DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kirre and Fas2

DIOPT Version :9

Sequence 1:	NP_001245505.1	Gene:	kirre / 31292	FlyBaseID:	FBgn0028369	Length:	956	Species:	Drosophila melanogaster
Sequence 2:	NP_001284854.1	Gene:	Fas2 / 31364	FlyBaseID:	FBgn0000635	Length:	885	Species:	Drosophila melanogaster

Alignment Length:	969	Identity:	194/969 - (20%)
Similarity:	309/969 - (31%)	Gaps:	334/969 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    91 QTAVVGSRVTLPCR--VMEK--VGALQWTKDDFGLGQHRN------LSGFERYSMVGSDEEGD-F 144
            |...||..:.|.||  |.|.  |..||| ||      :||      .:|..:..|......|: .
  Fly    42 QRKPVGKPLILTCRPTVPEPSLVADLQW-KD------NRNNTILPKPNGRNQPPMYTETLPGESL 99

  Fly   145 SLDIYPLMLDDDAKYQCQVGPGPQG--EQGIRSR-FAKLTVLVPPEAPKITQG-DYLVTTEDREI 205
            :|.|..|.::...||.|........  |:|:..: :..:|....||....|.| ||:|..|.:
  Fly   100 ALMITSLSVEMGGKYYCTASYANTEILEKGVTIKTYVAITWTNAPENQYPTLGQDYVVMCEVK-- 162

  Fly   206 ELECVSQGGKPAAEITWIDGLGNVLTKGIEYVKEPLADSRRITARSILKLAPKKEHHNTTFTCQA 270
                    ..|...|.|:.....:.|...:||    ..:..:..|::      :|.....:||:|
  Fly   163 --------ADPNPTIDWLRNGDPIRTTNDKYV----VQTNGLLIRNV------QESDEGIYTCRA 209

  Fly   271 Q-----NTADRTYRSAKLLLEVKYAPKVIVSVVGGALAGGKIP------EGAEVILSCQADANP- 323
            .     ...:||.|     :||...|::|           .:|      ||.....:|.|...|
  Fly   210 AVIETGELLERTIR-----VEVFIQPEII-----------SLPTNLEAVEGKPFAANCTARGKPV 258

  Fly   324 HELSYRWF-----IN----DELMTGDFTTKMIIHNVSRQYHDAIVKCEVVNAVGKSEQSKKLDIS 379
            .|:|  |.     :|    |.......|..:.|.:||:..:.... |...|..|..:|..||::.
  Fly   259 PEIS--WIRDATQLNVATADRFQVNPQTGLVTISSVSQDDYGTYT-CLAKNRAGVVDQKTKLNVL 320

  Fly   380 FGPVFRQRPVSVEADLGATVSMRCDVAGNPEPEI---EW------------------ISENSDQV 423
            ..|...:. .:|.......:::.|...|.|.|.|   .|                  :..|.|:.
  Fly   321 VRPQIYEL-YNVTGARTKEIAITCRAKGRPAPAITFRRWGTQEEYTNGQQDDDPRIILEPNFDEE 384

  Fly   424 VGVAAELKLKVSS---ETAGRYFCKAVVNGFPEIGAEA----TLYVKRAPIITSHKVQ----FGG 477
            .|.:.. .|::|:   ...|.|.|.|     ...||:|    .:.|:.||.. ||..:    |..
  Fly   385 RGESTG-TLRISNAERSDDGLYQCIA-----RNKGADAYKTGHITVEFAPDF-SHMKELPPVFSW 442

  Fly   478 VGGRVKIDCLAFSIPKAEHILWSFEGKIINMSSADPDIYIFEEHHLPEGVRAALIIRDSKATHFG 542
            ...:..:.|||..||.|. |.|.:.|:.|.      |:|......:..|.|:.||:......::.
  Fly   443 EQRKANLSCLAMGIPNAT-IEWHWNGRKIK------DLYDTNLKIVGTGPRSDLIVHPVTRQYYS 500

  Fly   543 KYNCTVMNSYGGDSLVITLLREPGNIPVLLVVMGSMFCVAIILMIVMIIIVYRKRRSRKKP---- 603
            .|.|...|.:|.....:.|  :...:|..:                          |..||
  Fly   501 GYKCIATNIHGTAEHDMQL--KEARVPDFV--------------------------SEAKPSQLT 537

  Fly   604 ---MPADVIPEASRGGDKLNELKSELRSKAYDVEYSEAGGD--GLAINLTQSPMPDVQMKGATLG 663
               |..|:...::..|         |...||.|:|.||...  ..|.|.:.||.....::|
  Fly   538 ATTMTFDIRGPSTELG---------LPILAYSVQYKEALNPDWSTAYNRSWSPDSPYIVEG---- 589

  Fly   664 VPLAGPVKFDERFS-------GDFGGDRYNRQCHIKNLKNQQETAYKGSPQ-------------- 707
              |....::..||:       |::|            :..||.|..:.:|:
  Fly   590 --LRPQTEYSFRFAARNQVGLGNWG------------VNQQQSTPRRSAPEEPKPLHNPVQHDKE 640

  Fly   708 ----ANGYAHYFE---------------YALDYSPPGGEGAAVVVGSGGVGKLKNGGMNSATLPH 753
                .:.|:.:||               |.:.|.|    |..:   ||...:|:| ..|:..:..
  Fly   641 EPVVVSPYSDHFELRWGVPADNGEPIDRYQIKYCP----GVKI---SGTWTELEN-SCNTVEVME 697

  Fly   754 SAAATVN---GG-------GAGNGGGASLPRN--------------QRHEIQQSQQSNGF-LGQP 793
            :.:..:.   |.       .|.|..|.|.|.:              ...::..|....|. :|..
  Fly   698 TTSFEMTQLVGNTYYRIELKAHNAIGYSSPASIIMKTTRGIDVIQVAERQVFSSAAIVGIAIGGV 762

  Fly   794 LL-------------QNGI-----------------DSRFSAIYG----NPYLRTNSSLLPPLPP 824
            ||             ..|:                 :::..::||    .||.   |..|...||
  Fly   763 LLLLFVVDLLCCITVHMGVMATMCRKAKRSPSEIDDEAKLGSLYGWRFPLPYC---SGQLVKEPP 824

  Fly   825 PSTANPAATPAPPPYHAARHGHAHHANGGLKHFVGGAVITT---------SPVGNVNIN 874
            ||     ..|.|||..                 :||:.::|         :|.|::..|
  Fly   825 PS-----PLPLPPPVK-----------------LGGSPMSTPLDEKEPLRTPTGSIKQN 861

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kirre	NP_001245505.1	Ig	87..183	CDD:299845	28/105 (27%)
		IG_like	88..182	CDD:214653	27/104 (26%)
		C2-set_2	189..279	CDD:285423	19/95 (20%)
		Ig_2	307..379	CDD:290606	21/87 (24%)
		I-set	382..462	CDD:254352	20/107 (19%)
		IGc2	396..446	CDD:197706	14/73 (19%)
		Ig	466..561	CDD:299845	24/98 (24%)
		IG_like	478..561	CDD:214653	20/82 (24%)
Fas2	NP_001284854.1	IG_like	39..133	CDD:214653	27/97 (28%)
		IG_like	144..226	CDD:214653	22/106 (21%)
		IGc2	152..209	CDD:197706	15/76 (20%)
		I-set	230..319	CDD:254352	23/102 (23%)
		IGc2	243..309	CDD:197706	16/68 (24%)
		IG_like	330..424	CDD:214653	19/99 (19%)
		IGc2	339..412	CDD:197706	15/78 (19%)
		Ig	447..518	CDD:143165	20/77 (26%)
		fn3	534..611	CDD:278470	19/91 (21%)
		FN3	640..735	CDD:238020	18/102 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810