DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kirre and side-VII

DIOPT Version :9

Sequence 1:	NP_001245505.1	Gene:	kirre / 31292	FlyBaseID:	FBgn0028369	Length:	956	Species:	Drosophila melanogaster
Sequence 2:	NP_001262432.1	Gene:	side-VII / 41184	FlyBaseID:	FBgn0037736	Length:	939	Species:	Drosophila melanogaster

Alignment Length:	964	Identity:	181/964 - (18%)
Similarity:	310/964 - (32%)	Gaps:	346/964 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   125 RNLSGFERYSMVGSDEEGDF-SLDI-----YPL-----------------MLDDDAKYQCQVGPG 166
            |:.|..||.::||...|||. ||..     ||.                 .|......:|::...
  Fly   144 RDSSNVERSTVVGPYSEGDIVSLKCQVIGGYPTPTISWYRDGIEIPCELSHLAGGKIIECEITLP 208

  Fly   167 PQGEQGIRSRFAKLTVLVPPEAPKITQ----------------GDYLVTTEDREIELECVSQGGK 215
            ..|.:.:.||.. ...|..|.||.:..                |.:...:..|..:|.|.|.|.:
  Fly   209 SLGREDLNSRLT-CRALSHPRAPIVEAVVQIDMNFAPLNIRLLGAHQPLSAGRRYDLLCQSAGSR 272

  Fly   216 PAAEITWIDGLGNVLTKGIEYVKEPLADSRRITARSILKLAPKKEHHNTTFTCQAQNTADRTYRS 280
            |.|.|||... |..|.|..|...   :|..:.|  |.|.::..|.......:|:|.|.|   ..|
  Fly   273 PPAVITWWQN-GIRLEKTTETTS---SDGNQTT--STLSISLSKSDAGKYLSCKAYNHA---VPS 328

  Fly   281 AKL----LLEVKYAPKVIVSVVGGALAGGKIPEGAEVILSCQADANPHELSYRWFINDELMTGDF 341
            ..|    .|:::|.|:..|. :|.:|....:.||.:|...|...|:|:.....|..|::.::.:.
  Fly   329 EPLEDGWKLDIQYVPEAYVR-LGTSLDPSTLREGTDVYFDCLVMAHPNVFRIEWRHNEQPLSHNI 392

  Fly   342 TTKMIIHNVSRQYHDAIVK-----------CEVVNAVGKSEQSK-KLDISFGPVFRQRP-----V 389
            :..:||.|     |..:::           |...||.|:...:. .|:|.:.|...|..     :
  Fly   393 SLGVIISN-----HSLVLQGVTRATAGNYSCVGFNAEGEGISAPFALNILYAPTCAQNQKKVYGI 452

  Fly   390 SVEADLGATVSMRCDVAGNP-EPEIEWISENSDQVVGVAAELKLKVSSETAGRYFCKAVVNGFPE 453
            :.:.|    ..:.|.|..|| |.|..|...||.:.:.||....::
  Fly   453 AKQED----AKVMCTVDANPREVEFSWTFNNSAESIDVATNHIIR-------------------- 493

  Fly   454 IGAEATLYVKRAPI----------ITSHKVQFGGVGGRVKIDC----LAFSIPKAEH-------- 496
              :..|..|...||          :.|:|:      |:.::.|    :|...|:..|
  Fly   494 --SGTTSIVTYTPITELDYGTLLCLASNKI------GKQRVPCVFHIIAAGRPEKVHNCTVNNIS 550

  Fly   497 -----------------------ILWSFEGKI-INMSSADPDIYIFEEHHLPEGVRAALIIRDSK 537
                                   :|.|:..:| .|::|..|...:       .|:....|.|
  Fly   551 MTSLTVTCSDGFNGGLPQSFNLELLDSYTQEIKANITSTIPKFTV-------PGLSPGSIYR--- 605

  Fly   538 ATHFGKYNCTVMNSYG-GDSLVI--TLLREP---------GNI-------PVLLVVMGSMFCVAI 583
                  .|....|:.| .|..::  .:||.|         .|:       ||:.:.:|  ..:|:
  Fly   606 ------LNIYAFNTKGRSDPAIVNAAMLRMPEKQLTSEQTHNLRAELLFSPVMSLTIG--LTLAV 662

  Fly   584 ILMIVMIIIVYR------KRRSRKK-----------PMPA-----------------DVIPEASR 614
            ::.::.||:..|      .||.:|:           |.|:                 ||:||:..
  Fly   663 LVAVLAIILALRIPCTASSRRRQKELSNENISRDESPGPSDKSSGSKEVDDCDEKNPDVVPESIE 727

  Fly   615 GGDKLNELKSELRSKAYDVEYSEAGGDGLAINLTQSPMPDVQMKGATLGVPLAGPVKFDERFSGD 679
            ..::...::.  |.:...::.:.:...|:.:|..|      .:..|.:.:          |.|..
  Fly   728 PDEQAESIRK--RQQISTIDTNRSPNRGIFVNEQQ------HLTAAEISL----------RASHG 774

  Fly   680 FGGDRYNRQCHIKNLKNQQETAYKGSPQANGYAHYFEYALDYSPPGGEGAAVVVGSGGVGKLKNG 744
            .|      .|.:::..:.|..:..|....|...|.:                           :.
  Fly   775 IG------YCTLRSGMHAQAQSSVGEISINVTPHVY---------------------------SN 806

  Fly   745 GMNSATLPHSAAATVNGGGAGNGGGASLPRNQRHEIQQSQQSNGFLG----QPLLQNGIDSRFSA 805
            .::..|||..::..|......|..||. |.:..|::...|......|    |||
  Fly   807 SISQCTLPRQSSQNVWNNYNCNITGAR-PTSTFHQLTFPQGRVNVGGHNPAQPL----------- 859

  Fly   806 IYG---NPYLRTNSSLLPPLPPPSTANPAATPAPPPYHAARHGHA---HHANGGLKHFVGGAVIT 864
             :|   :|...:|||:      .|:.|....|.|       ||..   ||.|
  Fly   860 -HGHAPSPSQASNSSM------ASSTNTLPQPHP-------HGRTIAMHHMN------------- 897

  Fly   865 TSPVGNVNINGGGGGGSTPSGGGGVGVGVAAGGSVSGSSSNLTASSNTLAATPL 918
                              .:..|.|.:|:|:.| :..:..|::....|: .|||
  Fly   898 ------------------QAQCGRVCIGIASDG-IHSAEQNVSDDEVTV-QTPL 931

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kirre	NP_001245505.1	Ig	87..183	CDD:299845	18/80 (23%)
		IG_like	88..182	CDD:214653	18/79 (23%)
		C2-set_2	189..279	CDD:285423	25/105 (24%)
		Ig_2	307..379	CDD:290606	17/83 (20%)
		I-set	382..462	CDD:254352	15/85 (18%)
		IGc2	396..446	CDD:197706	11/50 (22%)
		Ig	466..561	CDD:299845	22/143 (15%)
		IG_like	478..561	CDD:214653	18/121 (15%)
side-VII	NP_001262432.1	IG_like	32..134	CDD:214653
		V-set	32..134	CDD:284989
		IGc2	160..>214	CDD:197706	10/53 (19%)
		Ig	262..328	CDD:299845	22/74 (30%)
		IG_like	264..323	CDD:214653	20/64 (31%)
		IGc2	360..425	CDD:197706	15/69 (22%)
		Ig_3	456..519	CDD:290638	16/88 (18%)
		FN3	538..620	CDD:238020	15/97 (15%)
		FAM176	643..741	CDD:291517	17/101 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910