DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kirre and Ncam2

DIOPT Version :9

Sequence 1:	NP_001245505.1	Gene:	kirre / 31292	FlyBaseID:	FBgn0028369	Length:	956	Species:	Drosophila melanogaster
Sequence 2:	NP_981954.2	Gene:	Ncam2 / 288280	RGDID:	1303131	Length:	837	Species:	Rattus norvegicus

Alignment Length:	502	Identity:	111/502 - (22%)
Similarity:	189/502 - (37%)	Gaps:	96/502 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    95 VGSRVTLPCRVMEKVGALQWTKDDFGLGQHRNLSGFERYSMVGSDEEGDFS-LDIYPLMLDDDAK 158
            ||......|..:.:..::.|...     |...:...:|..:   .:||..| |.||...::|...
  Rat    34 VGESKFFTCTAIGEPESIDWYNP-----QGEKIISTQRVML---QKEGVRSRLTIYNANIEDAGI 90

  Fly   159 YQCQVGPG---PQGEQGIRSRFAKLT---VLVPPEAPKITQGDYLVTTEDREIELECVSQGGKPA 217
            |:||....   .|....:...:.|||   ||.|.|   ..||      ||.|:.....|   .||
  Rat    91 YRCQATDAKGQTQEATVVLEIYQKLTFREVLSPQE---FKQG------EDAEVVCRVSS---SPA 143

  Fly   218 AEITWIDGLGNVLTKGIEYVKEPLADSR-RITARSILKLAPKKEHHNTTFTCQAQNTADRTYRSA 281
            ..::|:.....|.|         :.|:| .:.|.:.|::....:.....:.|:.:..|.......
  Rat   144 PAVSWLYHNEEVTT---------IPDNRFAVLANNNLQILNINKSDEGIYRCEGRVEARGEIDFR 199

  Fly   282 KLLLEVKYAPKVIVSVVG-GALAGGKIPEGAEVILSCQADANPHELSYRWFINDELMTGD----- 340
            .:::.|...|.:::.... .|.|    ..|.|:.|:|:|..:| :.:..||.|.:|:..:
  Rat   200 DIIVIVNVPPAIVMPQKSFNATA----ERGEEMTLTCKASGSP-DPAISWFRNGKLIEENEKYIL 259

  Fly   341 --FTTKMIIHNVSRQYHDAIVKCEVVNAVGKSEQSKKLDISFGPVFRQRPVSVEADLGATVSMRC 403
              ..|::.:.|:..:...:.| |:..|..|:.::...|.:...|...|......::.| .|::.|
  Rat   260 KGSNTELTVRNIINKDGGSYV-CKATNKAGEDQKQAFLQVFVQPHILQLKNETTSENG-HVTLIC 322

  Fly   404 DVAGNPEPEIEW--------ISENSDQVVGVAAELK------------LKVSSETAGRYFCKAVV 448
            :..|.|.|||.|        .||......| ..|:|            :|:|.  :|||.|:|.
  Rat   323 EAEGEPVPEITWKRAIDGVTFSEGDKSPDG-RIEVKGQHGRSSLHIRDVKLSD--SGRYDCEAA- 383

  Fly   449 NGFPEIGAEAT---LYVKRAP-IITSHKVQFGGVGGRVKIDCLAFSIPKAEHILWSFEGKIINMS 509
               ..||....   |.::.|| .:::..:.:...|..:.|.|...:.|.|. |.|..|..::...
  Rat   384 ---SRIGGHQRSMHLDIEYAPKFVSNQTMYYSWEGNPINISCDVKANPPAS-IHWRREKLVLPAK 444

  Fly   510 SADPDIYIFEEHHLPE---GVRAALIIRDSKATHFGKYNCTVMNSYG 553
            :..         ||..   |.:..|.|..:....||:||||..|..|
  Rat   445 NTT---------HLKTHSVGRKMILEIAPTSDNDFGRYNCTATNRIG 482

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kirre	NP_001245505.1	Ig	87..183	CDD:299845	20/94 (21%)
		IG_like	88..182	CDD:214653	20/93 (22%)
		C2-set_2	189..279	CDD:285423	17/90 (19%)
		Ig_2	307..379	CDD:290606	17/78 (22%)
		I-set	382..462	CDD:254352	26/102 (25%)
		IGc2	396..446	CDD:197706	20/69 (29%)
		Ig	466..561	CDD:299845	22/92 (24%)
		IG_like	478..561	CDD:214653	21/79 (27%)
Ncam2	NP_981954.2	IgI_1_NCAM-2	21..113	CDD:409452	17/86 (20%)
		Ig strand B	38..42	CDD:409452	0/3 (0%)
		Ig strand C	50..54	CDD:409452	0/3 (0%)
		Ig strand E	76..80	CDD:409452	2/3 (67%)
		Ig strand F	90..95	CDD:409452	2/4 (50%)
		Ig strand G	104..107	CDD:409452	0/2 (0%)
		IGc2	128..189	CDD:197706	16/78 (21%)
		Ig strand B	130..139	CDD:409353	3/8 (38%)
		Ig strand C	145..153	CDD:409353	1/7 (14%)
		Ig strand C'	156..159	CDD:409353	1/11 (9%)
		Ig strand D	162..167	CDD:409353	1/4 (25%)
		Ig strand E	168..175	CDD:409353	1/6 (17%)
		IgI_1_MuSK	209..298	CDD:409562	20/94 (21%)
		Ig strand B	228..232	CDD:409562	1/3 (33%)
		Ig strand C	241..245	CDD:409562	0/3 (0%)
		Ig strand E	264..268	CDD:409562	1/3 (33%)
		Ig strand F	278..283	CDD:409562	2/5 (40%)
		Ig strand G	291..294	CDD:409562	0/2 (0%)
		Ig	300..397	CDD:416386	26/104 (25%)
		Ig strand A	300..305	CDD:409353	1/4 (25%)
		Ig strand A'	309..313	CDD:409353	0/3 (0%)
		Ig strand B	317..325	CDD:409353	2/7 (29%)
		Ig strand C	331..337	CDD:409353	3/5 (60%)
		Ig strand C'	340..343	CDD:409353	0/2 (0%)
		Ig strand D	353..359	CDD:409353	2/5 (40%)
		Ig strand E	362..368	CDD:409353	0/5 (0%)
		Ig strand F	376..384	CDD:409353	5/11 (45%)
		Ig strand G	387..397	CDD:409353	2/9 (22%)
		Ig_3	401..479	CDD:404760	20/87 (23%)
		Ig strand B	418..422	CDD:409353	1/3 (33%)
		Ig strand C	431..435	CDD:409353	1/4 (25%)
		Ig strand E	458..462	CDD:409353	1/3 (33%)
		Ig strand F	472..477	CDD:409353	3/4 (75%)
		Ig strand G	486..489	CDD:409353
		FN3	496..588	CDD:238020
		fn3	594..678	CDD:394996
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810