DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kirre and Sdk2

DIOPT Version :9

Sequence 1:	NP_001245505.1	Gene:	kirre / 31292	FlyBaseID:	FBgn0028369	Length:	956	Species:	Drosophila melanogaster
Sequence 2:	NP_766388.2	Gene:	Sdk2 / 237979	MGIID:	2443847	Length:	2176	Species:	Mus musculus

Alignment Length:	1021	Identity:	202/1021 - (19%)
Similarity:	312/1021 - (30%)	Gaps:	357/1021 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 ASSANDESKPKGGDNGGQHFAMEP-QDQTAVVGSRVTLPCRVMEKVGALQWTKDDFGLGQHRNLS 128
            ::.|.|:..|        :|..|| :.|..:.|:|:.|.|     :....|..:...|..:|.|:
Mouse    21 SAGAQDDVPP--------YFKTEPVRTQVHLEGNRLVLTC-----MAEGSWPLEFKWLHNNRELT 72

  Fly   129 GFE---RYSMVGSDE-EGDFSLDIYPLMLDDDAKYQCQVGPGPQGEQGIRSRFAKLTVLVPPEAP 189
            .|.   ||.:...|. ...|              |:|.|          |:|...|.     :..
Mouse    73 RFSLEYRYMITSLDRTHAGF--------------YRCIV----------RNRMGALL-----QRQ 108

  Fly   190 KITQGDYLVTTEDREIELECVSQG-----------GKPAAEITWI-DGLGNVLTKGIEYVKEPLA 242
            ...|..|:.:.|:.| :.:.|:.|           ..|..::||. ||.           |.|.:
Mouse   109 TEVQVAYMGSFEEGE-KRQSVNHGEAAVIRAPRISSFPRPQVTWFRDGR-----------KIPPS 161

  Fly   243 DSRRITARSILKLAPKKEHHNTTFTCQA---QNTADRTYRSAKLLLE------VKYAPKVIV--- 295
            ....||..:.|.:..........:..||   :|..::|.:...|.:|      ...||.:|:
Mouse   162 SRIAITLENTLVILSTVAPDAGRYYVQAVNDKNGDNKTSQPITLAVENVGGPADPIAPTIIIPPK 226

  Fly   296 --SVVGGALAGGKIPEGAEVILSCQADANP-HELSYRWFIND-ELMTG--DFTTKMIIHNVSRQY 354
              |||.|.         :||.:.|.|:|.| .:|...|..:. .|.:|  |:..::.|.|.:  .
Mouse   227 NTSVVAGT---------SEVTMECVANARPLIKLHIVWKKDGAPLSSGISDYNRRLTIANPT--V 280

  Fly   355 HDA-IVKCEVV---NAVGKSEQSKKLDISFGPVFRQRPV-SVEADLGATVSMRCDVAGNPEPEIE 414
            .|| ..:||.:   ::|....:...|.:...|.|.:.|. .:.|::...|.:.|...|.|.|.|.
Mouse   281 SDAGYYECEAMLRSSSVAPVTRGAYLSVLEPPQFVREPERHITAEMEKVVDIPCRAKGVPPPSIT 345

  Fly   415 WISENSDQVVGVAAELK------LKVSS---ETAGRYFCKAVVNGFPEIGAEATLYV---KRAPI 467
            |..:.:...||.....|      |::|.   :..|...|.| .|...|  |:.:.|:   ..||.
Mouse   346 WYKDAALVEVGKLTRFKQRSDGGLQISGLLPDDTGMLQCFA-HNAAGE--AQTSTYLAVTSIAPN 407

  Fly   468 ITSHKVQFGGVGG-RVKIDCLAFSIPKAEHILWSFEGKIINMSSAD-PDIYIFEEHHLPEGVRAA 530
            ||...:....:.| .|.:.|.....|:.. |.|....:|:...|.. |...:.|.        .:
Mouse   408 ITRGPLDSTVIDGMSVVLACETSGAPRPA-ITWQKGERILASGSVQLPRFTLLES--------GS 463

  Fly   531 LIIRDSKATHFGKYNCTVMNSYGGDSLVITLLREPGNIPVLLVVMGSMFCVAIILMIVMIIIVYR 595
            |:|..:..:..|.|.|...||.|.|.....|                              :|:.
Mouse   464 LLISPTHISDAGTYTCLATNSRGVDEASADL------------------------------VVWA 498

  Fly   596 KRRSRKKPMPADVI--PEASRGGDKLNELKSELRSKAYDVEYSEAGGDGLAINLTQSPMPDV--- 655
            :.|..|.|....||  .:||                             :...:|..|...|
Mouse   499 RTRITKPPQDQSVIKGTQAS-----------------------------MVCGVTHDPRVTVRYV 534

  Fly   656 -QMKGATLGVPLAGPVKFD--------ERFSGDF-----------GGDRYNRQCHIKNLKNQQET 700
             :..||||.|.....::.|        :.:|||.           |.|..|....::.|.:..|
Mouse   535 WEKDGATLAVETNPRIRLDRNGSLHISQTWSGDIGTYTCRVLSAGGNDSRNAHLRVRQLPHAPE- 598

  Fly   701 AYKGSPQA------------------NGYAHYFEYALDYSPPGG-----------EGAAVVVGSG 736
                .|.|                  :|.:....|.|:.|....           |..:|:|
Mouse   599 ----HPVATLSTVERRAINLTWAKPFDGNSPLMRYVLEMSENNAPWTILLASVDPEATSVMV--- 656

  Fly   737 GVGKLKNGGMNSATLPHSAAATVNGGGAG----NGGGASLPRNQRHEIQQSQQSNGFLGQPLLQN 797
                   .|:..|.........||..|.|    :....|||........|:..::|
Mouse   657 -------KGLVPARSYQFRLCAVNDVGKGQFSKDTERVSLPEEPPTAPPQNVIASG--------- 705

  Fly   798 GIDSRFSAIYGNPYLRTNSSLLPPLPPPSTANPAATPAPPPYHAARHGHAHHANGGLKHFVGGAV 862
                           |||.|::....||..:                    |.||.||.::....
Mouse   706 ---------------RTNQSIMIQWQPPPES--------------------HQNGILKGYIIRYC 735

  Fly   863 ITTSPVG---------NVN----------INGGGGGGSTPSGGGGV-----------GVGVAAGG 897
            :...|||         :||          .|......:..|.|.||           ||.....|
Mouse   736 LAGLPVGYQFKNITDADVNNLLLEDLIIWTNYEIEVAAYNSAGLGVYSSKVTEWTLQGVPTVPPG 800

  Fly   898 SVSGSSSNLTASSNTLAATPLAGGGVGNSGQCAQSPSGQFILSNNG 943
            :|...::|.|....|..|                 ||.|||   ||
Mouse   801 NVHAEATNSTTIRFTWNA-----------------PSPQFI---NG 826

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kirre	NP_001245505.1	Ig	87..183	CDD:299845	22/100 (22%)
		IG_like	88..182	CDD:214653	21/98 (21%)
		C2-set_2	189..279	CDD:285423	20/104 (19%)
		Ig_2	307..379	CDD:290606	19/79 (24%)
		I-set	382..462	CDD:254352	22/89 (25%)
		IGc2	396..446	CDD:197706	14/58 (24%)
		Ig	466..561	CDD:299845	22/96 (23%)
		IG_like	478..561	CDD:214653	19/84 (23%)
Sdk2	NP_766388.2	IG_like	44..113	CDD:214653	19/102 (19%)
		IGc2	44..102	CDD:197706	18/86 (21%)
		IG_like	124..207	CDD:214653	17/93 (18%)
		Ig	136..192	CDD:299845	12/66 (18%)
		IG_like	226..308	CDD:214653	23/92 (25%)
		IGc2	237..290	CDD:197706	15/54 (28%)
		I-set	312..401	CDD:254352	23/91 (25%)
		Ig	330..398	CDD:143165	18/70 (26%)
		I-set	406..496	CDD:254352	23/128 (18%)
		Ig	420..496	CDD:299845	20/114 (18%)
		Ig	506..590	CDD:299845	20/112 (18%)
		IG_like	506..590	CDD:214653	20/112 (18%)
		FN3	594..685	CDD:238020	16/105 (15%)
		FN3	697..790	CDD:238020	23/136 (17%)
		FN3	798..894	CDD:238020	13/49 (27%)
		FN3	899..987	CDD:238020
		FN3	997..1091	CDD:238020
		FN3	1103..1198	CDD:238020
		FN3	1205..1294	CDD:238020
		FN3	1305..1398	CDD:238020
		FN3	1404..1488	CDD:238020
		FN3	1507..1620	CDD:238020
		FN3	1630..1723	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1712..1734
		FN3	1728..1809	CDD:238020
		FN3	1841..1920	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2013..2032
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2043..2070
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2102..2176
		PDZ-binding. /evidence=ECO:0000269\|PubMed:20219992	2170..2176
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900