DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kirre and rig-3

DIOPT Version :9

Sequence 1:	NP_001245505.1	Gene:	kirre / 31292	FlyBaseID:	FBgn0028369	Length:	956	Species:	Drosophila melanogaster
Sequence 2:	NP_509155.1	Gene:	rig-3 / 180958	WormBaseID:	WBGene00004370	Length:	487	Species:	Caenorhabditis elegans

Alignment Length:	484	Identity:	97/484 - (20%)
Similarity:	159/484 - (32%)	Gaps:	139/484 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   307 IPEGAEVILSC--QADANPHELSYRW-------------------FINDELMTGDFTTKMIIHNV 350
            :.||.::::||  ::|...|:....|                   .:|::   |....|..:|..
Worm    51 VREGKKLMVSCVFESDEQIHKSDLLWKQANGNNIDGESNPSLFSVILNEK---GSKHRKTSLHFS 112

  Fly   351 SRQYHD-AIVKCEVVNAVGKS-EQSKKLDISFGPVFRQRPVSVEADLGATVSMRCDVA------- 406
            |....| .:..|....|.|:: |::.||.:.....:..:.....|.||..:::.|.|.
Worm   113 SVHTRDTGLYTCTGRTAGGENFEKTIKLVVLPAIEWNDKDTVKGALLGEPITIDCGVKGPSGKEP 177

  Fly   407 ------GNPEP---EIEWISENSDQVVGVAAE--------LKLKVSSETAGRYFCKAVVNGFPEI 454
                  ||.||   ||..|:.|...:..:..|        :.:::..||:...|  .||:
Worm   178 MIQMTNGNGEPLDEEIWTIAGNEATIDSLKKEHAELTVSCITIEMHQETSKEEF--PVVD----- 235

  Fly   455 GAEATLYVKRAP-IITSHKVQFGGVGGRVK---IDC-LAFSIPKAEHILWSFEGKIINMSSADPD 514
            ..:..:.|...| ..|...||:..:...|:   |.| :..|.|...|..:....:.|.||.   .
Worm   236 RKDVNIEVYTLPEFETEESVQYTVIDNHVRDAIIYCNVTHSFPPVRHYTFYHGDEEIKMSD---K 297

  Fly   515 IYIFEEHHLPEGVRAALIIRDSKATHFGKYNCTVMNSYGGDSLVITLLREPGNIPVLLVVMGSMF 579
            ..||....:.:|  |.|.|.:......|.|.|                 |..||...
Worm   298 FNIFVNVGVSQG--AHLKIHNVNENDLGTYKC-----------------EANNIKAK-------- 335

  Fly   580 CVAIILMIVMIIIVYRKRRSRKKPMPADVIPEASRGGDKLNELKSELRSKAYDVEYSEAGGDGLA 644
                         .|.....|:...||:         .|:..::.:..|..:.||..:...|
Worm   336 -------------SYHTIHLREANAPAE---------PKVTLIEDKRHSIIWKVESIDRDPD--- 375

  Fly   645 INLTQSPMPDVQMKGATLGVPLAGPVKFDERFSGDFGGDRYNRQCHI---KNLKNQQETAYKGSP 706
                 .||..|:::....|...|..|. ||..|     |.|.:...|   :|:|:.      |..
Worm   376 -----LPMTAVEIRHLRAGTAEASGVS-DEDIS-----DAYWKSHSIFMQRNIKDD------GIY 423

  Fly   707 QANGYAHYFEYALDYSP--PGGEGAAVVV 733
            :.||..|..||...:..  ..|.|.:||:
Worm   424 EINGLRHGHEYVWRFRQINEAGFGDSVVL 452

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kirre	NP_001245505.1	Ig	87..183	CDD:299845
		IG_like	88..182	CDD:214653
		C2-set_2	189..279	CDD:285423
		Ig_2	307..379	CDD:290606	19/94 (20%)
		I-set	382..462	CDD:254352	19/103 (18%)
		IGc2	396..446	CDD:197706	15/73 (21%)
		Ig	466..561	CDD:299845	22/99 (22%)
		IG_like	478..561	CDD:214653	18/86 (21%)
rig-3	NP_509155.1	IG_like	48..142	CDD:214653	19/93 (20%)
rig-3	NP_509155.1	Ig	267..341	CDD:319273	21/116 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900