DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kirre and USH2A

DIOPT Version :9

Sequence 1:	NP_001245505.1	Gene:	kirre / 31292	FlyBaseID:	FBgn0028369	Length:	956	Species:	Drosophila melanogaster
Sequence 2:	NP_996816.3	Gene:	USH2A / 7399	HGNCID:	12601	Length:	5202	Species:	Homo sapiens

Alignment Length:	713	Identity:	130/713 - (18%)
Similarity:	221/713 - (30%)	Gaps:	275/713 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 SSSSSSSSSSSGSSSAAASSANDESKPKGGD------NGGQHFAMEPQDQTAVVGSRVTLPCRVM 106
            |.:.::|:|..|..|.........|.|.|.:      .|.|...:.........|..:.....:.
Human  4506 SYTVTASNSQGGILSPLVKDRTSPSAPSGMEPPKLQARGPQEILVNWDPPVRTNGDIINYTLFIR 4570

  Fly   107 E------KVGALQWTKDDFGLGQH--RNLSGFERYSM----------VGSDEEGDFSLDIYPLML 153
            |      |:..:..|.:.||:..:  ..|..|.||.:          ..||.....:.:|.|||
Human  4571 ELFERETKIIHINTTHNSFGMQSYIVNQLKPFHRYEIRIQACTTLGCASSDWTFIQTPEIAPLM- 4634

  Fly   154 DDDAKYQCQVGPG---------------PQG----------EQGIRSRFAKLTVLVPPEAPKITQ 193
            ......:.|:.||               |.|          :...:.|.:...::....:.....
Human  4635 QPPPHLEVQMAPGGFQPTVSLLWTGPLQPNGKVLYYELYRRQIATQPRKSNPVLIYNGSSTSFID 4699

  Fly   194 GDYLVTTEDREIELECVSQGGKPAAEITWI-------DGLG----NVL--TKGIEYVKEP----- 240
            .:.|..|| .|.::..|:..||..:..||.       :||.    :|:  |:.:..:..|
Human  4700 SELLPFTE-YEYQVWAVNSAGKAPSSWTWCRTGPAPPEGLRAPTFHVISSTQAVVNISAPGKPNG 4763

  Fly   241 ------LADSRRITARSILK--LAPKKEHHN--------------TTFTCQAQN-TAD-RTYRSA 281
                  |..|....|.::|.  :|.::..|.              |.|.|.::. ||: ||:.:
Human  4764 IVSLYRLFSSSAHGAETVLSEGMATQQTLHGLQAFTNYSIGVEACTCFNCCSKGPTAELRTHPA- 4827

  Fly   282 KLLLEVKYAPKVIVSVVGGALAGGKIPEGAEVILSCQADANPHELSYRW----FINDELMTGDFT 342
                    .|..:.|...|.||.                   ...|:||    |.|.
Human  4828 --------PPSGLSSPQIGTLAS-------------------RTASFRWSPPMFPNG-------- 4857

  Fly   343 TKMIIHNVSRQYH-----DAIVKC-----------------------------EVV--NAVGKSE 371
               :||:...|:|     |:.:.|                             .||  |.||.:.
Human  4858 ---VIHSYELQFHVACPPDSALPCTPSQIETKYTGLGQKASLGGLQPYTTYKLRVVAHNEVGSTA 4919

  Fly   372 QSKKLDISFG-----PVFRQRPVSVEADLGATVSMRCDVAGNPEPEIEWISENSDQVVGVAAELK 431
            ...   |||.     |.:| .|.||:::|    |:.|         :.|    ||..: :..:||
Human  4920 SEW---ISFTTQKELPQYR-APFSVDSNL----SVVC---------VNW----SDTFL-LNGQLK 4962

  Fly   432 LKVSSETAGRYFCKAVVNGFPEIGAEATLYVKRAPIITSHKVQFGGV-----GGRVKIDCLAFSI 491
            ..|.::...|.:.          |.:.|||:.|    |:.|..|..|     .|.||...:.:..
Human  4963 EYVLTDGGRRVYS----------GLDTTLYIPR----TADKTFFFQVICTTDEGSVKTPLIQYDT 5013

  Fly   492 PKAEHILWSFEGKIINMSSADPDIYIFEEHHLPEGVRAALIIRDSKATHFGKYNCTVMNSYGGDS 556
            .....::.:..||                   .:|.|       ||:|.|          |....
Human  5014 STGLGLVLTTPGK-------------------KKGSR-------SKSTEF----------YSELW 5042

  Fly   557 LVITLLREPGNIPVLLVVMGSMFCVAIILMIVMIIIVYRKRRSRKKP---------MPADVIP 610
            .:           ||:.::| :..:||.|.:::...::::...|::|         .|.:|.|
Human  5043 FI-----------VLMAMLG-LILLAIFLSLILQRKIHKEPYIRERPPLVPLQKRMSPLNVYP 5093

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kirre	NP_001245505.1	Ig	87..183	CDD:299845	22/138 (16%)
		IG_like	88..182	CDD:214653	22/136 (16%)
		C2-set_2	189..279	CDD:285423	27/131 (21%)
		Ig_2	307..379	CDD:290606	16/111 (14%)
		I-set	382..462	CDD:254352	18/79 (23%)
		IGc2	396..446	CDD:197706	9/49 (18%)
		Ig	466..561	CDD:299845	16/99 (16%)
		IG_like	478..561	CDD:214653	13/87 (15%)
USH2A	NP_996816.3	LamGL	146..283	CDD:214722
		Laminin_N	291..516	CDD:413488
		EGF_Lam	517..565	CDD:238012
		EGF_Lam	574..639	CDD:238012
		Laminin_EGF	641..691	CDD:395007
		EGF_Lam	694..733	CDD:214543
		Laminin_EGF	747..795	CDD:395007
		EGF_Lam	794..844	CDD:238012
		EGF_Lam	847..897	CDD:214543
		EGF_Lam	900..948	CDD:238012
		EGF_Lam	950..1000	CDD:238012
		EGF_Lam	1001..>1037	CDD:238012
		fn3	1058..1132	CDD:394996
		fn3	1150..1227	CDD:394996
		FN3	1242..1357	CDD:238020
		FN3	1368..1451	CDD:214495
		LamG	1519..1678	CDD:238058
		LamG	1716..1868	CDD:238058
		FN3	1956..2051	CDD:238020
		FN3	2241..2313	CDD:238020
		FN3	2329..2428	CDD:238020
		FN3	2432..2528	CDD:238020
		FN3	2533..2619	CDD:238020
		FN3	2621..2719	CDD:238020
		FN3	2724..2799	CDD:238020
		FN3	2818..2920	CDD:238020
		FN3	2925..3015	CDD:238020
		FN3	3026..>3087	CDD:238020
		FN3	<3449..3494	CDD:238020
		FN3	3503..3586	CDD:238020
		FN3	3590..3676	CDD:238020
		FN3	3680..3767	CDD:238020
		fn3	3777..3856	CDD:394996
		FN3	3866..3960	CDD:238020
		FN3	3964..4057	CDD:238020
		fn3	4161..4247	CDD:394996
		FN3	4268..4351	CDD:238020
		fn3	4357..4428	CDD:394996
		FN3	4444..4516	CDD:238020	3/9 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	4518..4541		4/22 (18%)
		FN3	4529..4627	CDD:238020	17/97 (18%)
		FN3	4636..4730	CDD:238020	15/94 (16%)
		FN3	4826..4927	CDD:238020	24/142 (17%)
		PDZ-binding	5200..5202
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900