DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kirre and Ncam1

DIOPT Version :9

Sequence 1:	NP_001245505.1	Gene:	kirre / 31292	FlyBaseID:	FBgn0028369	Length:	956	Species:	Drosophila melanogaster
Sequence 2:	XP_038936733.1	Gene:	Ncam1 / 24586	RGDID:	67378	Length:	1136	Species:	Rattus norvegicus

Alignment Length:	1084	Identity:	223/1084 - (20%)
Similarity:	361/1084 - (33%)	Gaps:	319/1084 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    95 VGSRVTLPCRVMEKVGALQWTKDDF------GLGQHRNLSGF-----------ERYSMVGSDEEG 142
            :|:.|:|...::...|.:...:..|      |..:.:::|.|           :|.|:|.:|::.
  Rat    14 LGTAVSLQVDIVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLSPNQQRISVVWNDDDS 78

  Fly   143 DFSLDIYPLMLDDDAKYQCQV--GPGPQGEQGIRSR-FAKLTVLVPPEAPKITQGDYLVTTEDRE 204
            . :|.||...:||...|:|.|  ..|.|.|..:..: |.||.....|...:..:|      ||..
  Rat    79 S-TLTIYNANIDDAGIYKCVVTAEDGTQSEATVNVKIFQKLMFKNAPTPQEFKEG------EDAV 136

  Fly   205 IELECVSQGGKPAAEITWIDGLGNVLTKGIEYVKEPLADSRRITARSILKLAPKKEHHNTTFTCQ 269
            |..:.||  ..|...|....|...:|.|.:.::         :.:.:.|::...|:....|:.|:
  Rat   137 IVCDVVS--SLPPTIIWKHKGRDVILKKDVRFI---------VLSNNYLQIRGIKKTDEGTYRCE 190

  Fly   270 AQNTA--DRTYRSAKLLLEVKYAPKVIVSVVGGALAGGKIPEGAEVILSCQADANPHELSYRWFI 332
            .:..|  :..::..::::.|....:...|:|......|:     .|.|.|.||..| |.:..|..
  Rat   191 GRILARGEINFKDIQVIVNVPPTVQARQSIVNATANLGQ-----SVTLVCDADGFP-EPTMSWTK 249

  Fly   333 NDELMT-----------GDFTTKMIIHNVSRQYHDAIVKCEVVNAVGKSEQSKKLDISFGPVFRQ 386
            :.|.:.           .|.::::.|.||.:. .:|...|...|..|:.:.|..|.:...|....
  Rat   250 DGEPIENEEEDDEKHIFSDDSSELTIRNVDKN-DEAEYVCIAENKAGEQDASIHLKVFAKPKITY 313

  Fly   387 RPVSVEADLGATVSMRCDVAGNPEPEIEW------IS----------ENSDQVVG-VAAELKLKV 434
            .......:|...|::.|:.:|:|.|.|.|      ||          |..:.:.| :......:|
  Rat   314 VENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARV 378

  Fly   435 SSET--------AGRYFCKAVVNGFPEIGAEATLYVKRAPIITSHKVQFGGVGGRVKIDCLAFSI 491
            ||.|        ||.|.|.| .|...:......|.|:.||.:......:...|.:|.|.|..|:.
  Rat   379 SSLTLKSIQYTDAGEYICTA-SNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAY 442

  Fly   492 PKAEHILWSFEGKIINMSSADPDIYIFEEHHLPEGVRAALIIRDSKATHFGKYNCTVMNSYGGDS 556
            |.|. |.|..:|::: .||...:|.|:   :.|..  :.|.:.......||.||||.:|..|.:|
  Rat   443 PSAT-ISWFRDGQLL-PSSNYSNIKIY---NTPSA--SYLEVTPDSENDFGNYNCTAVNRIGQES 500

  Fly   557 LVITLLR-EPGNIPVLLVVMGSMFCVAIILMIVMIIIVYRKRRSRKKPMPADV-----IPEASRG 615
            |...|:: :..:.|.:                           .|.:|..:..     .|||: |
  Rat   501 LEFILVQADTPSSPSI---------------------------DRVEPYSSTAQVQFDEPEAT-G 537

  Fly   616 GDKLNELKSELR--------SKAYDVEYSEAGGDGLAINLTQSPMPDVQMKGATLG--------- 663
            |..:.:.|:|.:        ||.||.:  ||..:|:...:...|.....::.|.|.
  Rat   538 GVPILKYKAEWKSLGEEAWHSKWYDAK--EANMEGIVTIMGLKPETRYAVRLAALNGKGLGEISA 600

  Fly   664 ------VPLAGPVKFDE----RFSGDFGGDRYNRQCHIK-NLKNQQETAYKGSPQANGYAHYF-- 715
                  .|:..|....|    :..|..|.|..:    || ||..|.:   .|||    ..||.
  Rat   601 ATEFKTQPVHSPPPQGEPSAPKLEGQMGEDGNS----IKVNLIKQDD---GGSP----IRHYLVK 654

  Fly   716 ---EYALDYSP----PGG-------------EGAAVVVGSGGVGKLKNGGMNSATLPHSAAATVN 760
               :.|.::.|    |.|             |....||.....||.|.......|.....|...|
  Rat   655 YRAKLASEWKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQGKSKAAHFVFRTSAQPTAIPAN 719

  Fly   761 G-----------------------------------------------GGAGNG--------GGA 770
            |                                               |.||.|        |.|
  Rat   720 GSPTAGLSTGAIVGILIVIFVLLLVVMDITCYFLNKCGLLMCIAVNLCGKAGPGAKGKDMEEGKA 784

  Fly   771 SLPRNQ--------RHEIQQSQQSNGF----------LGQPLL---------------------Q 796
            :..:::        |.|.:::...:|.          |.:|.|                     .
  Rat   785 AFSKDESKEPIVEVRTEEERTPNHDGGKHTEPNETTPLTEPELPADTTATVEDMLPSVTTVTTNS 849

  Fly   797 NGIDSRFSAIYGNPYLRT---NSSLLPPLP--PPSTANPA--ATP--------APPPYHAARHG- 845
            :.|...|:....:|...|   .||:.||..  |.|.:.||  |||        :.||....:..
  Rat   850 DTITETFATAQNSPTSETTTLTSSIAPPATTVPESNSVPAGQATPSKGVTASSSSPPASVPKVAP 914

  Fly   846 ---------HAHHANGGLKHFV---GGAVITTSPVGNVNINGGGGGGS--------TPSGGGGVG 890
                     .|..|| .|...|   .|||::.|...:..........|        ||:|.....
  Rat   915 LVDLSDTPTSAPSAN-NLSSTVLANQGAVLSPSTPASAGETSKVPATSKPSPTPTPTPAGAASPL 978

  Fly   891 VGVAAGGSVSGSSSNLTASSNTLAATPLAGGGVGNSGQCAQSPS 934
            ..|||..:.:..:.....|:..|...|...|.|.|..:.|.:|:
  Rat   979 AAVAAPATEAPQAKQEAPSTKGLDPEPTQPGTVKNPTEAATAPA 1022

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kirre	NP_001245505.1	Ig	87..183	CDD:299845	26/107 (24%)
		IG_like	88..182	CDD:214653	26/106 (25%)
		C2-set_2	189..279	CDD:285423	16/91 (18%)
		Ig_2	307..379	CDD:290606	19/82 (23%)
		I-set	382..462	CDD:254352	24/104 (23%)
		IGc2	396..446	CDD:197706	19/74 (26%)
		Ig	466..561	CDD:299845	27/94 (29%)
		IG_like	478..561	CDD:214653	26/82 (32%)
Ncam1	XP_038936733.1	IgI_1_NCAM-1	20..116	CDD:409451	21/96 (22%)
		Ig strand B	37..41	CDD:409451	1/3 (33%)
		Ig strand C	51..55	CDD:409451	1/3 (33%)
		Ig strand E	79..83	CDD:409451	1/4 (25%)
		Ig strand F	93..98	CDD:409451	2/4 (50%)
		Ig strand G	107..110	CDD:409451	1/2 (50%)
		IG_like	124..190	CDD:214653	15/82 (18%)
		Ig strand B	135..139	CDD:409353	1/3 (33%)
		Ig strand C	148..152	CDD:409353	1/3 (33%)
		Ig strand E	172..176	CDD:409353	1/3 (33%)
		Ig strand F	186..191	CDD:409353	2/4 (50%)
		IgI_3_NCAM-1	211..308	CDD:143207	22/103 (21%)
		Ig strand B	231..235	CDD:143207	2/3 (67%)
		Ig strand C	244..248	CDD:143207	0/3 (0%)
		Ig strand E	271..275	CDD:143207	0/3 (0%)
		Ig strand F	285..290	CDD:143207	1/4 (25%)
		Ig strand G	298..301	CDD:143207	0/2 (0%)
		IgI_NCAM-1	307..413	CDD:143277	24/106 (23%)
		Ig strand B	326..330	CDD:143277	1/3 (33%)
		Ig strand C	339..343	CDD:143277	1/3 (33%)
		Ig strand E	379..383	CDD:143277	2/3 (67%)
		Ig strand F	393..398	CDD:143277	2/4 (50%)
		Ig strand G	406..409	CDD:143277	0/2 (0%)
		Ig_3	422..494	CDD:404760	22/78 (28%)
		Ig strand B	433..437	CDD:409353	2/3 (67%)
		Ig strand C	446..450	CDD:409353	1/4 (25%)
		Ig strand E	473..477	CDD:409353	1/3 (33%)
		Ig strand F	487..492	CDD:409353	3/4 (75%)
		FN3	509..606	CDD:238020	20/126 (16%)
		fn3	619..701	CDD:394996	22/92 (24%)
		Herpes_BLLF1	<842..1133	CDD:282904	41/182 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810