DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kirre and iglon5

DIOPT Version :9

Sequence 1:	NP_001245505.1	Gene:	kirre / 31292	FlyBaseID:	FBgn0028369	Length:	956	Species:	Drosophila melanogaster
Sequence 2:	NP_001017775.2	Gene:	iglon5 / 550472	ZFINID:	ZDB-GENE-050417-297	Length:	332	Species:	Danio rerio

Alignment Length:	390	Identity:	94/390 - (24%)
Similarity:	142/390 - (36%)	Gaps:	102/390 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 GDNGGQ--HFAMEPQDQTAVVGSRVTLPCRVMEKVGALQWTKDDFGLGQHRNL-SGFERYSM--- 135
            |.:|.|  .|...|.:.|.:.|..|.|.|::.|:|....|      |.:...| :|.:::|:
Zfish    20 GPSGAQAAEFGHLPDNITVLEGESVVLRCKIDEEVTHKAW------LNRSNILFTGTDKWSLDSR 78

  Fly   136 --VGSDEEGDFSLDIYPLMLDDDAKYQCQVGPGPQGEQGIRSRFAKLTVLVPPEAPKITQGDYLV 198
              :.::...|||:.|..:|:.|:..|.|..    |.....|:....|.|.||.....|:|...:
Zfish    79 VSLENNNNSDFSIRIERVMVADEGPYTCSF----QARNKPRTAHVYLIVQVPARIVNISQDKSV- 138

  Fly   199 TTEDREIELECVSQGGKPAAEITWIDGLGNVLTKGIEYVKEPLADSRRITARSILKLAPKKEHHN 263
             .|..::.|.|::. |:|...|||.|....:|.:|                 ..|::...|.|..
Zfish   139 -NEGEDVNLFCLAV-GRPEPTITWKDFKYGLLNEG-----------------EFLEITEIKRHQA 184

  Fly   264 TTFTCQAQN-TADRTYRSAKLLLEVKYAPKVIVSVVGGALAGGKIPEGAEVILSCQADANPHELS 327
            ..|.|...| .|....|..|  :.|.| |.:|..|.......||     ..||.|:|.|.| ..|
Zfish   185 EDFECITNNGVAPPDTRKVK--VTVNY-PPIITDVKNMPAQVGK-----TAILRCEAMAVP-TAS 240

  Fly   328 YRWFINDEL-MTGDFTTK---------MIIHNVSRQYHDAIVKCEVVNAVGKSEQSKKLDISFGP 382
            :.|:.:|.. :..|.|.|         ::..||:.: |.....|...|.:|.|..|..|   |.|
Zfish   241 FEWYRDDRRPVESDNTLKIKNEKTRSLLLFTNVTEK-HFGNYTCFASNRLGASNASMLL---FRP 301

  Fly   383 VFRQRPVSVEADLGATVSMRCDVAGNPEPEIEWISENSDQVVGVAAELKLKVSSETAGRYFCKAV 447
                         ||                         |.|.||.|..::|.  .|.:||.::
Zfish   302 -------------GA-------------------------VYGGAASLNGRLSG--VGLWFCLSI 326

Fly 448 447
Zfish 327 326

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kirre	NP_001245505.1	Ig	87..183	CDD:299845	24/101 (24%)
		IG_like	88..182	CDD:214653	24/99 (24%)
		C2-set_2	189..279	CDD:285423	20/90 (22%)
		Ig_2	307..379	CDD:290606	21/81 (26%)
		I-set	382..462	CDD:254352	12/66 (18%)
		IGc2	396..446	CDD:197706	11/49 (22%)
		Ig	466..561	CDD:299845
		IG_like	478..561	CDD:214653
iglon5	NP_001017775.2	IG_like	33..123	CDD:214653	24/99 (24%)
		Ig	35..123	CDD:299845	23/97 (24%)
		Ig	125..>183	CDD:299845	17/77 (22%)
		I-set	128..207	CDD:254352	22/100 (22%)
		IG_like	217..298	CDD:214653	22/87 (25%)
		ig	223..296	CDD:278476	21/79 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910