DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kirre and Igsf9b

DIOPT Version :9

Sequence 1:	NP_001245505.1	Gene:	kirre / 31292	FlyBaseID:	FBgn0028369	Length:	956	Species:	Drosophila melanogaster
Sequence 2:	NP_001363879.1	Gene:	Igsf9b / 315510	RGDID:	1564717	Length:	1441	Species:	Rattus norvegicus

Alignment Length:	1136	Identity:	214/1136 - (18%)
Similarity:	325/1136 - (28%)	Gaps:	476/1136 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly    87 EPQDQTAVVGSRVTLPCRVMEKVG------ALQWTKDDFGL-----------------------G 122
            ||:..||..|..|.|.|.|:..|.      .::|.|  ||:                       .
  Rat    29 EPEFVTARAGEGVVLRCDVIHPVTGQPPPYVVEWFK--FGVPIPIFIKFGYYPPHVDPEYAGRAS 91

  Fly   123 QHRNLSGFERYSMVGSDEEGDFSLDIYPLMLDDDAKYQCQVGPGPQGEQGIRSRFAKLTVLVPPE 187
            .|...|  .|...|.|:::|.:...:  ||||.            |.:......:..||:..||.
  Rat    92 LHDKAS--LRLEQVRSEDQGWYECKV--LMLDQ------------QYDTFHNGSWVHLTINAPPT 140

  Fly   188 APKITQGDYLVTTEDREIELECVSQGGKPAAEITWIDGLGNVLTKGIEYVKEPLADSRRITARSI 252
            ..: |...|:...|...|.:.|.: .|.|...:||:.. |.:|:...:|         :::..|:
  Rat   141 FTE-TPPQYIEAKEGGSITMTCTA-FGNPKPIVTWLKE-GTLLSASGKY---------QVSDGSL 193

  Fly   253 LKLAPKKEHHNTTFTCQAQNTADRTYRSAKLLLEVKYAPKVIVSVVGGALAGGKIPEGAEV---- 313
            ...:..:|... .:||:|.:.......:..||::   .|..|||.          ||...|
  Rat   194 TVTSVSREDRG-AYTCRAYSIQGEAVHTTHLLVQ---GPPFIVSP----------PENITVNISQ 244

  Fly   314 --ILSCQADANPHELSYRWFINDE--------------LMTGDFTTKMIIHNVSRQYHDA-IVKC 361
              :|:|:|:|.|..|:|.|:..||              |:.|    .:||..|..:  || ...|
  Rat   245 DALLTCRAEAYPGNLTYTWYWQDENVYFQNDLKLRVRILIDG----TLIIFRVKPE--DAGKYTC 303

  Fly   362 EVVNAVGKS-EQSKKLDISFG----------------------PVFRQ------------RPVSV 391
            ...|::|:| ..|..|.:.:.                      ||..:            ||:.|
  Rat   304 VPSNSLGRSPSASAYLTVQYPARVLNMPPVIYVPVGIHGYIRCPVDAEPPATVVKWNKDGRPLQV 368

  Fly   392 EADLGATV----SMR-------------------------------------------------- 402
            |.:||.|:    |:|
  Rat   369 EKNLGWTLMEDGSIRIEEATEEALGTYTCVPYNTLGTMGQSAPARLVLKDPPYFTVLPGWEYRQE 433

  Fly   403 --------CDVAGNPEPEIEWISENSDQVVGVAAELK-----------LKVSSETAGRYFCKA-- 446
                    |..||:|.|.|.|      :.||..:..|           ..:|.|..|.:.|.|
  Rat   434 AGRELLIPCAAAGDPFPVITW------RKVGKPSRSKHNALPSGSLQFRALSKEDHGEWECVATN 492

  Fly   447 ------------VVNGFPEI-----------------------GAEATLYVKRAPIITSHKVQFG 476
                        |:...|..                       |.|.|..|...|::  .:.|||
  Rat   493 VVTSITASTHLTVIGTSPHAPGSVRVHVSMTTANVSWEPGYDGGYEQTFSVWYGPLM--KRAQFG 555

  Fly   477 ----------------------------------------GVGGRVKIDCLAFSIPKAEHILW-- 499
                                                    .....|.::.|||.:...|.::.
  Rat   556 PHDWLSLSVPLGPSWLLVDSLEPETAYQFSVLAQNRLGTSAFSEVVTVNTLAFPVTTPEPLVLVT 620

  Fly   500 ---------SFEGKIINM-----SSADPDIYIFEEHHLPEGVRAALI---IRDSKATHFGK---- 543
                     :.:|.:::.     .|...|.||.|   ...|.|..::   |..:....|.|
  Rat   621 PPRCLTANRTQQGVLLSWLPPANHSFPIDRYIME---FRVGERWEMLDDAIPGTDGEFFAKDLSQ 682

  Fly   544 ---YNCTVMNSYGGDSLVITLLREPGNI---------------------PVLLVVMGSM-FCVAI 583
               |...|:      :::..|:.||.||                     |||..::.:: |..|.
  Rat   683 DTWYEFRVL------AVMQDLISEPSNIAGVSSTDIFPQPDLTDDGLARPVLAGIVATICFLAAA 741

  Fly   584 ILMIVMIIIVYRKRRSRKKPMPAD--------------------VIPEA-------SRGGD---- 617
            ||...:......|:|.||.....|                    |.||:       |...|
  Rat   742 ILFSTLAACFVNKQRKRKLKRKKDPPLSITHCRKSLESPLSSGKVSPESIRTLRAPSESSDDQGQ 806

  Fly   618 ----------KLNEL------KSELRSKAYDVEYSEA-------------GGDGLAINLTQSPMP 653
                      :..||      |..:.|:.|.|..:||             |.||..:.......|
  Rat   807 PAAKRMLSPTREKELSLYKKTKRAISSRKYSVAKAEAEAEATTPIELISRGPDGRFVMGPSEMEP 871

  Fly   654 DVQMKGATL-GVPLAGPVKFDERFSGDFGGDRYNRQ----CHIKNLKNQQETAYKGSPQANGYAH 713
            .|  ||..: |.|.|........|.   ..|..|..    ..:..||.|.      :|.::....
  Rat   872 SV--KGRRIEGFPFAEETDMYPEFR---QSDEENEDPLVPTSVAALKPQL------TPMSSSQDS 925

  Fly   714 YF---EYALDYSPPGGEGAAVVVGSGGVGKLKNGGMNSATLPHSAAATVNGGGAGNGGGASLPRN 775
            |.   .|:..:.|.|.||.     ||..|:|:..|  .|..|                   .||.
  Rat   926 YLPPPAYSPRFQPRGLEGP-----SGLGGRLQATG--QARPP-------------------APRP 964

  Fly   776 QRHEIQQSQQSNGFLGQ----PLLQNGIDSRFSAIYGNPYLRTNSSLLPPLPP------------ 824
            .:|.......|:...|:    |.....:.|..|::..:|.|.|......|..|
  Rat   965 FQHGQYYGYLSSSSPGEVEPPPFYMPEVGSPLSSVMSSPPLHTEGPFGHPTIPEENGENASNSTL 1029

  Fly   825 PSTANPAATPAPPPYHAARHGHAHHANGGLK 855
            |.|..|....:|.|:     |......|||:
  Rat  1030 PLTQTPTGGRSPEPW-----GRPEFPFGGLE 1055

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kirre	NP_001245505.1	Ig	87..183	CDD:299845	27/124 (22%)
		IG_like	88..182	CDD:214653	25/122 (20%)
		C2-set_2	189..279	CDD:285423	17/89 (19%)
		Ig_2	307..379	CDD:290606	26/93 (28%)
		I-set	382..462	CDD:254352	31/201 (15%)
		IGc2	396..446	CDD:197706	18/122 (15%)
		Ig	466..561	CDD:299845	22/160 (14%)
		IG_like	478..561	CDD:214653	18/108 (17%)
Igsf9b	NP_001363879.1	PHA03247	<898..1246	CDD:223021	40/195 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	918..1044		31/151 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1111..1332
		Ig	41..115	CDD:319273	15/77 (19%)
		I-set	139..225	CDD:369462	19/98 (19%)
		Ig	229..321	CDD:386229	29/107 (27%)
		Ig	<353..414	CDD:386229	9/60 (15%)
		Ig	438..502	CDD:319273	15/69 (22%)
		FN3	510..605	CDD:238020	10/96 (10%)
		FN3	621..703	CDD:238020	16/90 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	762..821		6/58 (10%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900