DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kirre and tutl

DIOPT Version :9

Sequence 1:	NP_001245505.1	Gene:	kirre / 31292	FlyBaseID:	FBgn0028369	Length:	956	Species:	Drosophila melanogaster
Sequence 2:	NP_001303307.1	Gene:	tutl / 46015	FlyBaseID:	FBgn0010473	Length:	1536	Species:	Drosophila melanogaster

Alignment Length:	819	Identity:	159/819 - (19%)
Similarity:	263/819 - (32%)	Gaps:	264/819 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    88 PQDQ---TAVVGSRVTLPCRV-------MEKVGALQWTKDDFGLGQHRNL------------SGF 130
            |:|.   ||::|..|...|.|       :..|  |||.|.....|....:            .|:
  Fly   132 PEDAVHITAILGEGVIFNCHVEFPNDHPVPYV--LQWDKKVSETGSDLPIYIWYESYPEHIEEGY 194

  Fly   131 E-RYSMVGSDEE-GDFSLDIYPLMLDDDAKYQCQV---GPGPQGEQGIRSRFAKLTVLVPPEAPK 190
            : |.|.|..|.. |..||::..:...|...|:|:|   ...|  :|.....:..|.|..||.. .
  Fly   195 KGRVSRVSQDSPFGSASLNLTNIRESDQGWYECKVVFLNRDP--KQHKNGTWFHLDVHAPPRF-S 256

  Fly   191 ITQGDYLVTTEDREIELECVSQGGKPAAEITWIDGLG--------NVLTKGIEYVKEPLADSRRI 247
            :|..|.:.......|.|.|.:. |.|..||.|.....        .:...|.|
  Fly   257 VTPEDIIYVNLGDSIILNCQAD-GTPTPEILWYKDANPVDPSPTVGIFNDGTE------------ 308

  Fly   248 TARSILKLAPKKEHHNTTFTCQAQNTADRTYRSAKLLLEVKYAPKVIVSVVGGALAGGKIP---- 308
                 |:::..:......:||.|:|...:...:|:::            :.|||:.  .:|
  Fly   309 -----LRISTIRHEDIGEYTCIARNGEGQVSHTARVI------------IAGGAVI--MVPPTNQ 354

  Fly   309 ---EGAEVILSCQADANPHELSYRWFINDE-------LMT-------GDFTTKMIIHNVSRQYHD 356
               ||.:||.||:|.|.|..::.||:....       |.|       |......|..:.|.||
  Fly   355 TKLEGEKVIFSCEAKAMPGNVTVRWYREGSPVREVAALETRVTIRKDGSLIINPIKPDDSGQY-- 417

  Fly   357 AIVKCEVVNAVGKSEQSK-------KLDISFGPVFRQRPVSVEADLGATVSMRCDVAGNPEPEIE 414
               .|||.|.:|..:.:.       ...::|.|..:..|..:..      .::|.:..:  |:::
  Fly   418 ---LCEVTNGIGDPQSASAYLSVEYPAKVTFTPTVQYLPFRLAG------VVQCYIKSS--PQLQ 471

  Fly   415 WISENSDQ------------VVGVAAELKLKVSSETAGRYFCKAVVNGFPEIGAEATL--YVKRA 465
            :::...|:            |:...:.|..:|:.|..|:|.| ...|.....||...:  .|::.
  Fly   472 YVTWTKDKRLLEPYQMKDIVVMANGSLLFTRVNEEHQGQYAC-TPYNAQGTAGASGVMDVLVRKP 535

  Fly   466 PIIT--SHKVQFGGVGGRVKIDCLAFSIPKAEH--ILWSFEGKIINMSSADPDIYIFEEHHLPEG 526
            |..|  ...:....||..|::.|.|......|.  |.|..:                |...|.|.
  Fly   536 PAFTVEPETLYQRKVGDSVEMHCDALEAEGTERPTIKWQRQ----------------EGEQLTES 584

  Fly   527 VR-------AALIIRDSKATHFGKYNCTVMNSYGGDSLVITLLREPGNIPVLLVVMGSMFCVAII 584
            .|       ..:.|.:.:...||.|.|.|.|.                             ||.:
  Fly   585 QRNRIKISGGNITIENLRREDFGYYQCVVSNE-----------------------------VATL 620

  Fly   585 LMIVMIIIVYRKRRSRKKPMPADVIPEASRGGDKLNELKSELRSKAYDVEYS----EAG-GDGLA 644
            :.:..::|     ...:...|.::..:|:.....|..|........|..:|:    ||| .|...
  Fly   621 MAVTQLVI-----EGTQPHAPYNITGKATESSITLQWLPGYSGGSEYKQDYTIWFREAGVNDWQT 680

  Fly   645 INLTQSPMPDVQMKGATLGVPLAGPVKFDERFSGD--FGGDRYNRQCHIKNLKN----------- 696
            |::|.|....|.:.|      ||....::.:..|.  .|....::...::.|::
  Fly   681 ISVTPSGSTQVTING------LASGTTYEFQVVGRNVLGDGMMSKVMTVRTLEDAPAAPRNVKAA 739

  Fly   697 --QQETAYKGSPQANGYAHYFEY--------ALDYSPPGGEGAAVVVGSGGVGKLKNGGMNSATL 751
              ..::.::..|.......||:.        .|.||||               ||:
  Fly   740 TQPPDSFFQLMPDEADLLAYFDIYFHTDSRGTLVYSPP---------------KLR--------- 780

  Fly   752 PHSAAATVNGGGAGNGGGASLPRNQRHEIQQSQQSNGFL 790
                   |.|...|.      |||    :..::.|||||
  Fly   781 -------VKGPKPGP------PRN----VSVTEVSNGFL 802

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kirre	NP_001245505.1	Ig	87..183	CDD:299845	29/121 (24%)
		IG_like	88..182	CDD:214653	29/120 (24%)
		C2-set_2	189..279	CDD:285423	17/97 (18%)
		Ig_2	307..379	CDD:290606	24/99 (24%)
		I-set	382..462	CDD:254352	15/93 (16%)
		IGc2	396..446	CDD:197706	10/61 (16%)
		Ig	466..561	CDD:299845	21/105 (20%)
		IG_like	478..561	CDD:214653	19/91 (21%)
tutl	NP_001303307.1	V-set	137..250	CDD:284989	27/116 (23%)
		IG_like	137..229	CDD:214653	23/93 (25%)
		I-set	253..341	CDD:254352	19/118 (16%)
		IGc2	268..331	CDD:197706	15/80 (19%)
		I-set	346..437	CDD:254352	24/97 (25%)
		Ig	349..437	CDD:299845	24/92 (26%)
		Ig	459..530	CDD:299845	13/73 (18%)
		IG_like	549..628	CDD:214653	21/123 (17%)
		IGc2	551..617	CDD:197706	18/110 (16%)
		FN3	633..725	CDD:238020	19/97 (20%)
		FN3	786..874	CDD:238020	9/27 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810