DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment kirre and fred

DIOPT Version :9

Sequence 1:NP_001245505.1 Gene:kirre / 31292 FlyBaseID:FBgn0028369 Length:956 Species:Drosophila melanogaster
Sequence 2:NP_608812.3 Gene:fred / 33613 FlyBaseID:FBgn0051774 Length:1447 Species:Drosophila melanogaster


Alignment Length:1284 Identity:261/1284 - (20%)
Similarity:385/1284 - (29%) Gaps:515/1284 - (40%)


- Green bases have known domain annotations that are detailed below.


  Fly    96 GSRVTLPCRVMEKVGA-------LQWT-----KDDFGLGQHRNLSGFERYSMVGSDEEGDF--SL 146
            |..:.|.||..|...:       .:||     .::..:|.          ..:.|:...||  |.
  Fly    30 GVDLVLKCRFTEHYDSTDFTFYWARWTCCPTLFENVAIGD----------VQLNSNYRLDFRPSR 84

  Fly   147 DIYPLMLD------DDAKYQCQV---GPGPQGEQGIRSRFAKLTVLVPPEAPKITQGDYLVTTED 202
            .||.|.:.      |:.:::|::   |.|..    :...|..||||..|..|.:|.|:..|.||:
  Fly    85 GIYDLQIKNTSYNRDNGRFECRIKAKGTGAD----VHQEFYNLTVLTAPHPPMVTPGNLAVATEE 145

  Fly   203 REIELECVSQGGKPAAEITWI-DG----LGNVLTKGIEYVKEPLADSRRITARSILKLAPKKEHH 262
            :.:||.|.|.||.|...|||. :|    |.:...||         .|:.....:.|::.|::...
  Fly   146 KPLELTCSSIGGSPDPMITWYREGSTVPLQSYALKG---------GSKNHYTNATLQIVPRRADD 201

  Fly   263 NTTFTCQAQNTA--DRTYRSAKLLLEVKYAPKVIVSVVGGALAGGKIPEGAEVILSCQADANPHE 325
            ...:.|...|.|  :.......:.|.|.|.|:|.|    |.....|:.......|.|:.||.|..
  Fly   202 GAKYKCVVWNRAMPEGHMLETSVTLNVNYYPRVEV----GPQNPLKVERDHVAKLDCRVDAKPMV 262

  Fly   326 LSYRWFINDELMTGDFTTKMIIHNVSRQYHDAIVKCEVVNAVGKS-EQSKKLDISFGPVFRQRPV 389
            .:.||..|.:.::.  |....|:.|:| :|.....|...|.:||: |:...||:.:.|:......
  Fly   263 SNVRWSRNGQYVSA--TPTHTIYRVNR-HHAGKYTCSADNGLGKTGEKDIVLDVLYPPIVFIESK 324

  Fly   390 SVEADLGATVSMRCDVAGNPEP-EIEWISENSDQVVGVAAELKL-KVSSETAGRYFCKAV----- 447
            :.||:.|.||.:||:|..||.| .:||:.|.:.........|.| .|.:|.||.|.|::|     
  Fly   325 THEAEEGETVLIRCNVTANPSPINVEWLKEGAPDFRYTGELLTLGSVRAEHAGNYICRSVNIMQP 389

  Fly   448 -----VNGFPEIG-AEATLYVKRAP---IITSHKVQFGGVGGRVKIDCLA----FSIPKAEHILW 499
                 |.|   :| :...|.|:..|   .||.:| ....||..|.:.|.|    :.:|:..   |
  Fly   390 FSSKRVEG---VGNSTVALLVRHRPGQAYITPNK-PVVHVGNGVTLTCSANPPGWPVPQYR---W 447

  Fly   500 --SFEGKIINMSS--ADPDIYIFEEHHLPEGVRAALIIRDSKATHFGKYNCTVMNSYGGDSLVIT 560
              ..:|.|.|...  |....|...:.||...               |||:|..:|..|...:...
  Fly   448 FRDMDGDIGNTQKILAQGPQYSIPKAHLGSE---------------GKYHCHAVNELGIGKIATI 497

  Fly   561 LL-----------------REPGNIPVLLVVMG---------------------SMFCVAII--- 584
            :|                 |..|::...:....                     .||.:...   
  Fly   498 ILEVHQPPQFLAKLQQHMTRRVGDVDYAVTCSAKGKPTPQIRWIKDGTEILPTRKMFDIRTTPTD 562

  Fly   585 ----LMIVMIIIVYRKRRSRKKPMPADVIPEASRG------GDKLNELKSELRSK---------- 629
                ::.|..|:.:   |.:.:|....::|. .||      .:.:|...|.:..:          
  Fly   563 AGGGVVAVQSILRF---RGKARPNGNQLLPN-DRGLYTCLYENDVNSANSSMHLRIEHEPIVIHQ 623

  Fly   630 ----AYDVEYSEAGGDGLAINLTQSPMPDVQMKGATLGVPLA----GPVKFDERFSGDFGGDRYN 686
                |||:..|..    :...:...|.|:.|.:......||.    |..:...|...:   |.|.
  Fly   624 YNKVAYDLRESAE----VVCRVQAYPKPEFQWQYGNNPSPLTMSSDGHYEISTRMENN---DVYT 681

  Fly   687 RQCHIKNLKNQQETAY-------------------KGSPQ------------------------- 707
            ....|.:|::.....|                   ||||:                         
  Fly   682 SILRIAHLQHSDYGEYICRAVNPLDSIRAPIRLQPKGSPEKPTNLKILEVGHNYAVLNWTPGFNG 746

  Fly   708 --------------------------ANGYAHYFE------------------------------ 716
                                      .|||...::                              
  Fly   747 GFMSTKYLVSYRRVATPREQTLSDCSGNGYIPSYQISSSSSNSNHEWIEFNCFKENPCKLAPLDQ 811

  Fly   717 --------YALD------YS-------------PP------------GGEGAA------------ 730
                    |||:      ||             ||            |...||            
  Fly   812 HQSYMFKVYALNSKGTSGYSNEILATTKVSKIPPPLHVSYDPNSHVLGINVAATCLSLIAVVESL 876

  Fly   731 ----------------VVVGSGGVGKLKNGGMNSATLP-HSAAATVNGGGAGNGGGASLPR---- 774
                            .::.||.....|...:|..:.| |...||.:|...|.|||:.|..    
  Fly   877 VTRDATVPMWEIVETLTLLPSGSETTFKEAIINHVSRPAHYTTATTSGRSLGVGGGSHLGEDRTM 941

  Fly   775 --------------------NQRH-------EIQQSQQSNG--------------------FLGQ 792
                                |..|       ||.:|...:.                    ||| 
  Fly   942 ALAETAGPGPVVRVKLCLRSNHEHCGAYANAEIGKSYMPHKSSMTTSALVAIIIASLSFVVFLG- 1005

  Fly   793 PLL--------QNGIDSRFSAIYG-----------NP-------Y-LRTNSSLLPPL---PPPST 827
             ||        ::......|::.|           ||       | |..::|..|.|   |..|.
  Fly  1006 -LLYAFCHCRRKHAAKKESSSVGGGVGGGNANATANPGSTGAKEYDLDLDASRRPSLSQDPQQSQ 1069

  Fly   828 ANPAATPAPPPYH---------------------AARHG---------HAHHANGGLKHFVGGAV 862
            ..|   |.||||:                     .|.|.         ..||:|.|...      
  Fly  1070 QQP---PPPPPYYPTGTLDSKDIGNGNGGMELTLTALHDPDEQLNMQQQQHHSNHGQYQ------ 1125

  Fly   863 ITTSPVGNVNINGG-GGGGSTPSGG-----GGVG------VGV--------------AAG--GSV 899
               .|...:.|.|| .|.|...|||     .|.|      :||              |||  |..
  Fly  1126 ---QPKAILGIYGGVAGSGGNNSGGQHPHSNGYGYHVTSAIGVDSDSYQVLPSVANSAAGSHGHG 1187

  Fly   900 SGSSSNLTA-SSNTLAATP----LAGGGVGNSG--QCAQSPSGQFILSN 941
            ||....|.| .|..|.|||    ::||...|||  ...|..|.:..|:|
  Fly  1188 SGHGHGLGAGESGPLEATPPTCNISGGSSSNSGINPMQQQHSARANLTN 1236

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kirreNP_001245505.1 Ig 87..183 CDD:299845 22/109 (20%)
IG_like 88..182 CDD:214653 21/108 (19%)
C2-set_2 189..279 CDD:285423 26/96 (27%)
Ig_2 307..379 CDD:290606 20/72 (28%)
I-set 382..462 CDD:254352 28/92 (30%)
IGc2 396..446 CDD:197706 20/51 (39%)
Ig 466..561 CDD:299845 24/105 (23%)
IG_like 478..561 CDD:214653 20/90 (22%)
fredNP_608812.3 Ig 29..126 CDD:299845 22/109 (20%)
IG_like 141..228 CDD:214653 24/95 (25%)
Ig 147..228 CDD:299845 21/89 (24%)
I-set 232..313 CDD:254352 24/87 (28%)
IGc2 250..302 CDD:197706 15/54 (28%)
IG_like 323..385 CDD:214653 22/61 (36%)
IGc2 330..385 CDD:197706 20/54 (37%)
Ig_2 416..501 CDD:290606 24/103 (23%)
IG_like 418..501 CDD:214653 22/101 (22%)
I-set 505..612 CDD:254352 13/110 (12%)
Ig 526..611 CDD:143165 11/88 (13%)
IG_like 633..715 CDD:214653 13/88 (15%)
Ig 635..713 CDD:143165 12/84 (14%)
FN3 720..838 CDD:238020 9/117 (8%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45451332
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - P PTHR11640
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
32.940

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