DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kirre and nrm

DIOPT Version :9

Sequence 1:	NP_001245505.1	Gene:	kirre / 31292	FlyBaseID:	FBgn0028369	Length:	956	Species:	Drosophila melanogaster
Sequence 2:	NP_001246890.1	Gene:	nrm / 40515	FlyBaseID:	FBgn0262509	Length:	2192	Species:	Drosophila melanogaster

Alignment Length:	860	Identity:	170/860 - (19%)
Similarity:	288/860 - (33%)	Gaps:	282/860 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 MRSSRLLVLPLILVLILTLLLQPIAVHAKSKKNKSSQSSHHGDSSSSSSSSSSSSGSSSAAASSA 68
            :|||  :.|.|:|||.|.|:                      |||::...::.|...|.:
  Fly    21 VRSS--ISLSLVLVLCLALV----------------------DSSTAQVDTTISQQESQS----- 56

  Fly    69 NDESKPKGGDNGGQHFAMEPQDQTAVVGSRVTLPCRV-MEKVG---ALQWTKDD-----FGLGQH 124
                                          |.|||.| .||.|   :|.|.|.|     ..||..
  Fly    57 ------------------------------VVLPCPVDAEKCGKLHSLNWFKGDDRIAAMLLGDS 91

  Fly   125 RNLSGFERYSMVGSDEEGDFSLDIYPLMLDDDAKYQCQVG---PGPQGE--QGIRSRFAKLTVLV 184
            ...|..:.:....:.|:..:.|.|..|.:.|:..|.|...   |....:  .|.|   .:|.|||
  Fly    92 NVTSVNKEFDERVTVEQNPYRLVIKDLKIADEDIYLCDTTFFIPEETCDNFNGYR---IELRVLV 153

  Fly   185 PP--------EAPKITQGDYLVTTEDRE-IELECVSQGGKPAAEITWIDGLGNVLTKGIEYVKEP 240
            ||        :..:|..|..:...::|: ::..|..:..:|..|::|..|...:.|....:   .
  Fly   154 PPTEVVILDAKGDRIKNGSVVGPMQERQSLKATCTVRNTRPQPEVSWFRGTKRLTTYSPTH---D 215

  Fly   241 LADSRRITARSILKLAPKKEHHNTTFTCQAQNTADRTYRSAKLLLEVKYAPKVIVSVVGGALAGG 305
            |.|. ..|:...|.....:|.......|:.::.|.:.....|..::::..|..|      .:.|.
  Fly   216 LVDG-LYTSTLELDWTLSREDLAQDIECRVKSAAIQNVTVTKFSVDLQVRPTSI------DINGV 273

  Fly   306 K--IPEGAEVILSCQADANPHELSYRWFINDELMT------------------GDFTTKM-IIHN 349
            |  ..:|::|:|:|........::..|:....:::                  |.|.|:. :|.|
  Fly   274 KHHTVQGSKVVLTCDIHGARPAVNLTWYNTTTIISSGENEITEVRSKSLEKSDGTFHTQSELIFN 338

  Fly   350 VSRQYHDAIVKCEVVNAVGKSEQSK------KLDISFGPVFRQRPVSVEADLGATVSMRCDVAGN 408
            .:|..:|.:.:||..|.|.:..:.|      .|::.:.||.:..|.::.|:....|.:.|:...|
  Fly   339 ATRFENDRVFRCEAENIVLQINREKPISSALTLEVLYPPVVKVSPSAITANTSEIVLLNCEYFAN 403

  Fly   409 PE--PEIEW--------ISENSDQVVGVAAELKLKVSS---ETAGRYFCKAVVN-GFPEIGAEAT 459
            |.  .::||        :::.:....|.:..:.|.:.|   |..|.|.|:...| |......:..
  Fly   404 PASLTQVEWYRNDILVNVNDTTHYKGGNSENVALVIKSTEKEDIGNYSCQLSNNIGKGTSDQKIN 468

  Fly   460 LYVKRAPIITSHKVQFGGV----GGRVKIDCLAFSIPKAEHILWSFEGKIINMSSADPDIY---- 516
            |.|:.||.:....:..|.|    ...|.:.|                    |:..|:|.:.
  Fly   469 LDVQYAPTVEILMIPEGPVKESDESNVTLFC--------------------NVLDANPSVLTKVR 513

  Fly   517 ------IFEEHHLP--EGVR--------AALIIRDSKATHFGKYNCTVMNSYG----GDSLVITL 561
                  :.:|  ||  |..|        :.|::.......|..|:|...|:.|    .:...:.:
  Fly   514 WYANSTLLKE--LPDCEETREDLCHIDPSKLLLESIGRGFFYNYSCEGFNAAGWGPRSEDKELLV 576

  Fly   562 LREPGNIPVLLVVMGSMFCVAIILMIVMIIIVYRKRRSRKKPMPADVIPEASRGGDKLNELKSEL 626
            ..|||  |..|    |.|         .::.|.:|..:....:.....||::|    ...|:
  Fly   577 HYEPG--PAAL----SHF---------PLVAVKKKSVTFSCSVDDPGFPESNR----FRWLR--- 619

  Fly   627 RSKAYDVEYSEAGGDGLAINLTQSPMPDVQMKGATLGVPLAGPVKFDER-----FSGDFGGD--- 683
                        ||.|        |:.|:..|..|:     .||..|.|     ::.:.||.
  Fly   620 ------------GGRG--------PLQDIVTKDWTV-----EPVGLDSRTNYSCYAYNEGGKGVM 659

  Fly   684 -RYNRQCH-----IKNLKNQQETAYKG----SPQA------------------------NGYAHY 714
             ..|.:.|     ||||     ..|.|    ||.|                        ...:.|
  Fly   660 ATVNLEVHAPPFFIKNL-----PPYTGILHSSPNATLTCRIECVPRCDISWQKDGVPIERNDSRY 719

  Fly   715 F--EYALDYSPPGGE 727
            |  |..:|.||..|:
  Fly   720 FIKEKYMDASPATGD 734

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kirre	NP_001245505.1	Ig	87..183	CDD:299845	26/109 (24%)
		IG_like	88..182	CDD:214653	26/107 (24%)
		C2-set_2	189..279	CDD:285423	16/90 (18%)
		Ig_2	307..379	CDD:290606	18/96 (19%)
		I-set	382..462	CDD:254352	20/93 (22%)
		IGc2	396..446	CDD:197706	13/62 (21%)
		Ig	466..561	CDD:299845	19/122 (16%)
		IG_like	478..561	CDD:214653	17/110 (15%)
nrm	NP_001246890.1	Ig	44..152	CDD:299845	28/145 (19%)
		Ig	176..248	CDD:299845	13/75 (17%)
		Ig	277..354	CDD:299845	14/76 (18%)
		IG_like	383..463	CDD:214653	17/79 (22%)
		Ig	394..463	CDD:143165	15/68 (22%)
		Ig_3	585..652	CDD:290638	20/111 (18%)
		Ig	685..>719	CDD:299845	3/33 (9%)
		IG_like	788..869	CDD:214653
		Ig	<811..869	CDD:299845
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910