DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kirre and Kirrel3

DIOPT Version :9

Sequence 1:	NP_001245505.1	Gene:	kirre / 31292	FlyBaseID:	FBgn0028369	Length:	956	Species:	Drosophila melanogaster
Sequence 2:	XP_038937320.1	Gene:	Kirrel3 / 315546	RGDID:	1311382	Length:	869	Species:	Rattus norvegicus

Alignment Length:	823	Identity:	223/823 - (27%)
Similarity:	328/823 - (39%)	Gaps:	167/823 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    79 NGGQ--HFAMEPQDQTAVVGSRVTLPCRVMEKVGALQWTKDDFGLGQHRNLSGFERYSMVGSDEE 141
            |.||  .|:.:||||..|.|..|||.|.:.|..|.:.|.||...||..|:||.:.:|.:||:...
  Rat    43 NEGQVYSFSQQPQDQVVVSGQPVTLLCAIPEYDGFVLWIKDGLALGVGRDLSSYPQYLVVGNHLS 107

  Fly   142 GDFSLDIYPLMLDDDAKYQCQVGPGPQGEQGIRSRFAKLTVLVPPEAPKITQGDYLVTTEDREIE 206
            |:..|.|....|.|||.|:||.     .:..||||.|:|||||||:.|.|..|..:.......:.
  Rat   108 GEHHLKILRAELQDDAVYECQA-----IQAAIRSRPARLTVLVPPDDPIILGGPVISLRAGDPLN 167

  Fly   207 LECVSQGGKPAAEITWIDGLGNVLTKGIEYVKEPLADSRRITARSILKLAPKKEHHNTTFTCQAQ 271
            |.|.:...||||.|.|: ..|.|: .|..|.|..|.|.:|.:..|.|.::|....:..:..|:|.
  Rat   168 LTCHADNAKPAASIIWL-RKGEVI-NGATYSKTLLRDGKRESIVSTLFISPGDVENGQSIVCRAT 230

  Fly   272 NTADRTYRSAKLLLEVKYAPKVIVSVVGGALAGGKIPEGAEVILSCQADANPHELSYRWFINDEL 336
            |.|....:...:.:::::.|.|.:||....:....|     |...|.|.|||....|||.....:
  Rat   231 NKAIPGGKETSVTIDIQHPPLVNLSVEPQPVLEDNI-----VTFHCSAKANPAVTQYRWAKRGHI 290

  Fly   337 M----------TGDFTTKMIIHNVSRQYHDAIVKCEVVNAVGKSEQSKKLDISFGPVFRQRPVSV 391
            :          |.|:|           |....|.|||.||:|.:..|:.:|:.|||.....|.|:
  Rat   291 IKEASGELYRTTVDYT-----------YFSEPVSCEVTNALGSTNLSRTVDVYFGPRMTSEPQSL 344

  Fly   392 EADLGATVSMRCDVAGNPEPEIEWISENSDQVVGVAAELKLK-VSSETAGRYFCKAVVNGFPEIG 455
            ..|||:.....|...|||...|.|:...|..|:.....|.|| |..|.||:|.|:|||   |.:|
  Rat   345 LVDLGSDAVFSCAWIGNPSLTIVWMKRGSGVVLSNEKTLTLKSVRQEDAGKYVCRAVV---PRVG 406

  Fly   456 A---EATLYVKRAPIITSHKVQFGGVGGRVKIDCLAFSIPKAEHILWSFEGKIINMSSADPDIYI 517
            |   |.||.|...|||:|.:.|....|.:.:|.|...|.|..:.|.||::..:  :.|.....|.
  Rat   407 AGEREVTLTVNGPPIISSTQTQHALHGEKGQIKCFIRSTPPPDRIAWSWKENV--LESGTSGRYT 469

  Fly   518 FEEHHLPEGVRAALIIRDSKATHFGK-YNCTVMNSYGGDSLVITLLREPG------------NIP 569
            .|..:..|||.:.|.|.:.....|.. ||||..||:|.|:.:|. |:|.|            ::|
  Rat   470 VETVNTEEGVISTLTISNIVRADFQTIYNCTAWNSFGSDTEIIR-LKEQGSEMKSGAGLEAESVP 533

  Fly   570 VLLVVMGSMFCVAIILMIVMIIIVYRKRRSRKKPMPADVIPEASRGG-----DKLNELKSELR-S 628
            :.:::..::......|:::..|:.:...||::           |.||     .:..|.|:.|| .
  Rat   534 MAVIIGVAVGAGVAFLVLMATIVAFCCARSQR-----------STGGRPGISGRGTEQKARLRLP 587

  Fly   629 KAYDVEYSEAGGDGLAINLTQSPMPDVQMKGATLGVPLAGPVKFDERF-------SGDFGGDRYN 686
            :..:::...:..:.:.:.:....             |.:|....|...       .|:|..|...
  Rat   588 RRANLKGVVSAKNDIRVEIVHKE-------------PASGREAEDHTTIKQLMMDRGEFQQDSVL 639

  Fly   687 RQCHIKNLKNQQETAYKGSPQANGY-------AHYFEYALDYS--------------PPGGEGAA 730
            :|..:  ||.:::.........|||       .|:....:..|              |.|.....
  Rat   640 KQLEV--LKEEEKEFQNLKDPTNGYYSVNTFKEHHSTPTISLSSCQPDLRPTGKQRVPTGMSFTN 702

  Fly   731 VVVGSGGVGKLKNGGMNSATLPHSAAATVNGGGAGNGGGASLPRNQRHEIQQSQQSNGFLGQPLL 795
            :.....|.|:|.:.| .|.|...:||       |......||.|..|
  Rat   703 IYSTLSGQGRLYDYG-QSVTAASAAA-------ANKMATCSLTRPAR------------------ 741

  Fly   796 QNGIDSRFSAIYGNPYLRTNSSLLPPLP-PPSTANPAATPAPP 837
                                  |||||| .||......||..|
  Rat   742 ----------------------LLPPLPTTPSPLPRTPTPVDP 762

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kirre	NP_001245505.1	Ig	87..183	CDD:299845	40/95 (42%)
		IG_like	88..182	CDD:214653	39/93 (42%)
		C2-set_2	189..279	CDD:285423	26/89 (29%)
		Ig_2	307..379	CDD:290606	23/81 (28%)
		I-set	382..462	CDD:254352	32/83 (39%)
		IGc2	396..446	CDD:197706	18/50 (36%)
		Ig	466..561	CDD:299845	31/95 (33%)
		IG_like	478..561	CDD:214653	26/83 (31%)
Kirrel3	XP_038937320.1	IG_like	54..143	CDD:214653	39/93 (42%)
		Ig strand A'	56..60	CDD:409353	2/3 (67%)
		Ig strand B	64..71	CDD:409353	4/6 (67%)
		Ig strand C	78..82	CDD:409353	1/3 (33%)
		Ig strand C'	84..87	CDD:409353	0/2 (0%)
		Ig strand D	97..101	CDD:409353	1/3 (33%)
		Ig strand E	104..116	CDD:409353	3/11 (27%)
		Ig strand G	132..143	CDD:409353	6/10 (60%)
		IgI_2_KIRREL3-like	149..246	CDD:409416	26/98 (27%)
		Ig strand B	166..170	CDD:409416	1/3 (33%)
		Ig strand C	180..184	CDD:409416	1/3 (33%)
		Ig strand E	210..214	CDD:409416	2/3 (67%)
		Ig strand F	224..229	CDD:409416	1/4 (25%)
		Ig strand G	239..242	CDD:409416	0/2 (0%)
		Ig	<267..334	CDD:416386	22/77 (29%)
		Ig strand B	267..274	CDD:409353	2/6 (33%)
		Ig strand C	279..286	CDD:409353	3/6 (50%)
		Ig strand C'	288..291	CDD:409353	0/2 (0%)
		Ig strand D	298..302	CDD:409353	0/3 (0%)
		Ig strand E	304..310	CDD:409353	3/16 (19%)
		Ig strand G	321..334	CDD:409353	3/12 (25%)
		Ig	335..416	CDD:416386	32/83 (39%)
		Ig strand A'	343..347	CDD:409353	1/3 (33%)
		Ig strand B	350..360	CDD:409353	1/9 (11%)
		Ig strand C	365..371	CDD:409353	2/5 (40%)
		Ig strand E	381..387	CDD:409353	2/5 (40%)
		IgI_5_KIRREL3	418..515	CDD:409479	31/99 (31%)
		Ig strand B	436..440	CDD:409479	1/3 (33%)
		Ig strand C	450..454	CDD:409479	1/3 (33%)
		Ig strand E	481..485	CDD:409479	1/3 (33%)
		Ig strand F	496..501	CDD:409479	3/4 (75%)
		Ig strand G	509..512	CDD:409479	0/2 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166342403
Domainoid	1	1.000	87	1.000	Domainoid score	I7807
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	259	1.000	Inparanoid score	I3044
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D141865at33208
OrthoFinder	1	1.000	-	-		FOG0001084
OrthoInspector	1	1.000	-	-		mtm8946
orthoMCL	1	0.900	-	-		OOG6_103358
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1593
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.700