DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kirre and NEGR1

DIOPT Version :9

Sequence 1:	NP_001245505.1	Gene:	kirre / 31292	FlyBaseID:	FBgn0028369	Length:	956	Species:	Drosophila melanogaster
Sequence 2:	NP_776169.2	Gene:	NEGR1 / 257194	HGNCID:	17302	Length:	354	Species:	Homo sapiens

Alignment Length:	321	Identity:	69/321 - (21%)
Similarity:	125/321 - (38%)	Gaps:	66/321 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    96 GSRVTLPCRVMEKVGALQWTKDDFGLGQHRNLS-----GFERYSM-----VGSDEEGDFSLDIYP 150
            |....|.|          :.:|....|...|.|     |.:::|:     :.:..:.|:||.|..
Human    53 GDTAVLRC----------YLEDGASKGAWLNRSSIIFAGGDKWSVDPRVSISTLNKRDYSLQIQN 107

  Fly   151 LMLDDDAKYQCQVGPGPQGEQGIRSRFAKLTVLVPPEAPKITQGDYLVTTEDREIELECVSQGGK 215
            :.:.||..|.|.|    |.:...|:....|||.|||:...|:..  :...|...:.|.|::. ||
Human   108 VDVTDDGPYTCSV----QTQHTPRTMQVHLTVQVPPKIYDISND--MTVNEGTNVTLTCLAT-GK 165

  Fly   216 PAAEITWIDGLGNVLTKGIEYVKEPLADSRRITARSILKLAPKKEHHNTTFTCQAQNTADRTYRS 280
            |...|:|         :.|....:|..:.:.:....|.:      .....:.|.|:|  |.::..
Human   166 PEPSISW---------RHISPSAKPFENGQYLDIYGITR------DQAGEYECSAEN--DVSFPD 213

  Fly   281 A-KLLLEVKYAPKVIVSVVGGALAGGKIPEGAEVILSCQADANPHELSYRWFIND-ELMTG---- 339
            . |:.:.|.:||.:      ..:..|.:..|...::.|:....|.. ::.|:..: :|..|
Human   214 VRKVKVVVNFAPTI------QEIKSGTVTPGRSGLIRCEGAGVPPP-AFEWYKGEKKLFNGQQGI 271

  Fly   340 ---DFTTKMI--IHNVSRQYHDAIVKCEVVNAVGKSEQSKKLDISFGPVFRQRPVSVEADL 395
               :|:|:.|  :.||: |.|.....|...|.:|.:..|..|:   .|...|..::..||:
Human   272 IIQNFSTRSILTVTNVT-QEHFGNYTCVAANKLGTTNASLPLN---PPSTAQYGITGSADV 328

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kirre	NP_001245505.1	Ig	87..183	CDD:299845	22/96 (23%)
		IG_like	88..182	CDD:214653	21/95 (22%)
		C2-set_2	189..279	CDD:285423	16/89 (18%)
		Ig_2	307..379	CDD:290606	18/81 (22%)
		I-set	382..462	CDD:254352	4/14 (29%)
		IGc2	396..446	CDD:197706	69/321 (21%)
		Ig	466..561	CDD:299845
		IG_like	478..561	CDD:214653
NEGR1	NP_776169.2	IG	47..135	CDD:214652	21/95 (22%)
		IGc2	152..210	CDD:197706	15/75 (20%)
		Ig_3	225..301	CDD:372822	16/83 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810