DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kirre and DIP-zeta

DIOPT Version :9

Sequence 1:	NP_001245505.1	Gene:	kirre / 31292	FlyBaseID:	FBgn0028369	Length:	956	Species:	Drosophila melanogaster
Sequence 2:	NP_723441.2	Gene:	DIP-zeta / 34231	FlyBaseID:	FBgn0051708	Length:	532	Species:	Drosophila melanogaster

Alignment Length:	440	Identity:	98/440 - (22%)
Similarity:	154/440 - (35%)	Gaps:	94/440 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 VLPLILVLILTLLLQPIAVHAKSKKNK-----------------SSQSSHHGDSSS--------- 49
            :||....||..||:  :|..|....||                 ::|..|...|.:
  Fly     1 MLPPSWHLIGALLV--LAATAGDSTNKIILPQILNGGGGGGGVGTAQGKHPSGSKTVATGVVPNF 63

  Fly    50 SSSSSSSSSGSSSAAASSANDESKPKGG---DNGGQH--------FAMEP------QDQTAVVGS 97
            ..::.:.:.|....|.|..........|   ..||.:        ...||      ::.|...|.
  Fly    64 GGAAGNGAGGGGPVAGSGTGSTVVGSNGVIVAGGGANVPTSNLNIVVEEPEFTEYIENVTVPAGR 128

  Fly    98 RVTLPCRVME----KVGALQWTKDDFGLGQHRNLSGFERYSMVGS--DEEGDFSLDIYPLMLDDD 156
            .|.|.|.|..    ||..:.:.:.......:..::...|.|:...  |....:.|.|..:..:|.
  Fly   129 NVKLGCSVKNLGSYKVAWMHFEQSAILTVHNHVITRNPRISVTHDKHDRHRTWYLHINNVHEEDR 193

  Fly   157 AKYQCQVGPGPQGEQGIRSRFAKLTVLVPPEAPKITQGDYLVTTEDREIELECVSQGGKPAAEIT 221
            .:|.||:     .....:::|..|.|:|||..........::..|...|.|.| ...|.|...|.
  Fly   194 GRYMCQI-----NTVTAKTQFGYLNVVVPPNIDDSLSSSDVIVREGANISLRC-RASGSPRPIIK 252

  Fly   222 W-IDGLGNVLTKGIEYVKEPLADSRRITARSILKLAPKKEHHNTTFTCQAQNTADRTYRSAKLLL 285
            | .|....:.......|.|...|:..||..|.|.:.        .:.|.|.|....|. |.::.:
  Fly   253 WKRDDNSRIAINKNHIVNEWEGDTLEITRISRLDMG--------AYLCIASNGVPPTV-SKRIKV 308

  Fly   286 EVKYAPKVIV--SVVGGALAGGKIPEGAEVILSCQADANPHELSYRW------FIND------EL 336
            .|.:.|.:::  .:||.       |||..|.:.|..:|:|..|:| |      .|:|      |.
  Fly   309 SVDFPPMLLIPHQLVGA-------PEGFNVTIECFTEAHPTSLNY-WTRGEGPIIHDSHKYKVEA 365

  Fly   337 MTG--DFTT--KMIIHNVSRQYHDAIVKCEVVNAVGKSEQSKKLDISFGP 382
            ..|  .:.|  |:.|.||| ...|.|.||...|..|:::...:|.:|:.|
  Fly   366 TVGLPAYKTHMKLTIINVS-SGDDGIYKCVAKNPRGETDGIIRLYVSYPP 414

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kirre	NP_001245505.1	Ig	87..183	CDD:299845	21/107 (20%)
		IG_like	88..182	CDD:214653	20/105 (19%)
		C2-set_2	189..279	CDD:285423	20/90 (22%)
		Ig_2	307..379	CDD:290606	27/87 (31%)
		I-set	382..462	CDD:254352	1/1 (100%)
		IGc2	396..446	CDD:197706
		Ig	466..561	CDD:299845
		IG_like	478..561	CDD:214653
DIP-zeta	NP_723441.2	IG_like	120..216	CDD:214653	20/100 (20%)
		Ig	130..200	CDD:143165	14/69 (20%)
		I-set	226..310	CDD:254352	21/93 (23%)
		IGc2	233..298	CDD:197706	19/73 (26%)
		Ig	313..410	CDD:299845	30/105 (29%)
		IG_like	325..410	CDD:214653	27/93 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810