DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kirre and lrit3a

DIOPT Version :9

Sequence 1:	NP_001245505.1	Gene:	kirre / 31292	FlyBaseID:	FBgn0028369	Length:	956	Species:	Drosophila melanogaster
Sequence 2:	NP_001122166.1	Gene:	lrit3a / 558559	ZFINID:	ZDB-GENE-080723-63	Length:	636	Species:	Danio rerio

Alignment Length:	340	Identity:	65/340 - (19%)
Similarity:	109/340 - (32%)	Gaps:	117/340 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   372 QSKKLDISFGPVFRQRPVSVEADLGATVSMRCDVAGNPEPEIEWISENSDQVVGVAAE------- 429
            |..:||....|........:.:.||:.|.:|||..|.|.|.:.|.:.:...|.....:
Zfish   242 QRAELDQCVKPTVMTSATKITSPLGSNVLLRCDANGFPTPTLLWTTADGSVVNNTVVQESPGEGV 306

  Fly   430 ----LKL-KVSSETAGRYFCKA-------------VVNG------FPEIG--------------- 455
                |.| .:..:.||.|.|||             .|:|      ||.|.
Zfish   307 RWSILSLHSIVFKDAGDYRCKAKNVAGNAEAYITLSVDGVQPTTPFPPINITKQPEDQPTTTFTP 371

  Fly   456 AEATLYVKRAPI-------------ITSHK--VQFGGV--------------------GGRVKID 485
            .:..|:...:||             :|:.|  :..|||                    |...|.|
Zfish   372 TKMPLFTSLSPITITTRPVMTTMPPLTTRKSPIPGGGVQRSPPAGDKPAKVQQSKNGKGSIKKSD 436

  Fly   486 CLAFSI----PKAEHILWSFEG-------KII--------NMSSADPDI---YIFEEHHLPEGVR 528
            .....:    .:...:|||.||       .::        :..:.|.::   .:..|:.:|..|.
Zfish   437 IRDIEVVEETTETAVLLWSAEGLPSDTPLTVVYFPYDAKDDKETVDTEVGQGKLLLEYLMPNQVY 501

  Fly   529 AALIIRDSKATHFGKYNCTVMNSYGGDSLVITLLREPGNIPVLLVVMGSMFCVAIILMIVM---I 590
            ...::..|.    ||..|.       |...:.:..|.|...||::.......:|:.|::|:   |
Zfish   502 TVCLVTKSS----GKEQCV-------DFSTLEIGGEEGQNKVLMIASAIACAIAVPLIVVLLYKI 555

  Fly   591 IIVYRKRRSRKKPMP 605
            :.:|.|..|.:...|
Zfish   556 LCLYCKGNSSRNNGP 570

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kirre	NP_001245505.1	Ig	87..183	CDD:299845
		IG_like	88..182	CDD:214653
		C2-set_2	189..279	CDD:285423
		Ig_2	307..379	CDD:290606	3/6 (50%)
		I-set	382..462	CDD:254352	26/125 (21%)
		IGc2	396..446	CDD:197706	16/61 (26%)
		Ig	466..561	CDD:299845	24/151 (16%)
		IG_like	478..561	CDD:214653	18/124 (15%)
lrit3a	NP_001122166.1	LRR_8	81..141	CDD:290566
		leucine-rich repeat	83..106	CDD:275378
		LRR_4	107..145	CDD:289563
		leucine-rich repeat	107..130	CDD:275378
		LRR_8	129..>171	CDD:290566
		LRR_4	129..170	CDD:289563
		leucine-rich repeat	131..154	CDD:275378
		leucine-rich repeat	155..168	CDD:275378
		TPKR_C2	199..249	CDD:301599	3/6 (50%)
		Ig	252..343	CDD:299845	20/90 (22%)
		IG_like	261..343	CDD:214653	19/81 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900