DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kirre and kirrel1

DIOPT Version :9

Sequence 1:	NP_001245505.1	Gene:	kirre / 31292	FlyBaseID:	FBgn0028369	Length:	956	Species:	Drosophila melanogaster
Sequence 2:	XP_012808656.1	Gene:	kirrel1 / 100489692	XenbaseID:	XB-GENE-483274	Length:	754	Species:	Xenopus tropicalis

Alignment Length:	829	Identity:	229/829 - (27%)
Similarity:	335/829 - (40%)	Gaps:	169/829 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 FAMEPQDQTAVVGSRVTLPCRVMEKVGALQWTKDDFGLGQHRNLSGFERYSMVGSDEEGDFSLDI 148
            |..||.|||.|.|.:|.|.|.|:...|.:|||||...||..:||..:.||.:||:.|.|.::|:|
Frog    23 FIQEPTDQTVVAGQKVVLTCVVLNYSGIVQWTKDGLALGLGQNLRIWPRYQIVGNVESGQYNLEI 87

  Fly   149 YPLMLDDDAKYQCQVGPGPQGEQGIRSRFAKLTVLVPPEAPKITQGDYLVTTEDREIELECVSQG 213
            ....:.|||.::||.     .|..:||:.||||||:|||.|.|..|..::........|.|.:..
Frog    88 SNASIVDDANFECQA-----TEAALRSQKAKLTVLIPPEDPVIEGGPEILLRAGTPTNLTCRANS 147

  Fly   214 GKPAAEITWI-DG---LGNVLTKGIEYVKEPLADSRRITARSILKLAPKKEHHNTTFTCQAQNTA 274
            .||.|.|.|. ||   .|:|      |..|.|||.:|.|..|.|.::|..:.....|||:..|.|
Frog   148 AKPPASIVWFRDGNQQAGDV------YSTEVLADGKRATTVSYLLISPTDQDIGRVFTCRTSNEA 206

  Fly   275 DRTYRSAKLLLEVKYAPKVIVSVVGGALAGGKIPEGAEVILSCQADANPHELSYRW----FINDE 335
            ..:.:...:.|.|.:.|.|.:|:     ....:.||..|..:|.|.|||....|||    .|.:.
Frog   207 IPSGKETSVKLNVHHPPTVTLSI-----HPQTVQEGERVRFTCSATANPEIKGYRWAKGGMIIES 266

  Fly   336 LMTGDFTTKMIIHNVSRQYHDAIVKCEVVNAVGKSEQSKKLDISFGPVFRQRPVSVEADLGATVS 400
            .....:.|:     |...:....|.|||.|.||.:..|..:|:.|.|.....|.....|:|:.|:
Frog   267 ARDSSYETQ-----VDYSFFTEPVSCEVHNEVGSTNVSTLVDVQFAPRVVVEPKPTTTDMGSDVT 326

  Fly   401 MRCDVAGNPEPEIEWISENSDQVVGVAAELKLK-VSSETAGRYFCKAVVNGFPEIGA---EATLY 461
            :.|..||||...:.|..:.|:.|:....:|.|| |..|.||.|.|||:|   |.||.   |.||:
Frog   327 LTCIWAGNPPLTLTWTKKGSNMVLSNGNQLFLKSVKQEDAGPYVCKAIV---PRIGVGEREVTLF 388

  Fly   462 VKRAPIITSHKVQFGGVGGRVKIDCLAFSIPKAEHILWSFEGKIINMSSADPDIYIFEEHHLPEG 526
            |...|||.|.:||:...|.:.|::|...|.|..:.|.|:::..::...:.:.  |..|......|
Frog   389 VNGPPIIASEEVQYAARGDKGKVECFIGSTPPPDRIAWAWKENVLETGTLER--YTVERTTSTSG 451

  Fly   527 VRAALIIRDSKATHF-GKYNCTVMNSYGGDSLVITLLREPGNIPVLLVVMGSMFCVAIILMI--- 587
            |.:.|.|.:...:.| .:||||..||:|..:.:|.|| |...:|| .::.|:.....|:::|
Frog   452 VLSTLTINNVMESDFQTRYNCTAWNSFGPGTAIIQLL-EREVVPV-GIIAGATIGAGILVIIFFG 514

  Fly   588 VMIIIVYRKRRSRKKPMPADVIPEASRGGDKLNELKSELRSKAYDVEYSEAGGDGLAINLTQSPM 652
            ..|..:||:|:..:|    ||...      || ::|.|..::.....:|:...|..:::.....|
Frog   515 FFIFFLYRRRKGSRK----DVTLR------KL-DIKVETVNREPLTLHSDREEDTSSVSTATRVM 568

  Fly   653 PDVQMKGATLGVPLAGPVKFDERFSGDFGGDRYNRQCHIKNLKNQQETAYKGSPQANGYAHYFEY 717
            ..:.           ...|.|.....|...|..:|:            .|:.....|||  |...
Frog   569 KAIY-----------SSFKDDVDLKQDLRCDTIDRE------------EYELKDPTNGY--YNVR 608

  Fly   718 ALDYSPPGGEGAAVVVGSGGVGKLKNGGMNSATLPHSAAATVNGGGAGNGGGASLPRNQRHEIQQ 782
            |.|..|                                                   |.|..:.|
Frog   609 AHDDRP---------------------------------------------------NSRTVLYQ 622

  Fly   783 SQQSNG---FLGQPLLQNGIDSRFSAIYGNPYLRTNSSLLPP-----LPPPSTANPAAT------ 833
            ..::.|   |.|:|      .||.|  :.:.|.:.||....|     ..|.:|..||.|
Frog   623 DYRTTGATRFDGRP------SSRLS--HSSGYAQLNSFSRAPASDYSTDPTTTVTPATTDTTSQL 679

  Fly   834 -------------PAPPPYHAARHGHAHHANGGLKHFVGGAVITTSPVG 869
                         |:...|...|.|:......|:..   |...|..|||
Frog   680 SYDNYEKFGTHGFPSSSGYPTFRLGYTQPTTTGMDR---GPYDTYDPVG 725

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kirre	NP_001245505.1	Ig	87..183	CDD:299845	41/95 (43%)
		IG_like	88..182	CDD:214653	39/93 (42%)
		C2-set_2	189..279	CDD:285423	29/93 (31%)
		Ig_2	307..379	CDD:290606	23/75 (31%)
		I-set	382..462	CDD:254352	31/83 (37%)
		IGc2	396..446	CDD:197706	19/50 (38%)
		Ig	466..561	CDD:299845	28/95 (29%)
		IG_like	478..561	CDD:214653	22/83 (27%)
kirrel1	XP_012808656.1	I-set	21..116	CDD:254352	41/97 (42%)
		Ig	22..116	CDD:299845	41/97 (42%)
		I-set	123..219	CDD:254352	30/101 (30%)
		Ig	138..219	CDD:299845	27/86 (31%)
		I-set	223..304	CDD:254352	25/90 (28%)
		Ig_2	227..305	CDD:290606	24/87 (28%)
		I-set	308..389	CDD:254352	31/83 (37%)
		Ig_2	311..389	CDD:290606	30/80 (38%)
		Ig5_KIRREL3	391..487	CDD:143306	28/97 (29%)
		IG_like	399..487	CDD:214653	24/89 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	45	1.000	Domainoid score	I12004
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	261	1.000	Inparanoid score	I3020
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D141865at33208
OrthoFinder	1	1.000	-	-		FOG0001084
OrthoInspector	1	1.000	-	-		mtm9365
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1593
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.970