DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kirre and Igsf9

DIOPT Version :9

Sequence 1:	NP_001245505.1	Gene:	kirre / 31292	FlyBaseID:	FBgn0028369	Length:	956	Species:	Drosophila melanogaster
Sequence 2:	NP_001100667.1	Gene:	Igsf9 / 304982	RGDID:	1304566	Length:	1179	Species:	Rattus norvegicus

Alignment Length:	849	Identity:	169/849 - (19%)
Similarity:	254/849 - (29%)	Gaps:	319/849 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    96 GSRVTLPCRVMEKVG-----ALQWTKDDFGLGQHRNLSGFERYSMVGSDEEGDF----------S 145
            |....|.|.::...|     .::|.:  ||.    .|..|.::.:.....:.|:          |
  Rat    34 GESAVLGCDLLPPAGRPPLHVIEWLR--FGF----LLPIFIQFGLYSPRIDPDYVGRVRLQTGAS 92

  Fly   146 LDIYPLMLDDDAKYQCQV------GPGPQGEQGIRSRFAKLTVLVPP---EAPKITQGDYLVTTE 201
            |.|..|.::|...|:|:|      .|......|   .:..|||..||   |.|.:.    |...|
  Rat    93 LQIEGLRVEDQGWYECRVLFLDQHSPEQDFANG---SWVHLTVNSPPQFQETPPLV----LEVKE 150

  Fly   202 DREIELECVSQGGKPAAEITWI-------DGLGNV-LTKGIEYVKEPLADSRRITARSILKLAPK 258
            ...:.|.||:. |.|...:||.       .|.|.| :..|..::       ||:...|.
  Rat   151 LEAVTLRCVAL-GSPQPYVTWKFRGQDLGKGQGQVQVRNGTLWI-------RRVERGSA------ 201

  Fly   259 KEHHNTTFTCQAQNTADRTYRSAKLLLEVKYAPKVIVSVVGGALAGGKIPEGAEVILSCQADANP 323
                 ..:||||.:|......:.:||:   ..|.|||....    ...:....:|.|:|:|:|.|
  Rat   202 -----GDYTCQASSTEGSVTHTTQLLV---LGPPVIVVPPN----NNTVNASQDVSLACRAEAYP 254

  Fly   324 HELSYRWFINDELMTGDFTTKMIIHNVSRQYHDAIVKCEVVNAVGKSEQSKKLDISFGPVFRQRP 388
            ..|:|.|          |..::.:.::||.                  ||           |.|
  Rat   255 ANLTYSW----------FQDRINVFHISRL------------------QS-----------RVR- 279

  Fly   389 VSVEADLGATVSMRCDVAGNPEPEIEWISENSDQVVGVAAELKLKVSSETAGRYFCKAVVNGFPE 453
            :.|:..|                   |:.               ....:.||.|.| ...||||.
  Rat   280 ILVDGSL-------------------WLQ---------------ATQPDDAGHYTC-VPSNGFPH 309

  Fly   454 -----------IGAEATLYVKRAPIITSHKVQFGGVGGRVKIDCLAFSIPKAEHILWSFEGKIIN 507
                       ..|:.|:.....|:         .:|.|..|.|...:.|....:.|:.:|:.:.
  Rat   310 PPSASAYLTVLYPAQVTVMPPETPL---------PIGMRGVIRCPVRANPPLLFVTWTKDGQALQ 365

  Fly   508 MSSADPDIYIFEEHHL-PEGVRAALIIRDSKATHFGKYNCTVMNSYGGDSLVITLLREPGNIPVL 571
            :..       |....| |||   :|:|........|:|:||..||.|          ..|:.||.
  Rat   366 LDK-------FPGWSLGPEG---SLVIALGNEDALGEYSCTPYNSLG----------TAGSSPVT 410

  Fly   572 LVVMGSMFCVAIILMIVMIIIVYRKRRSRKKPMPADVIPEASRGGDKLNELKSELRSKAYDVEYS 636
            .|::                          |..||.:        |:..|            ||.
  Rat   411 RVLL--------------------------KAPPAFI--------DQPKE------------EYF 429

  Fly   637 EAGGDGLAINLTQSPMPDVQMKGATLGVPLAGPVKFDERFSGDFGGDRYNRQCHIKNLKNQQETA 701
            :..|..|.|..:....|...:..|.:|..|.|..:.|.           |....::.|..:....
  Rat   430 QEVGRDLLIPCSARGDPPPIVSWAKVGRGLQGQAQVDS-----------NNSLILRPLTKEAHGR 483

  Fly   702 YKGSPQANGYAHYF----EYALDYSPPGGEGAAVVVGSGGVGKLKNGGMNSATLPHSAAATVNGG 762
            ::.|.: |..||..    .|.|..||      .||.             |.:.:|....|.|:..
  Rat   484 WECSAR-NAVAHVTISTNVYVLGTSP------HVVT-------------NVSVVPLPKGANVSWE 528

  Fly   763 GAGNGGG-----------ASLPRNQRHEIQQSQQSNG--FLGQPLLQNGIDSRFSAIYGN----- 809
            ...:||.           |..|....|:........|  .|..|.||.....:||.:..|
  Rat   529 PGFDGGYLQRFSVWYTPLAKRPDRAHHDWVSLAVPMGATHLLVPGLQAYTQYQFSVLAQNKLGSG 593

  Fly   810 PYLRTNSSL---------LPPLPPPSTANPAATPAPPPYHAARHGHAHHANGGLKHFVGGAVITT 865
            |:.....|:         :|.|||        |..|||....|                |.|...
  Rat   594 PFSEIVLSIPEGLPTTPAVPRLPP--------TEMPPPLSPPR----------------GLVAVR 634

  Fly   866 SPVG 869
            :|.|
  Rat   635 TPRG 638

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kirre	NP_001245505.1	Ig	87..183	CDD:299845	22/107 (21%)
		IG_like	88..182	CDD:214653	21/106 (20%)
		C2-set_2	189..279	CDD:285423	22/97 (23%)
		Ig_2	307..379	CDD:290606	14/71 (20%)
		I-set	382..462	CDD:254352	15/90 (17%)
		IGc2	396..446	CDD:197706	5/49 (10%)
		Ig	466..561	CDD:299845	22/95 (23%)
		IG_like	478..561	CDD:214653	21/83 (25%)
Igsf9	NP_001100667.1	IG	28..110	CDD:214652	17/81 (21%)
		Ig strand A	136..139	CDD:409353	1/2 (50%)
		IG_like	143..223	CDD:214653	22/102 (22%)
		Ig strand A'	145..148	CDD:409353	1/6 (17%)
		Ig strand B	154..161	CDD:409353	3/6 (50%)
		Ig strand C	167..172	CDD:409353	2/4 (50%)
		Ig strand C'	175..177	CDD:409353	0/1 (0%)
		Ig strand D	183..187	CDD:409353	1/3 (33%)
		Ig strand E	189..193	CDD:409353	1/3 (33%)
		Ig strand F	202..210	CDD:409353	4/7 (57%)
		Ig strand G	213..223	CDD:409353	1/9 (11%)
		Ig_3	226..305	CDD:404760	27/157 (17%)
		putative Ig strand A	226..230	CDD:409353	2/3 (67%)
		putative Ig strand A'	235..239	CDD:409353	0/3 (0%)
		putative Ig strand B	241..251	CDD:409353	3/9 (33%)
		putative Ig strand C'	267..270	CDD:409353	0/2 (0%)
		putative Ig strand D	279..282	CDD:409353	1/3 (33%)
		putative Ig strand E	284..290	CDD:409353	2/39 (5%)
		putative Ig strand F	297..305	CDD:409353	3/8 (38%)
		putative Ig strand G	310..319	CDD:409353	0/8 (0%)
		Ig	322..407	CDD:416386	25/113 (22%)
		Ig strand A'	324..328	CDD:409353	1/3 (33%)
		Ig strand B	333..347	CDD:409353	5/22 (23%)
		Ig strand C	353..359	CDD:409353	1/5 (20%)
		Ig strand C'	362..364	CDD:409353	0/1 (0%)
		Ig strand D	371..374	CDD:409353	0/2 (0%)
		Ig strand E	378..382	CDD:409353	2/6 (33%)
		Ig strand F	391..399	CDD:409353	4/7 (57%)
		Ig	418..503	CDD:416386	21/116 (18%)
		Ig strand A	418..421	CDD:409353	2/2 (100%)
		Ig strand A'	427..430	CDD:409353	2/2 (100%)
		Ig strand B	436..443	CDD:409353	2/6 (33%)
		Ig strand C	449..454	CDD:409353	0/4 (0%)
		Ig strand C'	457..459	CDD:409353	0/1 (0%)
		Ig strand D	462..466	CDD:409353	0/3 (0%)
		Ig strand E	469..473	CDD:409353	0/3 (0%)
		Ig strand F	482..490	CDD:409353	1/8 (13%)
		Ig strand G	493..503	CDD:409353	2/9 (22%)
		FN3	508..599	CDD:238020	21/109 (19%)
		FN3	625..715	CDD:238020	5/30 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	766..807
		PHA03247	<777..1062	CDD:223021
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	819..846
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	869..895
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	942..979
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1016..1079
		PDZ-binding. /evidence=ECO:0000250	1177..1179
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900