DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kirre and aebp1b

DIOPT Version :9

Sequence 1:	NP_001245505.1	Gene:	kirre / 31292	FlyBaseID:	FBgn0028369	Length:	956	Species:	Drosophila melanogaster
Sequence 2:	XP_696022.6	Gene:	aebp1b / 567630	ZFINID:	ZDB-GENE-030131-8546	Length:	1247	Species:	Danio rerio

Alignment Length:	268	Identity:	50/268 - (18%)
Similarity:	92/268 - (34%)	Gaps:	63/268 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKRMRSSRLLVLPLILVLILTLLLQPIAVHAKSKKNKSSQSSHHGDSSSSSSSSSSSSGSSSAAA 65
            |..:|:.:.||:..:.:|:.:..:..:..|:||:.:.:.:..|..|.:                .
Zfish     1 MLGLRNQKTLVVLCLSLLVPSWEVNGLTEHSKSEISHTDREQHVEDRN----------------V 49

  Fly    66 SSANDESKPKGGDNGGQHFAMEPQDQTAVVGSRVTLPCRVMEKVGALQWTKDDFG---LGQHRNL 127
            :|..|..:.|          :.|...|..||....|.|:|......:.|...: |   |.:|.||
Zfish    50 TSVEDLLQVK----------IIPPYATIEVGQHKQLLCKVSSDAKNINWVSPN-GEKVLTKHGNL 103

  Fly   128 SGFERYSMVGSDEEGDFSLDIYPLMLDDDAKYQCQVGPGPQGEQGIRSRFAKLTVLVPPEAPKIT 192
            ......|::.       ||.:....|::...|:|....|....|..    .||.:::     |..
Zfish   104 KVHNHGSVLS-------SLTVLNANLNNAGIYKCVATNGDTESQAT----VKLDIIL-----KRM 152

  Fly   193 QGDYLVTTEDREIELECVSQGGKPAAEITWIDGLGNVLTKGIEYVKEPLADSRRITARSILKLAP 257
            :.|  ...:.||..|:......||               |..:..|:|.::.:....:...|...
Zfish   153 RRD--TDRKGREKRLKEPKPSKKP---------------KASKPTKKPKSEKKGKGEKGGKKKGK 200

  Fly   258 KKEHHNTT 265
            |....:||
Zfish   201 KNREESTT 208

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kirre	NP_001245505.1	Ig	87..183	CDD:299845	23/98 (23%)
		IG_like	88..182	CDD:214653	23/96 (24%)
		C2-set_2	189..279	CDD:285423	14/77 (18%)
		Ig_2	307..379	CDD:290606
		I-set	382..462	CDD:254352
		IGc2	396..446	CDD:197706
		Ig	466..561	CDD:299845
		IG_like	478..561	CDD:214653
aebp1b	XP_696022.6	Ig	56..147	CDD:299845	24/112 (21%)
		IG_like	62..145	CDD:214653	21/94 (22%)
		FA58C	402..555	CDD:238014
		FA58C	403..556	CDD:214572
		Peptidase_M14_like	577..1036	CDD:299699
		Peptidase_M14NE-CP-C_like	1040..1115	CDD:200604
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900