DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kirre and dpr6

DIOPT Version :9

Sequence 1:	NP_001245505.1	Gene:	kirre / 31292	FlyBaseID:	FBgn0028369	Length:	956	Species:	Drosophila melanogaster
Sequence 2:	NP_001287018.1	Gene:	dpr6 / 50296	FlyBaseID:	FBgn0040823	Length:	396	Species:	Drosophila melanogaster

Alignment Length:	391	Identity:	81/391 - (20%)
Similarity:	129/391 - (32%)	Gaps:	123/391 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    88 PQDQTAVVGSRVTLPCRVMEKVG-ALQWTKDDFGLGQHRNL----------SGFERYSMVGSDEE 141
            |::.||::|....|.|||..... .:.|.:       ||::          :..:|:......:.
  Fly    80 PRNVTALMGKSAYLSCRVRNLANKTVSWIR-------HRDIHILTVGSYTYTSDQRFQATHHQDT 137

  Fly   142 GDFSLDIYPLMLDDDAKYQCQVGPGPQGEQGIRSRFAKLTVLVPPEAPKITQGDYLVTTEDREIE 206
            .|::|.|......|...|:||:...|     :||.|.:|.|:||  ...|..|..|...:...|.
  Fly   138 EDWTLQIKWAQKRDAGMYECQISTQP-----VRSYFVRLNVVVP--TATILGGPDLHVDKGSTIN 195

  Fly   207 LEC-VSQGGKPAAEITW------------------IDGLGNVLTKGIEYVKEPLADSRRITARSI 252
            |.| |....:|.|.|.|                  |...|:|.|..:......||||.:
  Fly   196 LTCTVKFSPEPPAYIFWYHHEEVINYDSSRGGVSVITEKGDVTTSFLLIQNADLADSGK------ 254

  Fly   253 LKLAPKKEHHNTTFTCQAQNTADRTYRSAKLLLEVKYAPKVIVSVVGGALAGGKIPEGAEVILS- 316
                         ::|...|....:.|..  :|.|:            |:..|:.||..:...|
  Fly   255 -------------YSCAPSNADVASVRVH--VLNVR------------AIISGEHPEAMQTGSSG 292

  Fly   317 CQADANPHELSYRWFINDELMTGDFTTKMIIHNVSRQYHDAIVKCEVVNAVGKSEQSKKLDISFG 381
            ||         |.| :...|:.|      ::...|.|...:.|...:.:::
  Fly   293 CQ---------YNW-LTIVLLLG------LVLCYSSQQCSSAVPASLTSSL-------------- 327

  Fly   382 PVFRQRPVSVEADLGATVSMRCDVAGNPEPEIEWISENSDQVVGVAAELKLKVSSETAGRYFCKA 446
            |:..|.|:...|  .||.:...:.|             |.:.|..|.......::.||.|..|.|
  Fly   328 PLPSQLPLPAAA--AATTTATGESA-------------SSESVTAARASAATTTTTTATRKRCPA 377

  Fly   447 V 447
            |
  Fly   378 V 378

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kirre	NP_001245505.1	Ig	87..183	CDD:299845	24/105 (23%)
		IG_like	88..182	CDD:214653	24/104 (23%)
		C2-set_2	189..279	CDD:285423	21/108 (19%)
		Ig_2	307..379	CDD:290606	12/72 (17%)
		I-set	382..462	CDD:254352	16/66 (24%)
		IGc2	396..446	CDD:197706	10/49 (20%)
		Ig	466..561	CDD:299845
		IG_like	478..561	CDD:214653
dpr6	NP_001287018.1	V-set	79..174	CDD:284989	24/105 (23%)
		IG_like	80..175	CDD:214653	25/106 (24%)
		IG_like	184..271	CDD:214653	20/107 (19%)
		IGc2	191..262	CDD:197706	17/89 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810