DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kirre and DIP-beta

DIOPT Version :9

Sequence 1:	NP_001245505.1	Gene:	kirre / 31292	FlyBaseID:	FBgn0028369	Length:	956	Species:	Drosophila melanogaster
Sequence 2:	NP_001138225.1	Gene:	DIP-beta / 33125	FlyBaseID:	FBgn0259245	Length:	555	Species:	Drosophila melanogaster

Alignment Length:	411	Identity:	93/411 - (22%)
Similarity:	157/411 - (38%)	Gaps:	110/411 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    85 AMEP------QDQTAVVGSRVTLPCRVMEKVGA-------------LQWTKDD----FGLGQHRN 126
            |.||      ::.|...|...|..| |:..:|.             :.|.|.|    ..:.:| .
  Fly    95 AFEPDFVIPLENVTIAQGRDATFTC-VVNNLGGHRVSGDGSSAPAKVAWIKADAKAILAIHEH-V 157

  Fly   127 LSGFERYSMVGSDEEGDFSLDIYPLMLDDDAKYQCQVGPGPQGEQGIRSRFAKLTVLVPPE-APK 190
            ::..:|.| |..::...::|:|..:.::|..||.|||...|     ::.:.|.|.|::||: ..:
  Fly   158 ITNNDRLS-VQHNDYNTWTLNIRGVKMEDAGKYMCQVNTDP-----MKMQTATLEVVIPPDIINE 216

  Fly   191 ITQGDYLVTTEDREIELECVSQGGKPAAEITWIDGLGNVLTKGIEYVKEPLADSRRITARS---- 251
            .|.||.:| .|....:|.|.:: |.|..:|||                 ...|.|.|.||:
  Fly   217 ETSGDMMV-PEGGSAKLVCRAR-GHPKPKITW-----------------RREDGREIIARNGSHQ 262

  Fly   252 ----------ILKLAPKKEHHNTTFTCQAQNTADRTYRSAKLLLEVKYAPKVIV--SVVGGALAG 304
                      :|.|:.........:.|.|.|....|. |.::.|:|.:.|.|.|  .:||.
  Fly   263 KTKAQSVEGEMLTLSKITRSEMGAYMCIASNGVPPTV-SKRMKLQVHFHPLVQVPNQLVGA---- 322

  Fly   305 GKIPEGAEVILSCQADANPHELSYRWFINDE-LMTGD-----------FTTKMIIHNVSRQYHD- 356
               |...:|.|.|..:|:|..::|....|.| ::.||           :..:||:|....|..|
  Fly   323 ---PVLTDVTLICNVEASPKAINYWQRENGEMIIAGDRYALTEKENNMYAIEMILHIKRLQSSDF 384

  Fly   357 AIVKCEVVNAVGKSEQSKKL-----------------DISFGPVFRQRPVSVEADLGATVSMRCD 404
            ...||...|::|.:|.:.:|                 ::|...|.::...|.:........:..|
  Fly   385 GGYKCISKNSIGDTEGTIRLYEMERPGKKILRDDDLNEVSKNEVVQKDTRSEDGSRNLNGRLYKD 449

  Fly   405 VAGNPEPEIEWISENSDQVVG 425
            .|.:..|     :..|||::|
  Fly   450 RAPDQHP-----ASGSDQLLG 465

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kirre	NP_001245505.1	Ig	87..183	CDD:299845	26/118 (22%)
		IG_like	88..182	CDD:214653	25/116 (22%)
		C2-set_2	189..279	CDD:285423	23/103 (22%)
		Ig_2	307..379	CDD:290606	22/101 (22%)
		I-set	382..462	CDD:254352	9/44 (20%)
		IGc2	396..446	CDD:197706	7/30 (23%)
		Ig	466..561	CDD:299845
		IG_like	478..561	CDD:214653
DIP-beta	NP_001138225.1	I-set	98..209	CDD:254352	26/118 (22%)
		ig	102..195	CDD:278476	21/95 (22%)
		IG_like	219..307	CDD:214653	24/107 (22%)
		Ig	221..307	CDD:299845	23/105 (22%)
		Ig	311..404	CDD:299845	26/99 (26%)
		IG_like	327..405	CDD:214653	20/77 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810