DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kirre and kirrel3b

DIOPT Version :9

Sequence 1:	NP_001245505.1	Gene:	kirre / 31292	FlyBaseID:	FBgn0028369	Length:	956	Species:	Drosophila melanogaster
Sequence 2:	XP_021323594.1	Gene:	kirrel3b / 572369	ZFINID:	ZDB-GENE-100713-3	Length:	795	Species:	Danio rerio

Alignment Length:	599	Identity:	182/599 - (30%)
Similarity:	273/599 - (45%)	Gaps:	65/599 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 FAMEPQDQTAVVGSRVTLPCRVMEKVGALQWTKDDFGLGQHRNLSGFERYSMVGSDEEGDFSLDI 148
            |:.:|||...|.|..|||||.:....|.:.|.:|...||..|:|||:.||::||....|:..|.|
Zfish    31 FSQQPQDLVVVAGQPVTLPCSIPGYHGVVLWLRDGLALGVGRDLSGYPRYAVVGDHGSGEHHLRI 95

  Fly   149 YPLMLDDDAKYQCQVGPGPQGEQGIRSRFAKLTVLVPPEAPKITQGDYLVTTEDREIELECVSQG 213
            ..:.|.|||.::||.     .:..:|||.|:|||||||:.|.||.|..:.......:.|.|.:..
Zfish    96 QKVELMDDAVFECQA-----IQAAMRSRPARLTVLVPPDDPMITGGPVVSLRAGDPLNLTCHADN 155

  Fly   214 GKPAAEITWIDGLGNVLTKGIEYVKEPLADSRRITARSILKLAPKKEHHNTTFTCQAQNTADRTY 278
            .||||.|.||.. |.|| .|..|.|..|.|.||.:..|.|.::...........|:|.|.|....
Zfish   156 AKPAASIIWIRN-GEVL-NGAMYSKTLLRDGRRESTVSTLYISASNIESGQKIICRASNKAVPNG 218

  Fly   279 RSAKLLLEVKYAPKVIVSVVGGALAGGKIPEGAEVILSCQADANPHELSYRWFINDEL---MTGD 340
            :...:.:::::.|.|.:||     ....:.||..|...|.|.|||....|:|.....:   ::||
Zfish   219 KETSVTIDIQHLPLVNLSV-----EPQPVLEGNLVKFHCSAKANPPVTQYKWAKGGSVIKEVSGD 278

  Fly   341 FTTKMIIHNVSRQYHDAIVKCEVVNAVGKSEQSKKLDISFGPVFRQRPVSVEADLGATVSMRCDV 405
             |.::|   |...:....|.|||.|.:|.:..|:.:|:.|||.....|.|::.|||:.....|..
Zfish   279 -TYEVI---VDHSFFTEPVSCEVTNPLGSTNISRNVDVYFGPRMAAEPQSLQVDLGSDAVFNCAW 339

  Fly   406 AGNPEPEIEWISENSDQVVGVAAELKLK-VSSETAGRYFCKAVVNGFPEIGA---EATLYVKRAP 466
            .|||...|.|:...|..|:.....|.|| |..|.||:|.|:|||   |.:||   |.:|.|...|
Zfish   340 TGNPSLTIVWMKRGSGVVLSNENILTLKSVRQEDAGKYVCRAVV---PRVGAAEKEVSLTVNGPP 401

  Fly   467 IITSHKVQFGGVGGRVKIDCLAFSIPKAEHILWSFEGKIINMSSADPDIYIFEEHHLPEGVRAAL 531
            .|:|.:......|.:.:|.|...|.|..:.|.||::..:  :.|.....|..|.....:||.:.|
Zfish   402 TISSTQTHQAPHGEKGQIKCFIRSTPPPDRIAWSWKETV--LESGTSGRYTVETVSTEDGVLSTL 464

  Fly   532 IIRDSKATHFGK-YNCTVMNSYGGDSLVITLLREPG---NIPVLLVV---MGSMFCVAIILMIVM 589
            .:.:.....|.. ||||..||:|.|:.:|.|..:.|   ::||.:::   :|:.  ||.|:::..
Zfish   465 TMSNIVPADFQTIYNCTAWNSFGSDTEIIRLKEQGGSQDSLPVAVIIGVAVGAF--VAFIVLMGT 527

  Fly   590 IIIVYRKRRSRKK--------------PMPADVIPEASRGGDKL------------NELKSELRS 628
            |......|..|||              .:|..:..:......|:            |:::.|:..
Zfish   528 IGAFCCTRSQRKKSAHLCTEDAHLVMPTLPTSICAQQRELASKIKTENLKGVVSAKNDIRVEIVH 592

  Fly   629 KAYDV--EYSEAGG 640
            |.::.  |..|..|
Zfish   593 KDHNAARESEEHSG 606

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kirre	NP_001245505.1	Ig	87..183	CDD:299845	38/95 (40%)
		IG_like	88..182	CDD:214653	37/93 (40%)
		C2-set_2	189..279	CDD:285423	29/89 (33%)
		Ig_2	307..379	CDD:290606	23/74 (31%)
		I-set	382..462	CDD:254352	31/83 (37%)
		IGc2	396..446	CDD:197706	18/50 (36%)
		Ig	466..561	CDD:299845	27/95 (28%)
		IG_like	478..561	CDD:214653	24/83 (29%)
kirrel3b	XP_021323594.1	IG_like	35..124	CDD:214653	37/93 (40%)
		Ig2_KIRREL3-like	146..227	CDD:143236	25/82 (30%)
		Ig_2	235..312	CDD:316418	24/85 (28%)
		I-set	316..397	CDD:333254	31/83 (37%)
		Ig5_KIRREL3	399..496	CDD:143306	27/98 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	84	1.000	Domainoid score	I8167
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	273	1.000	Inparanoid score	I2950
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D141865at33208
OrthoFinder	1	1.000	-	-		FOG0001084
OrthoInspector	1	1.000	-	-		mtm6357
orthoMCL	1	0.900	-	-		OOG6_103358
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.870