVEADLGATVSMRCDV 405
            :|           |....|.|||.||:|.:..|:.:|:.|||.....|.|:..|||:.....|..
Human   341 YT-----------YFSEPVSCEVTNALGSTNLSRTVDVYFGPRMTTEPQSLLVDLGSDAIFSCAW 394

  Fly   406 AGNPEPEIEWISENSDQVVGVAAELKLK-VSSETAGRYFCKAVVNGFPEIGA---EATLYVKRAP 466
            .|||...|.|:...|..|:.....|.|| |..|.||:|.|:|||   |.:||   |.||.|...|
Human   395 TGNPSLTIVWMKRGSGVVLSNEKTLTLKSVRQEDAGKYVCRAVV---PRVGAGEREVTLTVNGPP 456

  Fly   467 IITSHKVQFGGVGGRVKIDCLAFSIPKAEHILWSFEGKIINMSSADPDIYIFEEHHLPEGVRAAL 531
            ||:|.:.|....|.:.:|.|...|.|..:.|.||::..:  :.|.....|..|.....|||.:.|
Human   457 IISSTQTQHALHGEKGQIKCFIRSTPPPDRIAWSWKENV--LESGTSGRYTVETISTEEGVISTL 519

  Fly   532 IIRDSKATHFGK-YNCTVMNSYGGDSLVITLLREPG------------NIPVLLVVMGSMFCVAI 583
            .|.:.....|.. ||||..||:|.|:.:|. |:|.|            ::| :.|::|......:
Human   520 TISNIVRADFQTIYNCTAWNSFGSDTEIIR-LKEQGSEMKSGAGLEAESVP-MAVIIGVAVGAGV 582

  Fly   584 ILMIVMIIIV----YRKRRSRKKPMPADVIPEASRGGDKLNELKSELRSKAYDVEYSEAGGDGLA 644
            ..:::|..||    .|.:|:.|..:.|.            |:::.|:..|.     ..:|.:|..
Human   583 AFLVLMATIVAFCCARSQRNLKGVVSAK------------NDIRVEIVHKE-----PASGREGEE 630

  Fly   645 INLTQSPMPDVQMKGATLGVPLAGPVKFDERFSGDFGGDRYNRQCHIKNLKNQQETAYKGSPQAN 709
            .:..:..|.|                      .|:|..|...:|..:  ||.:::.........|
Human   631 HSTIKQLMMD----------------------RGEFQQDSVLKQLEV--LKEEEKEFQNLKDPTN 671

  Fly   710 GY-------AHY-------------------------FEYALDYSPPGGE------GAAVVVGSG 736
            ||       .|:                         ..:...||...|:      |...|:|.|
Human   672 GYYSVNTFKEHHSTPTISLSSCQPDLRPAGKQRVPTGMSFTNIYSTLSGQGRLYDYGQRFVLGMG 736

  Fly   737 GVG------KLKNGGM--NSATLPHSAAATVNGGGAGNG-----GGASLPRNQRHEIQQSQQSN 787
            ...      :.:.|.:  :|:.|.....::|:..|..:|     ..:....:..|..|.|.|::
Human   737 SSSIELCEREFQRGSLSDSSSFLDTQCDSSVSSSGKQDGYVQFDKASKASASSSHHSQSSSQNS 800

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kirre	NP_525059.2	IG_like	88..182	CDD:214653	39/93 (42%)
		Ig strand B	99..103	CDD:409552	3/3 (100%)
		Ig strand E	144..148	CDD:409552	1/3 (33%)
		Ig strand F	158..163	CDD:409552	2/4 (50%)
		C2-set_2	189..279	CDD:400489	26/89 (29%)
		Ig strand C	219..223	CDD:409416	1/3 (33%)
		Ig strand E	251..255	CDD:409416	2/3 (67%)
		Ig strand F	265..270	CDD:409416	1/4 (25%)
		Ig strand G	280..283	CDD:409416	0/2 (0%)
		Ig_2	307..379	CDD:464026	23/81 (28%)
		Ig	382..462	CDD:472250	32/83 (39%)
		Ig strand B	399..403	CDD:409353	0/3 (0%)
		Ig strand C	412..417	CDD:409353	2/4 (50%)
		Ig strand F	441..446	CDD:409353	2/4 (50%)
		Ig strand G	455..458	CDD:409353	2/5 (40%)
		Ig	466..561	CDD:472250	31/95 (33%)
		Ig strand B	482..486	CDD:409353	1/3 (33%)
		Ig strand C	496..500	CDD:409353	1/3 (33%)
		Ig strand E	529..533	CDD:409353	1/3 (33%)
		Ig strand F	543..548	CDD:409353	3/5 (60%)
		Ig strand G	556..559	CDD:409353	0/2 (0%)
KIRREL3	NP_001428181.1	None