DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kirre and Sdk2

DIOPT Version :9

Sequence 1:	NP_001245505.1	Gene:	kirre / 31292	FlyBaseID:	FBgn0028369	Length:	956	Species:	Drosophila melanogaster
Sequence 2:	XP_006247755.1	Gene:	Sdk2 / 360652	RGDID:	1310397	Length:	2175	Species:	Rattus norvegicus

Alignment Length:	1018	Identity:	204/1018 - (20%)
Similarity:	315/1018 - (30%)	Gaps:	351/1018 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 ASSANDESKPKGGDNGGQHFAMEP-QDQTAVVGSRVTLPCRVMEKVGALQWTKDDFGLGQHRNLS 128
            ::.|.|:..|        :|..|| :.|..:.|:|:.|.|     :....|..:...|..:|.|:
  Rat    20 SAGAQDDVPP--------YFKTEPVRTQVHLEGNRLVLTC-----MAEGSWPLEFKWLHNNRELT 71

  Fly   129 GFE---RYSMVGSDE-EGDFSLDIYPLMLDDDAKYQCQVGPGPQGEQGIRSRFAKLTVLVPPEAP 189
            .|.   ||.:...|. ...|              |:|.|          |:|...|.     :..
  Rat    72 RFSLEYRYMITSLDRTHAGF--------------YRCIV----------RNRMGALL-----QRQ 107

  Fly   190 KITQGDYLVTTEDREIELECVSQG-----------GKPAAEITWI-DGLGNVLTKGIEYVKEPLA 242
            ...|..|:.:.|:.| :.:.||.|           ..|..::||. ||.           |.|.:
  Rat   108 TEVQVAYMGSFEEGE-KHQSVSHGEAAVIKAPRISSFPRPQVTWFRDGR-----------KIPPS 160

  Fly   243 DSRRITARSILKLAPKKEHHNTTFTCQA---QNTADRTYRSAKLLLE------VKYAPKVIV--- 295
            ....||..:.|.:..........:..||   :|..::|.:...|.:|      ...||.:|:
  Rat   161 SRIAITLENTLVILSTVAPDAGRYYVQAVNDKNGDNKTSQPITLAVENVGGPADPIAPTIIIPPK 225

  Fly   296 --SVVGGALAGGKIPEGAEVILSCQADANP-HELSYRWFINDELMT---GDFTTKMIIHN--VSR 352
              |||.|.         :||.:.|.|:|.| .:|...|..:..|::   .|:..::.|.|  ||
  Rat   226 NTSVVAGT---------SEVTMECVANARPLIKLHIVWKKDGALLSNGISDYNRRLTITNPMVS- 280

  Fly   353 QYHDA-IVKCEVV---NAVGKSEQSKKLDISFGPVFRQRPV-SVEADLGATVSMRCDVAGNPEPE 412
               || ..:||.:   ::|....:...|.:...|.|.:.|. .:.|::...|.:.|...|.|.|.
  Rat   281 ---DAGYYECEAMLRSSSVAPVTRGAYLSVLEPPQFVREPERHITAEMEKVVDIPCRAKGVPPPS 342

  Fly   413 IEWISENSDQVVGVAAELK------LKVSS---ETAGRYFCKAVVNGFPEIGAEATLYV---KRA 465
            |.|..:.:...||.....|      |::|.   :..|...|.| .|...|  |:.:.|:   ..|
  Rat   343 ITWYKDAALVEVGKLTRFKQRSDGGLQISGLLPDDTGMVQCFA-HNAAGE--AQTSTYLAVTSIA 404

  Fly   466 PIITSHKVQFGGVGG-RVKIDCLAFSIPKAEHILWSFEGKIINMSSAD-PDIYIFEEHHLPEGVR 528
            |.||...:....:.| .|.:.|.....|:.. |.|....:|:...|.. |...:.|.
  Rat   405 PNITRGPLDSTVIDGMSVVLACETSGAPRPA-ITWQKGERILASGSVQLPRFTLLES-------- 460

  Fly   529 AALIIRDSKATHFGKYNCTVMNSYGGDSLVITLLREPGNIPVLLVVMGSMFCVAIILMIVMIIIV 593
            .:|:|..:..:..|.|.|...||.|.|.....|                              :|
  Rat   461 GSLLISPTHISDAGTYTCLATNSRGVDEASADL------------------------------VV 495

  Fly   594 YRKRRSRKKPMPADVI--PEASRGGDKLNELKSELRSKAYDVEYSEAGGDGLAINLTQSPMPDV- 655
            :.:.|..|.|....||  .:||                             :...:|..|...|
  Rat   496 WARTRITKPPQDQSVIKGTQAS-----------------------------MVCGVTHDPRVTVR 531

  Fly   656 ---QMKGATLGVPLAGPVKFD--------ERFSGDFG---------GDRYNRQCHIK-------- 692
               :..||||.|.....::.|        :.:|||.|         |...:|..|::
  Rat   532 YVWEKDGATLAVETNPRIRLDRNGSLHISQTWSGDIGTYTCRVLSAGGNDSRNAHLRVRQLPHAP 596

  Fly   693 -----NLKNQQETAYK--GSPQANGYAHYFEYALDYSPPGG-----------EGAAVVVGSGGVG 739
                 .|...:..|..  .:...:|.:....|.|:.|....           |..:|:|
  Rat   597 EHPVATLSTMERRAINLTWAKPFDGNSPLMRYILEMSENNAPWTILLASVDPEATSVMV------ 655

  Fly   740 KLKNGGMNSATLPHSAAATVNGGGAG----NGGGASLPRNQRHEIQQSQQSNGFLGQPLLQNGID 800
                .|:..|.........||..|.|    :....|||........|:..::|
  Rat   656 ----KGLVPARSYQFRLCAVNDVGKGQFSKDTERVSLPEEPPTAPPQNVIASG------------ 704

  Fly   801 SRFSAIYGNPYLRTNSSLLPPLPPPSTANPAATPAPPPYHAARHGHAHHANGGLKHFVGGAVITT 865
                        |||.|::....||..:                    |.||.||.::....:..
  Rat   705 ------------RTNQSIMIQWQPPPES--------------------HQNGILKGYIIRYCLAG 737

  Fly   866 SPVG---------NVN----------INGGGGGGSTPSGGGGV-----------GVGVAAGGSVS 900
            .|||         :||          .|......:..|.|.||           ||.....|:|.
  Rat   738 LPVGYQFKNITDADVNNLLLEDLIIWTNYEIEVAAYNSAGLGVYSSKVTEWTLQGVPTVPPGNVH 802

  Fly   901 GSSSNLTASSNTLAATPLAGGGVGNSGQCAQSPSGQFILSNNG 943
            ..::|.||...|..|                 ||.|||   ||
  Rat   803 AEATNSTAIRFTWNA-----------------PSPQFI---NG 825

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kirre	NP_001245505.1	Ig	87..183	CDD:299845	22/100 (22%)
		IG_like	88..182	CDD:214653	21/98 (21%)
		C2-set_2	189..279	CDD:285423	21/104 (20%)
		Ig_2	307..379	CDD:290606	20/81 (25%)
		I-set	382..462	CDD:254352	22/89 (25%)
		IGc2	396..446	CDD:197706	14/58 (24%)
		Ig	466..561	CDD:299845	22/96 (23%)
		IG_like	478..561	CDD:214653	19/84 (23%)
Sdk2	XP_006247755.1	IG_like	43..112	CDD:214653	19/102 (19%)
		IGc2	43..101	CDD:197706	18/86 (21%)
		IG_like	123..206	CDD:214653	18/93 (19%)
		Ig	135..191	CDD:299845	12/66 (18%)
		IG_like	225..307	CDD:214653	24/94 (26%)
		IGc2	236..289	CDD:197706	16/56 (29%)
		I-set	311..400	CDD:254352	23/91 (25%)
		Ig	329..397	CDD:143165	18/70 (26%)
		I-set	405..495	CDD:254352	23/128 (18%)
		Ig	419..495	CDD:299845	20/114 (18%)
		Ig	505..589	CDD:299845	21/112 (19%)
		IG_like	505..589	CDD:214653	21/112 (19%)
		FN3	593..684	CDD:238020	15/100 (15%)
		FN3	696..789	CDD:238020	23/136 (17%)
		FN3	797..893	CDD:238020	14/49 (29%)
		FN3	898..986	CDD:238020
		FN3	996..1090	CDD:238020
		FN3	1102..1197	CDD:238020
		FN3	1204..1293	CDD:238020
		FN3	1304..1397	CDD:238020
		FN3	1403..1487	CDD:238020
		FN3	1506..1619	CDD:238020
		FN3	1629..1722	CDD:238020
		FN3	1727..1808	CDD:238020
		FN3	1840..1919	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900