DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kirre and Opcml

DIOPT Version :9

Sequence 1:	NP_001245505.1	Gene:	kirre / 31292	FlyBaseID:	FBgn0028369	Length:	956	Species:	Drosophila melanogaster
Sequence 2:	XP_017450901.1	Gene:	Opcml / 116597	RGDID:	620635	Length:	354	Species:	Rattus norvegicus

Alignment Length:	417	Identity:	92/417 - (22%)
Similarity:	145/417 - (34%)	Gaps:	123/417 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LVLP---LILVLILTLLLQPIAVHAKSKKNKSSQSSHHGDSSSSSSSSSSSSGSSSAAASSANDE 71
            |.||   |::|.:..|.|.|..|..:|                                   .|.
  Rat     7 LFLPWKCLVVVSLRLLFLVPTGVPVRS-----------------------------------GDA 36

  Fly    72 SKPKGGDNGGQHFAMEPQDQTAVVGSRVTLPCRVMEKVGALQWTKDDFGLGQHRNLSGFERYS-- 134
            :.||..||           .|...|...||.|.:.::|..:.|......|     .:|.:::|
  Rat    37 TFPKAMDN-----------VTVRQGESATLRCTIDDRVTRVAWLNRSTIL-----YAGNDKWSID 85

  Fly   135 -----MVGSDEEGDFSLDIYPLMLDDDAKYQCQVGPGPQGEQGIRSRFAKLTVLVPPEAPKITQG 194
                 :|.:..:  :|:.|..:.:.|:..|.|.|    |.:...::....|.|.|||:...|:..
  Rat    86 PRVIILVNTPTQ--YSIMIQNVDVYDEGPYTCSV----QTDNHPKTSRVHLIVQVPPQIMNISSD 144

  Fly   195 DYLVTTEDREIELECVSQGGKPAAEITW-----IDGLGNVLTKGIEYVKEPLADSRRITARSILK 254
              :...|...:.|.|::. |:|...:||     .:|.|        :|.|.          ..|:
  Rat   145 --ITVNEGSSVTLLCLAI-GRPEPTVTWRHLSVKEGQG--------FVSED----------EYLE 188

  Fly   255 LAPKKEHHNTTFTCQAQN-TADRTYRSAKLLLEVKYAPKVIVSVVGGALAGGKIPEGAEVILSCQ 318
            ::..|...:..:.|.|.| .|....|..|  :.|.|.|.:..:...|...|.|      .||||:
  Rat   189 ISDIKRDQSGEYECSALNDVAAPDVRKVK--ITVNYPPYISKAKNTGVSVGQK------GILSCE 245

  Fly   319 ADANPHELSYRWFIND-ELMTG---------DFTTKMIIHNVSRQYHDAIVKCEVVNAVGKSEQS 373
            |.|.| ...::||..| .|.||         ...:.:...|||.:.:.... |...|.:|.:..|
  Rat   246 ASAVP-MAEFQWFKEDTRLATGLDGVRIENKGRISTLTFFNVSEKDYGNYT-CVATNKLGNTNAS 308

  Fly   374 KKL-DISFGPVFRQRPVSVEADLGATV 399
            ..| :||        |.|..|..||.:
  Rat   309 ITLYEIS--------PSSAVAGPGAVI 327

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kirre	NP_001245505.1	Ig	87..183	CDD:299845	19/102 (19%)
		IG_like	88..182	CDD:214653	19/100 (19%)
		C2-set_2	189..279	CDD:285423	18/95 (19%)
		Ig_2	307..379	CDD:290606	21/82 (26%)
		I-set	382..462	CDD:254352	5/18 (28%)
		IGc2	396..446	CDD:197706	2/4 (50%)
		Ig	466..561	CDD:299845
		IG_like	478..561	CDD:214653
Opcml	XP_017450901.1	Ig	44..132	CDD:416386	20/109 (18%)
		Ig strand A'	44..49	CDD:409353	2/15 (13%)
		Ig strand B	51..59	CDD:409353	3/7 (43%)
		CDR1	59..63	CDD:409353	0/3 (0%)
		FR2	64..70	CDD:409353	1/5 (20%)
		Ig strand C	64..70	CDD:409353	1/5 (20%)
		CDR2	71..83	CDD:409353	2/16 (13%)
		Ig strand C'	72..76	CDD:409353	1/8 (13%)
		Ig strand C'	80..83	CDD:409353	0/2 (0%)
		FR3	84..118	CDD:409353	7/39 (18%)
		Ig strand D	87..94	CDD:409353	1/6 (17%)
		Ig strand E	97..103	CDD:409353	1/7 (14%)
		Ig strand F	110..118	CDD:409353	3/11 (27%)
		CDR3	119..123	CDD:409353	0/3 (0%)
		Ig strand G	123..132	CDD:409353	1/8 (13%)
		FR4	125..132	CDD:409353	1/6 (17%)
		Ig_3	135..206	CDD:404760	18/91 (20%)
		Ig strand A	135..138	CDD:409353	2/2 (100%)
		Ig strand A'	144..148	CDD:409353	0/5 (0%)
		Ig strand B	151..160	CDD:409353	2/8 (25%)
		Ig strand C	165..170	CDD:409353	1/4 (25%)
		Ig strand C'	171..174	CDD:409353	0/2 (0%)
		Ig strand F	198..206	CDD:409353	2/7 (29%)
		Ig_3	223..300	CDD:404760	21/84 (25%)
		putative Ig strand A	224..230	CDD:409353	1/5 (20%)
		Ig strand B	240..244	CDD:409353	2/3 (67%)
		Ig strand C	253..257	CDD:409353	0/3 (0%)
		Ig strand E	279..283	CDD:409353	0/3 (0%)
		Ig strand F	293..298	CDD:409353	1/5 (20%)
		Ig strand G	306..309	CDD:409353	0/2 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900