DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kirre and robo4

DIOPT Version :9

Sequence 1:	NP_001245505.1	Gene:	kirre / 31292	FlyBaseID:	FBgn0028369	Length:	956	Species:	Drosophila melanogaster
Sequence 2:	XP_689255.3	Gene:	robo4 / 560765	ZFINID:	ZDB-GENE-020809-1	Length:	1134	Species:	Danio rerio

Alignment Length:	840	Identity:	169/840 - (20%)
Similarity:	264/840 - (31%)	Gaps:	292/840 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   259 KEHHNTTFTCQAQNTADRTYR--SAKLLLE------VKYAPKVIVSVVGGALAGGKIPEGAEVIL 315
            |.|.......|..:..||.:|  .::|:.|      |.:...|:|.|            |:...|
Zfish    38 KGHLRHRLMHQRASHRDRAHRRKGSRLVSEINLPRIVHHPSDVVVRV------------GSPATL 90

  Fly   316 SCQADANPHELSYRWFINDELMTGDFTTKM------------------IIHNVSRQYHDAIVKCE 362
            ||:|:.|| |.:.:|..|.:.:.   |.||                  ::.....|.|:|:..|.
Zfish    91 SCRAEGNP-EPTIQWLRNGQPLD---TDKMDAQSQPIVLPDGSLFFFSVVPGRKGQSHEAVYACI 151

  Fly   363 VVNAVGKSEQSKKLDISFGPV---FRQRPVSVEADLGATVSMRCD-VAGNPEPEIEW------IS 417
            ..|::|.: .|:...:....:   ||.:|..||..:|...::.|. ..|:|||.:.|      |:
Zfish   152 AHNSIGNA-TSRNASLHIAALREDFRVQPSDVEVAIGEMATINCSPPVGHPEPNVTWRKDGILIN 215

  Fly   418 ENSDQVVGVAAELKLKV-----SSETAGRYFCKAV-VNGFPEIGAEATLYVKRAPIITSH----K 472
            .:::..    .|||.|:     ....:|.|.|.|. :.|..|..| |.|.|...|::...    .
Zfish   216 SSNEHY----TELKGKLIIAPAQKNDSGVYSCIASNMIGVRESRA-ARLSVLAKPVLLRKPEDVS 275

  Fly   473 VQFGGVGGRVKIDCLAFSIPKAEHILWSFE-GKIINMSSADPDIYIFEEHHLPEGVRAALIIRDS 536
            ||   :|...:..|.|...|... |.||.| |.:.|      ..|:....|       :|.|...
Zfish   276 VQ---LGESAQFFCEADGDPMPS-IEWSREQGPLPN------GRYLINPDH-------SLQIHYV 323

  Fly   537 KATHFGKYNCTVMNSYGGDSLVITLLREPGNIPVLLVVMGSMFCVAIILMIVMIIIVYRKRRSRK 601
            .|...|:|:|||.|..|.......||.|
Zfish   324 TAQDMGRYSCTVENKLGVSVASAQLLVE------------------------------------- 351

  Fly   602 KPMPADVIPEASRGGDKLNELKSELRSKAYDVEYSEAGGDGLAINLTQSPMPDVQMKGATLG--- 663
                       ..||.:|.:|..||.:....:|       .:.:..|.|.|..|..|..:.|
Zfish   352 -----------DAGGTRLRDLHKELSALRVSLE-------NVTVMSTASNMSQVMWKLQSFGSQP 398

  Fly   664 ------------------------VPL------AGPVKFDERFS---GDFGGDRYNRQCHIKNLK 695
                                    ||.      .||:|...::.   ..:|...|.|:.:.::|:
Zfish   399 HYLEGFEVLYRSLLPASSDWTAQRVPQPSLHTHVGPLKRGYKYEFKVRPYGSSLYGRESNTRHLR 463

  Fly   696 NQQETAYKGSPQ---------ANGYAHYFEYALDYSPPGGEGAAVVVGSGGVGKLK-------NG 744
             ..|.....:||         .|...|     |.:.||..:....::....|..::       |.
Zfish   464 -VPEIVPSAAPQDVSITMPAERNDTVH-----LSWEPPPHDAHNGIIQGYQVWCVESEEQTSFNW 522

  Fly   745 GMNSATLPHS--------------AAATVNGGGAGNGGGASLPRNQRHEIQQSQQSNGFLGQPLL 795
            .::|.|  ||              ..|.|||.|.|                  .||:.:   .||
Zfish   523 TVDSGT--HSIEIFTLLPSRLYWVTVAAVNGAGVG------------------VQSDPY---KLL 564

  Fly   796 QNGIDSRFSAIYGNPY---LRTNSSLLPPLPPPSTANPAAT-------------------PAPPP 838
               |:||..|   .||   :.:.|..:..:..|.......|                   ||.|.
Zfish   565 ---IESRLEA---TPYQTGILSMSHFVSVIKEPVFIGSVGTLLWCVLMITAVFLYRRHIRPANPS 623

  Fly   839 YHAARHGHAHHANGGLKHFVGGAVITTSPVGNVNINGGGGGGSTPSGGGGVGVGVAAGGSVSGSS 903
            ..::........:..:||.:..   ..||.    |:||...||......|:.........:..::
Zfish   624 GKSSGLYRLESEDLIIKHRMAA---PDSPW----ISGGWRPGSNSEPKQGLWTPSQENSGLRRTT 681

  Fly   904 SNLTASS--NTL-AATP---------------LAGGGV---GNSGQCAQSPSGQFILSNN 942
            ..:|...  |.| :|.|               |.|.|:   .:.|:|.:.|.|...|.|:
Zfish   682 LPITVKKDPNPLRSAVPIVPDNCGVYGTFYVDLTGNGLKTFNSPGRCPRMPHGNSQLQNS 741

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kirre	NP_001245505.1	Ig	87..183	CDD:299845
		IG_like	88..182	CDD:214653
		C2-set_2	189..279	CDD:285423	5/19 (26%)
		Ig_2	307..379	CDD:290606	20/89 (22%)
		I-set	382..462	CDD:254352	26/95 (27%)
		IGc2	396..446	CDD:197706	15/61 (25%)
		Ig	466..561	CDD:299845	25/99 (25%)
		IG_like	478..561	CDD:214653	22/83 (27%)
robo4	XP_689255.3	Ig1_Robo	70..169	CDD:143317	24/115 (21%)
		I-set	71..168	CDD:254352	24/113 (21%)
		I-set	175..261	CDD:254352	26/90 (29%)
		Ig2_Robo	177..261	CDD:143201	24/88 (27%)
		I-set	265..350	CDD:254352	26/101 (26%)
		Ig	282..350	CDD:299845	22/81 (27%)
		FN3	373..448	CDD:214495	12/81 (15%)
		FN3	472..560	CDD:238020	21/112 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900