DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kirre and dscamb

DIOPT Version :9

Sequence 1:	NP_001245505.1	Gene:	kirre / 31292	FlyBaseID:	FBgn0028369	Length:	956	Species:	Drosophila melanogaster
Sequence 2:	XP_009289749.1	Gene:	dscamb / 386937	ZFINID:	ZDB-GENE-031118-67	Length:	2020	Species:	Danio rerio

Alignment Length:	1027	Identity:	205/1027 - (19%)
Similarity:	325/1027 - (31%)	Gaps:	351/1027 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    86 MEPQDQTAVVGSRVTLPCRVMEKVGALQWTKDDFGLGQHRN-----------LSGFERYSMVGSD 139
            :.|:.....|||:|:|.|.|   .|:     |:|.:..:||           ::|....::|
Zfish   318 VSPRKVRGSVGSQVSLFCSV---TGS-----DEFDITWYRNAEKIYQGINVRITGINNENLV--- 371

  Fly   140 EEGDFSLDIYPLMLDDDAKYQCQVGPGPQGEQGIRSRFAKLTVLVPPEAPKITQG-DYLVTTEDR 203
            .||        :...|...|||....|....|.:      :.|::....|||... ...|.:.:.
Zfish   372 MEG--------MAKSDGGAYQCFARNGKMSTQDL------VQVVLEDGTPKILSAFSEKVVSPNE 422

  Fly   204 EIELECVSQGGKPAAEITW--------------IDGLGNVLTKG--IEYVK---EPLAD------ 243
            .|.|.|..: |.|...:||              :|.:  :.|:|  :.|:.   ..::|
Zfish   423 PISLVCHVK-GTPLPTVTWTLDDDPVIKDSNHRMDRI--ITTEGHVLSYLNVSHTQVSDGGVYRC 484

  Fly   244 -----------SRRITARSILKLAPKK-------------------------------------- 259
                       ..||..|....:.|.|
Zfish   485 TCNNSAGSVSYQARINVRGPASIRPMKNVTAIAGRDTYIHCRIIGYPYYSIKWYKDSNLLPFNHR 549

  Fly   260 ----EHHNTTFTCQAQNTADRTYRSAKLLLEVKYAPKVIVSVVGGALAGGKIPE----------- 309
                |::.|......||:.:..|....|:...|...:.:...|       |:|.
Zfish   550 QRAFENNGTLKLSNVQNSDEGEYTCYVLVDPEKQIHRSVHVTV-------KVPPLIQHSDSQSAS 607

  Fly   310 -GAEVILSCQADANPHELSYRWF-----INDELMTG----DFTTKMIIHNVSRQYHDAIVKCEVV 364
             |..|.:.|...:....:|..|.     ||..|...    |||:.:.|.|:| :.|:....|...
Zfish   608 IGQRVFIPCVVISGDLPMSITWHKDGRPINASLGVTIDNIDFTSSLRISNLS-EIHNGSYTCIAR 671

  Fly   365 NAVGKSEQSKKLDISFGPVFRQRPVSVEADLGATVSMRCDVAGNPEPEIEW-------------I 416
            |.....|.|.:|.:...|.|..:|...:...|.:|::.|...|||.|.|.|             |
Zfish   672 NEAAAVEHSIQLIVKVPPHFEVQPKDQDGIYGKSVTLNCSAKGNPIPTIVWNHSKGAGVPQFQPI 736

  Fly   417 SENSDQVVGVA--AELKLK-VSSETAGRYFCKAVVNGFPEIGAEAT----LYVKRAPIITSH-KV 473
            :.||...|.:.  ..|.:| |..|.||.|.|| |.|   ::||:.:    |.||...:|||: ..
Zfish   737 ALNSGSRVQLLENGSLLIKHVLEEDAGFYLCK-VSN---DVGADISKSMYLTVKIPAMITSYPNT 797

  Fly   474 QFGGVGGRVKIDCLAFSIPKAEHILWSFEGKIINMSSADPDI--YIFEEHHLPEGVRAALIIRDS 536
            .....|...::.|.|.. .|...:.|..|..|||     ||:  |:.....:.:.|.:.|.|..:
Zfish   798 TRAEQGHMTEMSCTAHG-EKPIKVRWEKESHIIN-----PDMSRYVVTVKEVGDEVISTLQILHT 856

  Fly   537 KATHFGKYNCTVMNSYGGDSLVITL------------LRE--------------PGNIPVLLVVM 575
            .....|.::|..:||||.|..:|.|            :||              .||.|
Zfish   857 VREDSGFFSCIAINSYGEDKGIIQLIVQDRPDPPEVEIREVKDRTIALRWTMGFDGNSP------ 915

  Fly   576 GSMFCVAIILMIVMIIIVYRKRRS--RKKPMPADVIPE-----------ASRGGDKL---NELKS 624
                       |....|.|:.:.:  ....|..||.|:           ||....::   |::..
Zfish   916 -----------ITGYDINYKNKSASWASSQMTKDVSPQLNQATIIELHPASTYNIRMFAKNQIGE 969

  Fly   625 ELRSKAYDVEYSEAGGDGLAINLTQSPMPDVQMKGAT---LGVPLAGPVKFDERFSGDFGGDRYN 686
            ...|....:...||..||       :|. |||::..:   :.|....|.|
Zfish   970 SRPSNELTITTDEAPPDG-------APQ-DVQLEAISSQGIKVTWKPPHK--------------- 1011

  Fly   687 RQCHIKN-LKNQQETAYK-----GSPQAN----------------GYAHYFEYALDYSP------ 723
               |::| |....:..|:     ||||.|                ....|.:|.:....
Zfish  1012 ---HLQNGLIRSYQVCYREFGTGGSPQYNTINVDTTGDIETLTLDNLKKYTQYEVRVQAANRAGM 1073

  Fly   724 -PGGEGAAVVVGSGGVGKLKNGGMNSATLPHSAAAT--------VNGGGAGNG--GGASLPRNQR 777
             |..|...:........:.....:.:||.|.:.:.:        :||...|..  ..|:||..:.
Zfish  1074 GPTSEEITITTLEDVPSRPPENVVTTATTPETISLSWSALPKEALNGMLLGYRVIFWANLPDGEL 1138

  Fly   778 HEIQQSQQSNGFLGQPLLQ----------------NGIDSRFSAIYGNPYLRTNSSLLPPLPPPS 826
            .||:....:...|....|:                :|:.|.      ..|.||...:  |.||..
Zfish  1139 GEIRNITTTKPSLELERLEKYTNYSIQVLAFTRAGDGVRSE------QIYTRTKEDV--PGPPAG 1195

  Fly   827 TANPAATPA-------PPPYHAARHGHAHHANGGLKHFVGGAVITTSPVGNV 871
            ....|:|.:       ||          |..||.::.::   |..::|...|
Zfish  1196 VKAAASTSSVVFVSWLPP----------HKLNGIIRKYI---VFCSNPYPTV 1234

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kirre	NP_001245505.1	Ig	87..183	CDD:299845	23/106 (22%)
		IG_like	88..182	CDD:214653	23/104 (22%)
		C2-set_2	189..279	CDD:285423	25/168 (15%)
		Ig_2	307..379	CDD:290606	21/92 (23%)
		I-set	382..462	CDD:254352	30/99 (30%)
		IGc2	396..446	CDD:197706	21/65 (32%)
		Ig	466..561	CDD:299845	26/97 (27%)
		IG_like	478..561	CDD:214653	23/84 (27%)
dscamb	XP_009289749.1	I-set	132..198	CDD:254352
		I-set	225..310	CDD:254352
		IGc2	239..300	CDD:197706
		IG_like	320..400	CDD:214653	23/104 (22%)
		IGc2	328..391	CDD:197706	19/81 (23%)
		IG_like	417..501	CDD:214653	15/86 (17%)
		Ig	424..498	CDD:143165	12/76 (16%)
		IG_like	511..592	CDD:214653	8/80 (10%)
		IGc2	518..576	CDD:197706	5/57 (9%)
		I-set	595..685	CDD:254352	21/90 (23%)
		Ig	612..682	CDD:143165	18/70 (26%)
		I-set	689..785	CDD:254352	30/99 (30%)
		Ig7_DSCAM	706..785	CDD:143211	26/82 (32%)
		IG_like	795..883	CDD:214653	24/93 (26%)
		Ig	803..890	CDD:299845	24/92 (26%)
		FN3	887..980	CDD:238020	16/109 (15%)
		FN3	987..1084	CDD:238020	21/122 (17%)
		FN3	1092..1185	CDD:238020	16/98 (16%)
		FN3	1190..1279	CDD:238020	13/58 (22%)
		IGc2	1302..1367	CDD:197706
		FN3	1398..1471	CDD:238020
		FN3	1485..1557	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810