DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kirre and lrit1a

DIOPT Version :9

Sequence 1:	NP_001245505.1	Gene:	kirre / 31292	FlyBaseID:	FBgn0028369	Length:	956	Species:	Drosophila melanogaster
Sequence 2:	NP_001018174.2	Gene:	lrit1a / 553943	ZFINID:	ZDB-GENE-040924-5	Length:	643	Species:	Danio rerio

Alignment Length:	268	Identity:	59/268 - (22%)
Similarity:	89/268 - (33%)	Gaps:	98/268 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   220 ITWID-GLGNVLTKGIEYVKEPLADSRRITARS---ILKLAPKKEHHNTTFTCQAQNTADRTYRS 280
            ||::| ...|:||...|.:...|.....:.|.|   ||.|      |:..:.|..     |.|.
Zfish   157 ITYLDLSSNNLLTVPAEVLNTWLTIKPTLGAESSKLILGL------HDNPWLCDC-----RLYD- 209

  Fly   281 AKLLLEVKYAPKVIVSVVGGALAGGKIPEGAEVILSCQADANPHELSYRWFINDELMTGDFTTKM 345
               |::.:.:|.:.|:.:             :..|.|   |:|..||...|.:.||.
Zfish   210 ---LVQFQKSPSLSVAFI-------------DTRLRC---ADPESLSGVLFSDAELR-------- 247

  Fly   346 IIHNVSRQYHDAIVKCEVVNAVGKSEQSKKLDISFGPVFRQRPVSVEADLGATVSMRCDVAGNPE 410
                          :|:                  ||........|.:.:|..|.:||...|.|.
Zfish   248 --------------RCQ------------------GPRVHTAVARVRSAVGNNVLLRCGTVGVPI 280

  Fly   411 PEIEW------------ISENSDQ-----VVGVAAELKLKVSSETAGRYFCKAVVNGFPEIGAEA 458
            ||:.|            :.|||.:     ::.|.|     ||....|:|.||| .|......|..
Zfish   281 PELAWRRADGKPLNGTVLLENSKEGIVWSILSVPA-----VSYRDTGKYICKA-TNYAGSAEAVI 339

  Fly   459 TLYVKRAP 466
            :|.:..||
Zfish   340 SLIINDAP 347

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kirre	NP_001245505.1	Ig	87..183	CDD:299845
		IG_like	88..182	CDD:214653
		C2-set_2	189..279	CDD:285423	16/62 (26%)
		Ig_2	307..379	CDD:290606	10/71 (14%)
		I-set	382..462	CDD:254352	26/96 (27%)
		IGc2	396..446	CDD:197706	19/66 (29%)
		Ig	466..561	CDD:299845	1/1 (100%)
		IG_like	478..561	CDD:214653
lrit1a	NP_001018174.2	leucine-rich repeat	61..84	CDD:275378
		LRR_8	63..119	CDD:290566
		LRR_RI	<77..175	CDD:238064	7/17 (41%)
		leucine-rich repeat	85..108	CDD:275378
		LRR_8	108..167	CDD:290566	3/9 (33%)
		leucine-rich repeat	109..132	CDD:275378
		leucine-rich repeat	133..156	CDD:275378
		leucine-rich repeat	157..170	CDD:275378	5/12 (42%)
		LRRCT	199..243	CDD:214507	13/68 (19%)
		I-set	252..343	CDD:254352	26/96 (27%)
		Ig	259..333	CDD:299845	23/79 (29%)
		fn3	448..515	CDD:278470
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900