DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kirre and nphs1

DIOPT Version :9

Sequence 1:	NP_001245505.1	Gene:	kirre / 31292	FlyBaseID:	FBgn0028369	Length:	956	Species:	Drosophila melanogaster
Sequence 2:	NP_001035777.1	Gene:	nphs1 / 692352	ZFINID:	ZDB-GENE-051102-1	Length:	1242	Species:	Danio rerio

Alignment Length:	964	Identity:	209/964 - (21%)
Similarity:	315/964 - (32%)	Gaps:	355/964 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 GGQHFAMEPQDQTAVVGSRVTLPCRVMEKVGALQWTKDDFGLGQHRNLSGFERYSMVGSDEEGDF 144
            |.|.|..||::.|...|:...|.|.|:...||:||.||...|...|:|.|:.||||.|..::|.:
Zfish    25 GQQAFKTEPRNVTVRAGATALLKCEVLRASGAVQWVKDGLLLRPLRSLPGYPRYSMTGDQKKGQY 89

  Fly   145 SLDIYPLMLDDDAKYQCQVG--------------------------------PGPQGEQ------ 171
            .|.|..:.|:||..|:||||                                |..:|||
Zfish    90 HLQILDVTLEDDGPYECQVGRSESSRPIVSRTVWLNVQIPSSQPYFQLESEEPWVEGEQYTVTCI 154

  Fly   172 -----------------------------------------GIRSRFA----KLT---------- 181
                                                     .||:|.:    :||
Zfish   155 APDAKPPAEITIFRDGEELLESESYTMSGSQDKLQNTHAEVTIRARSSDDTRRLTCRAKNPASPR 219

  Fly   182 ---------VLVPPEAPKITQGDYLVTTEDREI------ELECVSQGGKPAAEITWIDGLGNVLT 231
                     |..||:||.|      :..|:.|:      ::.|:|.||.|.|.:.|... |.||:
Zfish   220 ALETGMTMKVYFPPQAPMI------MGLENEEVKAGSFLKVVCMSYGGNPLATLHWTKN-GEVLS 277

  Fly   232 KG--IEYVKEPLADSRRITARSILKLAPKKEHHNTTFTCQAQNTADRTYRSAKLLLEVKYAPKVI 294
            ..  :::|      |||  |.|:||:..|.|.::....||:.|...|:..|....|.|.:.|..:
Zfish   278 TSWDVDFV------SRR--ASSVLKMEVKPEDNHAVLQCQSINQVTRSPMSLTRTLTVPFEPAEV 334

  Fly   295 VSVVGGALAGGKIPEGAEVILSCQADANPHELSYRWFINDELMT------------GDFTTKMII 347
            .     .|...:..||.|:.|||...::...:..||::..:.:.            |..|...:.
Zfish   335 T-----LLGSFEAVEGEEINLSCSTSSSNPPVHIRWWLGFKELNRTEVTFAEGDNGGMMTVSNLT 394

  Fly   348 HNVSRQYHDAIVKCEVVNAVGK--SEQSKKLDISFGPVFRQR------PVSVEADLGATVSMRC- 403
            |.|||:.:...::||..|...:  |.::.:|.:.:.|   |:      |.:|....|:|:.:.|
Zfish   395 HKVSREDNGLSLQCEAFNKGTRFSSVRAAELIVYYPP---QKVWLDAPPPNVFLHSGSTLRLVCF 456

  Fly   404 DVAGNPEPEIEWISEN------SDQVV---GVAAELKLKV-SSETAGRYFCKAVVNGFPEIGAEA 458
            ...|||..::.|:..|      |.||.   ||:.||.|.: .|:....|.|.:.......:.|:
Zfish   457 SSGGNPTGQLTWLKNNKVVLTASKQVSSERGVSRELLLTLHPSDNLATYRCDSSNKAKKVLSAQ- 520

  Fly   459 TLYVKRAPIITSHKVQFGGV-------------GGRVKIDCLAFSIPKAEHILWSFEGKII---- 506
                      |..:|.|..|             |..:.:||||.|.....:|.||. |.:|
Zfish   521 ----------TKFRVLFPAVSVKIVAKQKELRRGQTLDLDCLAGSSNPTANISWSL-GPVILKGV 574

  Fly   507 ----------NMSSADPDIYIFEEHH-------------LPEGVR-------------------A 529
                      .||.........|.||             |.|||.                   .
Zfish   575 DQAPKRAEFGGMSRTSKLSLTLEPHHWRKRITCQAFSNVLSEGVNNFYSLDVLFPPEFSAEQPDE 639

  Fly   530 ALIIRDSKATHFGKYNCTVMNSYGGDSLVITLLREPGNIPVLLVVMGSMFCVAIILMIVMIIIVY 594
            ..:|.|..||                 |...:...|..|....:..|..            ::..
Zfish   640 VQVIEDETAT-----------------LPAKVSANPDEITCEWIFQGEK------------LVKE 675

  Fly   595 RKRRSRKKPMPADVIPEASR-GGDKLNEL-------KSELRSKAYDVEYSEAGGDGLAINLTQSP 651
            |..|........:::..:.| |||.:.|.       :::||   .||:||
Zfish   676 RDPRYTFSDWTLEIVNVSRRDGGDYIIECSNAEGSNRTKLR---LDVQYS--------------- 722

  Fly   652 MPDVQMK--------GAT---LGVPLAGPV---KFDERFSGDFGGDRYNRQCHIKNLKNQQETAY 702
             |.|:||        |.|   |.|..|.|:   .|..::.|:  |:|             .|...
Zfish   723 -PTVRMKSDPVFVNIGDTADLLCVADANPITSSMFSWKWMGE--GER-------------DELGE 771

  Fly   703 KGSPQANGYAHYFEYALD------------YSPPGG-EGAAVVVGSGGVGKLKNGGMNSATLPHS 754
            :......|....:|...|            .||.|. ||..:|   .....|:.|       |..
Zfish   772 ESEDDGTGVLTIYEVTRDRAGVYQCTADNGISPTGSVEGQLIV---RFAPDLQKG-------PQW 826

  Fly   755 AAATVNGGGAGNGG----GASLPRNQRHEIQQSQQSNGF---LGQPLLQNGIDS 801
            ......|.|:.:..    ...:||     :|.....|||   ||.|..:...:|
Zfish   827 RKVASRGDGSNDANVVCQAQGVPR-----VQFRWAKNGFPLDLGNPRYEETTES 875

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kirre	NP_001245505.1	Ig	87..183	CDD:299845	42/197 (21%)
		IG_like	88..182	CDD:214653	41/195 (21%)
		C2-set_2	189..279	CDD:285423	28/97 (29%)
		Ig_2	307..379	CDD:290606	19/85 (22%)
		I-set	382..462	CDD:254352	24/96 (25%)
		IGc2	396..446	CDD:197706	19/60 (32%)
		Ig	466..561	CDD:299845	29/153 (19%)
		IG_like	478..561	CDD:214653	26/141 (18%)
nphs1	NP_001035777.1	IG_like	33..126	CDD:214653	32/92 (35%)
		Ig	133..216	CDD:386229	9/82 (11%)
		Ig	261..313	CDD:386229	19/60 (32%)
		Ig	333..419	CDD:386229	18/90 (20%)
		ig	439..511	CDD:365836	21/71 (30%)
		IG_like	637..719	CDD:214653	17/113 (15%)
		Ig_3	723..800	CDD:372822	18/91 (20%)
		Ig_hNephrin_like	814..922	CDD:143250	16/77 (21%)
		FN3	921..1012	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D141865at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920