DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kirre and si:dkey-24p1.1

DIOPT Version :9

Sequence 1:	NP_001245505.1	Gene:	kirre / 31292	FlyBaseID:	FBgn0028369	Length:	956	Species:	Drosophila melanogaster
Sequence 2:	NP_001091715.1	Gene:	si:dkey-24p1.1 / 556718	ZFINID:	ZDB-GENE-060503-631	Length:	1043	Species:	Danio rerio

Alignment Length:	971	Identity:	177/971 - (18%)
Similarity:	300/971 - (30%)	Gaps:	365/971 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 KSSQSSHHGDSSSSSSSSSSSSGSSSAAASSA------NDES-----KPKGGDNGGQ------HF 84
            ||.|:.....|.|......:..|.:....:..      .|::     :|...|:..|      ..
Zfish   196 KSGQTPEWTSSPSKEMIIETEKGENGTQVTKLKLTVTWKDDNRILSCRPANSDDSCQIRNITLSV 260

  Fly    85 AMEPQDQTAVVGSR-------VTLPC--RVMEKVGALQWTKDDFGLGQHRNLSGFERYSMVGSDE 140
            ...|::..|.|.|.       |||.|  |...:| ...|.|        :|....::.|
Zfish   261 EYSPKETHASVSSNDVKETNSVTLSCTSRGRPEV-TYTWFK--------KNKGKLQQIS------ 310

  Fly   141 EGDFSLDIYPLMLDDDAKYQCQ----VGPGPQGEQGIRSRFAK--LTVLVPPEAPKITQGDYLVT 199
                .||:..:..:|..:|.|:    :|.....|..|..:|..  :||..|.....|.:||
Zfish   311 ----DLDLRQMKPEDSGEYYCEAKNSLGVMKSNEISINVKFGPKGVTVTPPYNINDIKEGD---- 367

  Fly   200 TEDREIELEC-VSQGGKPAAEITWIDGLGNVLTKGIEYVKEPLADSRRITARSILKLAPKKEHHN 263
                .:.|:| |.:...||:...|...     .:..:...|...| |::||      |.:|
Zfish   368 ----TVTLKCSVERQNPPASRFVWYKN-----NRIQQETSETFID-RKVTA------AVQK---- 412

  Fly   264 TTFTCQAQNTADRTYRSAKLLLEVKYAPKVIVSVVGGALAGGKIPEGAEVILSCQADANPHELSY 328
              :.|:|.|..::. :|.:|.:.|||:|:.| ::.|..    .:..|:.:.|:|.|||:|..: |
Zfish   413 --YKCEANNGINKG-QSQELTVNVKYSPRNI-NIQGKT----SVKVGSRLELTCSADAHPQPV-Y 468

  Fly   329 RWFI---------------------------------------------------NDELM----- 337
            :|..                                                   |..||
Zfish   469 KWTFPPGLSFSPLSKGKLETQPVTIEHAGEYTCGVTNTIGTKSESTNVKVLYPPRNINLMMQSEV 533

  Fly   338 ----------------TGDFTTKMIIHNV---------SRQYHDAIV-------------KCEVV 364
                            |..||....:.|:         |.:|.:.::             ||...
Zfish   534 REFEVISVICTVQSFPTSKFTVTKNLDNLLNIPECRRNSTEYENKVIIFLNVTESDAGTYKCTAK 598

  Fly   365 NAVGKSEQSKKLDISFGPVFRQRPVSVEAD--LGATVSMRCDVAGNPE-PEIEWISENSDQVVGV 426
            |..|:.|.:|||.:.:.|  :....|.:.|  ..:.:::.|:...||. ...||...|:.|...:
Zfish   599 NTEGQEETNKKLTVLYAP--KNVTASFKGDQKSASELTLTCEACSNPPVSSYEWTKLNNGQFETL 661

  Fly   427 AAELKLKVSS---ETAGRYFCKAVVNGFPEIGAEAT----LYVKRAPIIT-SHKVQFGGVGG-RV 482
            ....:|..:|   ..:|:|.|.|    :..||...:    :.||..|.|| .|......... .|
Zfish   662 KQHQQLHFNSLEISDSGQYVCIA----YNAIGKAKSPPLDIRVKYTPNITIVHNTTTSAQWNLPV 722

  Fly   483 KIDCLAFSIPKAEHILWSFEGKIINMSSADPDIYIFEEHHLPEGVRAALIIRDSKATHFGKYNCT 547
            .:.|:|.:.|.|....|..:.....:.|...:..:     ||:..              |.|.||
Zfish   723 YLSCIADAHPPATEYKWYRQEDNTTVLSQQQNFTV-----LPQNP--------------GLYYCT 768

  Fly   548 VMNSYG-GDSLVITLLREPGNIPVLLVVMGSMFCVAIILMIVMIIIVYRKRRSRKKPMPADVIPE 611
            ..|..| ..|..|.|.     :...|.|...:....|.|:::::::::..||:..|     :..:
Zfish   769 ATNDIGLSRSKQIALF-----VSTSLSVFLKIVLPIIFLLVLIVVVIFLIRRNIIK-----IRSD 823

  Fly   612 ASRGGDKL-----------------------NELKSELR---------SKAYDVEYSEAGGDGLA 644
            ...|.|.|                       |..:..|.         :.:|.::.|:....|..
Zfish   824 QQSGADNLLCLFPAFLSRSSRVQNLFLLGSRNNTQENLSLDDPNYAQVNLSYPIQPSQNPTQGQD 888

  Fly   645 INLTQSPMPDVQMKGATLGVPLAGPVKFDERFSGDFGGDRYNRQCHIKNLKNQQETAYKGSPQAN 709
            :|  ..|.|::|    |:...:..|.|..:|.|.                |.||:|
Zfish   889 LN--PRPKPNIQ----TVYAAIKLPQKKQKRHSP----------------KQQQKT--------- 922

  Fly   710 GYAHYFEYALDYSPPGGEGAAVVVGSGGVGKLKNGGMNSATL------------PHSAAATVNGG 762
                                         |.:.|..||..||            |.::|..
Zfish   923 -----------------------------GNMDNTSMNYVTLDFKGQNEPRKIMPETSAVY---- 954

  Fly   763 GAGNGGGASLPRNQRHEIQQSQQSNGFLGQPLLQNGIDSRFSAIYGNPYLRTNSSLLPPLP 823
                   |.:.||::.:..|::.|:                       |...:|:..|.||
Zfish   955 -------AMVSRNKQAKSSQAENSD-----------------------YENVSSACAPKLP 985

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kirre	NP_001245505.1	Ig	87..183	CDD:299845	24/110 (22%)
		IG_like	88..182	CDD:214653	23/108 (21%)
		C2-set_2	189..279	CDD:285423	19/90 (21%)
		Ig_2	307..379	CDD:290606	26/165 (16%)
		I-set	382..462	CDD:254352	18/89 (20%)
		IGc2	396..446	CDD:197706	12/53 (23%)
		Ig	466..561	CDD:299845	21/97 (22%)
		IG_like	478..561	CDD:214653	17/84 (20%)
si:dkey-24p1.1	NP_001091715.1	Ig	37..153	CDD:299845
		IG_like	276..345	CDD:214653	18/87 (21%)
		IGc2	280..334	CDD:197706	15/72 (21%)
		IG_like	364..431	CDD:214653	20/93 (22%)
		Ig_2	365..433	CDD:290606	20/94 (21%)
		IG_like	443..518	CDD:214653	10/79 (13%)
		IGc2	451..508	CDD:197706	9/57 (16%)
		IG_like	532..612	CDD:214653	14/79 (18%)
		Ig	<570..602	CDD:299845	5/31 (16%)
		IG_like	616..694	CDD:214653	18/83 (22%)
		Ig_2	631..700	CDD:290606	15/72 (21%)
		IG_like	721..791	CDD:214653	19/93 (20%)
		Ig_2	721..785	CDD:290606	18/87 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910