DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kirre and SDK2

DIOPT Version :9

Sequence 1:	NP_001245505.1	Gene:	kirre / 31292	FlyBaseID:	FBgn0028369	Length:	956	Species:	Drosophila melanogaster
Sequence 2:	NP_001138424.1	Gene:	SDK2 / 54549	HGNCID:	19308	Length:	2172	Species:	Homo sapiens

Alignment Length:	1028	Identity:	203/1028 - (19%)
Similarity:	312/1028 - (30%)	Gaps:	371/1028 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 ASSANDESKPKGGDNGGQHFAMEP-QDQTAVVGSRVTLPCRVMEKVGALQWTKDDFGLGQHRNLS 128
            |:.|.|:..|        :|..|| :.|..:.|:|:.|.|     :....|..:...|..:|.|:
Human    17 AARAQDDVSP--------YFKTEPVRTQVHLEGNRLVLTC-----MAEGSWPLEFKWLHNNRELT 68

  Fly   129 GFE---RYSMVGSDE-EGDFSLDIYPLMLDDDAKYQCQVGPGPQGEQGIRSRFAKLTVLVPPEAP 189
            .|.   ||.:...|. ...|              |:|.|          |:|...|.     :..
Human    69 KFSLEYRYMITSLDRTHAGF--------------YRCIV----------RNRMGALL-----QRQ 104

  Fly   190 KITQGDYLVTTEDREIELECVSQG-----------GKPAAEITWI-DGLGNVLTKGIEYVKEPLA 242
            ...|..|:.:.|:.| :.:.||.|           ..|..::||. ||.           |.|.:
Human   105 TEVQVAYMGSFEEGE-KHQSVSHGEAAVIRAPRIASFPQPQVTWFRDGR-----------KIPPS 157

  Fly   243 DSRRITARSILKLAPKKEHHNTTFTCQA---QNTADRTYRSAKLLLE------VKYAPKVIV--- 295
            ....||..:.|.:..........:..||   :|..::|.:...|.:|      ...||.:|:
Human   158 SRIAITLENTLVILSTVAPDAGRYYVQAVNDKNGDNKTSQPITLTVENVGGPADPIAPTIIIPPK 222

  Fly   296 --SVVGGALAGGKIPEGAEVILSCQADANP-HELSYRWFINDELMTG---DFTTKMIIHNVSRQY 354
              |||.|.         :||.|.|.|:|.| .:|...|..:..|::|   |...::.|.|.:..
Human   223 NTSVVAGT---------SEVTLECVANARPLIKLHIIWKKDGVLLSGGISDHNRRLTIPNPTGS- 277

  Fly   355 HDA-IVKCEVV---NAVGKSEQSKKLDISFGPVFRQRPV-SVEADLGATVSMRCDVAGNPEPEIE 414
             || ..:||.|   ::|....:...|.:...|.|.:.|. .:.|::...|.:.|...|.|.|.|.
Human   278 -DAGYYECEAVLRSSSVPSVVRGAYLSVLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSIT 341

  Fly   415 WISENSDQVVGVAAELK--------LKVSS---ETAGRYFCKAVVNGFPEIGAEATLYVKR-API 467
            |..:.:  ||.|....:        |::|.   :..|.:.|.| .|...|:.....|.|.. ||.
Human   342 WYKDAA--VVEVEKLTRFRQRNDGGLQISGLVPDDTGMFQCFA-RNAAGEVQTSTYLAVTSIAPN 403

  Fly   468 ITSHKVQFGGVGG-RVKIDCLAFSIPKAEHILWSFEGKIINMSSADPDIYIFEEHHLPEGV---R 528
            ||...:....:.| .|.:.|.....|:.. |.|....:|:...|.          .||...   .
Human   404 ITRGPLDSTVIDGMSVVLACETSGAPRPA-ITWQKGERILASGSV----------QLPRFTPLES 457

  Fly   529 AALIIRDSKATHFGKYNCTVMNSYGGDSLVITLLREPGNIPVLLVVMGSMFCVAIILMIVMIIIV 593
            .:|:|..:..:..|.|.|...||.|.|.....|                              :|
Human   458 GSLLISPTHISDAGTYTCLATNSRGVDEASADL------------------------------VV 492

  Fly   594 YRKRRSRKKPMPADVI--PEASRGGDKLNELKSELRSKAYDVEYSEAGGDGLAINLTQSPMPDV- 655
            :.:.|..|.|....||  .:||                             :...:|..|...:
Human   493 WARTRITKPPQDQSVIKGTQAS-----------------------------MVCGVTHDPRVTIR 528

  Fly   656 ---QMKGATLGVPLAGPVKFD--------ERFSGDFG---------GDRYNRQCH--IKNLKNQQ 698
               :..|||||......::.|        :.:|||.|         |...:|..|  ::.|.:..
Human   529 YIWEKDGATLGTESHPRIRLDRNGSLHISQTWSGDIGTYTCRVISAGGNDSRSAHLRVRQLPHAP 593

  Fly   699 ETAYKGSPQA------------------NGYAHYFEYALDYSPPGGEGAAVVVGSGGVGKLKNGG 745
            |     .|.|                  :|.:....|.|:.|........::
Human   594 E-----HPVATLSTVERRAINLTWTKPFDGNSPLIRYILEMSENNAPWTVLL------------- 640

  Fly   746 MNSATLPHSAAATVNG--------------GGAGNG------GGASLPRNQRHEIQQSQQSNGFL 790
              ::..|.:.:.||.|              ...|.|      ...|||........|:..::|
Human   641 --ASVDPKATSVTVKGLVPARSYQFRLCAVNDVGKGQFSKDTERVSLPEEPPTAPPQNVIASG-- 701

  Fly   791 GQPLLQNGIDSRFSAIYGNPYLRTNSSLLPPLPPPSTANPAATPAPPPYHAARHGHAHHANGGLK 855
                                  |||.|::....||..:                    |.||.||
Human   702 ----------------------RTNQSIMIQWQPPPES--------------------HQNGILK 724

  Fly   856 HFVGGAVITTSPVG---------NVN----------INGGGGGGSTPSGGGGV-----------G 890
            .::....:...|||         :||          .|......:..|.|.||           |
Human   725 GYIIRYCLAGLPVGYQFKNITDADVNNLLLEDLIIWTNYEIEVAAYNSAGLGVYSSKVTEWTLQG 789

  Fly   891 VGVAAGGSVSGSSSNLTASSNTLAATPLAGGGVGNSGQCAQSPSGQFILSNNG 943
            |.....|:|...::|.|....|..|                 ||.|||   ||
Human   790 VPTVPPGNVHAEATNSTTIRFTWNA-----------------PSPQFI---NG 822

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kirre	NP_001245505.1	Ig	87..183	CDD:299845	22/100 (22%)
		IG_like	88..182	CDD:214653	21/98 (21%)
		C2-set_2	189..279	CDD:285423	21/104 (20%)
		Ig_2	307..379	CDD:290606	21/79 (27%)
		I-set	382..462	CDD:254352	22/91 (24%)
		IGc2	396..446	CDD:197706	14/60 (23%)
		Ig	466..561	CDD:299845	22/98 (22%)
		IG_like	478..561	CDD:214653	19/86 (22%)
SDK2	NP_001138424.1	Ig	27..109	CDD:299845	23/115 (20%)
		IG_like	40..109	CDD:214653	19/102 (19%)
		I-set	120..203	CDD:254352	18/93 (19%)
		Ig	132..210	CDD:299845	16/88 (18%)
		IG_like	222..304	CDD:214653	25/92 (27%)
		IGc2	233..286	CDD:197706	16/54 (30%)
		I-set	308..397	CDD:254352	22/91 (24%)
		Ig	326..394	CDD:143165	17/70 (24%)
		I-set	402..492	CDD:254352	23/130 (18%)
		Ig	416..492	CDD:299845	20/116 (17%)
		Ig	502..586	CDD:299845	20/112 (18%)
		IG_like	502..586	CDD:214653	20/112 (18%)
		FN3	590..681	CDD:238020	13/110 (12%)
		FN3	693..786	CDD:238020	23/136 (17%)
		FN3	794..890	CDD:238020	13/49 (27%)
		FN3	895..983	CDD:238020
		FN3	993..1087	CDD:238020
		FN3	1099..1194	CDD:238020
		FN3	1201..1290	CDD:238020
		FN3	1301..1394	CDD:238020
		FN3	1400..1484	CDD:238020
		FN3	1503..1616	CDD:238020
		FN3	1626..1719	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1707..1729
		FN3	1724..1805	CDD:238020
		FN3	1837..1916	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2039..2067
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2098..2172
		PDZ-binding. /evidence=ECO:0000250\|UniProtKB:Q6V4S5	2166..2172
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900