DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kirre and NTM

DIOPT Version :9

Sequence 1:	NP_001245505.1	Gene:	kirre / 31292	FlyBaseID:	FBgn0028369	Length:	956	Species:	Drosophila melanogaster
Sequence 2:	NP_001338930.1	Gene:	NTM / 50863	HGNCID:	17941	Length:	367	Species:	Homo sapiens

Alignment Length:	323	Identity:	72/323 - (22%)
Similarity:	125/323 - (38%)	Gaps:	65/323 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 ANDESKPKGGDNGGQHFAMEPQDQTAVVGSRVTLPCRVMEKVGALQWTKDDFGLGQHRNLSGFER 132
            :.|.:.||..||           .|...|...||.|.:..:|..:.|......|     .:|.::
Human    33 SGDATFPKAMDN-----------VTVRQGESATLRCTIDNRVTRVAWLNRSTIL-----YAGNDK 81

  Fly   133 YSM-----VGSDEEGDFSLDIYPLMLDDDAKYQCQVGPGPQGEQGIRSRFAKLTVLVPPEAPKIT 192
            :.:     :.|:.:..:|::|..:.:.|:..|.|.|    |.:...::....|.|.|.|:..:|:
Human    82 WCLDPRVVLLSNTQTQYSIEIQNVDVYDEGPYTCSV----QTDNHPKTSRVHLIVQVSPKIVEIS 142

  Fly   193 QGDYLVTTEDREIELECVSQGGKPAAEITWIDGLGNVLTKGIEYVKEPLADSRRITARSILKLAP 257
            ..  :...|...|.|.|::. |:|...:||    .::..|.:.:|.|.          ..|::..
Human   143 SD--ISINEGNNISLTCIAT-GRPEPTVTW----RHISPKAVGFVSED----------EYLEIQG 190

  Fly   258 KKEHHNTTFTCQAQN-TADRTYRSAKLLLEVKYAPKVIVSVVGGALAGGKIPEGAEVILSCQADA 321
            .....:..:.|.|.| .|....|..|  :.|.|.|.:      ....|..:|.|.:..|.|:|.|
Human   191 ITREQSGDYECSASNDVAAPVVRRVK--VTVNYPPYI------SEAKGTGVPVGQKGTLQCEASA 247

  Fly   322 NPHELSYRWFINDE-LMTG---------DFTTKMIIHNVSRQYHD-AIVKCEVVNAVGKSEQS 373
            .| ...::|:.:|: |:.|         .|.:|:|..|||.  || ....|...|.:|.:..|
Human   248 VP-SAEFQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSE--HDYGNYTCVASNKLGHTNAS 307

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kirre	NP_001245505.1	Ig	87..183	CDD:299845	18/100 (18%)
		IG_like	88..182	CDD:214653	18/98 (18%)
		C2-set_2	189..279	CDD:285423	17/90 (19%)
		Ig_2	307..379	CDD:290606	23/78 (29%)
		I-set	382..462	CDD:254352
		IGc2	396..446	CDD:197706
		Ig	466..561	CDD:299845
		IG_like	478..561	CDD:214653
NTM	NP_001338930.1	Ig	44..132	CDD:416386	19/107 (18%)
		Ig strand A'	44..49	CDD:409353	2/15 (13%)
		Ig strand B	51..59	CDD:409353	3/7 (43%)
		CDR1	59..63	CDD:409353	0/3 (0%)
		FR2	64..70	CDD:409353	1/5 (20%)
		Ig strand C	64..70	CDD:409353	1/5 (20%)
		CDR2	71..83	CDD:409353	2/16 (13%)
		Ig strand C'	72..76	CDD:409353	1/8 (13%)
		Ig strand C'	80..83	CDD:409353	0/2 (0%)
		FR3	84..118	CDD:409353	7/37 (19%)
		Ig strand D	87..94	CDD:409353	1/6 (17%)
		Ig strand E	97..103	CDD:409353	1/5 (20%)
		Ig strand F	110..118	CDD:409353	3/11 (27%)
		CDR3	119..123	CDD:409353	0/3 (0%)
		Ig strand G	123..132	CDD:409353	1/8 (13%)
		FR4	125..132	CDD:409353	1/6 (17%)
		Ig_3	136..205	CDD:404760	16/85 (19%)
		Ig strand A'	142..147	CDD:409353	0/6 (0%)
		Ig strand B	153..160	CDD:409353	3/6 (50%)
		Ig strand C	166..171	CDD:409353	2/8 (25%)
		Ig strand D	177..180	CDD:409353	0/2 (0%)
		Ig strand E	184..190	CDD:409353	1/5 (20%)
		Ig strand F	197..204	CDD:409353	1/6 (17%)
		Ig strand G	211..219	CDD:409353	2/9 (22%)
		Ig_3	222..299	CDD:404760	22/85 (26%)
		putative Ig strand A	223..229	CDD:409353	1/11 (9%)
		Ig strand B	239..243	CDD:409353	1/3 (33%)
		Ig strand C	252..256	CDD:409353	0/3 (0%)
		Ig strand E	278..282	CDD:409353	1/3 (33%)
		Ig strand F	292..297	CDD:409353	1/4 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810