DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kirre and NCAM1

DIOPT Version :9

Sequence 1:	NP_001245505.1	Gene:	kirre / 31292	FlyBaseID:	FBgn0028369	Length:	956	Species:	Drosophila melanogaster
Sequence 2:	NP_001229536.1	Gene:	NCAM1 / 4684	HGNCID:	7656	Length:	884	Species:	Homo sapiens

Alignment Length:	807	Identity:	164/807 - (20%)
Similarity:	275/807 - (34%)	Gaps:	221/807 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    95 VGSRVTLPCRVMEKVGALQWTKDDF------GLGQHRNLSGF-----------ERYSMVGSDEEG 142
            :|:.|:|...::...|.:...:..|      |..:.:::|.|           :|.|:|.:|:..
Human    14 LGTAVSLQVDIVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSS 78

  Fly   143 DFSLDIYPLMLDDDAKYQCQVGPGPQGEQGIRSR-------FAKLTVLVPPEAPKITQGDYLVTT 200
            . :|.||...:||...|:|.|    .||.|..|.       |.||.....|...:..:|
Human    79 S-TLTIYNANIDDAGIYKCVV----TGEDGSESEATVNVKIFQKLMFKNAPTPQEFREG------ 132

  Fly   201 EDREIELECVSQGGKPAAEITWIDGLGNVLTKGIEYVKEPLADSRRITARSILKLAPKKEHHNTT 265
            ||..|..:.||  ..|...|....|...:|.|.:.::         :.:.:.|::...|:....|
Human   133 EDAVIVCDVVS--SLPPTIIWKHKGRDVILKKDVRFI---------VLSNNYLQIRGIKKTDEGT 186

  Fly   266 FTCQAQNTA--DRTYRSAKLLLEVK---YAPKVIVSVVGGALAGGKIPEGAEVILSCQADANPHE 325
            :.|:.:..|  :..::..::::.|.   .|.:.||:.....        |..|.|.|.|:..| |
Human   187 YRCEGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANL--------GQSVTLVCDAEGFP-E 242

  Fly   326 LSYRWFINDE----------LMTGDFTTKMIIHNVSRQYHDAIVKCEVVNAVGKSEQSKKLDISF 380
            .:..|..:.|          .:..|.::::.|..|.:. .:|...|...|..|:.:.:..|.:..
Human   243 PTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKN-DEAEYICIAENKAGEQDATIHLKVFA 306

  Fly   381 GPVFRQRPVSVEADLGATVSMRCDVAGNPEPEIEWISENSDQVVGVAAELK-------------- 431
            .|...........:|...|::.|:.:|:|.|.|.|.:...:    :::|.|
Human   307 KPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRN----ISSEEKASWTRPEKQEVHAP 367

  Fly   432 ---------------------------------LKVSSET--------AGRYFCKAVVNGFPEIG 455
                                             .:|||.|        ||.|.|.| .|...:..
Human   368 WNWQVGRQKGQAGSAGFPGSHETLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTA-SNTIGQDS 431

  Fly   456 AEATLYVKRAPIITSHKVQFGGVGGRVKIDCLAFSIPKAEHILWSFEGKIINMSSADPDIYIFEE 520
            ....|.|:.||.:......:...|.:|.|.|..|:.|.|. |.|..:|::: .||...:|.|:
Human   432 QSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSAT-ISWFRDGQLL-PSSNYSNIKIY-- 492

  Fly   521 HHLPEGVRAALIIRDSKATHFGKYNCTVMNSYGGDSLVITLLR-EPGNIPVLLVVMGSMFCVAII 584
             :.|..  :.|.:.......||.||||.:|..|.:||...|:: :..:.|.:
Human   493 -NTPSA--SYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPSSPSI------------- 541

  Fly   585 LMIVMIIIVYRKRRSRKKPMPADV-----IPEASRGGDKLNELKSELR--------SKAYDVEYS 636
                          .:.:|..:..     .|||: ||..:.:.|:|.|        ||.||.:
Human   542 --------------DQVEPYSSTAQVQFDEPEAT-GGVPILKYKAEWRAVGEEVWHSKWYDAK-- 589

  Fly   637 EAGGDGLAINLTQSPMPDVQMKGATLGVPLAGPVKFDERF--------------SGDFGGDRYNR 687
            ||..:|:...:...|.....::.|.|.....|.:.....|              .|..|.|..:
Human   590 EASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVQGEPSAPKLEGQMGEDGNS- 653

  Fly   688 QCHIK-NLKNQQETAYKGSPQANGYAHYFEYALDYSP----PGG-------------EGAAVVVG 734
               || ||..|.:   .|||..:....|...:.::.|    |.|             |....||.
Human   654 ---IKVNLIKQDD---GGSPIRHYLVRYRALSSEWKPEIRLPSGSDHVMLKSLDWNAEYEVYVVA 712

  Fly   735 SGGVGKLKNGGMNSATLPHSAAATVNG 761
            ....||.|.......|.....|...||
Human   713 ENQQGKSKAAHFVFRTSAQPTAIPANG 739

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kirre	NP_001245505.1	Ig	87..183	CDD:299845	27/111 (24%)
		IG_like	88..182	CDD:214653	27/110 (25%)
		C2-set_2	189..279	CDD:285423	16/91 (18%)
		Ig_2	307..379	CDD:290606	17/81 (21%)
		I-set	382..462	CDD:254352	22/134 (16%)
		IGc2	396..446	CDD:197706	17/104 (16%)
		Ig	466..561	CDD:299845	27/94 (29%)
		IG_like	478..561	CDD:214653	26/82 (32%)
NCAM1	NP_001229536.1	Ig1_NCAM-1	20..115	CDD:143273	22/99 (22%)
		IG	124..190	CDD:214652	15/82 (18%)
		Ig	211..307	CDD:325142	20/105 (19%)
		Ig	306..438	CDD:325142	22/136 (16%)
		Ig_3	447..519	CDD:316449	22/78 (28%)
		FN3	534..631	CDD:238020	22/126 (17%)
		fn3	639..720	CDD:306538	20/87 (23%)
		Trypan_PARP	<792..>864	CDD:330686
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810