DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment kirre and ed

DIOPT Version :9

Sequence 1:NP_001245505.1 Gene:kirre / 31292 FlyBaseID:FBgn0028369 Length:956 Species:Drosophila melanogaster
Sequence 2:NP_001260013.1 Gene:ed / 33619 FlyBaseID:FBgn0000547 Length:1332 Species:Drosophila melanogaster


Alignment Length:1240 Identity:267/1240 - (21%)
Similarity:402/1240 - (32%) Gaps:463/1240 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly    99 VTLPCRVMEKVGA-------LQWTK-----DDFGLGQHRNLSGFERYSMVGSDEEGDFSLDIYPL 151
            :||.||..:|..|       .:||.     |:..:|:.:..||   |.:....|.|.:.|.|..:
  Fly    54 LTLKCRFNDKYEANDFSFFWTRWTANPAQFDNVAIGEVQLSSG---YRLDFQPERGIYDLQIKNV 115

  Fly   152 MLD-DDAKYQCQV---GPGPQGEQGIRSRFAKLTVLVPPEAPKITQGDYLVTTEDREIELECVSQ 212
            ..: |:.:::|::   |.|..    :...|..||||.||..|.|:.|:..|.|||:.:||.|.|.
  Fly   116 SYNRDNGRFECRIKAKGTGAD----VHQEFHNLTVLTPPHPPVISPGNIAVATEDKPMELTCSSI 176

  Fly   213 GGKPAAEITWI-DGLGNVLTKGIEYVKEPLADSRRITARSILKLAPKKEHHNTTFTCQAQNTA-- 274
            ||.|...|||. :|....|...:  :|....|.   ...:.|.:.|::|.....:.|..:|.|  
  Fly   177 GGSPDPTITWYREGSNTPLPATV--LKGGTKDQ---PTNATLSIIPRREDDGAKYKCVVRNRAMN 236

  Fly   275 DRTYRSAKLLLEVKYAPKVIVSVVGGALAGGKIPEGAE----VILSCQADANPHELSYRWFINDE 335
            :.....|...|.|.|.|:|.|        |.:.|...|    ..|.|..||.|...:.||..|  
  Fly   237 EGKRLEATATLNVNYYPRVEV--------GPENPLRVERDRTAKLECNVDAKPKVPNVRWNRN-- 291

  Fly   336 LMTGDFTTKMIIHNVSR-QYHDA-IVKCEVVNAVGKS-EQSKKLDISFGPVFRQRPVSVEADLGA 397
               |.|.:..::|.:.| ...|| ...|...|.:||: ||...|||.:.|:......:.||:.|.
  Fly   292 ---GRFISSSLVHTIHRVSVQDAGKYTCIADNGLGKTGEQELILDILYPPMVVIESKTREAEEGD 353

  Fly   398 TVSMRCDVAGNPEP-EIEWISENSDQVVGVAAELKL-KVSSETAGRYFCKAVVNGFPEIGAE--- 457
            ||::||:|..||.| .|||:.|||.........|.| .|.::.||.|.|:| ||.....|.|   
  Fly   354 TVTIRCNVTANPAPVTIEWLKENSPDFRYNGDVLTLTSVRADHAGNYICRA-VNIMQSQGMERSE 417

  Fly   458 ------ATLYVKRAP---IITSHKVQFGGVGGRVKIDCLA----FSIPKAEHILW--SFEGKIIN 507
                  ..|.|:..|   .||.:| ....||..|.:.|.|    :.:|:..   |  ..:|:   
  Fly   418 RVGNSTVALLVRHRPGQAYITPNK-PVVHVGNGVTLTCSANPPGWPVPQYR---WFRDMDGE--- 475

  Fly   508 MSSADPDIYIFEEHHLPEGVRAALIIRDSKATHF---GKYNCTVMNSYGGDSLVITLLREPGNIP 569
            .||....:....::.:|:             .|.   |||:|..:|.. |..::.|::.|....|
  Fly   476 FSSTQKILAQGPQYSIPK-------------AHLGNEGKYHCHAVNEL-GIGMMATIVLEIHQPP 526

  Fly   570 VLLVVMGSMFCVAIILMIVMIIIVYRKRR-----------SRKKPMPA--------DVIPEAS-- 613
            ..|..:..                :..||           ::.||.|:        :::||.:  
  Fly   527 QFLAKLQQ----------------HMTRRVADTDYTVTCSAKGKPAPSVKWLKDAVEILPEENLY 575

  Fly   614 ----------------------RG-----------GDK-------LNELKS-----ELRSK---- 629
                                  ||           ||:       .||:.|     :||.:    
  Fly   576 EVQTNPDQGLNGMVTVQSQLKFRGKARPNGNALVPGDRGLYTCLYQNEVNSANSSMQLRIEHEPI 640

  Fly   630 --------AYDV-EYSEA-------------------------GGDG-----------------L 643
                    |:|: |.:|.                         ..||                 |
  Fly   641 VLHQYNKVAFDIRETAEVVCKVQAYPKPEFQWQFGNNPSPLTMSSDGHYEISTTTDNNDIYTSVL 705

  Fly   644 AIN-LTQSPMPDVQMKGA----TLGVPL----AGP------------------VKFDERFSGDFG 681
            .|| ||.|...:...:.|    |:..|:    .||                  :.:|..|.|...
  Fly   706 KINSLTHSDYGEYTCRVANTLDTIRAPIRLQQKGPPEKPTNLRATEVGHNYVSLSWDPGFDGGLS 770

  Fly   682 GDR----YNR--------------------------------QCHIKNLKNQQETAYKG---SPQ 707
            ..:    |.|                                .|.:..|:..|..|:|.   :|:
  Fly   771 KTKFFVSYRRVAMPREEQLIPDCATLANSNSAWVEVDCQRDIPCKVTALEQHQSYAFKVKALNPK 835

  Fly   708 ANG-YAHYFEYALDYS---PP------------GGEGAAVVVGSGGVGKLKNGGMNSATLPHSAA 756
            ::. |:.........|   ||            |.:..|..:....|.:    .|.:|..|.:|.
  Fly   836 SDSPYSSEIMVTTKVSRIPPPLQVTYEPNTRTLGIDVGATCLNLVAVVE----SMVNADSPMAAW 896

  Fly   757 ATV----------NG------------GGAGNGGGASLPRNQRHEIQQSQQSNGFLGQPLL-QNG 798
            ..|          ||            |....|||.:|    .|.|.:.:..||.....|. :|.
  Fly   897 EVVTTMDNLQLSGNGPTHKEKIIDRIIGARRVGGGRAL----GHTISEDEDDNGLNSLALEDENS 957

  Fly   799 IDSRF---------------SAIYGNPYLRTNSSLLPPL-------------------------- 822
            ...|.               .|..|.||:...::|..|.                          
  Fly   958 PTVRVKLCLRTNPEHCGDYTDAEIGRPYIAEANALATPTLIAIIVSCVVFALFAGLILMFCRCKR 1022

  Fly   823 ----------------PPPSTANPAATPAPPPY----------------------------HAAR 843
                            ..||........|||||                            :|.:
  Fly  1023 NQSKKSAAAKDYEMDSVRPSIVAAQQNQAPPPYYPASGLDNKALEHSMDLALSMEDQKTALYATQ 1087

  Fly   844 HGHAHHANGGLKHF-VGGAVITTSPVGNVNINGGGGGGSTPSGGGGVGV----GVAA-------- 895
            :|:::|...|:... :||.|:.....|:|....|||.|..  ||.||||    |::|        
  Fly  1088 NGYSYHPGSGVVGVGMGGGVVGVGVGGSVVSGMGGGVGGI--GGSGVGVNGIPGLSAHTMPGNEW 1150

  Fly   896 ----------GGSVSGSSSNLTASSNTLAATPLAGGGVGNSGQCAQSPSGQFILSNNGKGHTQKG 950
                      ..|.:|.|.|   |.::|....::...|||.....|:|..|::......|:   .
  Fly  1151 VNMGYMENNYSNSNNGGSVN---SQDSLWQVKMSAAAVGNQQGMVQAPMNQYVEQQPAYGY---D 1209

  Fly   951 PLATH 955
            || ||
  Fly  1210 PL-TH 1213

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kirreNP_001245505.1 Ig 87..183 CDD:299845 24/99 (24%)
IG_like 88..182 CDD:214653 23/98 (23%)
C2-set_2 189..279 CDD:285423 27/92 (29%)
Ig_2 307..379 CDD:290606 24/78 (31%)
I-set 382..462 CDD:254352 31/90 (34%)
IGc2 396..446 CDD:197706 22/51 (43%)
Ig 466..561 CDD:299845 22/106 (21%)
IG_like 478..561 CDD:214653 18/91 (20%)
edNP_001260013.1 Ig 50..147 CDD:299845 24/99 (24%)
I-set 146..249 CDD:254352 33/107 (31%)
Ig 168..249 CDD:299845 22/85 (26%)
IGc2 268..323 CDD:197706 16/59 (27%)
Ig_3 341..406 CDD:290638 25/65 (38%)
Ig_2 437..514 CDD:290606 21/97 (22%)
I-set 526..633 CDD:254352 16/122 (13%)
Ig 546..632 CDD:143165 12/85 (14%)
IG_like 654..736 CDD:214653 13/81 (16%)
Ig 656..734 CDD:143165 12/77 (16%)
FN3 741..848 CDD:238020 12/106 (11%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45451333
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - P PTHR11640
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
32.940

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