DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kirre and CG33543

DIOPT Version :9

Sequence 1:	NP_001245505.1	Gene:	kirre / 31292	FlyBaseID:	FBgn0028369	Length:	956	Species:	Drosophila melanogaster
Sequence 2:	NP_001014458.3	Gene:	CG33543 / 3346207	FlyBaseID:	FBgn0053543	Length:	468	Species:	Drosophila melanogaster

Alignment Length:	396	Identity:	91/396 - (22%)
Similarity:	146/396 - (36%)	Gaps:	107/396 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 LILTLLLQPIAVHAKSKKNKSSQSSHHGDSSSSSSSSSSSSGSSSAAASSANDESKPKGGDNGGQ 82
            |:|.||.|..|:                   .....|:||.||.:..|......:.|
  Fly    10 LLLLLLSQNAAI-------------------LGQLDSTSSGGSGTGGAPPDRPPTPP-------- 47

  Fly    83 HFAMEPQDQ--TAVVGSRVTLPCRVMEKVGALQWTKDDFGLGQHR-NLSGFERYSMVGSDEEGDF 144
             .:::|...  |..|.....:.|:.::|....:| :|.  .||.| |..|...   :.....|..
  Fly    48 -LSLQPSTPSITHFVNESFIIFCQTVQKDIDTKW-RDP--RGQTRENTKGRVH---IEKKTTGLL 105

  Fly   145 SLDIYPLMLDDDAKYQCQVGPGPQGEQGI---RSRFAKLTVLVPPEAPKITQG---DYLVTTEDR 203
            :|....:.|:|...:.|:|.....|.:.:   |...|...:||   ..||:.|   ......|.|
  Fly   106 ALVFEHIALEDRGNWTCEVNGNRNGNRNVNVEREFLASFELLV---NQKISFGKTEQVQSVREGR 167

  Fly   204 EIELECVSQGGKPAAEITWI----------DGLGNVLTKGIEYVKEPLADSRRITARSILKLAPK 258
            :..:.|..: |.||.|::|:          ....|.|:.|:.......||:...|.|: :::.|
  Fly   168 DAMVNCFVE-GMPAPEVSWLYNGEYINTVNSTKHNRLSNGLYIRNVSQADAGEYTCRA-MRITP- 229

  Fly   259 KEHHNTTFTCQAQNTADRTYRSAKLLLEVKYAP--------KVIVSVVGGALAGGKIPEGAEVIL 315
                  ||:...|.|         :||.:::.|        .|..:.||||           |.|
  Fly   230 ------TFSDSDQIT---------ILLRIQHKPHWFFNETLPVQYAYVGGA-----------VNL 268

  Fly   316 SCQADANPHELSYRWFINDELMTG--------DF--TTKMIIHNVSRQYHDAIVKCEVVNAVGKS 370
            ||.|...|.. |:.|..|::.:.|        |:  |.::.:.|.| |:.|  .||:|.|.:|..
  Fly   269 SCDAMGEPPP-SFTWLHNNKGIVGFNHRIFVADYGATLQLQMKNAS-QFGD--YKCKVANPLGML 329

  Fly   371 EQSKKL 376
            |:..||
  Fly   330 ERVIKL 335

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kirre	NP_001245505.1	Ig	87..183	CDD:299845	21/101 (21%)
		IG_like	88..182	CDD:214653	21/99 (21%)
		C2-set_2	189..279	CDD:285423	23/102 (23%)
		Ig_2	307..379	CDD:290606	24/80 (30%)
		I-set	382..462	CDD:254352
		IGc2	396..446	CDD:197706
		Ig	466..561	CDD:299845
		IG_like	478..561	CDD:214653
CG33543	NP_001014458.3	IGc2	165..224	CDD:197706	14/59 (24%)
		IG_like	256..336	CDD:214653	29/95 (31%)
		IGc2	263..327	CDD:197706	23/78 (29%)
		FN3	341..445	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900